Article
Chemistry, Analytical
Thomas Guiho, Victor Manuel Lopez-Alvarez, Paul Cvancara, Arthur Hiairrassary, David Andreu, Thomas Stieglitz, Xavier Navarro, David Guiraud
Summary: Peripheral Nerve Stimulation (PNS) is a promising method for functional restoration after neural impairments, but is limited by spatial selectivity. The introduction of the new multichannel stimulator STIMEP opens up possibilities for further advancement of PNS paradigms.
Article
Medicine, General & Internal
David Martin-Caro Alvarez, Diego Serrano-Munoz, Juan Jose Fernandez-Perez, Julio Gomez-Soriano, Juan Avendano-Coy
Summary: This study investigated the effects of high-frequency alternating currents (HFAC) on the peripheral nervous system in healthy volunteers. The results showed that percutaneous stimulation with 20 kHz HFAC led to a reversible reduction in strength.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Marion Badi, Sophie Wurth, Ilaria Scarpato, Evgenia Roussinova, Elena Losanno, Andrew Bogaard, Maude Delacombaz, Simon Borgognon, Paul Cvancara, Florian Fallegger, David K. Su, Eric Schmidlin, Gregoire Courtine, Jocelyne Bloch, Stephanie P. Lacour, Thomas Stieglitz, Eric M. Rouiller, Marco Capogrosso, Silvestro Micera
Summary: This study demonstrated the effectiveness of intrafascicular peripheral electrodes in producing functional grasps and sustained forces in monkeys, with important implications for potential clinical applications in restoring hand control for paralyzed individuals.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
David Martin-Caro Alvarez, Diego Serrano-Munoz, Juan Jose Fernandez-Perez, Julio Gomez-Soriano, Juan Avendano-Coy
Summary: This study evaluated the effect of percutaneous HFAC at 30 kHz on sensory-motor nerve conduction in healthy volunteers. The results showed that the active group had increased pressure pain threshold during and after the stimulation compared to the sham group. Participants in the active group also reported more feelings of numbness and heaviness. No intergroup differences were observed in the remaining outcome variables.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Jialiang Chen, Yihua Zhong, Jicheng Wang, Bing Shen, Jonathan Beckel, William C. de Groat, Changfeng Tai
Summary: This study investigates the impact of temperature on nerve conduction block induced by high-frequency (kHz) stimulation. Results show that at a lower temperature of 15 degrees C, both 2- and 10-kHz stimulations caused an initial muscle contraction followed by nerve block. The threshold for acute block was significantly higher for 10 kHz compared to 2 kHz. However, at a higher temperature of 20 degrees C, the threshold for acute block with 10-kHz stimulation decreased, while 2-kHz stimulation induced a tonic muscle contraction and a poststimulation block.
Article
Chemistry, Analytical
Raviraj Thakur, Felix P. Aplin, Gene Y. Fridman
Summary: The study developed a silicone-based nerve cuff lead for stimulating and recording nerves, providing greater spatial separation and reversible nerve block through the delivery of direct current. Unlike most metallic electrodes, this cuff was manufactured using consumer-grade equipment, making it a cost-effective solution for neuro modulation experiments.
Article
Engineering, Biomedical
Thomas Eggers, Joseph Kilgore, David Green, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
Summary: The study successfully combined DC and KHFAC into a waveform named CROW, which can reduce the onset response and achieve effective nerve block, providing broader possibilities for clinical application of electrical nerve block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
L. Savannah Dewberry, Alexander B. Dru, Maxwell Gravenstine, Brian Nguyen, James Anderson, Sasha Vaziri, Daniel J. Hoh, Kyle D. Allen, Kevin J. Otto
Summary: The study showed that HF block can rapidly reduce tactile sensitivity in a limb with neuropathic injury. No significant increase in gait disability was observed during HF block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Shane A. Bender, David B. Green, Robert J. Daniels, Stephen P. Ganocy, Niloy Bhadra, Tina L. Vrabec
Summary: Electrical conduction block of the vagus nerve was studied to characterize its effects on heart rate dynamics. The results show that complete block and partial block can be achieved using direct current (DC) at different amplitudes. The amplitude of DC was found to significantly predict the induction time for complete block, and the blocking duration and injected charge were significant in predicting the recovery time.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Yuyang Xie, Peijun Qin, Tianruo Guo, Amr Al Abed, Nigel H. Lovell, David Tsai
Summary: A computational toolkit was developed to create nerve stimulation models and study fiber responses under different electrode arrangements and stimulation waveforms. The toolkit allows bi-directional transfer of results and provides an agile and efficient design method for improving the design of intrafascicular implants.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Otorhinolaryngology
James T. Heaton, James B. Kobler, Mark P. Ottensmeyer, Robert H. Petrillo, Monica A. Tynan, Robert E. Hillman, Steven M. Zeitels
Summary: A new method for tracking recovery after nerve injury was studied, using subcutaneous electrical connection ports to repeatedly connect to nerve cuff or intramuscular electrodes for periodic assessments of nerve and muscle function over long periods.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, Research & Experimental
Katherine Shapiro, Wenbin Guo, Kody Armann, Natalie Pace, Bing Shen, Jicheng Wang, Jonathan Beckel, William de Groat, Changfeng Tai
Summary: The study found that low-frequency biphasic stimulation can induce poststimulation block, which is reversible, and the duration of stimulation required for inducing block increases with frequency. The results of this study provide an opportunity for the development of new neuromodulation devices.
