CD4+T-bet+, CD4+pSTAT3+ and CD8+T-bet+ T cells accumulate in peripheral blood during NZB treatment

Loss of STAT3 in CD4 + T Cells Prevents Development of Experimental Autoimmune Diseases

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Cutting Edge: T-bet and IL-27R Are Critical for In Vivo IFN-  Production by CD8 T Cells during Infection

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Natalizumab drug holiday in multiple sclerosis: Poorly Tolerated

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Effects of Natalizumab on Circulating B Cells, T Regulatory Cells and Natural Killer Cells

(2010) Norman Putzki et al.   EUROPEAN NEUROLOGY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

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STAT1-dependent IgG cell-surface expression in a human B cell line derived from a STAT1-deficient patient

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Pathogenic CD8+T cells in multiple sclerosis

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Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12

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T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

(2009) Yuhong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles

(2009) Sara Abromson-Leeman et al.   JOURNAL OF NEUROIMMUNOLOGY

Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells

(2009) P. Kivisakk et al.   NEUROLOGY

Monoclonal antibodies in MS: Mechanisms of action

(2009) B. Bielekova et al.   NEUROLOGY

Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab

(2008) Maria del Pilar Martin   ARCHIVES OF NEUROLOGY

Interferon-β increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity

(2008) M. Krumbholz et al.   BRAIN

Induction of systemic TNFα in Natalizumab-treated multiple sclerosis

(2008) M. Khademi et al.   EUROPEAN JOURNAL OF NEUROLOGY

Regulatory T cells fail to suppress CD4+ T-bet+T cells in relapsing multiple sclerosis patients

(2008) Giovanni Frisullo et al.   IMMUNOLOGY

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis

(2008) M. Krumbholz et al.   NEUROLOGY

Effects of Natalizumab Treatment on Foxp3+ T Regulatory Cells

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