How the ubiquitous GPCR receptor family selectively activates signalling pathways

Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation

(2018) Kjetil Wessel Andressen et al.   FASEB JOURNAL

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

(2018) Javier García-Nafría et al.   eLife

Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

(2018) Yanyong Kang et al.   NATURE

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

(2018) Christopher J. Draper-Joyce et al.   NATURE

Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go

(2018) Javier García-Nafría et al.   NATURE

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

(2017) G. Glenn Gregorio et al.   NATURE

A kinetic view of GPCR allostery and biased agonism

(2017) J Robert Lane et al.   Nature Chemical Biology

Discovery of new GPCR ligands to illuminate new biology

(2017) Bryan L Roth et al.   Nature Chemical Biology

Mechanistic insights into GPCR–G protein interactions

(2016) Jacob P Mahoney et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Heterotrimeric G-proteins: a short history

(2006) Graeme Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY