Article
Multidisciplinary Sciences
Zu Ye, Shengfeng Xu, Yin Shi, Albino Bacolla, Aleem Syed, Davide Moiani, Chi-Lin Tsai, Qiang Shen, Guang Peng, Paul G. Leonard, Darin E. Jones, Bin Wang, John A. Tainer, Zamal Ahmed
Summary: In this study, GRB2 was found to play a crucial role in DNA double-strand break repair by forming a complex with MRE11 to promote efficient homology-directed repair initiation and releasing MRE11 through ubiquitination. Depletion of RBBP6 leads to prolonged HDR defects, highlighting GRB2's importance in the repair process.
Article
Biochemistry & Molecular Biology
Ya Wang, Yuanbing Yao, Qunhui Wei, Shichao Long, Yuqiao Chen, Jinru Xie, Rong Tan, Wei Jiang, Qian Zhang, Dongbo Wu, Shuai Xiao, Fengyi Wan, Kai Fu
Summary: TRIM24, an oncogene overexpressed in cancers, has been identified as a novel signaling molecule in response to DNA double-strand breaks (DSBs). It promotes the recruitment of the MRN complex and activation of downstream signaling. Depletion of TRIM24 enhances sensitivity to cancer therapy and inhibits tumor growth. This study highlights the potential of TRIM24 as a therapeutic target for tumor treatment.
Article
Biochemistry & Molecular Biology
Jozef Ba Tran, Michal Padjasek, Artur Krezel
Summary: The metal binding at protein-protein interfaces is still a field that has not been thoroughly studied. This study uses sequence-structure-stability analysis of human Rad50 protein to identify the structural components that increase the stability of the protein complex. The study also reveals that phosphorylation of the zinc hook domain weakens its stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Adel Alblihy, Ahmed Shoqafi, Michael S. Toss, Mashael Algethami, Anna E. Harris, Jennie N. Jeyapalan, Tarek Abdel-Fatah, Juliette Servante, Stephen Y. T. Chan, Andrew Green, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Summary: The MRN complex is critical for genomic stability and its low expression in breast cancer is associated with aggressive histopathological phenotypes and poor survival outcomes. Low nuclear RAD50 transcripts, as well as overexpression of hsa-miR-494 and hsa-miR-99b microRNAs, are correlated with adverse clinical outcomes, indicating that MRN status could be a useful tool for stratifying tumors for precision medicine strategies.
Article
Multidisciplinary Sciences
Kyungmin Kim, Thomas W. Kirby, Lalith Perera, Robert E. London
Summary: The study investigated the phosphopeptide binding characteristics of Nbs1 BRCT1/2 and identified structural homology with TopBP1 BRCT7/8 through molecular modeling. These features provide insight into the basis for interaction of SDT motifs with the BRCT1/2 domains and allowed identification of high and low affinity ligands.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ann-Kathrin Mehnert, Marco Prorocic, Annick Dujeancourt-Henry, Sebastian Hutchinson, Richard McCulloch, Lucy Glover
Summary: In Trypanosoma brucei, RAD50 and MRE11 are essential for RAD51-dependent homologous recombination and phosphorylation of histone H2A following a DNA double strand break. RAD50 suppresses DSB repair using short stretches of homology at a subtelomeric locus, while MRE11 directs DSB resection at the same locus. Loss of either MRE11 or RAD50 leads to increased diversity of expressed VSG variants following DSB repair, suggesting that MRN promotes stringent homologous recombination at subtelomeric loci and restrains antigenic variation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biology
Lucy Ghantous, Yael Volman, Ruth Hefez, Ori Wald, Esther Stern, Tomer Friehmann, Ayelet Chajut, Edwin Bremer, Michal Dranitzki Elhalel, Jacob Rachmilewitz
Summary: CD47 is upregulated following DNA damage, including irradiation, which depends on the key factor Mre11 in the DNA damage response pathway. CD47 is a cell surface ligand expressed on all nucleated cells and acts as an immune checkpoint protein to prevent phagocytosis. It is constitutively overexpressed in many tumors, but the underlying mechanism(s) for CD47 overexpression is unclear.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Aleksandar Zdravkovic, James M. Daley, Arijit Dutta, Tatsuya Niwa, Yasuto Murayama, Shuji Kanamaru, Kentaro Ito, Takahisa Maki, Bilge Argunhan, Masayuki Takahashi, Hideo Tsubouchi, Patrick Sung, Hiroshi Iwasaki
Summary: The Mre11-Rad50-Nbs1 complex is critical for repairing DNA double-strand breaks through homologous recombination, with its endonuclease activity being stimulated by Ctp1 phosphorylation. The recruitment of the highly conserved extreme C terminus of Ctp1 plays a pivotal role in the activation of the Mre11 endonuclease. This stimulatory mechanism appears to be generalizable to the human CtIP equivalent, suggesting an evolutionary conservation of this function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Yilun Sun, Eroica Soans, Margarita Mishina, Elena Petricci, Yves Pommier, Karin C. Nitiss, John L. Nitiss
Summary: This study investigated the covalent complexes between TOP2 protein and DNA using an optimized ICE assay. The results showed that the absence or inhibition of MRE11 resulted in elevated levels of TOP2 covalent complexes, while overexpression of MRE11 could remove TOP2 covalent complexes. In addition, inhibition of VCP/p97 led to increased levels of TOP2 covalent complexes and prevented the removal of TOP2 covalent complexes by MRE11 overexpression. These findings suggest the existence of multiple pathways for proteolytic processing of TOP2 prior to nucleolytic processing.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Nada Albarakati, Hanin Al-Ghamdi, Batla Al-Sowayan, Alaa Alshareeda
Summary: This study explores the biological and prognostic significance of RAD21, RAD50, and BARD1 mRNA levels in bladder cancer patients with low and high expression of ERBB2. The results indicate that increased expression levels of RAD21, RAD50, and BARD1 are associated with poor prognosis in ERBB2-low tumors. These findings provide potential prognostic markers, particularly in ERBB2-low bladder cancer cases.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Robert Gnugge, Giordan Reginato, Petr Cejka, Lorraine S. Symington
Summary: DNA double-strand breaks (DSBs) are cytotoxic genome lesions that must be accurately and efficiently repaired to maintain genome integrity. The Mre11-Rad50-Xrs2 (MRX) complex in yeast initiates nucleolytic processing of DSBs for repair by homologous recombination through 5'-terminated DSB end nicking. The study reveals that the Ku70-Ku80 complex directs DSB-proximal nicks and that repetitive MRX cleavage extends the length of resection tracts. The findings also show that local DNA sequence and chromatin features influence MRX activity.
Review
Biochemistry & Molecular Biology
Rashmi Panigrahi, J. N. Mark Glover
Summary: Genomic integrity is threatened by double-strand breaks, and understanding the structural principles of signaling proteins at the break site is crucial for anti-cancer therapy development. Despite challenges due to their complexity, recent advances in protein expression and cryo-EM have improved our understanding of these large multidomain proteins.
BIOCHEMICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Vera M. Kissling, Giordano Reginato, Eliana Bianco, Kristina Kasaciunaite, Janny Tilma, Gea Cereghetti, Natalie Schindler, Sung Sik Lee, Raphael Guerois, Brian Luke, Ralf Seidel, Petr Cejka, Matthias Peter
Summary: This study reveals the oligomerization mechanism of the Mre11-Rad50 complex and its functional significance in DNA damage repair. The results show that Rad50 mediates the oligomerization of the Mre11-Rad50 complex, and its mutations may be linked to hereditary cancer predisposition.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yael Volman, Ruth Hefetz, Eithan Galun, Jacob Rachmilewitz
Summary: Cells have evolved DNA damage response (DDR) strategies to combat DNA lesions. DDR relies on intranuclear protein networks and is also regulated by EGFR signaling pathways. The expression of Mig-6, a regulator of EGFR signaling, is reduced in damaged cells, leading to enhanced EGFR phosphorylation and downstream signaling. This phenomenon does not occur in cells deficient of Mre-11 or when treated with MRN inhibitor, mirin.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Mahtab Beikzadeh, Michael P. Latham
Summary: The Mre11-Rad50-Nbs1/Xrs2 protein complex is crucial in detecting and repairing DNA double strand breaks, but little is known about the transitions between different structural states. Solution state NMR spectroscopy and other biophysical techniques have provided important insights into the structures and dynamics associated with Mre11-Rad50 functions.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Oncology
Valentina Maggio, Veronica Canovas, Alex J. Felix, Valenti Gomez, Ines de Torres, Maria Eugenia Semidey, Juan Morote, Veronique Noe, Carlos J. Ciudad, Rosanna Paciucci
Article
Genetics & Heredity
Hilde Van Esch, Rita Colnaghi, Kathleen Freson, Petro Starokadomskyy, Andreas Zankl, Liesbeth Backx, Iga Abramowicz, Emily Outwin, Luis Rohena, Claire Faulkner, Gary M. Leong, Ruth A. Newbury-Ecob, Rachel C. Challis, Katrin Ounap, Jacques Jaeken, Eve Seuntjens, Koen Devriendt, Ezra Burstein, Karen J. Low, Mark O'Driscoll
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Genetics & Heredity
Yigit Karasozen, Joshua W. Osbun, Carolina Angelica Parada, Tina Busald, Philip Tatman, Luis F. Gonzalez-Cuyar, Christopher J. Hale, Diana Alcantara, Mark O'Driscoll, William B. Dobyns, Mitzi Murray, Louis J. Kim, Peter Byers, Michael O. Dorschner, Manuel Ferreira
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Review
Cell Biology
Ramazan Gundogdu, Alexander Hergovich
Review
Pharmacology & Pharmacy
Valenti Gomez, Rami Mustapha, Kenrick Ng, Tony Ng
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Can Ali Agca, Mahinur Kirici, Victor S. Nedzvetsky, Ramazan Gundogdu, Artem A. Tykhomyrov
CHEMISTRY & BIODIVERSITY
(2020)
Article
Biochemistry & Molecular Biology
Valenti Gomez, Thomas R. Eykyn, Rami Mustapha, Fabian Flores-Borja, Victoria Male, Paul R. Barber, Antonia Patsialou, Ryan Green, Fani Panagaki, Chun W. Li, Gilbert O. Fruhwirth, Susana Ros, Kevin M. Brindle, Tony Ng
Article
Biochemistry & Molecular Biology
Mehmet Kadir Erdogan, Ibrahim Halil Gecibesler, Yakup Yapar, Ramazan Gundogdu, Mahinur Kirici, Lutfi Behcet, Parham Taslimi
Summary: The study evaluated the antioxidant, enzyme inhibitory, and anticancer properties of endemic Saponaria prostrata subsp. anatolica. Results showed that the plant exhibited promising acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase inhibitory activities, as well as significant anticancer effects on breast and colorectal cancer cell lines.
BIOORGANIC CHEMISTRY
(2021)
Article
Toxicology
Abdullah Aslan, Seda Beyaz, Ozlem Gok, Muhammed Ismail Can, Gozde Parlak, Ibrahim Hanifi Ozercan, Ramazan Gundogdu
Summary: In this study, it was found that royal jelly can reduce lipid peroxidation and certain protein expression levels in heart tissue, while increasing the expression levels of some proteins, indicating its potential therapeutic effect on heart diseases.
TOXICOLOGY MECHANISMS AND METHODS
(2021)
Article
Clinical Neurology
Jo M. Vanoevelen, Jorgen Bierau, Janine C. Grashorn, Ellen Lambrichs, Erik-Jan Kamsteeg, Levinus A. Bok, Ron A. Wevers, Marjo S. van der Knaap, Marianna Bugiani, Junmei Hu Frisk, Rita Colnaghi, Mark O'Driscoll, Debby M. E. Hellebrekers, Richard Rodenburg, Carlos R. Ferreira, Han G. Brunner, Arthur van den Wijngaard, Ghada M. H. Abdel-Salam, Liya Wang, Constance T. R. M. Stumpel
Summary: The study reveals that impairing the biosynthesis of dTTP, a crucial DNA building block, leads to early-onset neurodegenerative disease characterized by severe microcephaly and growth retardation. Microcephaly, neuronal cell death, and early lethality were replicated in dtymk mutant zebrafish models. Furthermore, increased ribonucleotide incorporation in the genome and impaired responses to DNA damage were observed in these mutant zebrafish, providing novel insights into the pathophysiology of the disease. The loss-of-function of DTYMK was identified as the cause of this severe postnatal neurodegenerative disease, emphasizing the essential role of dTTP synthesis in maintaining genome stability and neuronal survival.
ACTA NEUROPATHOLOGICA
(2022)
Article
Cell Biology
Ramazan Gundogdu, M. Kadir Erdogan, Angeliki Ditsiou, Victoria Spanswick, Juan Jose Garcia-Gomez, John A. Hartley, Fumiko Esashi, Alexander Hergovich, Valenti Gomez
Summary: The study reveals that hMOB2 regulates double-strand break repair by homologous recombination, impacting the response of cancer cells to treatment. Loss of hMOB2 increases vulnerability of cancer cells to PARP inhibitors.
CELLULAR SIGNALLING
(2021)
Review
Biochemistry & Molecular Biology
Choon Ping Tan, Laura Sinigaglia, Valenti Gomez, Joanna Nicholls, Nagy A. Habib
Summary: RNA activation (RNAa) is a mechanism in which RNA oligos increase the transcription output of target genes, with small activating RNA (saRNA) representing a new class of therapeutic drugs to rescue downregulation of critical genes in diseases. MTL-CEBPA, a compound using CEBPA-51 saRNA to reverse downregulation in oncogenic processes, has entered clinical trials for hepatocellular carcinoma treatment, showing potential therapeutic effects.
Article
Anatomy & Morphology
Abdullah Aslan, Ozlem Gok, Seda Beyaz, Muhammed Ismail Can, Gozde Parlak, Ramazan Gundogdu, Ibrahim Hanifi Ozercan, Serpil Baspinar
Summary: The study found that royal jelly can reduce oxidative stress and inflammatory response caused by fluoride damage in rats. Royal jelly can decrease the degree of lung damage caused by fluoride and promote the repair and protection of lung tissue.
Article
Allergy
Mathijs Willemsen, John S. Barber, Erika Van Nieuwenhove, Frederik Staels, Margaux Gerbaux, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Vasiliki Lagou, Nancy Boeckx, Jessica Filtjens, Amber De Visscher, Patrick Matthys, Rik Schrijvers, Thomas Tousseyn, Mark O'Driscoll, Giorgia Bucciol, Susan Schlenner, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston
Summary: This study reported a patient with severe congenital neutropenia and syndromic features, and a homozygous missense mutation in the DBF4 gene was identified using whole exome sequencing. This mutation caused defects in granulocyte differentiation and DNA replication, resulting in impaired immune system function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)