Editorial Material
Microbiology
John D. Ryan, David E. Nelsona
Summary: Researchers conducted a screen for Chlamydia pneumoniae effectors in Chlamydia trachomatis, identifying several new proteins translocated during infection, and demonstrating the use of new genetic approaches in characterizing virulence factors of other Chlamydia species.
JOURNAL OF BACTERIOLOGY
(2021)
Review
Immunology
Brittany Jury, Charlotte Fleming, Wilhelmina M. Huston, Laurence Don Wai Luu
Summary: This mini-review outlines the factors related to the developmental cycle phase and specific pathogenesis activity of Chlamydia trachomatis, highlighting their importance for future genetic research. The factors discussed include developmental cycle stages, gene expression regulatory factors, type III secretion system and their effectors, and individual virulence factors with known impacts.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Arkaprabha Banerjee, David E. Nelson
Summary: Various species of obligate intracellular bacteria in the genus Chlamydia, while sharing similar developmental cycles, differ in host preferences and pathogenic potential. Recent advancements in research methods have provided new possibilities for studying these important pathogens.
PATHOGENS AND DISEASE
(2021)
Article
Immunology
Arkaprabha Banerjee, David E. Nelson
Summary: Contemporary molecular genetic tools have been used to dissect the pathogenic properties of obligate intracellular bacteria in the genus Chlamydia. These bacteria share similar biphasic developmental cycles but vary in host preferences and pathogenic potential. Recent advancements in genetic engineering methods for C. trachomatis have opened up exciting new possibilities for studying this group of important pathogens.
PATHOGENS AND DISEASE
(2021)
Review
Endocrinology & Metabolism
Lucas S. Santana, Augusto G. Guimaraes, Madson Q. Almeida
Summary: Primary aldosteronism (PA) is the most common form of secondary arterial hypertension, and recent advances in understanding its pathogenesis, including genetic mutations and the activation of calcium signaling, have expanded our knowledge of familial hyperaldosteronism. Additionally, the use of CYP11B2 staining to guide genetic investigations of adrenal lesions has had a significant impact on our understanding of PA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Xiaojing Zheng, Wujuan Zhong, Catherine M. O'Connell, Yutong Liu, Catherine L. Haggerty, William M. Geisler, Gloria E. Anyalechi, Robert D. Kirkcaldy, Harold C. Wiesenfeld, Sharon L. Hillier, Michael P. Steinkampf, Karen R. Hammond, Jason Fine, Yun Li, Toni Darville
Summary: The study identified 112 infertility genome-wide association study loci, with 31 associated with Chlamydia trachomatis ascension. These single-nucleotide polymorphisms altered chlamydial ascension by modulating expression of mediator genes.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Derek J. J. Fisher, Paul A. A. Beare
Summary: The ability to genetically manipulate pathogens is crucial for understanding host-pathogen interactions and developing treatment strategies. Methods for modifying obligate intracellular bacterial pathogens have been limited, but significant progress has been made in the past few decades. This review highlights recent genetic achievements and developments for several important pathogens and discusses future research directions. Overall, the future looks promising for unraveling the molecular pathogenic mechanisms of these significant pathogens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Weiqiang Wan, Danni Li, Dan Li, Jun Jiao
Summary: Chlamydia trachomatis, the most impactful species among the Chlamydia spp., is a major cause of bacterial sexually transmitted diseases and preventable blindness. The unique intracellular parasitism and biphasic developmental cycle of C. trachomatis pose barriers to genetic manipulation tools development. Recent advancements in genetic manipulation techniques for C. trachomatis include chemical mutagenesis, targeted gene knockout using group II introns, fluorescence-reported allelic exchange mutagenesis (FRAEM), CRISPR interference (CRISPRi), and transposon mutagenesis, which are discussed in this review along with new challenges in Chlamydia genetics.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Joanna Y. Wang, Lisa R. Young
Summary: Pulmonary fibrosis is a serious disease with limited treatment options due to a lack of understanding of its underlying pathophysiology. This review explores insights into the mechanisms of pulmonary fibrosis derived from genetic forms of the disease, providing potential targets for therapy.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paul El Meouchy, Mohamad Wahoud, Sabine Allam, Roy Chedid, Wissam Karam, Sabine Karam
Summary: Obesity and hypertension are closely related, with obesity interfering with the endocrine and immune systems and increasing the risk of insulin resistance, diabetes, hypertension, and cardiovascular disease. Genetics, environment, metabolism, and mitochondrial factors also play a significant role in obesity and hypertension. Bariatric surgery is the most reliable method for weight loss, but new medications offer promising alternatives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Defeng Guan, Lihui Zhao, Xin Shi, Xiaoling Ma, Zhou Chen
Summary: Copper is an essential trace element for the structure and metabolism of human tissue. Excessive intake or abnormal accumulation of copper in the body can lead to damage and cell death. Interestingly, many types of cancer have been found to have elevated copper levels, and tumor cells are more dependent on copper than normal cells. The correlation between copper and cancer has potential implications for tumor therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Chie Kikutake, Mikita Suyama
Summary: This study investigates the association between mutations in open chromatin regions and their possible functions. The findings suggest that highly mutated open chromatin regions play an important role in cancer pathogenesis and are associated with patient prognosis.
Review
Biochemistry & Molecular Biology
Tasuku Tamai, Kenji Ihara
Summary: Celiac disease is an autoimmune disease caused by gluten ingestion that primarily affects the small intestine. It is prevalent worldwide, but often goes undiagnosed, especially in Asian countries like Japan. This paper provides an overview of the epidemiology, diagnosis, and treatment of celiac disease, as well as summarizing reported Japanese cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Simone Filardo, Marisa Di Pietro, Rosa Sessa
Summary: Chlamydia trachomatis remains a significant public health issue with over 130 million new cases annually. The infection can be asymptomatic in around 80% of women and 50% of men. Various cell types are involved in C. trachomatis infection, leading to a range of pathologies in both genders. While two-dimensional in vitro cellular models have been used, they have limitations in replicating the complex structures of in vivo human tissues. This article provides an overview of cutting-edge three-dimensional cell-culture models and discusses future perspectives in C. trachomatis research.
Article
Genetics & Heredity
Aude-Anais Olijnik, Noemi B. A. Roy, Caroline Scott, Joseph A. Marsh, Jill Brown, Karin Lauschke, Katrine Ask, Nigel Roberts, Damien J. Downes, Sanja Brolih, Errin Johnson, Barbara Xella, Melanie Proven, Ria Hipkiss, Kate Ryan, Per Frisk, Johan Makk, Eva-Lena Maria Stattin, Nandini Sadasivam, Louisa McIlwaine, Quentin A. Hill, Raffaele Renella, Jim R. Hughes, Richard J. Gibbons, Anja Groth, Peter J. McHugh, Douglas R. Higgs, Veronica J. Buckle, Christian Babbs
Summary: The study identified novel pathogenic variants in CDA-I patients, revealing genetic heterogeneity in the disease. The findings suggest that C15orf41 may be the key determinant of CDA-I, offering new insights into the disease mechanism.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Nanoscience & Nanotechnology
Lingxiao Xie, Xiong Ding, Rachel Budry, Guangzhao Mao
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Oncology
Nadia Saadat, Fangchao Liu, Brittany Haynes, Pratima Nangia-Makker, Xun Bao, Jing Li, Lisa A. Polin, Smiti Gupta, Guangzhao Mao, Malathy P. Shekhar
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Chemistry, Multidisciplinary
Myunggi An, Chunsong Yu, Jingchao Xi, Joyce Reyes, Guangzhao Mao, Wei-Zen Wei, Haipeng Liu
Article
Clinical Neurology
Fangchao Liu, Yanhua Zhang, Janelle Schafer, Guangzhao Mao, Harry G. Goshgarian
JOURNAL OF SPINAL CORD MEDICINE
(2019)
Correction
Nanoscience & Nanotechnology
Brittany Haynes, Yanhua Zhang, Fangchao Liu, Jing Li, Sarah Petit, Hend Kothayer, Xun Bao, Andrew D. Westwell, Guangzhao Mao, Malathy P. V. Shekhar
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Physiology
Abdulghani Sankari, Zeljka Minic, Pershang Farshi, Medea Shanidze, Wafaa Mansour, Fangchao Liu, Guangzhao Mao, Harry G. Goshgarian
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Materials Science, Multidisciplinary
Xuecheng Yu, Mohamed Kilani, Abdurrafay Siddiqui, Guangzhao Mao
ADVANCED MATERIALS TECHNOLOGIES
(2020)
Article
Oncology
Branislava Janic, Stephen L. Brown, Ryan Neff, Fangchao Liu, Guangzhao Mao, Yalei Chen, Latoya Jackson, Indrin J. Chetty, Benjamin Movsas, Ning Wen
Summary: Gold nanoparticles have shown to enhance the efficacy of cancer radiotherapy by localizing radiation energy in tumors, leading to improved cell death. The size of nanoparticles plays a role in this enhancement, with different sizes affecting intracellular targeting and immunological responses.
CANCER BIOLOGY & THERAPY
(2021)
Article
Pathology
Ashapurna Sarma, Ambikai Gajan, Seongho Kim, Katherine Gurdziel, Guangzhao Mao, Pratima Nangia-Makker, Malathy P. V. Shekhar
Summary: Canonical Wnt signaling plays a critical role in melanocyte lineage commitment and melanoma development. RAD6B, a ubiquitin-conjugating enzyme involved in translesion DNA synthesis, enhances beta-catenin stability/activity through a proteasome-insensitive polyubiquitination process. Targeting RAD6B through genetic knockout or selective small-molecule inhibition has been shown to inhibit melanoma cell proliferation and reduce metastasis, suggesting a potential novel strategy for treating melanomas with dysregulated canonical Wnt signaling.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Xin Geng, Shuwei Li, Lalani Mawella-Vithanage, Tao Ma, Mohamed Kilani, Bingwen Wang, Lu Ma, Chathuranga C. Hewa-Rahinduwage, Alina Shafikova, Eranda Nikolla, Guangzhao Mao, Stephanie L. Brock, Liang Zhang, Long Luo
Summary: The study introduces a novel bimetallic PbCdSe quantum dot gel sensor with high sensitivity and fast response for detecting NO2 gas. By employing the strategy of atomically dispersed metal ions, the sensor achieves an optimal combination of response and recovery, leading to high performance in NO2 detection.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Yifang Wang, Mohannad Mayyas, Jiong Yang, Mohammad B. Ghasemian, Jianbo Tang, Maedehsadat Mousavi, Jialuo Han, Mostak Ahmed, Mahroo Baharfar, Guangzhao Mao, Yin Yao, Dorna Esrafilzadeh, David Cortie, Kourosh Kalantar-Zadeh
Summary: The method presented in the study utilizes liquid metal-based technology to achieve room temperature deposition and patterning of MoO2, providing a new way of fabrication. Through laser writing technique, electrically conductive MoO2 patterns can be obtained on desired substrates. The electrical conductivity and plasmonic properties of MoO2 are analyzed and demonstrated.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Md Musfizur Hassan, Malsha Hettiarachchi, Mohamed Kilani, Xiaohua Gao, Abdulghani Sankari, Cyrille Boyer, Guangzhao Mao
Summary: Respiratory dysfunction is a major cause of death in SCI patients. By utilizing neural tracing proteins to bypass the blood-brain barrier and target respiratory motoneurons in the spinal cord and brainstem, this study introduces a novel approach to deliver drugs with reduced side effects and improved efficacy for treating SCI-related respiratory issues.
ACS CHEMICAL NEUROSCIENCE
(2021)
Meeting Abstract
Oncology
Branislava Janic, Stephen Brown, Ryan Neff, Fangchao Liu, Kevin Bobbitt, Guangzhao Mao, Indrin Chetty, Benjamin Movsas, Ning Wen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
B. Janic, R. Neff, S. L. Brown, F. Liu, G. Mao, I. J. Chetty, B. Movsas, N. Wen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Electrochemistry
Disni Gunasekera, Mohamed Kilani, Xuecheng Yu, Qianjin Chen, Guangzhao Mao, Long Luo
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2019)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)