Article
Chemistry, Multidisciplinary
Flavia Zisi Tegou, Diana Velluto, Aaron A. Stock, Samantha N. Fitzgerald, Samuel Stealey, Silviya P. Zustiak, Allison L. Bayer, Alice A. Tomei
Summary: This study developed a polyethylene glycol hydrogel platform for sustained release of beta cell antigens and CCL21 immunomodulatory molecule, enabling the development of antigen-specific tolerance therapies for Type-I Diabetes.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Natalin J. Valeff, Maria S. Ventimiglia, Marcos Dibo, Udo R. Markert, Federico Jensen
Summary: B1 B cells, a distinct subpopulation of B cells, have been controversial in their role during pregnancy. This study revealed an expanded and proliferative splenic B1 B cell population in mice during pregnancy, accompanied by an immunoregulatory phenotype, suggesting their critical role in the intricate process of pregnancy tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ashley L. Severance, Jeremy M. Kinder, Lijun Xin, Ashley R. Burg, Tzu-Yu Shao, Giang Pham, Tamara Tilburgs, Wendy A. Goodman, Sam Mesiano, Sing Sing Way
Summary: During pregnancy, progesterone stimulates the expansion of regulatory T cells to promote immune tolerance, ensuring fetal growth and preventing rejection from the mother's immune system. This study reveals the role of progesterone in promoting fetal tolerance and establishes a molecular link between immune and other physiological adaptations during pregnancy.
Article
Oncology
Daniel A. Zlotoff, Malek Z. O. Hassan, Amna Zafar, Raza M. Alvi, Magid Awadalla, Syed S. Mahmood, Lili Zhang, Carol L. Chen, Stephane Ederhy, Ana Barac, Dahlia Banerji, Maeve Jones-O'Connor, Sean P. Murphy, Merna Armanious, Brian J. Forrestal, Michael C. Kirchberger, Otavio R. Coelho-Filho, Muhammad A. Rizvi, Gagan Sahni, Anant Mandawat, Carlo G. Tocchetti, Sarah Hartmann, Hannah K. Gilman, Eduardo Zatarain-Nicolas, Michael Mahmoudi, Dipti Gupta, Ryan Sullivan, Sarju Ganatra, Eric H. Yang, Lucie M. Heinzerling, Franck Thuny, Leyre Zubiri, Kerry L. Reynolds, Justine Cohen, Alexander R. Lyon, John Groarke, Paaladinesh Thavendiranathan, Anju Nohria, Michael G. Fradley, Tomas G. Neilan
Summary: In ICI myocarditis, the QRS duration is prolonged and associated with increased MACE risk, while there is no association between the QTc interval and MACE.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Pharmacology & Pharmacy
Yang Yang, Pere Santamaria
Summary: In the past two decades, research on nanoparticle/microparticle-based compounds for treating autoimmune diseases has experienced explosive growth. Compounds have been evaluated using a variety of materials with different shapes, sizes, surface chemistries, and structures, incorporating various active pharmaceutical ingredients. These compounds can be categorized into four groups based on their intended mechanisms of action.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Lakshmipriya Perincherry, Lukasz Stepien, Soniya Eppurathu Vasudevan
Summary: Plants utilize a variety of defense mechanisms when facing stress, with continuous activation of defense pathways potentially leading to abnormal phenotypes. Self-immunity can cause tissue damage, but the possibility of engineered protective autoimmunity requires further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Emmanuel Cosson, Elhadji Mamadou Moussa Thioye, Sopio Tatulashvili, Eric Vicaut, Etienne Larger, Meriem Sal, Sara Pinto, Emmanuelle Fabre, Yoann Lalatonne, Angela Sutton, Charlotte Nachtergaele, Jean-Jacques Portal, Mohamed Zerguine, Lionel Carbillon, Helene Bihan
Summary: This study explored the association between the presence of glutamic acid decarboxylase antibodies (GADA) and other adverse pregnancy outcomes in women with hyperglycemia in pregnancy (HIP). The results showed that GADA was not associated with HIP-related adverse pregnancy outcomes except for a lower risk of cesarean delivery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Antonia N. Policheni, Charis E. Teh, Alissa Robbins, Selma Tuzlak, Andreas Strasser, Daniel H. D. Gray