Article
Chemistry, Analytical
M. Ivette Muzquiz, Landan Mintch, M. Ryne Horn, Awadh Alhawwash, Rizwan Bashirullah, Michael Carr, John H. Schild, Ken Yoshida
Summary: The study successfully demonstrated the high degree of nerve block achieved by LFACb waveform in blocking bradycardic effect induced by vagal stimulation in rats, showing its effectiveness and reversibility.
Article
Neurosciences
Nikhil S. Chandra, Weston M. McCarron, Ying Yan, Luis C. Ruiz, Eric G. Sallinger, Nathan K. Birenbaum, Harold Burton, Leonard Green, Daniel W. Moran, Wilson Z. Ray, Matthew R. MacEwan
Summary: The study investigated the viability of the MSE as a sensory feedback interface through a rat sciatic nerve and behavioral model, finding that the MSE can elicit sensory percepts at low current levels and laying the groundwork for future experiments to study other devices, stimulus parameters, and task paradigms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Geumbee Lee, Emily Ray, Hong -Joon Yoon, Sabrina Genovese, Yeon Sik Choi, Min-Kyu Lee, Samet Sahin, Ying Yan, Hak-Young Ahn, Amay J. Bandodkar, Joohee Kim, Minsu Park, Hanjun Ryu, Sung Soo Kwak, Yei Hwan Jung, Arman Odabas, Umang Khandpur, Wilson Z. Ray, Matthew R. MacEwan, John A. Rogers
Summary: This study introduces a bioresorbable nerve stimulator that can provide pain relief through electrical nerve block without the need for surgical extraction. The device is designed to minimize adverse effects and disappears harmlessly in the body after use, making it a potential alternative to addictive drugs for pain treatment.
Article
Anesthesiology
Scott F. Lempka, Cameron C. McIntyre, Kevin L. Kilgore, Andre G. Machado
Article
Computer Science, Interdisciplinary Applications
Tina Vrabec, Niloy Bhadra, Jesse Wainright, Narendra Bhadra, Manfred Franke, Kevin Kilgore
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2016)
Article
Rehabilitation
Anne M. Bryden, Harry A. Hoyen, Michael. W. Keith, Melvin Mejia, Kevin L. Kilgore, Gregory A. Nemunaitis
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2016)
Article
Engineering, Biomedical
Tina Vrabec, Niloy Bhadra, Gustaf Van Acker, Narendra Bhadra, Kevin Kilgore
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2017)
Article
Engineering, Biomedical
Narendra Bhadra, Emily Foldes, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
JOURNAL OF NEURAL ENGINEERING
(2018)
Article
Engineering, Biomedical
Manfred Franke, Tina Vrabec, Jesse Wainright, Niloy Bhadra, Narendra Bhadra, Kevin Kilgore
JOURNAL OF NEURAL ENGINEERING
(2014)
Article
Neurosciences
Emilie H. Lothet, Kevin L. Kilgore, Niloy Bhadra, Narendra Bhadra, Tina Vrabec, Yves T. Wang, E. Duco Jansen, Michael W. Jenkins, Hillel J. Chiel
Article
Biochemical Research Methods
Leah Marie Roldan, Thomas E. Eggers, Kevin L. Kilgore, Narendra Bhadra, Tina Vrabec, Niloy Bhadra
JOURNAL OF NEUROSCIENCE METHODS
(2019)
Article
Engineering, Biomedical
Tina L. Vrabec, Jesse S. Wainright, Narendra Bhadra, Laura Shaw, Kevin L. Kilgore, Niloy Bhadra
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2019)
Article
Biochemical Research Methods
N. Bhadra, E. L. Foldes, M. R. Gerges, D. M. Ackermann, N. Bhadra, K. L. Kilgore
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Engineering, Biomedical
Thomas Eggers, Joseph Kilgore, David Green, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
Summary: The study successfully combined DC and KHFAC into a waveform named CROW, which can reduce the onset response and achieve effective nerve block, providing broader possibilities for clinical application of electrical nerve block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Andrew Goh, David Roberts, Jesse Wainright, Narendra Bhadra, Kevin Kilgore, Niloy Bhadra, Tina Vrabec
Summary: The application of direct current (DC) can produce rapid and reversible nerve conduction block, but prolonged charge injection may cause damage to nervous tissue. This study evaluates the surface stability of activated carbon and platinum black electrodes in vitro, providing insights for future development of HCM electrodes for in vivo nerve conduction block.
Article
Engineering, Biomedical
Shane A. Bender, David B. Green, Robert J. Daniels, Stephen P. Ganocy, Niloy Bhadra, Tina L. Vrabec
Summary: Electrical conduction block of the vagus nerve was studied to characterize its effects on heart rate dynamics. The results show that complete block and partial block can be achieved using direct current (DC) at different amplitudes. The amplitude of DC was found to significantly predict the induction time for complete block, and the blocking duration and injected charge were significant in predicting the recovery time.
JOURNAL OF NEURAL ENGINEERING
(2023)
Proceedings Paper
Engineering, Biomedical
Tina L. Vrabec, Kevin L. Kilgore, Jesse S. Wainright, Niloy Bhadra
2019 9TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2019)