Article
Biochemistry & Molecular Biology
Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S. -S. Wang, Shiu-Huey Chou, Ta-Hsien Lin
Summary: This study aimed to develop DOXO-coupled glycated BSA nanoparticles and improve their targeting capability towards GLUT5 transporters over-expressed on breast cancer cells. The synthesized nanoparticles had a spherical shape with a hydrodynamic diameter of approximately 60.74 nm and a zeta-potential of approximately -42.20 mV. Furthermore, the DOXO-coupled glycated BSA nanoparticles exhibited cytotoxicity towards both MCF-7 and MDA-MB-231 cells. Overall, this research demonstrates the potential of drug-coupled glycated BSA nanoparticles as a targeted drug delivery platform for breast cancer therapy. Rating: 9/10.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Haroon Iqbal, Anam Razzaq, Naveed Ullah Khan, Saif Ur Rehman, Thomas J. Webster, Run Xiao, Farid Menaa
Summary: This study developed albumin-coated nanoparticles loaded with lapatinib in order to improve the efficiency of targeted cancer therapy. The nanoparticles exhibited high drug loading capacity and entrapment efficiency, and showed superior cell uptake, tumor accumulation, and blood residence time compared to free lapatinib and uncoated nanoparticles. Moreover, they demonstrated excellent biosafety.
BIOMATERIALS ADVANCES
(2022)
Review
Biophysics
Shalvi Sinai Kunde, Sarika Wairkar
Summary: This review summarizes the development of albumin nanoparticles for chemotherapeutic drug delivery and their targeted approach for breast cancer. The article also introduces the multifunctional therapies available using albumin nanoparticles as a treatment and diagnostic method for breast cancer.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Yan Li, Xiang Chen, Qiannan Zhu, Rui Chen, Lu Xu, Shuo Li, Xiaoqing Shi, Haiping Xu, Yinggang Xu, Weiwei Zhang, Xiaofeng Huang, Xiaoming Zha, Jue Wang
Summary: The study compared the efficacy and safety of 2-weekly nanoparticle albumin-bound paclitaxel (nP) and 3-weekly docetaxel regimens as neoadjuvant systemic therapy for breast cancer. The nP group achieved higher pathological complete response rates, especially in patients with triple-negative tumor cells and high Ki67 levels. However, grades 3-4 peripheral sensory neuropathies were more frequent in the nP group.
Article
Pharmacology & Pharmacy
Min Ye, Wei Huang, Rui Liu, Yingli Kong, Yang Liu, Xiaole Chen, Jianhua Xu
Summary: The study demonstrated that the combination treatment of ganetespib and lapatinib has synergistic inhibitory effects on HER2-positive breast cancer cells, enhancing antitumor activity through multiple pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Ana Carla Castro-Guijarro, Angel Matias Sanchez, Marina Ines Flamini, Christoph F. A. Vogel
Summary: This study aims to identify biomarkers for predicting disease progression and therapy efficacy in HER2-positive breast cancer, as well as to overcome resistance. Combining anti-HER2 therapies shows potential in inhibiting cell adhesion and migration critical for cancer metastasis. Deregulated proteins in resistant cells may serve as potential biomarkers of therapy response and resistance. These findings are promising for personalized breast cancer management to maximize the safety and efficacy of anti-HER2 therapies.
Review
Chemistry, Medicinal
Binghong He, Qiong Yang
Summary: Low-density lipoprotein (LDL) is a natural lipoprotein that transports cholesterol in the circulatory system and can potentially be used as a drug carrier for targeted delivery. LDL can bind to the LDL receptor (LDLR) and enter the cell via LDLR-mediated endocytosis. This review summarizes the properties of LDL, different types of LDL-based delivery nanoparticles, loading strategies, and recent advancements in anti-tumor research.
Article
Chemistry, Multidisciplinary
Arvie Camille V. de Guzman, Md. Abdur Razzak, Joong Hee Cho, Ji Yi Kim, Shin Sik Choi
Summary: This study fabricated curcumin nanoparticles using human serum albumin as a carrier and found that these nanoparticles could ameliorate Parkinson's disease features in a C. elegans model.
Article
Pharmacology & Pharmacy
Nurdan Sena Degirmenci, Merve Uslu, Oguz Kaan Krbas, Fikrettin Sahin, Evren Onay Uar
Summary: Exosomes, as natural vesicle nanocarriers, have the advantages of biocompatibility, natural form, high stability, and low toxicity. Loading chemotherapeutic drugs into exosomes derived from non-cancerous cells can enhance the effectiveness of drug treatment without interfering with the drug's mechanism of action.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rashidra R. Walker, Jankiben R. Patel, Akash Gupta, A. Michael Davidson, Christopher C. Williams, Florastina Payton-Stewart, Stephen M. Boue, Matthew E. Burow, Rahul Khupse, Syreeta L. Tilghman
Summary: The combination treatment of glyceollins and lapatinib could reduce the proliferation of hormone-dependent letrozole-resistant breast cancer cells by inducing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jing Han, Hongbo Qu, Mingli Han, Yichao Ding, Mingwei Xie, Jianguo Hu, Yuanwen Chen, Huaying Dong
Summary: Trastuzumab resistance poses a significant challenge in treating HER-2-positive breast cancer. This study reveals that MSC-induced upregulation of AGAP2-AS1 promotes stemness and trastuzumab resistance through activating FAO. AGAP2-AS1 may serve as a promising predictive biomarker and therapeutic target for these patients.
Article
Pharmacology & Pharmacy
Yanhao Zhang, Ji Wang, Hanlei Xing, Chao Liu, Xinsong Li
Summary: In this study, a redox-responsive paclitaxel-pentadecanoic acid prodrug conjugate embedded human serum albumin nanoparticles (HPTX NPs) were developed for cancer chemotherapy. The HPTX NPs exhibited high drug loading, longer drug retention, more effective tumor growth inhibition, and lower systemic toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Gabriele Mazzuferi, Tiziana Bacchetti, Md Obaidul Islam, Gianna Ferretti
Summary: Breast cancer is a major cause of female mortality, with recent studies focusing on the role of lipoproteins, cholesterol metabolism alterations, and oxidative stress in the molecular mechanism of the disease. Low levels of HDL-C have been suggested as a risk factor for breast cancer, but conflicting results have been reported. Alterations in enzyme activity associated with HDL and higher levels of lipid peroxidation markers in breast cancer patients suggest dysfunctional HDL may play a role in the disease.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Oncology
Binghe Xu, Min Yan, Fei Ma, Xichun Hu, Jifeng Feng, Quchang Ouyang, Zhongsheng Tong, Huiping Li, Qingyuan Zhang, Tao Sun, Xian Wang, Yongmei Yin, Ying Cheng, Wei Li, Yuanting Gu, Qianjun Chen, Jinping Liu, Jing Cheng, Cuizhi Geng, Shukui Qin, Shusen Wang, Jinsong Lu, Kunwei Shen, Qiang Liu, Xiaojia Wang, Hong Wang, Ting Luo, Jin Yang, Yudong Wu, Zhiyong Yu, Xiaoyu Zhu, Chunxia Chen, Jianjun Zou
Summary: The study assessed the efficacy and safety of pyrotinib plus capecitabine in HER2-positive metastatic breast cancer patients after trastuzumab. The interim analysis showed that pyrotinib plus capecitabine significantly improved progression-free survival compared to lapatinib plus capecitabine, with manageable toxicity. This treatment could be considered as an alternative option for patients in this setting.
Article
Pharmacology & Pharmacy
Shalvi Sinai Kunde, Sarika Wairkar
Summary: In this study, raloxifene hydrochloride (RLX) was loaded into bovine serum albumin nanoparticles (RLX-BSANPs) and further modified with folic acid (FA) to achieve targeted breast cancer therapy. The optimized nanoparticles showed small particle size and high entrapment efficiency. In vitro experiments demonstrated that FA-modified nanoparticles had strong inhibitory effects on breast cancer cells and induced cell apoptosis through folate receptor-mediated endocytic uptake.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Masoud Farshbaf, Hadi Valizadeh, Yunes Panahi, Yousef Fatahi, Meiwan Chen, Amir Zarebkohan, Huile Gao
Summary: In order to successfully translate targeting nanomedicines from bench to bedside, it is necessary to address the common issues of rapid clearance and off-target accumulation. This phenomenon, known as protein corona (PC) formation, occurs when targeting nanoparticles encounter the bloodstream and interact with plasma proteins. The present review discusses the impact of PC on the biological behavior of targeting nanomedicines, as well as the best simulated environment and latest characterization techniques for PC analysis. The article also highlights recent progress in manipulating nano-bio interfaces to achieve optimal therapeutic outcomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Liqiang Chen, Chendong Liu, Yucheng Xiang, Jiayan Lyu, Zhou Zhou, Tao Gong, Huile Gao, Lian Li, Yuan Huang
Summary: A new strategy for targeting the endoplasmic reticulum (ER) is proposed in this study, which utilizes homologous cancer cell membrane-coated nanoparticles (HCC@NP) to overcome the limited accumulation and rapid exocytosis of nanodrugs in the ER. The strategy achieves high-efficiency and long-term ER retention, inducing potent immunogenic cell death and promoting anti-tumor immunity.
Review
Chemistry, Multidisciplinary
Shaojun Peng, Fengfeng Xiao, Meiwan Chen, Huile Gao
Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.
Article
Pharmacology & Pharmacy
Yang Zhou, Fan Tong, Weilong Gu, Siqin He, Xiaotong Yang, Jiamei Li, Yue-Dong Gao, Huile Gao
Summary: By utilizing a modified nanocarrier, this study proposes a sequentially responsive platform to enhance photodynamic therapy and overcome hypoxia resistance, leading to improved anti-tumor outcomes.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Mingming Han, Jingjing Yao, Jiwu Huang, Yan Tang, Xianwen Wu, Bingan Lu, Jiang Zhou
Summary: Aqueous rechargeable Zn//MnO2 batteries are a promising candidate for future energy storage systems due to their economic and environmental advantages. However, poor reaction kinetics and capacity degradation hinder the performance of Zn//MnO2 batteries. This study demonstrates that defects engineering and phase transformation can enhance ion/charge transfer kinetics and structural stability, leading to a high discharge capacity of 285 mAh/g and capacity retention of 81% after 500 cycles in the aqueous Zn//A-MnO2 system.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Rui Liu, Cong Luo, Zhiqing Pang, Jinming Zhang, Shaobo Ruan, Meiying Wu, Lei Wang, Tao Sun, Nan Li, Liang Han, Jinjin Shi, Yuanyu Huang, Weisheng Guo, Shaojun Peng, Wenhu Zhou, Huile Gao
Summary: Decades have passed since the approval of the first nanoparticles-based medicine for human cancer treatment, and research and development in nanoparticles for drug delivery have been continuing. Today, there have been significant advancements in nanoparticles, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines, and nano-antibodies. These nanoparticles have shown great potential in the treatment and diagnosis of challenging diseases such as cancer and neurodegenerative diseases, making them promising drug carriers and therapeutic agents in the future.