Summary: By investigating compound mutant mice, researchers discovered a cooperative relationship between AIRE and PD-1, the loss of which can lead to spontaneous and lethal autoimmune disease. These findings have important implications for our understanding of how immune checkpoint blockade and defects in central tolerance can synergize to elicit autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Naomi Benne, Danielle ter Braake, Arie Jan Stoppelenburg, Femke Broere
Summary: This article discusses the strategy of using nanoparticles to deliver antigens and restore immune tolerance. It highlights potential cell targets and application methods for nanoparticles, as well as how nanoparticles carrying immunomodulators can activate tolerance in other antigen-presenting cell types. It also emphasizes the importance of considering relevant factors when translating animal studies to clinical applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ranjeny Thomas, Jose M. Carballido, Johnna D. Wesley, Simi T. Ahmed
Summary: Antigen-specific immunotherapy shows promise for treating type 1 diabetes, but faces obstacles in clinical translation. The key to overcoming these challenges lies in collaboration and cooperation among various stakeholders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Qi Ke, Ashley Nicole Greenawalt, Veera Manukonda, Xingqi Ji, Roland Michael Tisch
Summary: Inflammasome molecules are receptors that trigger proinflammatory responses against microbial infections. Dysregulation of inflammasome activity has been associated with chronic inflammation and autoimmune diseases. Inflammasome activation affects both innate and adaptive immune effectors as well as resident cells in target tissues, contributing to autoimmune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Francesca Motta, Veronica Codullo, Veronique Ramoni, Stefania Cesari, Giuseppina Ferrario, Giacomo Fiandrino, Fausta Beneventi, Stefania Rampello, Hanna Johnsson, Carlomaurizio Montecucco, Gerard J. Graham
Summary: This study aimed to compare placental alterations in SSc patients with other rheumatic diseases and healthy controls. The results showed that inflammatory changes characterize placentas from rheumatic disease patients and may predispose to obstetric complications.
Article
Immunology
Geraldo Magela Fernandes, Lizandra Moura Paravidine Sasaki, Gabriela Profirio Jardim-Santos, Heidi Luise Schulte, Felipe Motta, Angelo Pereira da Silva, Aleida Oliveira de Carvalho, Yacara Ribeiro Pereira, Caroline de Oliveira Alves, David Alves de Araujo Junior, Dayde Lane Mendonca-Silva, Karina Nascimento Costa, Maria Eduarda Canellas de Castro, Lucas Lauand, Rodrigo de Resende Nery, Rosana Tristao, Patricia Shu Kurizky, Otavio de Toledo Nobrega, Laila Salmen Espindola, Luiz Claudio Goncalves de Castro, Patricia Nessralla Alpoim, Lara Carvalho Godoi, Luci Maria Sant Ana Dusse, Jordana Grazziela Alves Coelho-dos-Reis, Laurence Rodrigues do Amaral, Matheus de Souza Gomes, Pedro Luiz Lima Bertarini, Joaquim Pedro Brito-de-Sousa, Ismael Artur da Costa-Rocha, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhaes, Andrea Teixeira-Carvalho, Alberto Moreno Zaconeta, Alexandre Anderson de Sousa Munhoz Soares, Valeria Valim, Ciro Martins Gomes, Cleandro Pires de Albuquerque, Olindo Assis Martins-Filho, Licia Maria Henrique da Mota
Summary: This study aimed to characterize the immunological status of pregnant women with convalescent COVID-19 at different pregnancy trimesters. The results showed that pregnant women with COVID-19 had higher levels of chemokines, cytokines, and growth factors compared to the control group. The study suggests an imbalanced immune response during convalescent COVID-19 infection in pregnant women, which may contribute to late complications in the post-symptomatic phase.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Thiago Alves da Costa, Jacob N. Peterson, Julie Lang, Jeremy Shulman, Xiayuan Liang, Brian M. Freed, Susan A. Boackle, Pilar Lauzurica, Raul M. Torres, Roberta Pelanda
Summary: The study using a human immune system mouse model revealed a distinctive phenotype of human autoreactive immature B cells and their presence in human bone marrow samples. Additionally, alterations in marker expression were observed in mice engrafted with human immune systems genetically predisposed to autoimmunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
