Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice

(2015) Leonie Rouleau et al.   Contrast Media & Molecular Imaging

Measurement of Nanomaterials in Foods: Integrative Consideration of Challenges and Future Prospects

(2014) Christopher Szakal et al.   ACS Nano

High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology

(2014) Christa Watson et al.   ACS Nano

Methods to Evaluate Uptake of Engineered Nanomaterials by the Alimentary Tract

(2014) Heather Alger et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Measurement Methods to Detect, Characterize, and Quantify Engineered Nanomaterials in Foods

(2014) Gurmit Singh et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Engineered Nanoscale Food Ingredients: Evaluation of Current Knowledge on Material Characteristics Relevant to Uptake from the Gastrointestinal Tract

(2014) Rickey Y. Yada et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Measurement Methods for the Oral Uptake of Engineered Nanomaterials from Human Dietary Sources: Summary and Outlook

(2014) Christopher Szakal et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Measurement Methods to Evaluate Engineered Nanomaterial Release from Food Contact Materials

(2014) Gregory O. Noonan et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

ITS-NANO - Prioritising nanosafety research to develop a stakeholder driven intelligent testing strategy

(2014) Vicki Stone et al.   Particle and Fibre Toxicology

In Vitro Enhancement of Mouse T Helper 2 Cell Sensitization to Ovalbumin Allergen by Carbon Black Nanoparticles

(2014) David E. Lefebvre et al.   TOXICOLOGICAL SCIENCES

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model

(2014) Fransisca Leonard   ALTEX-Alternatives to Animal Experimentation

Estimating the effective density of engineered nanomaterials for in vitro dosimetry

(2014) Glen DeLoid et al.   Nature Communications

A Multi-Stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment

(2013) Andre E. Nel et al.   ACS Nano

In vitro and in vivo models for the study of oral delivery of nanoparticles

(2013) Jennifer M. Gamboa et al.   ADVANCED DRUG DELIVERY REVIEWS

More than two decades of Apc modeling in rodents

(2013) Maged Zeineldin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Minimal Intestinal Epithelial Cell Toxicity in Response to Short- and Long-Term Food-Relevant Inorganic Nanoparticle Exposure

(2013) Christie McCracken et al.   CHEMICAL RESEARCH IN TOXICOLOGY

An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles

(2013) Concetta Giovino et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The oral cavity as a biological barrier system: Design of an advanced buccal in vitro permeability model

(2013) Birgit J. Teubl et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development of cardiac safety translational tools for QT prolongation and torsade de pointes

(2013) Luis G Valerio et al.   Expert Opinion on Drug Metabolism & Toxicology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles

(2013) M.Gulrez Zariwala et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Improved Transport and Absorption through Gastrointestinal Tract by PEGylated Solid Lipid Nanoparticles

(2013) Hong Yuan et al.   MOLECULAR PHARMACEUTICS

Modulation of the pharmacokinetics of zinc oxide nanoparticles and their fates in vivo

(2013) Hee-Jeong Paek et al.   Nanoscale

Analytically monitored digestion of silver nanoparticles and their toxicity on human intestinal cells

(2013) Linda Böhmert et al.   Nanotoxicology

Design of Biorelevant Test Setups for the Prediction of Diclofenac In Vivo Features After Oral Administration

(2013) Marie Guhmann et al.   PHARMACEUTICAL RESEARCH

Changes in silver nanoparticles exposed to human synthetic stomach fluid: Effects of particle size and surface chemistry

(2013) Samuel K. Mwilu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Brief report: CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells

(2013) Adam D. Gracz et al.   STEM CELLS

In silico modeling to predict drug-induced phospholipidosis

(2013) Sydney S. Choi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Distribution, Elimination, and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-Day Oral Exposure

(2012) Meike van der Zande et al.   ACS Nano

Presence of Nano-Sized Silica during In Vitro Digestion of Foods Containing Silica as a Food Additive

(2012) Ruud Peters et al.   ACS Nano

Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma

(2012) Katherine S. Garman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Biomarkers intersect with the exposome

(2012) Stephen M. Rappaport   BIOMARKERS

Consensus hologram QSAR modeling for the prediction of human intestinal absorption

(2012) Tiago L. Moda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

(2012) Vikash Kumar Sinha et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

In vitro 3D human small intestinal villous model for drug permeability determination

(2012) Jiajie Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Defining new criteria for selection of cell-based intestinal models using publicly available databases

(2012) Jon Christensen et al.   BMC GENOMICS

The NutriChip project – translating technology into nutritional knowledge

(2012) Guy Vergères et al.   BRITISH JOURNAL OF NUTRITION

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

(2012) Helinor Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

Improving Oral Absorption Via Drug-Loaded Nanocarriers: Absorption Mechanisms, Intestinal Models and Rational Fabrication

(2012) Mohammad-Ali Shahbazi et al.   CURRENT DRUG METABOLISM

Animal Models of Carcinogenesis in Inflamed Colorectum: Potential Use in Chemoprevention Study

(2012) Takuji Tanaka   CURRENT DRUG TARGETS

Animal Models of Inflammatory Bowel Diseases: Illuminating the Pathogenesis of Colitis, Ileitis and Cancer

(2012) Markus F. Neurath   DIGESTIVE DISEASES

Tracing Bioavailability of ZnO Nanoparticles Using Stable Isotope Labeling

(2012) Fiona Larner et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Human small intestinal and colonic tissue mounted in the Ussing chamber as a tool for characterizing the intestinal absorption of drugs

(2012) Veronika Rozehnal et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

(2012) Volodymyr Tryndyak et al.   FASEB JOURNAL

Anti-inflammatory properties of fruit juices enriched with pine bark extract in an in vitro model of inflamed human intestinal epithelium: The effect of gastrointestinal digestion

(2012) Carmen Frontela-Saseta et al.   FOOD AND CHEMICAL TOXICOLOGY

Celiac Disease: An Immunological Jigsaw

(2012) Bertrand Meresse et al.   IMMUNITY

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Enhanced cell uptake of superparamagnetic iron oxide nanoparticles through direct chemisorption of FITC-Tat-PEG600-b-poly(glycerol monoacrylate)

(2012) Chenhong Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Prediction of the human oral bioavailability by using in vitro and in silico drug related parameters in a physiologically based absorption model

(2012) Paulo Paixão et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Drug delivery to inflamed colon by nanoparticles: Comparison of different strategies

(2012) Régis Coco et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exploring uptake mechanisms of oral nanomedicines using multimodal nonlinear optical microscopy

(2012) Natalie Laura Garrett et al.   Journal of Biophotonics

Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa—A first in vivo study in human patients

(2012) Carsten Schmidt et al.   JOURNAL OF CONTROLLED RELEASE

Validation of an In Vitro Digestive System for Studying Macronutrient Decomposition in Humans

(2012) Katrin A. Kopf-Bolanz et al.   JOURNAL OF NUTRITION

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Parallel Artificial Membrane Permeability Assay (PAMPA) - Is it Better than Caco-2 for Human Passive Permeability Prediction?

(2012) J. M. Reis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Erratum

(2012)   Nanomedicine

Behaviour of silver nanoparticles and silver ions in anin vitrohuman gastrointestinal digestion model

(2012) Agata P. Walczak et al.   Nanotoxicology

Interactions of engineered nanomaterials in physiological media and implications forin vitrodosimetry

(2012) Joel Cohen et al.   Nanotoxicology

Intestinal barrier function in health and gastrointestinal disease

(2012) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Reply to comment on Fisichella et al. (2012), “Intestinal toxicity evaluation of TiO2 degraded surface-treated nanoparticles: a combined physico-chemical and toxicogenomics approach in Caco-2 cells” by Faust et al.

(2012) Matthieu Fisichella et al.   Particle and Fibre Toxicology

Intestinal toxicity evaluation of TiO2 degraded surface-treated nanoparticles: a combined physico-chemical and toxicogenomics approach in caco-2 cells

(2012) Matthieu Fisichella et al.   Particle and Fibre Toxicology

Systems Biological Approach of Molecular Descriptors Connectivity: Optimal Descriptors for Oral Bioavailability Prediction

(2012) Shiek S. S. J. Ahmed et al.   PLoS One

The complexity of nanoparticle dissolution and its importance in nanotoxicological studies

(2012) Superb K. Misra et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Alterations in physical state of silver nanoparticles exposed to synthetic human stomach fluid

(2012) Kim R. Rogers et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Applying quantitative structure–activity relationship approaches to nanotoxicology: Current status and future potential

(2012) David A. Winkler et al.   TOXICOLOGY

Good Caco-2 cell culture practices

(2012) Manuela Natoli et al.   TOXICOLOGY IN VITRO

Separating uncertainty and physiological variability in human PBPK modelling: The example of 2-propanol and its metabolite acetone

(2012) Daan Huizer et al.   TOXICOLOGY LETTERS

Characterization of Translocation of Silver Nanoparticles and Effects on Whole-Genome Gene Expression Using an In Vitro Intestinal Epithelium Coculture Model

(2011) Hans Bouwmeester et al.   ACS Nano

Bioavailability and Toxicokinetics of citrate-coated silver nanoparticles in rats

(2011) Kwangsik Park et al.   ARCHIVES OF PHARMACAL RESEARCH

Radiolabelling of engineered nanoparticles for in vitro and in vivo tracing applications using cyclotron accelerators

(2011) N. Gibson et al.   ARCHIVES OF TOXICOLOGY

Alternatives to animal testing: current status and future perspectives

(2011) Manfred Liebsch et al.   ARCHIVES OF TOXICOLOGY

Identifying cell and molecular stress after radiation in a three-dimensional (3-D) model of oral mucositis

(2011) Maria Polikandritou Lambros et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine

(2011) Jacqueline Pusch et al.   BIOMATERIALS

Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles

(2011) Birgit K. Gaiser et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives

(2011) Stephen T. Buckley et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Approaches to the safety assessment of engineered nanomaterials (ENM) in food

(2011) Andrew Cockburn et al.   FOOD AND CHEMICAL TOXICOLOGY

Oral premalignant lesions: from the pathological viewpoint

(2011) Toshiyuki Izumo   International Journal of Clinical Oncology

Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa

(2011) Sarah Dünnhaupt et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Physical Changes in White and Brown Rice during Simulated Gastric Digestion

(2011) Fanbin Kong et al.   JOURNAL OF FOOD SCIENCE

Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan

(2011) Juan Manuel Llabot et al.   JOURNAL OF MICROENCAPSULATION

Hemin-coupled iron(III)-hydroxide nanoparticles show increased uptake in Caco-2 cells

(2011) Markus Richard Jahn et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Everted gut sac model as a tool in pharmaceutical research: limitations and applications

(2011) Mohd Aftab Alam et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Evaluation of tissue engineered models of the oral mucosa to investigate oral candidiasis

(2011) Nishant P. Yadev et al.   MICROBIAL PATHOGENESIS

Evaluation of a physiologicalin vitrosystem to study the transport of nanoparticles through the buccal mucosa

(2011) Eva Roblegg et al.   Nanotoxicology

Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging

(2011) Teng Luo et al.   OPTICS EXPRESS

Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate

(2011) Katrin Loeschner et al.   Particle and Fibre Toxicology

The Effect of Composition and Gastric Conditions on the Self-Emulsification Process of Ibuprofen-Loaded Self-Emulsifying Drug Delivery Systems: A Microscopic and Dynamic Gastric Model Study

(2011) Annalisa Mercuri et al.   PHARMACEUTICAL RESEARCH

Application of Method Suitability for Drug Permeability Classification

(2010) Donna A. Volpe   AAPS Journal

Preparation and Evaluation of Taste-Masked Donepezil Hydrochloride Orally Disintegrating Tablets

(2010) Yi-Dong Yan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Proteomics-based identification of haptoglobin as a novel plasma biomarker in oral squamous cell carcinoma

(2010) Chih-Ho Lai et al.   CLINICA CHIMICA ACTA

An appraisal of the published literature on the safety and toxicity of food-related nanomaterials

(2010) Jeffrey W. Card et al.   CRITICAL REVIEWS IN TOXICOLOGY

DMBA-induced hamster buccal pouch carcinoma and VX2-induced rabbit cancer as a model for human oral carcinogenesis

(2010) Yuk-Kwan Chen et al.   Expert Review of Anticancer Therapy

Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract

(2010) Jonathan J. Powell et al.   JOURNAL OF AUTOIMMUNITY

A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach

(2010) Fanbin Kong et al.   JOURNAL OF FOOD SCIENCE

How Well Can the Caco-2/Madin−Darby Canine Kidney Models Predict Effective Human Jejunal Permeability?†

(2010) Alex Avdeef et al.   JOURNAL OF MEDICINAL CHEMISTRY

Barrier Properties of Gastrointestinal Mucus to Nanoparticle Transport

(2010) Jason S. Crater et al.   MACROMOLECULAR BIOSCIENCE

Dynamic Dissolution: A Step Closer to Predictive Dissolution Testing?

(2010) Mark McAllister   MOLECULAR PHARMACEUTICS

A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro

(2010) Fransisca Leonard et al.   MOLECULAR PHARMACEUTICS

Combinatorial QSAR Modeling of Human Intestinal Absorption

(2010) Claudia Suenderhauf et al.   MOLECULAR PHARMACEUTICS

Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

(2010) Hans Bouwmeester et al.   Nanotoxicology

Presence and risks of nanosilica in food products

(2010) Susan Dekkers et al.   Nanotoxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

The Uncertainty of Nanotoxicology: Report of a Society for Risk Analysis Workshop

(2010) Richard A. Canady   RISK ANALYSIS

Defining conditions for the co-culture of Caco-2 and HT29-MTX cells using Taguchi design

(2010) Xiu-Min Chen et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

(2009) Michael B. Bolger et al.   AAPS Journal

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Toxicity and cellular responses of intestinal cells exposed to titanium dioxide

(2009) Brian A. Koeneman et al.   CELL BIOLOGY AND TOXICOLOGY

Transport of chitosan–DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes

(2009) Irina Kadiyala et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Introduction to computational oral absorption simulation

(2009) Kiyohiko Sugano   Expert Opinion on Drug Metabolism & Toxicology

Combining the Dynamic TNO-Gastrointestinal Tract System with a Caco-2 Cell Culture Model: Application to the Assessment of Lycopene and α-Tocopherol Bioavailability from a Whole Food

(2009) Emmanuelle Déat et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vitro digestion methods for assessing the effect of food structure on allergen breakdown

(2009) Martin Wickham et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Selective Adhesion of Nanoparticles to Inflamed Tissue in Gastric Ulcers

(2009) Saad Hasani et al.   PHARMACEUTICAL RESEARCH

Intestinal Epithelial Cells In Vitro

(2009) Dharam P. Chopra et al.   STEM CELLS AND DEVELOPMENT

Nanotechnology and its applications in the food sector

(2009) Nesli Sozer et al.   TRENDS IN BIOTECHNOLOGY

Passive oral drug absorption can be predicted more reliably by experimental than computational models—Fact or myth

(2008) Johanna Linnankoski et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Model Stomach System to Investigate Disintegration Kinetics of Solid Foods during Gastric Digestion

(2008) F. Kong et al.   JOURNAL OF FOOD SCIENCE

Optimized dispersion of nanoparticles for biological in vitro and in vivo studies

(2008) Peter Bihari et al.   Particle and Fibre Toxicology

Familial adenomatous polyposis and the small bowel: A loco-regional review and current management strategies

(2008) O.C.C. Will et al.   PATHOLOGY RESEARCH AND PRACTICE

Review of health safety aspects of nanotechnologies in food production

(2008) Hans Bouwmeester et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Azoxymethane-induced rat aberrant crypt foci: Relevance in studying chemoprevention of colon cancer

(2008) Jayadev Raju   WORLD JOURNAL OF GASTROENTEROLOGY