CHINESE CHEMICAL LETTERS
(2023)
Article
Pharmacology & Pharmacy
Wenfeng Jia, Rui Liu, Yushan Wang, Chuan Hu, Wenqi Yu, Yang Zhou, Ling Wang, Mengjiao Zhang, Huile Gao, Xiang Gao
Summary: In this study, a dual-response shape transformation and charge reversal strategy was designed to improve the anti-tumor effect using chemo-photodynamic therapy. The tumor microenvironment-responsive nanoparticles were constructed to achieve charge reversal, size reduction, and enhanced tumor penetration, and induce tumor cell death by releasing chemotherapy drugs through the photosensitizer.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Wenwen Xu, Mingyu Xu, Yumeng Xiao, Lu Yu, Huiru Xie, Xuehua Jiang, Meiwan Chen, Huile Gao, Ling Wang
Summary: This study reveals the impact of clinical status, specifically comorbidities like type 2 diabetes mellitus (T2DM), on the protein corona (PC) composition and active targeting capability of ligand-modified nanoparticles. The results demonstrate that the presence of T2DM in non-small cell lung cancer (NSCLC) mice alters the active targeting ability of transferrin-modified PEGylated polystyrene nanoparticles (Tf-PNs), leading to increased accumulation of Tf-PNs in tumor tissues. Analysis of the PC from different disease states suggests that Tf modification does not significantly affect PC formation, while the PC composition in the NSCLC comorbid with T2DM model contains more proteins like fibrin and clusterin.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rui Liu, Wenfeng Jia, Yushan Wang, Chuan Hu, Wenqi Yu, Yuan Huang, Ling Wang, Huile Gao
Summary: This study investigated the fate of gold nanoclusters in brain delivery and found that they are mainly eliminated via the glymphatic system and blood-brain barrier. Microglia were found to promote this process.
Review
Pharmacology & Pharmacy
Zhaofeng Li, Wei Zhang, Zhong Zhang, Huile Gao, Yi Qin
Summary: Bone metastases are recognized as common metastases that affect patient quality of life and survival. Nanomedicine, as a new treatment strategy, shows great potential for the treatment of bone metastases.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Xiaotong Yang, Wenqin Yang, Xue Xia, Ting Lei, Zhihang Yang, Wenfeng Jia, Yang Zhou, Guo Cheng, Huile Gao
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with no effective treatment. In this study, a multifunctional nanocarrier was developed to deliver beta-site precursor protein cleaving enzyme-1 (BACE1) siRNA and rapamycin into the brain via intranasal administration. The results showed that this nanocarrier significantly improved the cognitive ability of transgenic AD mice.
Review
Chemistry, Multidisciplinary
Kamil G. Gareev, Denis S. Grouzdev, Veronika V. Koziaeva, Nikita O. Sitkov, Huile Gao, Tatiana M. Zimina, Maxim Shevtsov
Summary: Biomimetic nanomaterials (BNMs) are functional materials that mimic the structure of natural prototypes. This review provides an overview of the classification and applications of BNMs.
Article
Pharmacology & Pharmacy
Zhihang Yang, Yufan Du, Lei Lei, Xue Xia, Xiaorong Wang, Fan Tong, Yuan Li, Huile Gao
Summary: In this study, a human serum albumin-based co-delivery system of IBR and HCQ was developed for the treatment of glioma. The system improved the bioavailability of IBR, enhanced the sensitivity of glioma to IBR, and inhibited the prosurvival autophagy induced by IBR through HCQ. The in vitro and in vivo experiments demonstrated the cytotoxicity and prolonged survival time of IBR&HCQ HSA NPs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Tina Sepasi, Farhad Bani, Reza Rahbarghazi, Abbas Ebrahimi-Kalan, Mohammad-Reza Sadeghi, Seyedeh Zahra Alamolhoda, Amir Zarebkohan, Tahereh Ghadiri, Huile Gao
Summary: This study successfully designed an efficient biocarrier for brain gene delivery using CDX-modified chitosan nanoparticles, leading to the expression of the target protein. However, these nanoparticles also showed distribution in other organs.
Review
Nanoscience & Nanotechnology
Yujun Song, Chuan Hu, Yao Fu, Huile Gao
Summary: The blood-brain barrier (BBB) plays a crucial role in controlling the transfer of substances between blood and brain. During the development of brain tumors, the blood-brain tumor barrier (BBTB) forms, posing a challenge for effective drug delivery. This review summarizes strategies for overcoming BBTB and improving drug penetration efficiency.