Article
Clinical Neurology
Chunrong Tao, Mengmeng Gu, Pengfei Xu, Jinjing Wang, Lulu Xiao, Wei Gui, Fengli Li, Shiyi Jiang, Xinfeng Liu, Wei Hu, Wen Sun
Summary: The study found a dose-response association between SLEs and PSF in patients with acute ischemic stroke, with a significant positive relationship between the number of SLEs and severity of fatigue. Furthermore, increased exposure to SLEs during follow-up was associated with a lower rate of fatigue decline, indicating a potential impact of SLEs on PSF over time.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miki Suemura, Shusaku Shibutani, Hiroyuki Iwata
Summary: Endocytosis plays a crucial role in cancer proliferation and metastasis. Recent studies have shown that endocytosis inhibitors can suppress cancer cell growth and migration. In this study, the endocytosis inhibitor dynasore was found to reduce cell viability and induce apoptosis in multiple cancer cell lines. Dynasore also activated the ATRChk1 DNA damage response and the apoptosis was sensitized by an ATR inhibitor. These findings suggest that endocytosis inhibitors may suppress DNA replication and their anti-cancer effects can be enhanced by DNA damage response inhibitors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Editorial Material
Microbiology
Charles S. Cockell
Summary: The author discusses environments devoid of actively metabolizing or reproducing life, which can serve as negative controls for understanding microbial processes in geochemical cycles. These environments also offer insights into the extent of biosphere expansion and the caution needed in interpreting life detection instrument results.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Clinical Neurology
Alfonso Martinisi, Martin Flach, Frederik Sprenger, Stephan Frank, Markus Tolnay, David T. Winkler
Summary: The study showed that toxic tau species causing neuronal dysfunction can be cleared without inducing seeding effects, suggesting an effective therapeutic intervention in tauopathies. Moreover, recovered mice did not develop more motor impairment or tau pathology in the long term compared to control groups.
Article
Computer Science, Artificial Intelligence
Thomas Weise, Zhize Wu, Xinlu Li, Yan Chen, Joerg Laessig
Summary: Fitness assignment process transforms the features of a candidate solution to a scalar fitness, which is used for selection. Frequency fitness assignment (FFA) assigns a fitness value based on the encounter frequency of the objective value during selection and aims to minimize it. FFA algorithms are unbiased and invariant under objective function value transformations, leading to improved performance in certain difficult problems.
IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION
(2023)
Article
Multidisciplinary Sciences
Sara Minarro, Victoria Reyes-Garcia, Shankar Aswani, Samiya Selim, Christopher P. Barrington-Leigh, Eric D. Galbraith
Summary: The study suggests that high levels of subjective well-being can be achieved with minimal monetization, even in very low-income communities, challenging the perception that economic growth will raise life satisfaction among low-income populations. As monetization levels increase, the drivers of happiness shift from enjoying experiential activities in contact with nature to social and economic factors.
Article
Surgery
Motokazu Sugimoto, Naoto Gotohda, Masashi Kudo, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi
Summary: This study aimed to evaluate the necessity of intraoperative drain placement (IDP) in laparoscopic liver resection (LLR). After comparing clinicopathological data and postoperative outcomes between patients with and without IDP, the study found that the incidence and severity of postoperative complications were similar in both groups, indicating that LLR can be safely performed without IDP.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Plant Sciences
Arejacy A. Silva, Mario Carvalho, Joao Coutinho, Ernesto Vasconcelos, David Fangueiro
Summary: This study aimed to evaluate the agronomic effects of new management strategies for using dairy slurry as fertilizer in conservation agriculture. The results showed that acidified dairy slurry performed similarly to traditional injection methods in terms of yield, nutrient recovery, and soil properties, making it a sustainable alternative to replace mineral fertilizer.
Article
Biochemistry & Molecular Biology
Ramya Ravindranathan, Kavya Raveendran, Frantzeskos Papanikos, Pedro A. San-Segundo, Attila Toth
Summary: The generation of haploid gametes relies on a modified version of homologous recombination in meiosis. Meiotic recombination is initiated by programmed DNA double-stranded breaks (DSBs) and involves chromosomal synapsis to enhance DSB repair. However, synapsis defects can lead to apoptosis in oocytes due to unresolved DSBs. Surprisingly, even in mutants lacking programmed DSBs, apoptosis and numerous RAD51 foci, indicative of unknown origin DSBs, were observed in SPO11-deficient oocytes. It was found that RAD51 is an unreliable marker for DSBs in oocytes, and SPO11-deficient oocytes have fewer persistent ssDNAs compared to wild-type oocytes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Engineering, Mechanical
Jude Shalitha Perera, Nelson Lam
Summary: In hilly urban areas, reinforced concrete barriers with a layer of gabions are commonly used for hillslope protection. The gabions provide additional protection by avoiding localized failure caused by direct contact with fallen boulders, while also acting as a cushion to reduce momentum transfer and bending of the barrier wall. This study presents a new design procedure that considers the cushioning mechanism of gabions in multiple strike scenarios.
INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Reem Ali, Mustapha Aouida, Abdallah Alhaj Sulaiman, Srinivasan Madhusudan, Dindial Ramotar
Summary: Cisplatin is one of the oldest chemotherapeutic agents and has been used to treat various types of cancer. However, tumor cells often develop resistance mechanisms, limiting the effectiveness of cisplatin treatment. Extensive molecular and genetic profiling of patients is needed to identify individuals who can benefit from cisplatin therapy, and combining it with targeted therapies may improve treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Hongki Song, William T. Wickner, Adam Linstedt
Summary: The yeast vacuolar membrane fusion process can be achieved using a synthetic tether instead of the HOPS complex. This suggests that Sec17 and Sec18 play a crucial role in membrane fusion and may have a general role in promoting fusion across different cellular processes.
Article
Clinical Neurology
Joshua Chiappelli, Mark Kvarta, Heather Bruce, Shuo Chen, Peter Kochunov, L. Elliot Hong
Summary: This study found a significant association between stressful life events and openness to experience, with participants with a history of depression exhibiting higher levels of openness. Furthermore, openness to experience was related to overall intelligence but not processing speed or working memory. The findings suggest that openness to experience may partially mediate the relationship between stressful life events and depression in rural populations with high social and environmental homogeneity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Angelo Azzi
Summary: This article evaluates the meaning, appropriate usage, and misusage of the terms oxidative stress, oxidative eustress, and oxidative distress. It reveals that oxidative stress and oxidative damage are often incorrectly used as synonyms. The term eustress, intended to signify good stress, is also found unsuitable for indicating signaling by reactive molecules that can have variable effects. The defined oxidative distress is identified as oxidative damage rather than oxidative stress. Additionally, damaging oxidations and signaling oxidant events, both positive and negative, can coexist in different locations within a cell, tissue, or body. The measurement of oxidant events in body fluids or tissue samples can only reflect the combined effects of non-separable events, sometimes with opposite effects. Officially approved therapies to prevent or cure oxidative stress or oxidative damage are currently lacking.
Article
Environmental Sciences
Roberto-Carlos Ramirez-Diaz, Dorian Prato-Garcia
Summary: Life cycle assessment and kinetic modeling were used to analyze the impact of thermal intensification on the Fenton process. Results showed that increasing temperature could significantly reduce treatment time and electricity use. However, beyond a certain temperature, energy use and emissions did not decrease further. The environmental footprint of the process is mainly influenced by energy use and operating pH, while utilizing energy from wastewater can lower global warming potential.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Cell Biology
Valenti Gomez, Ramazan Gundogdu, Marta Gomez, Lily Hoa, Neelam Panchal, Mark O'Driscoll, Alexander Hergovich
CELLULAR SIGNALLING
(2015)
Article
Genetics & Heredity
Nataliya Di Donato, Andreas Rump, Ghayda M. Mirzaa, Diana Alcantara, Antony Oliver, Evelin Schrock, William B. Dobyns, Mark O'Driscoll
Article
Genetics & Heredity
James T. Bennett, Tiong Yang Tan, Diana Alcantara, Martine Tetrault, Andrew E. Timms, Dana Jensen, Sarah Collins, Malgorzata J. M. Nowaczyk, Marjorie J. Lindhurst, Katherine M. Christensen, Stephen R. Braddock, Heather Brandling-Bennett, Raoul C. M. Hennekam, Brian Chung, Anna Lehman, John Su, SuYuen Ng, David J. Amor, Jacek Majewski, Les G. Biesecker, Kym M. Boycott, William B. Dobyns, Mark O'Driscoll, Ute Moog, Laura M. McDonell
AMERICAN JOURNAL OF HUMAN GENETICS
(2016)
Article
Biochemistry & Molecular Biology
Tom Stiff, Teresa Casar Tena, Mark O'Driscoll, Penny A. Jeggo, Melanie Philipp
HUMAN MOLECULAR GENETICS
(2016)
Article
Biochemistry & Molecular Biology
Iga Abramowicz, Gillian Carpenter, Mariaevelina Alfieri, Rita Colnaghi, Emily Outwin, Philippe Parent, Christel Thauvin-Robinet, Daniela Iaconis, Brunella Franco, Mark O'Driscoll
HUMAN MOLECULAR GENETICS
(2017)
Article
Oncology
Mark O'Driscoll
JOURNAL OF PATHOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Diana Alcantara, Frances Elmslie, Martine Tetreault, Eric Bareke, Taila Hartley, Jacek Majewski, Kym Boycott, A. Micheil Innes, David A. Dyment, Mark O'Driscoll
HUMAN MOLECULAR GENETICS
(2017)
Article
Genetics & Heredity
Ghayda M. Mirzaa, Benjamin Vitre, Gillian Carpenter, Iga Abramowicz, Joseph G. Gleeson, Alex R. Paciorkowski, Don W. Cleveland, William B. Dobyns, Mark O'Driscoll
Article
Genetics & Heredity
Ying Qiao, Kajari Mondal, Valentina Trapani, Jiadi Wen, Gillian Carpenter, Robert Wildin, E. Magda Price, Richard J. Gibbons, Jennifer Eichmeyer, Ruby Jiang, Barbara DuPont, Sally Martell, Suzanne M. E. Lewis, Wendy P. Robinson, Mark O'Driscoll, Federica I. Wolf, Michael E. Zwick, Evica Rajcan-Separovic
Article
Genetics & Heredity
Hilde Van Esch, Rita Colnaghi, Kathleen Freson, Petro Starokadomskyy, Andreas Zankl, Liesbeth Backx, Iga Abramowicz, Emily Outwin, Luis Rohena, Claire Faulkner, Gary M. Leong, Ruth A. Newbury-Ecob, Rachel C. Challis, Katrin Ounap, Jacques Jaeken, Eve Seuntjens, Koen Devriendt, Ezra Burstein, Karen J. Low, Mark O'Driscoll
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Genetics & Heredity
Yigit Karasozen, Joshua W. Osbun, Carolina Angelica Parada, Tina Busald, Philip Tatman, Luis F. Gonzalez-Cuyar, Christopher J. Hale, Diana Alcantara, Mark O'Driscoll, William B. Dobyns, Mitzi Murray, Louis J. Kim, Peter Byers, Michael O. Dorschner, Manuel Ferreira
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Clinical Neurology
Jo M. Vanoevelen, Jorgen Bierau, Janine C. Grashorn, Ellen Lambrichs, Erik-Jan Kamsteeg, Levinus A. Bok, Ron A. Wevers, Marjo S. van der Knaap, Marianna Bugiani, Junmei Hu Frisk, Rita Colnaghi, Mark O'Driscoll, Debby M. E. Hellebrekers, Richard Rodenburg, Carlos R. Ferreira, Han G. Brunner, Arthur van den Wijngaard, Ghada M. H. Abdel-Salam, Liya Wang, Constance T. R. M. Stumpel
Summary: The study reveals that impairing the biosynthesis of dTTP, a crucial DNA building block, leads to early-onset neurodegenerative disease characterized by severe microcephaly and growth retardation. Microcephaly, neuronal cell death, and early lethality were replicated in dtymk mutant zebrafish models. Furthermore, increased ribonucleotide incorporation in the genome and impaired responses to DNA damage were observed in these mutant zebrafish, providing novel insights into the pathophysiology of the disease. The loss-of-function of DTYMK was identified as the cause of this severe postnatal neurodegenerative disease, emphasizing the essential role of dTTP synthesis in maintaining genome stability and neuronal survival.
ACTA NEUROPATHOLOGICA
(2022)
Article
Allergy
Mathijs Willemsen, John S. Barber, Erika Van Nieuwenhove, Frederik Staels, Margaux Gerbaux, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Vasiliki Lagou, Nancy Boeckx, Jessica Filtjens, Amber De Visscher, Patrick Matthys, Rik Schrijvers, Thomas Tousseyn, Mark O'Driscoll, Giorgia Bucciol, Susan Schlenner, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston
Summary: This study reported a patient with severe congenital neutropenia and syndromic features, and a homozygous missense mutation in the DBF4 gene was identified using whole exome sequencing. This mutation caused defects in granulocyte differentiation and DNA replication, resulting in impaired immune system function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Clinical Neurology
Diana Alcantara, Andrew E. Timms, Karen Gripp, Laura Baker, Kaylee Park, Sarah Collins, Chi Cheng, Fiona Stewart, Sarju G. Mehta, Anand Saggar, Laszlo Sztriha, Melinda Zombor, Oana Caluseriu, Ronit Mesterman, Margot I. Van Allen, Adeline Jacquinet, Sofia Ygberg, Jonathan A. Bernstein, Aaron M. Wenger, Harendra Guturu, Gill Bejerano, Natalia Gomez-Ospina, Anna Lehman, Enrico Alfei, Chiara Pantaleoni, Valerio Conti, Renzo Guerrini, Ute Moog, John M. Graham, Robert Hevner, William B. Dobyns, Mark O'Driscoll, Ghayda M. Mirzaa
Article
Medicine, Research & Experimental
Hani Bagheri, Chansonette Badduke, Ying Qiao, Rita Colnaghi, Iga Abramowicz, Diana Alcantara, Christopher Dunham, Jiadi Wen, Robert S. Wildin, Malgorzata J. M. Nowaczyk, Jennifer Eichmeyer, Anna Lehman, Bruno Maranda, Sally Martell, Xianghong Shan, Suzanne M. E. Lewis, Mark O'Driscoll, Cheryl Y. Gregory-Evans, Evica Rajcan-Separovic
