Icariin Is A PPARα Activator Inducing Lipid Metabolic Gene Expression in Mice

Effect of Icariin on UDP-Glucuronosyltransferases in Mouse Liver

(2014) Shang-Fu Xu et al.   PLANTA MEDICA

Learning to Program the Liver

(2013) Curtis D. Klaassen   Annual Review of Pharmacology and Toxicology

Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway

(2013) Hai Yan Quan et al.   BIOCHEMICAL PHARMACOLOGY

The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulation in nonalcoholic fatty liver disease

(2013) Carla Guzmán et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

(2013) Pooja Jha et al.   HEPATOLOGY

Green Tea Polyphenols Alleviate Obesity in Broiler Chickens through the Regulation of Lipid-Metabolism-Related Genes and Transcription Factor Expression

(2013) Jinbao Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quantification of Mitochondrial Acetylation Dynamics Highlights Prominent Sites of Metabolic Regulation

(2013) Amelia J. Still et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptive responses by mouse fetus to a maternal HLE diet by downregulating SREBP1: a microarray- and bio-analytic-based study

(2013) Huan-Ling Yu et al.   JOURNAL OF LIPID RESEARCH

Liver Fatty Acid Binding Protein Gene-Ablation Exacerbates Weight Gain in High-Fat Fed Female Mice

(2013) Avery L. McIntosh et al.   LIPIDS

Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-α activation

(2013) LIJUAN SHI et al.   Molecular Medicine Reports

Icariin Attenuates the Enhanced Prothrombotic State in Atherosclerotic Rabbits Independently of Its Lipid-Lowering Effects

(2013) Wei-ping Zhang et al.   PLANTA MEDICA

Identification of Diverse Lipid Droplet Targeting Motifs in the PNPLA Family of Triglyceride Lipases

(2013) Sricharan Murugesan et al.   PLoS One

Inhibitors of Fatty Acid Synthesis Induce PPARα-Regulated Fatty Acidβ-Oxidative Genes: Synergistic Roles of L-FABP and Glucose

(2013) Huan Huang et al.   PPAR Research

Refocusing Peroxisome Proliferator Activated Receptor-α: A New Insight for Therapeutic Roles in Diabetes

(2013) Hannah Seok et al.   Diabetes & Metabolism Journal

Impact of L-FABP and glucose on polyunsaturated fatty acid induction of PPARα-regulated β-oxidative enzymes

(2012) Anca D. Petrescu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Resveratrol Helps Recovery from Fatty Liver and Protects against Hepatocellular Carcinoma Induced by Hepatitis B Virus X Protein in a Mouse Model

(2012) H.-C. Lin et al.   Cancer Prevention Research

Overexpression of CD36 and Acyl-CoA Synthetases FATP2, FATP4 and ACSL1 Increases Fatty Acid Uptake in Human Hepatoma Cells

(2012) Julia Krammer et al.   International Journal of Medical Sciences

Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo

(2012) Hua Xin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

(2012) Sander M. Houten et al.   JOURNAL OF LIPID RESEARCH

Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism

(2011) Barbara De Filippis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex

(2011) Kwangwon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats

(2011) Min-You Qi et al.   JOURNAL OF ETHNOPHARMACOLOGY

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver

(2011) Mohamed A. Abdelmegeed et al.   JOURNAL OF NUTRITION

Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway

(2011) Beatriz Puisac et al.   MOLECULAR BIOLOGY REPORTS

Enhanced peroxisomal β-oxidation metabolism in visceral adipose tissues of high-fat diet-fed obesity-resistant C57BL/6 mice

(2011) WEI-DONG XIE et al.   Experimental and Therapeutic Medicine

Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE

(2010) Morris A. Kostiuk et al.   FASEB JOURNAL

Herba Epimedii: Anti-Oxidative Properties and Its Medical Implications

(2010) Stephen Cho Wing Sze et al.   MOLECULES

Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats

(2010) Fei Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats

(2010) J. Guo et al.   PHYTOMEDICINE

Peroxisome proliferator-activated receptor-alpha (PPARα): At the crossroads of obesity, diabetes and cardiovascular disease

(2009) Jean-Charles Fruchart   ATHEROSCLEROSIS

PROTECTIVE EFFECTS OF ICARIIN ON COGNITIVE DEFICITS INDUCED BY CHRONIC CEREBRAL HYPOPERFUSION IN RATS

(2009) Rui-Xia Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Icariin inhibits beta-amyloid peptide segment 25–35 induced expression of β-secretase in rat hippocampus

(2009) Jing Nie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Long-chain fatty acid effects on peroxisome proliferator-activated receptor-α-regulated genes in Madin-Darby bovine kidney cells: Optimization of culture conditions using palmitate

(2009) B.J. Thering et al.   JOURNAL OF DAIRY SCIENCE