Article
Multidisciplinary Sciences
Xiaoyu Liu, Hao Zhang, Chuanfen Li, Zhibin Chen, Qian Gao, Muxuan Han, Feng Zhao, Dan Chen, Qiuyue Chen, Minghui Hu, Zifa Li, Sheng Wei, Xiwen Geng
Summary: This study aimed to determine the optimal dose and administration duration of curcumin in alleviating the movement symptoms of Parkinson's disease. The results showed that a 160 mg/kg/d treatment for 2 weeks was the most effective in improving behavioral disorders, while the 40/80 mg/kg/d treatments had limited effectiveness. Comparing the effects of 1-week and 2-week interventions, the 2-week treatment showed better alleviation of symptoms.
Article
Multidisciplinary Sciences
Andrea Slezia, Panna Hegedus, Evgeniia Rusina, Katalin Lengyel, Nicola Solari, Attila Kaszas, Diana Balazsfi, Boris Botzanowski, Emma Acerbo, Florian Missey, Adam Williamson, Balazs Hangya
Summary: Studying animal models allows us to better understand the mechanisms of Parkinson's disease. However, current models mainly focus on late-stage symptoms, leaving a gap in our knowledge of early-stage changes. In this study, a graded-dose unilateral 6-OHDA model was established in mice, and the behavioral, neuronal, and ultrastructural features were analyzed within the first two weeks of lesion induction. The results showed that mild degeneration of dopaminergic neurons can lead to motor deficits shortly after striatal lesions, suggesting that this model can be used to study the early stages of Parkinson's disease in mice.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
William Tanguay, Charles Ducrot, Nicolas Giguere, Marie-Josee Bourque, Louis-Eric Trudeau
Summary: In Parkinson's disease, dopamine neurons in the substantia nigra pars compacta show unique vulnerability due to their large axonal arbors. By inducing partial SNc lesions in neonatal mice, researchers found that adult mice exhibited compensatory axonal sprouting in SNc DA neurons after neuronal loss.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Clinical Neurology
Tushar Kamath, Evan Z. Macosko
Summary: Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. Recent advances in genomic profiling have identified specific pathways and genetic variants involved in the susceptibility of dopaminergic neurons in Parkinson's disease. This provides new opportunities for understanding and developing therapies for this complex disorder.
MOVEMENT DISORDERS
(2023)
Article
Nutrition & Dietetics
Anais Marie, Julien Leroy, Morgane Darricau, Serge Alfos, Veronique De Smedt-Peyrusse, Emmanuel Richard, Sylvie Vancassel, Clementine Bosch-Bouju
Summary: Vitamin A supplementation partially alleviates motor alterations and improves striatal function in a rat model of PD, suggesting a potential beneficial preventive approach for the disease.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Review
Endocrinology & Metabolism
Vandana Zaman, Donald C. Shields, Ramsha Shams, Kelsey P. Drasites, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: Parkinson's disease is a neurodegenerative disorder linked to the loss of dopaminergic neurons in the substantia nigra. The disease's etiology is still unclear, but interactions between external and internal factors may play a crucial role in its onset and progression. Research in animal models and post-mortem human tissue has identified cellular and molecular changes in the diseased brain, indicating complex interactions between different glial cell types and molecular pathways.
METABOLIC BRAIN DISEASE
(2021)
Article
Multidisciplinary Sciences
Esther Gramage, Jorge Saiz, Rosalia Fernandez-Calle, Yasmina B. Martin, Maria Uribarri, Marcel Ferrer-Alcon, Coral Barbas, Gonzalo Herradon
Summary: This study found that overexpression of PTN has a neuroprotective effect in a mouse model of Parkinson's Disease and identified potential lipid-related drug candidates for Parkinson's Disease.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Bira Arumndari Nurrahma, Tu-Hsueh Yeh, Rong-Hong Hsieh, Shu-Ping Tsao, Chia-Wen Chen, Yen-Peng Lee, Chun-Hsu Pan, Hui-Yu Huang
Summary: The study suggests that mangosteen pericarp extract may delay the progression of Parkinson's disease by counteracting oxidative stress and improving gut microbiota composition.
Article
Neurosciences
Arnaud Pautrat, Racha Al Tannir, Karin Pernet-Gallay, Remi Soutrenon, Estelle Vendramini, Valerie Sinniger, Paul G. Overton, Olivier David, Veronique Coizet
Summary: The presence of central neuropathic pain in Parkinson's disease suggests that the brain circuits involved in pain processing may be dysfunctional. This study provides evidence that dysfunction in the subthalamic nucleus and/or substantia nigra pars reticulata may affect the processing of pain signals in the parabrachial nucleus (PBN) and lead to cellular and molecular adaptations in this structure. Rat models of Parkinson's disease with varying levels of dopaminergic lesions were used to demonstrate enhanced nociceptive responses in the substantia nigra reticulata and inhibited nociceptive responses and increased expression of GABA(A) receptors in the PBN following a total dopaminergic lesion. These findings suggest that molecular changes within the PBN, particularly increased GABA(A) expression, may contribute to the development of central neuropathic pain in Parkinson's disease.
