期刊
SCIENCE ADVANCES
卷 8, 期 40, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abp9169
关键词
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资金
- Querrey Simpson Institute for Bioelectronics
- NCI [P30-CA060553]
- Korea Institute for Advancement of Technology - Korea Government (MOTIE) [P0017305]
- NIH [1K99HL155844-01A1]
- Turkish Fulbright Commission [FY-2020-TRPD-10]
- Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Orthopedic Research Program [W81XWH-17-PRORP-ARA]
- Ministry of Health & Welfare (MOHW), Republic of Korea [P0017305] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study introduces a bioresorbable nerve stimulator that can provide pain relief through electrical nerve block without the need for surgical extraction. The device is designed to minimize adverse effects and disappears harmlessly in the body after use, making it a potential alternative to addictive drugs for pain treatment.
Local electrical stimulation of peripheral nerves can block the propagation of action potentials, as an attractive alternative to pharmacological agents for the treatment of acute pain. Traditional hardware for such purposes, however, involves interfaces that can damage nerve tissue and, when used for temporary pain relief, that impose costs and risks due to requirements for surgical extraction after a period of need. Here, we introduce a bioresorb-able nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disap-pears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids.
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