Aflatoxin and deconstruction of type I, iterative polyketide synthase function

Systematic Domain Swaps of Iterative, Nonreducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming

(2014) Adam G. Newman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-ribosomal Propeptide Precursor in Nocardicin A Biosynthesis Predicted from Adenylation Domain Specificity Dependent on the MbtH Family Protein NocI

(2013) Jeanne M. Davidsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach

(2013) Morten Thrane Nielsen et al.   PLoS One

Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis

(2013) Ahmed al Fahad et al.   Chemical Science

Demonstration of Starter Unit Interprotein Transfer from a Fatty Acid Synthase to a Multidomain, Nonreducing Polyketide Synthase

(2012) Jennifer Foulke-Abel et al.   CHEMBIOCHEM

Enzyme-Substrate Complementarity Governs Access to a Cationic Reaction Manifold in the P450BM3-Catalysed Oxidation of Cyclopropyl Fatty Acids

(2012) Max J. Cryle et al.   CHEMISTRY-A EUROPEAN JOURNAL

Interrogation of Global Active Site Occupancy of a Fungal Iterative Polyketide Synthase Reveals Strategies for Maintaining Biosynthetic Fidelity

(2012) Anna L. Vagstad et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis

(2010) Hui Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New insights into the formation of fungal aromatic polyketides

(2010) Jason M. Crawford et al.   NATURE REVIEWS MICROBIOLOGY

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

(2010) T. P. Korman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

(2009) Paul R. Ortiz de Montellano   CHEMICAL REVIEWS

The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry

(2009) Hui Hong et al.   FEBS Journal

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

(2009) Jason M. Crawford et al.   NATURE

Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical “Starter-Unit Effect”

(2008) Jason M. Crawford et al.   CHEMBIOCHEM

Deconstruction of Iterative Multidomain Polyketide Synthase Function

(2008) J. M. Crawford et al.   SCIENCE