Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

Development of a universal glycosyltransferase assay amenable to high-throughput formats

(2011) Hyun Soo Lee et al.   ANALYTICAL BIOCHEMISTRY

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Precision Polysaccharide Synthesis Catalyzed by Enzymes

(2011) Jun-ichi Kadokawa   CHEMICAL REVIEWS

Rational Design of an Aryl-C-Glycoside Catalyst from a Natural Product O-Glycosyltransferase

(2011) Johannes Härle et al.   CHEMISTRY & BIOLOGY

Warfarin Glycosylation Invokes a Switch from Anticoagulant to Anticancer Activity

(2011) Pauline Peltier-Pain et al.   ChemMedChem

A new perspective on the pharmacoeconomics of colchicine

(2011) Albert I. Wertheimer et al.   CURRENT MEDICAL RESEARCH AND OPINION

Glycosyltransferases as biocatalysts

(2011) Monica M Palcic   CURRENT OPINION IN CHEMICAL BIOLOGY

CysteineS-glycosylation, a new post-translational modification found in glycopeptide bacteriocins

(2011) Judith Stepper et al.   FEBS LETTERS

Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution

(2011) Rocco Moretti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

(2011) Yu-Chen Liu et al.   Nature Chemical Biology

Sublancin is not a lantibiotic but an S-linked glycopeptide

(2011) Trent J Oman et al.   Nature Chemical Biology

Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions

(2011) Richard W Gantt et al.   Nature Chemical Biology

Characterization of the TDP-d-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-d-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate

(2011) Madan K. Kharel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities

(2011) D. S. Palacios et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RecombinantE. coliPrototype Strains forin VivoGlycorandomization

(2010) Gavin J. Williams et al.   ACS Chemical Biology

Mechanistic Insight into Enzymatic Glycosyl Transfer with Retention of Configuration through Analysis of Glycomimetic Inhibitors

(2010) James C. Errey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Approaches to Glycobiology

(2010) Laura L. Kiessling et al.   Annual Review of Biochemistry

Engineered Biosynthesis of Gilvocarcin Analogues with Altered Deoxyhexopyranose Moieties

(2010) Micah D. Shepherd et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of a novel UDP-sugar pyrophosphorylase with a broad substrate specificity inTrypanosoma cruzi

(2010) Ting Yang et al.   BIOCHEMICAL JOURNAL

Practical Preparation ofD-Galactosyl-β1→4-L-rhamnose Employing the Combined Action of Phosphorylases

(2010) Masahiro NAKAJIMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials

(2010) Lesley A Smith et al.   BMC CANCER

Phosphorylase-catalyzed N-formyl-α-glucosaminylation of maltooligosaccharides

(2010) Satoshi Kawazoe et al.   CARBOHYDRATE RESEARCH

New approaches to enzymatic glycoside synthesis through directed evolution

(2010) Roman Kittl et al.   CARBOHYDRATE RESEARCH

Efficient synthesis of 6′-sialyllactose, 6,6′-disialyllactose, and 6′-KDO-lactose by metabolically engineered E. coli expressing a multifunctional sialyltransferase from the Photobacterium sp. JT-ISH-224

(2010) Sophie Drouillard et al.   CARBOHYDRATE RESEARCH

Efficient one-pot enzymatic synthesis of α-(1→4)-glucosidic disaccharides through a coupled reaction catalysed by Lactobacillus acidophilus NCFM maltose phosphorylase

(2010) Hiroyuki Nakai et al.   CARBOHYDRATE RESEARCH

Glycosyltransferases and their Assays

(2010) Gerd K. Wagner et al.   CHEMBIOCHEM

Enzymatic Thioxyloside Synthesis: Characterization of Thioglycoligase Variants Identified from A Site-Saturation Mutagenesis Library ofBacillus CirculansXylanase

(2010) Zachary Armstrong  et al.   CHEMBIOCHEM

O-Glycoligases, a new category of glycoside bond-forming mutant glycosidases, catalyse facile syntheses of isoprimeverosides

(2010) Young-Wan Kim et al.   CHEMICAL COMMUNICATIONS

Redesign of Polyene Macrolide Glycosylation: Engineered Biosynthesis of 19-(O)-Perosaminyl- Amphoteronolide B

(2010) Eve Hutchinson et al.   CHEMISTRY & BIOLOGY

Applications of synthetic carbohydrates to chemical biology

(2010) Bernd Lepenies et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

New structures, chemical functions, and inhibitors for glycosyltransferases

(2010) Rajarshi Roychoudhury et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Colchicine in clinical medicine. A guide for internists

(2010) Giuseppe Cocco et al.   European Journal of Internal Medicine

Discovery and design of carbohydrate-based therapeutics

(2010) Laura Cipolla et al.   Expert Opinion on Drug Discovery

Trapping and characterization of covalent intermediates of mutant retaining glycosyltransferases

(2010) Naoto Soya et al.   GLYCOBIOLOGY

Enzymatic synthesis of vancomycin derivatives using galactosyltransferase and sialyltransferase

(2010) Tae-Jin Oh et al.   JOURNAL OF ANTIBIOTICS

Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase from Leishmania major

(2010) Achim Dickmanns et al.   JOURNAL OF MOLECULAR BIOLOGY

Carbohydrate-Based Bioactive Compounds for Medicinal Chemistry Applications

(2010) L. Cipolla et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Natural glycoconjugates with antitumor activity

(2010) Barbara La Ferla et al.   NATURAL PRODUCT REPORTS

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase

(2010) Hiroyuki Nakai et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides

(2010) Anand Krishnan V. Iyer et al.   ACS Medicinal Chemistry Letters

Chemical Approaches To Perturb, Profile, and Perceive Glycans

(2009) Nicholas J. Agard et al.   ACCOUNTS OF CHEMICAL RESEARCH

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and characterization of hydroquinone fructoside using Leuconostoc mesenteroides levansucrase

(2009) Jin Kang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recent Developments in Glycoside Synthesis with Glycosynthases and Thioglycoligases

(2009) Bojana Rakić et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

(2009) Tom Juncker et al.   BIOCHEMICAL PHARMACOLOGY

Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives

(2009) Li Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins

(2009) Lutz Heide   BIOTECHNOLOGY ADVANCES

Enzymatic synthesis of alkyl glucosides using Leuconostoc mesenteroides dextransucrase

(2009) Young-Min Kim et al.   BIOTECHNOLOGY LETTERS

Improving the therapeutic index of anthracycline chemotherapy: Focus on liposomal doxorubicin (Myocet™)

(2009) R.C.F. Leonard et al.   BREAST

Synthesis of highly ordered cellulose II in vitro using cellodextrin phosphorylase

(2009) Masao Hiraishi et al.   CARBOHYDRATE RESEARCH

A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase

(2009) Li Cai et al.   CHEMICAL COMMUNICATIONS

Enzymatic synthesis of UDP-GlcNAc/UDP-GalNAc analogs using N-acetylglucosamine 1-phosphate uridyltransferase (GlmU)

(2009) Wanyi Guan et al.   CHEMICAL COMMUNICATIONS

Chimeric Glycosyltransferases for the Generation of Hybrid Glycopeptides

(2009) Andrew W. Truman et al.   CHEMISTRY & BIOLOGY

Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives

(2009) Carlos Olano et al.   CHEMISTRY & BIOLOGY

Doxorubicin: The Good, the Bad and the Ugly Effect

(2009) Cristina Carvalho et al.   CURRENT MEDICINAL CHEMISTRY

Enzymatic transglycosylation for glycoconjugate synthesis

(2009) Lai-Xi Wang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Indolocarbazole antitumour compounds by combinatorial biosynthesis

(2009) José A Salas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Update on carbohydrate-containing antibacterial agents

(2009) Georg Schitter et al.   Expert Opinion on Drug Discovery

Single amino acid mutations ofMedicagoglycosyltransferase UGT85H2 enhance activity and impart reversibility

(2009) Luzia V. Modolo et al.   FEBS LETTERS

Transglucosylation of caffeic acid by a recombinant sucrose phosphorylase in aqueous buffer and aqueous-supercritical CO2 media

(2009) Min Hye Shin et al.   FOOD CHEMISTRY

Modulation of Deoxysugar Transfer by the Elloramycin Glycosyltransferase ElmGT through Site-Directed Mutagenesis

(2009) A. Ramos et al.   JOURNAL OF BACTERIOLOGY

Identification of Galacturonic Acid-1-phosphate Kinase, a New Member of the GHMP Kinase Superfamily in Plants, and Comparison with Galactose-1-phosphate Kinase

(2009) Ting Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LeishmaniaUDP-sugar Pyrophosphorylase

(2009) Sebastian Damerow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cloning of Glucuronokinase from Arabidopsis thaliana, the Last Missing Enzyme of themyo-Inositol Oxygenase Pathway to Nucleotide Sugars

(2009) Anja Maria Pieslinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Glycosyltransferase UGT78G1 Reveal the Molecular Basis for Glycosylation and Deglycosylation of (Iso)flavonoids

(2009) Luzia V. Modolo et al.   JOURNAL OF MOLECULAR BIOLOGY

A survey of chemical methods for sugar-nucleotide synthesis

(2009) Gerd K. Wagner et al.   NATURAL PRODUCT REPORTS

Designer enzymes for glycosphingolipid synthesis by directed evolution

(2009) Susan M Hancock et al.   Nature Chemical Biology

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

(2009) Thomas J. Boltje et al.   Nature Chemistry

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of cellobiose from starch by the successive actions of two phosphorylases

(2009) Masayuki Suzuki et al.   New Biotechnology

Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides

(2009) Rahman M. Mizanur et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Remodeling bacterial polysaccharides by metabolic pathway engineering

(2009) W. Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives

(2009) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-throughput pH indicator assay for screening glycosyltransferase saturation mutagenesis libraries

(2008) Mattias Persson et al.   ANALYTICAL BIOCHEMISTRY

A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay

(2008) Rocco Moretti et al.   ANALYTICAL BIOCHEMISTRY

Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase

(2008) Richard W. Gantt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification

(2008) Christopher J. Thibodeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering Ribonucleoside Triphosphate Specificity in a Thymidylyltransferase†

(2008) David L. Jakeman et al.   BIOCHEMISTRY

Teaching old enzymes new tricks: engineering and evolution of glycosidases and glycosyl transferases for improved glycoside synthesisThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

(2008) Fathima Aidha Shaikh et al.   Biochemistry and Cell Biology

Glycosyltransferase-catalyzed synthesis of bioactive oligosaccharides

(2008) Carel A.G.M. Weijers et al.   BIOTECHNOLOGY ADVANCES

Expanding substrate specificity of GT-B fold glycosyltransferase via domain swapping and high-throughput screening

(2008) Sung-Hee Park et al.   BIOTECHNOLOGY AND BIOENGINEERING

The in vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI

(2008) Changsheng Zhang et al.   CHEMBIOCHEM

Glycosylation of Acyclic and Cyclic Aglycone Substrates by Macrolide Glycosyltransferase DesVII/DesVIII: Analysis and Implications

(2008) Svetlana A. Borisova et al.   CHEMBIOCHEM

Glycosylated Derivatives of Steffimycin: Insights into the Role of the Sugar Moieties for the Biological Activity

(2008) Carlos Olano et al.   CHEMBIOCHEM

Inactivation of the Ketoreductase gilU Gene of the Gilvocarcin Biosynthetic Gene Cluster Yields New Analogues with Partly Improved Biological Activity

(2008) Tao Liu et al.   CHEMBIOCHEM

Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

(2008) Silvia Marchesan et al.   CHEMICAL COMMUNICATIONS

Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides

(2008) Stephen A. Beaton et al.   CHEMICAL COMMUNICATIONS

A Universal Screening Assay for Glycosynthases: Directed Evolution of Glycosynthase XynB2(E335G) Suggests a General Path to Enhance Activity

(2008) Alon Ben-David et al.   CHEMISTRY & BIOLOGY

Optimizing Glycosyltransferase Specificity via “Hot Spot” Saturation Mutagenesis Presents a Catalyst for Novobiocin Glycorandomization

(2008) Gavin J. Williams et al.   CHEMISTRY & BIOLOGY

Biochemical and Structural Insights of the Early Glycosylation Steps in Calicheamicin Biosynthesis

(2008) Changsheng Zhang et al.   CHEMISTRY & BIOLOGY

The impact of enzyme engineering upon natural product glycodiversification

(2008) Gavin J Williams et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Biosynthesis and Genetic Engineering of Lipopeptide Antibiotics Related to Daptomycin

(2008) Richard Baltz   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Glycosyltransferases, Important Tools for Drug Design

(2008) Andriy Luzhetskyy et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Stereoselective Chemoenzymatic Synthesis of UDP-1,2-cis-furanoses from α,β-Furanosyl 1-Phosphates

(2008) Pauline Peltier et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Bidirectional N-acetylglucosamine transfer mediated by  -1,4-N-acetylglucosaminyltransferase III

(2008) T. Okada et al.   GLYCOBIOLOGY

A Bifunctional Enzyme with L-Fucokinase and GDP-L-fucose Pyrophosphorylase Activities Salvages Free L-Fucose inArabidopsis

(2008) Toshihisa Kotake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Delivery of Glycan-Based Paclitaxel Prodrugs to Cancer Cells via Glucose Transporters

(2008) Yih-Shyan Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity

(2008) Irfan Baig et al.   JOURNAL OF NATURAL PRODUCTS

In VitroCharacterization of the Enzymes Involved in TDP-d-Forosamine Biosynthesis in the Spinosyn Pathway ofSaccharopolysporaspinosa

(2008) Lin Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution

(2008) Gavin J Williams et al.   Nature Protocols

Engineered biosynthesis of hybrid macrolide polyketides containing d-angolosamine and d-mycaminose moieties

(2008) Ursula Schell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

EscherichiacoliGlucuronylsynthase:  An Engineered Enzyme for the Synthesis of β-Glucuronides

(2008) Shane M. Wilkinson et al.   ORGANIC LETTERS

Enhancing the Divergent Activities of Betulinic Acid via Neoglycosylation

(2008) Randal D. Goff et al.   ORGANIC LETTERS

The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades

(2008) Zhichuan Li et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Involvement of CD44, a molecule with a thousand faces, in cancer dissemination

(2008) David Naor et al.   SEMINARS IN CANCER BIOLOGY

Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells

(2008) Bryan P. Toole et al.   SEMINARS IN CANCER BIOLOGY

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry

Reversible Sialylation:  Synthesis of Cytidine 5‘-Monophospho-N-acetylneuraminic Acid from Cytidine 5‘-Monophosphate with α2,3-Sialyl O-Glycan-, Glycolipid-, and Macromolecule-Based Donors Yields Diverse Sialylated Products†

(2007) E. V. Chandrasekaran et al.   BIOCHEMISTRY

Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins

(2007) Joseph M. Langenhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates

(2007) Malcolm P. Huestis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enzyme-Catalyzed Synthesis of Furanosyl Nucleotides

(2007) Shannon C. Timmons et al.   ORGANIC LETTERS