TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

(2013) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

(2013) Filip Van Hauwermeiren et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins

(2013) Indrajit Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

(2013) R E Vandenbroucke et al.   Mucosal Immunology

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis

(2011) Steven J. McElroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Tumor Necrosis Factor Inhibits Glucocorticoid Receptor Function in Mice

(2011) Tom Van Bogaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

ER stress and the unfolded protein response in intestinal inflammation

(2010) Michael A. McGuckin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

(2010) Malin E. V. Johansson et al.   PLoS One

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

(2010) Johan H. van Es et al.   Nature Communications

Positive Role of CCAAT/Enhancer-Binding Protein Homologous Protein, a Transcription Factor Involved in the Endoplasmic Reticulum Stress Response in the Development of Colitis

(2009) Takushi Namba et al.   AMERICAN JOURNAL OF PATHOLOGY

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

(2009) Fang Zhao et al.   DEVELOPMENTAL BIOLOGY

Type I interferon drives tumor necrosis factor–induced lethal shock

(2009) Liesbeth Huys et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

(2009) Malin E. V. Johansson et al.   JOURNAL OF PROTEOME RESEARCH

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn’s disease

(2008) V. Strugala et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

IL-17 produced by Paneth cells drives TNF-induced shock

(2008) Nozomi Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE