Article
Chemistry, Multidisciplinary
Yanqiu Song, Mingming Li, Na Song, Xin Liu, Guangyao Wu, Hao Zhou, Jiafu Long, Linqi Shi, Zhilin Yu
Summary: This study reported the self-amplifying assembly of peptides in macrophages to improve the anti-inflammatory efficacy of conventional drugs. By coassembling an enzyme-responsive peptide with its derivative, the assembly of peptides was promoted by the enzyme NQO1. This amplifying assembling system was used to deliver dexamethasone to acute injured lungs, resulting in enhanced anti-inflammatory efficacy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Philippe Grenier, Valerie Chenard, Nicolas Bertrand
Summary: Polyethylene glycol (PEG) is commonly found in nanomedicines and pharmaceuticals, and recent studies have shown that anti-PEG antibodies are present in a significant portion of the human population. Understanding the mechanisms behind the immune response to PEG is crucial, as these antibodies can impact the efficacy of PEGylated therapeutics. This study investigates the immune response to polymeric nanoparticles administered through different routes, and the results suggest that the mechanisms involved vary depending on the administration route. Knowledge of these mechanisms can be utilised to design nanomedicines that engage the immune system in specific ways.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Ahmad Reza Bagheri, Nahal Aramesh, Muhammad Bilal, Jiafu Xiao, Hae-Won Kim, Bing Yan
Summary: Cancer has become one of the leading causes of death in recent years, prompting researchers to explore new approaches like carbon nanomaterials for therapy. These materials possess unique physicochemical properties that can enhance cancer treatment effectiveness and reduce side effects.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Kohei Matsuoka, Mizuki Yamada, Noriaki Fukatsu, Kyoichi Goto, Misae Shimizu, Ayako Kato, Yoshimi Kato, Hiroshi Yukawa, Yoshinobu Baba, Mitsuo Sato, Kazuhide Sato
Summary: Monitoring the effectiveness of NIR-PIT can be done by measuring SUPR. In this study, fluorescent signals and ultrasound imaging were used to evaluate SUPR, and indicators related to therapeutic effect were discovered.
Article
Nanoscience & Nanotechnology
Rui Yang, Jiayan Huang, Min Liao, Jianbo Huang, Binyang Gao, Huan Zhang, Jie Zhou, Jinshun Xu, Qiang Lu
Summary: This study successfully developed an oxygen-sufficient nanoplatform with multi-modal imaging capability to enhance the effectiveness of microwave dynamic therapy (MDT) against hypoxic tumors. The nanoplatform exhibited suitable size, improved stability, enhanced cellular uptake, and mitochondria targeting capacity. Additionally, it demonstrated excellent in vitro and in vivo imaging capabilities. The in vivo experiments confirmed the safety and significant tumor growth inhibition of the nanoplatform. Overall, this study presents a promising strategy for treating hypoxic tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Danielle Brain, Alex Plant-Hately, Bethany Heaton, Usman Arshad, Christopher David, Christian Hedrich, Andrew Owen, Neill J. Liptrott
Summary: The immune pathology of COVID-19 is complex, involving activation and interaction of multiple systems. Therapeutic approaches mainly focus on inhibiting coagulation, immune suppression, and cytokine-directed blocking agents. Improvement and focus on individual systems are needed for better prognosis and well-being.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Engineering, Biomedical
Lingdong Jiang, Danyang Chen, Zhaokui Jin, Chao Xia, Qingqing Xu, Mingjian Fan, Yunlu Dai, Jia Liu, Yuanpei Li, Qianjun He
Summary: In this study, a peptide-based nanoparticle was developed for tumor-targeted delivery of nanomedicine. The nanoparticle could release nitric oxide (NO) and undergo structural transformation upon light irradiation, leading to enhanced intratumoral retention and sensitizing photodynamic therapy (PDT).
BIOACTIVE MATERIALS
(2022)
Review
Gastroenterology & Hepatology
Yu-Chu He, Zi-Ning Hao, Zhuo Li, Da-Wei Gao
Summary: Colorectal cancer has gained attention due to its increasing incidence. Conventional chemotherapy drugs have limitations in clinical application due to lack of specificity and severe side effects. Nanomedicines with enhanced permeability and retention, tumor targeting, and multimodal therapeutic strategies have shown potential for colon cancer treatment. This review summarizes the advances in nanomedicine-based therapeutic strategies including chemotherapy, radiotherapy, phototherapy, chemodynamic therapy, gas therapy, and immunotherapy, and discusses the mechanisms, limitations, improvements, and future perspectives of these therapies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
Ryo Kinoshita, Yu Ishima, Victor T. G. Chuang, Hiroshi Watanabe, Taro Shimizu, Hidenori Ando, Keiichiro Okuhira, Masaki Otagiri, Tatsuhiro Ishida, Toru Maruyama
Summary: Human serum albumin (HSA) is a versatile drug carrier with active tumor targeting capacity, especially in delivering antitumor drugs. HSA dimer (HSA-d) has been found to be more effective in tumor distribution and can improve the efficacy of nanotechnology. HSA-d-doxorubicin (HSA-d-DOX) shows significantly higher cytotoxicity in vitro and inhibits tumor growth in human pancreatic tumors.
Editorial Material
Chemistry, Multidisciplinary
Mitsuru Hashida
Summary: This article reviews the theory of enhanced permeability and retention (EPR) effect proposed by Professor Hiroshi Maeda, which is considered as the physiological principal mechanism of intra-tumoral accumulation of large molecules and small particles. The concept of EPR effect has led to the development of nanoplatforms for cancer chemotherapy, such as polymer conjugates, liposomes, polymeric micelles, and nanoparticles.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biotechnology & Applied Microbiology
Seyyed Emad Hooshmand, Makkieh Jahanpeimay Sabet, Akbar Hasanzadeh, Seyede Mahtab Kamrani Mousavi, Niloofar Haeri Moghaddam, Seyed Aghil Hooshmand, Navid Rabiee, Yong Liu, Michael R. Hamblin, Mahdi Karimi
Summary: Gene therapy using histidine-based carriers has shown promise in delivering nucleic acids into target cells. This review discusses the diversity and biocompatibility of histidine-enhanced gene delivery systems, as well as the conjugation methods with linear polymers. The challenges, opportunities, and future research trends of histidine-based gene delivery are also investigated.
JOURNAL OF GENE MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Zhongying Gong, Baolong Zhou, Xiaoying Liu, Juanjuan Cao, Zexin Hong, Jingye Wang, Xirui Sun, Xiaomeng Yuan, Haining Tan, Hongjie Ji, Jingkun Bai
Summary: Temporal persistence is crucial for nanocarriers, like spatial accuracy. A drug delivery approach based on tumor microenvironment-sensitive enzyme has been designed to enhance nanotherapy efficacy. The amphiphilic peptide AYR can morphologically transform into nanofibers under the influence of ALP, allowing rapid drug release and improved drug delivery strategy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Ming-Ming Chen, Hai-Li Hao, Wei Zhao, Xueli Zhao, Hong-Yuan Chen, Jing-Juan Xu
Summary: In this study, a multifunctional nanoplatform, DOX-Pt-tipped Au@ZIF-8, was successfully fabricated by integrating an anticancer drug and plasmonic bimetal heterostructures. This nanoplatform exhibited outstanding synergistic plasmon-enhanced chemo-phototherapy, providing a rational approach for PT/CT imaging-guided cancer treatment.
Review
Oncology
Atsushi Makimoto, Jun Fang, Hiroshi Maeda
Summary: P-THP, a polymer-conjugated anticancer agent, targets tumor tissue selectively via the EPR effect, releasing active pirarubicin molecules with potential to minimize toxicities and maximize chemotherapy efficacy.
Article
Chemistry, Multidisciplinary
Dongmei Xi, Ning Xu, Xiang Xia, Chao Shi, Xiaojing Li, Dongsheng Wang, Saran Long, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: In this study, a photosensitizer assembly nanosystem was developed to enhance tumor retention for efficient photodynamic therapy. The long tumor retention time of the photosensitizer nanoparticles allowed for single-dose injection and multiple light treatments, resulting in a high inhibition rate of over 90% for tumor growth.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Shen Yu Helvig, Laura Woythe, Simon Pham, Gizem Bor, Helene Andersen, Seyed Moein Moghimi, Anan Yaghmur
Summary: The stabilization of nanodispersions by nonionic mPEG-lipids of different types and concentrations can modulate the internal structure of nanoparticles, leading to variable levels of complement activation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Editorial Material
Biotechnology & Applied Microbiology
S. Moein Moghimi
Review
Pharmacology & Pharmacy
Rachael Dixon, Eldhose Skaria, Wing Man Lau, Philip Manning, Mark A. Birch-Machin, S. Moein Moghimi, Keng Wooi Ng
Summary: Recent infectious disease outbreaks have emphasized the importance of rapid and accurate diagnosis for effective treatment and prevention of transmission. Point-of-care microneedle diagnostic devices offer a promising solution by providing minimally invasive, real-time diagnosis. Further development in this field holds significant potential for improving infectious disease diagnostics.
