Critical issues and pitfalls in serum and plasma handling for complement analysis in nanomedicine and bionanotechnology

Nanoparticle Surface Engineering with Heparosan Polysaccharide Reduces Serum Protein Adsorption and Enhances Cellular Uptake

(2022) Wen Yang et al.   NANO LETTERS

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

(2021) Lin-Ping Wu et al.   Nature Communications

The need for robust characterization of nanomaterials for nanomedicine applications

(2021) Morteza Mahmoudi   Nature Communications

Expanding Horizons in Complement Analysis and Quality Control

(2021) Ashley Frazer-Abel et al.   Frontiers in Immunology

Complement opsonization of nanoparticles: Differences between humans and preclinical species

(2021) Yue Li et al.   JOURNAL OF CONTROLLED RELEASE

Complement activation by drug carriers and particulate pharmaceuticals: Principles, challenges and opportunities

(2020) S. Moein Moghimi et al.   ADVANCED DRUG DELIVERY REVIEWS

Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments

(2020) Rebecca L Pinals et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Interplay between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses

(2019) Seyed Moein Moghimi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interplay of protein corona and immune cells controls blood residency of liposomes

(2019) Francesca Giulimondi et al.   Nature Communications

C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes

(2018) Regina Tavano et al.   ACS Nano

Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection/infusion reactions

(2018) Seyed Moein Moghimi   DRUG DISCOVERY TODAY

Translational gaps in animal models of human infusion reactions to nanomedicines

(2018) S Moein Moghimi et al.   Nanomedicine

Minimum information reporting in bio–nano experimental literature

(2018) Matthew Faria et al.   Nature Nanotechnology

Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles

(2018) Vivian P. Vu et al.   Nature Nanotechnology

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

(2018) Mariana Gaya da Costa et al.   Frontiers in Immunology

Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice

(2017) Linping Wu et al.   MOLECULAR IMMUNOLOGY

Anticoagulants Influence the Performance of In Vitro Assays Intended for Characterization of Nanotechnology-Based Formulations

(2017) Edward Cedrone et al.   MOLECULES

Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona

(2017) Giulio Caracciolo et al.   TRENDS IN BIOTECHNOLOGY

Platelet mimicry: The emperor's new clothes?

(2016) Seyed Moein Moghimi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C

(2016) Kimball Aaron Geno et al.   PeerJ

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Complement-Coagulation Cross-Talk: A Potential Mediator of the Physiological Activation of Complement by Low pH

(2015) Hany Ibrahim Kenawy et al.   Frontiers in Immunology

Commercially Available Complement Component-Depleted Sera Are Unexpectedly Codepleted of Ficolin-2

(2014) Allison M. Brady et al.   Clinical and Vaccine Immunology

Ficolin-2 reveals different analytical and biological properties dependent on different sample handling procedures

(2013) Estrid Hein et al.   MOLECULAR IMMUNOLOGY

Protein instability following transport or storage on dry ice

(2013) Brian M Murphy et al.   NATURE METHODS

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Heparin/heparan sulphate interactions with complement--a possible target for reduction of renal function loss?

(2013) A. Zaferani et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Genomic perspectives in inter-individual adverse responses following nanomedicine administration: The way forward

(2012) S. Moein Moghimi et al.   ADVANCED DRUG DELIVERY REVIEWS

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

(2012) Anna Åkesson et al.   RSC Advances

Proteins of the Innate Immune System Crystallize on Carbon Nanotubes but Are Not Activated

(2011) Wai Li Ling et al.   ACS Nano

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Curvature of Synthetic and Natural Surfaces Is an Important Target Feature in Classical Pathway Complement Activation

(2010) Martin Bjerregård Pedersen et al.   JOURNAL OF IMMUNOLOGY

Preparing serum for functional complement assays

(2009) P.J. Lachmann   JOURNAL OF IMMUNOLOGICAL METHODS

Coexistence of Closed and Open Conformations of Complement Factor B in the Alternative Pathway C3bB(Mg2+) Proconvertase

(2009) E. Torreira et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Activates Complement by Distinctly Different Mechanisms In Vitro and In Vivo: Indirect Complement Activation by Virions In Vivo

(2009) J. Tian et al.   JOURNAL OF VIROLOGY

Immunodeficiency Associated withFCN3Mutation and Ficolin-3 Deficiency

(2009) Lea Munthe-Fog et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA