Article
Clinical Neurology
Friederike Neuss, Felix von Podewils, Zhong Irene Wang, Marie Suesse, Uwe Klaus Zettl, Matthias Grothe
Summary: This study described a cohort of patients with both MS and epileptic seizures, finding that a significant percentage of MS patients with seizures had competing causes at the time of the first seizure. A detailed diagnostic setup including patient history, EEG, and MRI is recommended for evaluation and treatment decisions.
JOURNAL OF NEUROLOGY
(2021)
Review
Medicine, General & Internal
Vasileios Giannopapas, Lina Palaiodimou, Dimitrios Kitsos, Georgia Papagiannopoulou, Konstantina Stavrogianni, Athanasios Chasiotis, Maria Kosmidou, John S. Tzartos, George P. Paraskevas, Daphne Bakalidou, Georgios Tsivgoulis, Sotirios Giannopoulos
Summary: The interactions between Diabetes Mellitus type II (DMII) and Multiple Sclerosis (MS) result in higher levels of fatigue, increased risk of physical disability, accelerated cognitive decline, lower quality of life, and higher frequency of depression. This affects the disability progression and functional capacity of MS patients, adding to their psychological and economic burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Viktoria Papp, Melinda Magyari, Orhan Aktas, Thomas Berger, Simon A. Broadley, Philippe Cabre, Anu Jacob, Jun-ichi Kira, Maria Isabel Leite, Romain Marignier, Katsuichi Miyamoto, Jacqueline Palace, Albert Saiz, Maria Sepulveda, Olafur Sveinsson, Zsolt Illes
Summary: The systematic review of worldwide prevalence, incidence, and demographic characteristics of NMOSD highlighted variations among different geographic areas and ethnicities, with prominent female predominance in adults and peak incidence and prevalence in middle-aged adults. African ethnicity had the highest incidence and prevalence of NMOSD, whereas White ethnicity had the lowest, suggesting the need for further epidemiologic studies to investigate genetic effects and etiologic factors.
Article
Clinical Neurology
Lara Marie Pangan Lo, Bruce Taylor, Tania Winzenberg, Andrew J. Palmer, Leigh Blizzard, Ingrid van der Mei
Summary: The study found that the prevalence of comorbidities in patients with multiple sclerosis increases over the course of the disease, and there were no significant differences in prevalence between different onset types. Early and ongoing screening and management of comorbidities are crucial for improving quality of life for patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
F. B. S. Briggs, E. Hill, H. Abboud
Summary: The study found that hypertension is significantly more common in the multiple sclerosis (MS) population compared to the non-MS population, regardless of sex and race. Hypertension was more prevalent in the MS population, highlighting the need for aggressive screening and management of hypertension in this group.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Immunology
Wenjing Cheng, Qing Zhao, Chengzhen Li, Yunzhi Xu
Summary: Excessive immune activation within the lesion site can be observed after stroke onset. Interaction between peripheral and resident immunity on systemic immunity and clinical outcomes after stroke onset is summarized. Potential immunotherapeutic strategies are also discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Rheumatology
Majd Bairkdar, Marios Rossides, Helga Westerlind, Roger Hesselstrand, Elizabeth Arkema, Marie Holmqvist
Summary: This study conducted a systematic review and meta-analysis on the incidence and prevalence of SSc worldwide, finding significant regional and gender differences in reported estimates, with more recent studies reporting higher estimates than older ones.
Review
Neurosciences
Eunhee Kim, Sunghee Cho
Summary: Stroke triggers excessive immune activation in the brain tissue, involving intricate interactions between infiltrating peripheral immune cells and resident immune cells. Limited immune cells need to be appropriately distributed between the CNS and periphery to mount a necessary post-stroke inflammatory response while maintaining peripheral immunity. Understanding the distinct roles of CNS and peripheral immunity in their concerted action against ischemic insults is crucial in stroke pathophysiology.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Gorica D. Maric, Tatjana D. Pekmezovic, Sarlota T. Mesaros, Olivera S. Tamas, Jovana B. Ivanovic, Vanja N. Martinovic, Marko M. Andabaka, Aleksa Lj. Jovanovic, Nikola D. Veselinovic, Darija B. Kisic-Tepavcevic, Jelena S. Drulovic
Summary: The study found that the most common comorbidities in MS patients in Belgrade, Serbia were psychiatric and cardiovascular diseases, with depression and hypertension being the most prevalent single comorbidities. Type 2 diabetes was significantly more prevalent in patients with primary progressive MS compared to other MS phenotypes. The study also identified a positive correlation between number of comorbidities and progression index, as well as a higher risk of developing comorbidities in patients treated with disease-modifying therapies.
NEUROLOGICAL SCIENCES
(2021)
Review
Immunology
Ruth Ann Marrie, John D. Fisk, Kathryn Fitzgerald, Kaarina Kowalec, Colleen Maxwell, Dalia Rotstein, Amber Salter, Helen Tremlett
Summary: Comorbid conditions commonly affect people with multiple sclerosis (MS) and have significant impacts on their disease course and outcomes. Studies have shown that people with MS have higher incidence rates of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and psychiatric disorders compared to those without MS. Comorbidities are associated with higher relapse rates, greater physical and cognitive impairments, lower quality of life, and increased mortality among MS patients. Additionally, comorbidity is linked to increased healthcare utilization, costs, and work impairment at the societal level. The management of comorbidities should be integrated into MS care, and optimal care models need to be determined.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Lara Marie Pangan Lo, Bruce V. Taylor, Tania Winzenberg, Andrew J. Palmer, Leigh Blizzard, Mohammad Akhtar Hussain, Ingrid van der Mei
Summary: This study identified distinct comorbidity patterns in multiple sclerosis (MS) patients, with women, older individuals, obese individuals, and those with higher disability levels being more likely to have higher levels of comorbidity. These findings suggest opportunities for more personalized approaches to comorbidity prevention and treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Stephanie P. Jones, Kamran Baqai, Andrew Clegg, Rachel Georgiou, Harris Cath, Emma-Joy Holland, Yogeshwar Kalkonde, Catherine E. Lightbody, Pallab B. K. Maulik, Padma M. Srivastava, Pandian J. Durai, Patel Kulsum, P. N. Sylaja, Caroline L. Watkins, Hackett L. Maree
Summary: The burden of stroke is increasing in India, with a lack of available data and uniform methods in previous studies. Further high-quality evidence is needed to guide stroke policy and inform the development of stroke services in India.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Il-doo Kim, John W. Cave, Sunghee Cho
Summary: Obese mice with acute stroke showed increased mortality, infarct volume, swelling, and blood-brain barrier disruption, along with elevated VEGF-A and VEGFR2 expression. Aflibercept could reduce brain edema and vascular permeability, improving stroke outcomes in obese subjects.
Article
Immunology
Xiangxiang Hong, Xin Wang, Xinming Rang, Xinyue Yin, Xuemei Zhang, Rui Wang, Duo Wang, Tingting Zhao, Jin Fu
Summary: This study explored the shared mechanism and candidate drugs of MS and SS, identifying JAK-STAT signaling pathway as a vital role and potential therapies for their comorbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Fardowsa L. A. Yusuf, Ayesha Asaf, Ruth Ann Marrie, Ping Li, Kyla McKay, Yinshan Zhao, Feng Zhu, Colleen Maxwell, Helen Tremlett
Summary: Canada has one of the highest rates of paediatric-onset multiple sclerosis (PoMS) globally, and the prevalence, but not incidence, has increased over time. Allocation of resources to support the growing youth population with MS should be a priority.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Editorial Material
Clinical Neurology
Gary Cutter
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Sammita Satyanarayan, Gary Cutter, Stephen Krieger, Stacey Cofield, Jerry S. Wolinsky, Fred Lublin
Summary: The stringency of relapse definition affects measurements of relapse rate and composite endpoints in RRMS. Even with the most inclusive relapse definition, 43% of patients did not have durable worsening in the clinical trial. Therefore, relapse definition and durability should be considered in RRMS research to avoid overestimating disease progression.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Robert W. Motl, Ariel Kidwell-Chandler, Brian M. Sandroff, Lara A. Pilutti, Gary R. Cutter, Roberto Aldunate, Rachel E. Bollaert
Summary: A randomized controlled trial was conducted to examine the effectiveness of an Internet-based behavioral intervention on increasing physical activity in persons with multiple sclerosis (MS). The study found that the intervention led to immediate and sustained increases in moderate-to-vigorous physical activity among participants. This study provides evidence for a scalable approach to promote physical activity in persons with MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Alyssa N. Nylander, Jessica Singh, Shane Poole, Annika Anderson, Ruth Ann Marrie, Hope Rugo, Riley Bove
Summary: In this study, a case series of multiple sclerosis (MS) patients diagnosed with breast cancer was analyzed retrospectively to understand the clinical characteristics and treatment strategies. The study found that the relapse rate of MS during breast cancer treatment was low, and the neurologic function scores of the patients remained stable. This study provides valuable information for understanding the clinical management of patients with concurrent MS and breast cancer.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Ruth Ann Marrie
Summary: Comorbidity is common in people with multiple sclerosis (MS) and has significant impacts on outcomes such as relapses, disability progression, quality of life, healthcare use, and mortality. It is important to prevent and treat comorbidity effectively in people with MS by evaluating comorbidity, understanding its management in the context of MS, testing interventions tailored to MS patients, and determining optimal care models for comorbidity management.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Raffaele Palladino, Ruth Ann Marrie, Azeem Majeed, Jeremy Chataway
Summary: This study investigates the prevalence of diabetes and hypertension, as well as the usage of antidiabetic, antihypertensive, and lipid-lowering medications in people with multiple sclerosis (PwMS) at the time of diagnosis. The results show that PwMS have higher prevalence of diabetes and hypertension, but lower usage of corresponding medications. It is suggested that clinical guidelines should be developed to improve vascular management in PwMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Fardowsa L. A. Yusuf, Ayesha Asaf, Ruth Ann Marrie, Ping Li, Kyla McKay, Yinshan Zhao, Feng Zhu, Colleen Maxwell, Helen Tremlett
Summary: Canada has one of the highest rates of paediatric-onset multiple sclerosis (PoMS) globally, and the prevalence, but not incidence, has increased over time. Allocation of resources to support the growing youth population with MS should be a priority.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Urology & Nephrology
Michael Allon, Alian Al-Balas, Carlton J. Young, Gary R. Cutter, Timmy Lee
Summary: This study compared two strategies for the choice of initial vascular access in hemodialysis patients. The results showed that a more selective approach to arteriovenous fistula (AVF) placement can reduce the frequency of vascular access procedures and the cost of access management.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Clinical Neurology
Ruth Ann Marrie, Charles N. Bernstein, Casandra Dolovich, James M. Bolton, Lesley A. Graff, Carol A. Hitchon, Lisa M. Lix, James J. Marriott, John D. Fisk
Summary: This study aimed to assess the association between health-related quality of life (HRQoL) and depression, anxiety, fatigue, cognition, physical functioning, and physical comorbidities in multiple sclerosis (MS) patients. The results showed that increases in depression and fatigue were associated with decreases in physical HRQoL, while increases in depression, anxiety, and comorbidity count were associated with decreases in mental HRQoL.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Alan J. Thompson, Marcello Moccia, Maria Pia Amato, Peter A. Calabresi, Marcia Finlayson, Annie Hawton, Fred D. Lublin, Ruth Ann Marrie, Xavier Montalban, Michael Panzara, Maria Pia Sormani, Jon Strum, Barbara G. Vickrey, Timothy Coetzee
Summary: The survey results show that stakeholders of multiple sclerosis (MS) believe that the current clinical course descriptors need to change and support a mechanism-driven framework for describing MS. Clinical validation and ease of communication with patients are the most important considerations when developing a new framework.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Clinical Neurology
Emma Gray, Anneesa Amjad, Jenny Robertson, Judy Beveridge, Susan Scott, Guy Peryer, Marie Braisher, Cheryl Pugh, Sara Peres, Ruth Ann Marrie, Maria Pia Sormani, Jeremy Chataway
Summary: A rapid review on patient and public involvement (PPI) in multiple sclerosis (MS) clinical trials over the past 5 years revealed that only 8 trials mentioned PPI, mostly due to funding requirements. The OCTOPUS trial, an example of PPI in progressive MS, involved individuals affected by MS in governance and decision-making processes, resulting in a more accessible and inclusive trial design. Enhancing PPI in future MS clinical trials is crucial for improving study quality and relevance.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Clinical Neurology
Ruth Ann Marrie, Jeremy Chataway, Barbara E. Bierer, Marcia Finlayson, Elena H. Martinez-Lapiscina, Jennifer Panagoulias, Maria Pia Sormani, Mitzi Joi Williams, Lilyana Amezcua
Summary: This article summarizes recommendations for enhancing diversity and inclusion in clinical trials for multiple sclerosis (MS), including the use of diversity plans, community engagement and education, cultural competency training, adaptive designs, and reducing participant burden.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Clinical Neurology
Maria Pia Sormani, Jeremy Chataway, David M. Kent, Ruth Ann Marrie
Summary: Multiple sclerosis (MS) has varied outcomes, and evaluating heterogeneity of treatment effect (HTE) is important. Various statistical techniques can assess HTE, with multivariable predictive approaches offering more patient-centered results. This review examines methods used to estimate HTE in MS clinical trials.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Clinical Neurology
Ruth Ann Marrie, Maria Pia Sormani, Sean Apap Mangion, Francesca Bovis, Winson Y. Cheung, Gary R. Cutter, Peter Feys, Michael D. Hill, Marcus Werner Koch, Morgan McCreary, Ellen M. Mowry, Jay J. H. Park, Fredrik Piehl, Amber Salter, Jeremy Chataway
Summary: The current designs for clinical trials treating progressive multiple sclerosis (MS) have limitations and have not been successful. This paper discusses complex innovative trial designs and intermediate and composite outcomes to improve trial design efficiency in MS. Recommendations include increasing the use of complex innovative designs, developing biomarkers to enrich trial populations, prioritizing intermediate outcomes targeting therapeutic mechanisms, and investigating data linkage for long-term outcomes. Novel trial designs and further development of intermediate outcomes may improve clinical trial efficiency and address novel therapeutic questions in MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)