ACTA PHARMACEUTICA SINICA B
(2021)
Editorial Material
Immunology
Qiang Ma, Kenneth Michael Pollard, Jared M. Brown, Paola Italiani, Seyed Moein Moghimi
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Physical
Gizem Bor, Stefan Salentinig, Evrim Sahin, Begum Nur Odevci, Martin Roursgaard, Letizia Liccardo, Petra Hamerlik, Seyed Moein Moghimi, Anan Yaghmur
Summary: Lyotropic non-lamellar liquid crystalline (LLC) nanoparticles are versatile injectable nanopharmaceuticals with tunable structural features and capability of loading various drugs. Colloidal stability, structural transitions, and cell interaction kinetics of these nanoparticles in the absence of secondary emulsifiers and organic solvents have been studied, providing insights for improved engineering in pharmaceutical development.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Hanmant Gaikwad, Yue Li, Guankui Wang, Ronghui Li, Shaodong Dai, Cody Rester, Ross Kedl, Laura Saba, Nirmal K. Banda, Robert Scheinman, Casey Patrick, Krishna M. G. Mallela, S. Moein Moghimi, Dmitri Simberg
Summary: This study investigates the role of neutralizing antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 in complement activation and opsonization. The researchers found that anti-RBD antibodies can fix complement, but each antibody has limited ability to bind complement. Additionally, complement-dependent uptake was only observed in vaccinated donors with high anti-RBD titers.
Editorial Material
Biotechnology & Applied Microbiology
Seyed Moein Moghimi, Dmitri Simberg
Article
Chemistry, Multidisciplinary
S. Moein Moghimi, Dmitri Simberg
Summary: The complement system is a group of proteins that protect the body from intruders but can cause inflammation if overactivated. Careful assessment of complement activation is important for particulate medicines to ensure their therapeutic potential. However, handling and characterization of sera/plasma are often neglected in research, highlighting the need for quality assessment guidelines.
Letter
Multidisciplinary Sciences
Seyed M. Moghimi
Review
Pharmacology & Pharmacy
H. B. Haroon, A. C. Hunter, Z. S. Farhangrazi, S. M. Moghimi
Summary: This article provides a brief history of the development of long circulating nanoparticles and highlights important lessons learned in camouflaging nanoparticles to avoid rapid interception by Kupffer cells.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
S. Moein Moghimi, Hajira B. Haroon, Anan Yaghmur, Dmitri Simberg, Panagiotis N. Trohopoulos
Summary: The contribution of the complement system to host defence and homeostasis is well recognized. The mechanisms underlying complement activation by particulate systems are still not fully understood. Activation of the complement cascade can promote inflammatory reactions. Controlled antibody binding and sensing of particles by complement pattern-recognition molecules can trigger complement activation. Particle curvature and spacing arrangement of surface functional groups are important parameters modulating complement responses through engagement with antibodies and complement pattern-recognition molecules. Better understanding of these parameters could enable the engineering of drug carriers and biomedical platforms with tunable complement responses.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
S. Moein Moghimi, Hajira B. Haroon, Anan Yaghmur, A. Christy Hunter, Emanuele Papini, Z. Shadi Farhangrazi, Dmitri Simberg, Panagiotis N. Trohopoulos
Summary: The complement system, professional phagocytes, and other immune cells play important roles in the innate immune system's defense against tissue injury and foreign particles, including nano-pharmaceuticals. While the interaction between nanopharmaceuticals and the immune system can be beneficial for immune modulation and treatment of phagocytic cell disorders, it is crucial to understand the mechanisms involved and evaluate the balance between beneficial and adverse reactions. Adverse infusion reactions to approved nanopharmaceuticals in humans serve as an example. In this article, we discuss the collective opinions and findings from our laboratories regarding nanoparticle-mediated complement and leukocyte/macrophage responses.
JOURNAL OF CONTROLLED RELEASE
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Seyed Moein Moghimi, Rebecca McCullough, Dmitri Simberg
Article
Chemistry, Multidisciplinary
Arnaldur Hall, Jiri Bartek, Ernst Wagner, Ulrich Lachelt, Seyed Moein Moghimi
Summary: Recent clinical success with Onpattro and cationic ionizable lipid nanoparticle-based mRNA vaccines has sparked renewed interest in the development of synthetic cationic vectors for nucleic acid delivery. However, concerns remain regarding their impact on cellular metabolism and cytotoxicity. In this study, the authors systematically investigate the effect of a sequence-defined four-arm oligo(ethanamino)amide transfectant on cellular homeostasis using bioenergetic and biomembrane integrity probing. They identify metabolically safe building units for transfectant engineering and demonstrate the usefulness of their screening strategy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Anan Yaghmur, S. Moein Moghimi
Summary: Nonlamellar lyotropic liquid crystalline (LLC) nanoparticles are versatile nano-self-assemblies used for drug solubilization and targeted drug delivery. LLC nanodispersions are heterogeneous with distinct internal architecture and morphology, coexisting with micelles and vesicles. LLC nanoparticles have diversity in drug solubilization, encapsulation, and release rate.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