NPJ PARKINSONS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Clinical Neurology
Burak Cem Soner, Eda Acikgoz, Salim Yalcin Inan, Sule Ayla, Ayse Saide Sahin, Gulperi Oktem
Summary: Parkinson's disease is a common neurodegenerative disorder with no known cure. Research shows that CAPE treatment can improve motor performance and prevent neuronal loss induced by 6-OHDA, suggesting its potential as a promising clinical agent for PD treatment.
PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Rahul Gaurav, Lydia Yahia-Cherif, Nadya Pyatigorskaya, Graziella Mangone, Emma Biondetti, Romain Valabregue, Claire Ewenczyk, R. Matthew Hutchison, Jesse M. Cedarbaum, Jean-Christophe Corvol, Marie Vidailhet, Stephane Lehericy
Summary: The study found a progressive decrease in neuromelanin-based substantia nigra signal and volume in PD patients, which could serve as a noninvasive assessment marker for disease progression.
MOVEMENT DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
John A. Collins, Maryna Kapustina, Jesalyn A. Bolduc, James F. W. Pike, Brian O. Diekman, Kimberlee Mix, Susan Chubinskaya, Emrah Eroglu, Thomas Michel, Leslie B. Poole, Cristina M. Furdui, Richard F. Loeser
Summary: SIRT6, a nuclear localized deacetylase protein, is a critical regulator of aging processes. It can promote resistance to oxidative stress and influences specific members of the Prx catalytic cycle in chondrocytes to maintain redox homeostasis. Age and oxidative stress conditions alter SIRT6 activity, suggesting potential therapeutic targets for maintaining redox balance in joint tissues and preventing osteoarthritis progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, In-Su Kim, Yuxi Lin, Young-Ho Lee, Dong-Kug Choi
Summary: In Parkinson's disease, the aggregated alpha-synuclein in Lewy bodies and mitochondrial dysfunction play crucial roles in neurodegeneration, with interactions between aggregated alpha-synuclein and mitochondria potentially leading to neuronal loss, making it an emerging drug target for Parkinson's disease treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Spandana Rajendra Kopalli, Kyu-Min Cha, Jae Youl Cho, Si-Kwan Kim, Sushruta Koppula
Summary: The study found that Cordycepin from Cordyceps militaris has protective effects against ageing and oxidative stress-induced male infertility.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Agronomy
Spandana Rajendra Kopalli, Kyu-Min Cha, Jae Youl Cho, Si-Kwan Kim, Sushruta Koppula
Summary: This study investigated the beneficial effects of cordycepin on aging-associated testicular inflammation and serum biochemical changes in naturally aged rats. The results showed that cordycepin treatment significantly improved the altered biochemical parameters and attenuated the increased expression of inflammatory mediators in aged rats.
Review
Biochemistry & Molecular Biology
Riya Kulkarni, Akshata Thakur, Hemant Kumar
Summary: Disturbance in the neuronal network can lead to instability in microtubules, hindering intra-axonal transport and making it difficult to reestablish the broken network. Peripheral nervous system neurons have the ability to stabilize microtubules, while central nervous system neurons form growth-incompetent structures. Understanding microtubule dynamics is crucial in developing therapeutic strategies for diseases involving disrupted microtubule networks.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Santimoy Sen, Sheetal Lagas, Abhishek Roy, Hemant Kumar
Summary: Cells rely on a balanced cytoskeleton to maintain cellular integrity and regulate signaling pathways. Dysregulation of the cytoskeleton can lead to various pathological conditions, and targeting cytoskeletal dynamics may provide new therapeutic approaches for these diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Cell Biology
Manjeet Chopra, Ankita Bhagwani, Hemant Kumar
Summary: Endothelial cells and pericytes play important roles in blood vessels, with their interaction crucial for angiogenesis and wound healing. Understanding the surface markers, spatiotemporal association, and signaling pathways associated with traumatic spinal cord injury can lead to the identification of new therapeutic targets and preventive strategies.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Divya Goyal, Hemant Kumar
Summary: Endothelial damage, astrogliosis, microgliosis, and neuronal degeneration are common events after spinal cord injury (SCI). Conventional techniques like 2-dimensional histology and immunohistochemistry (IHC) are used to visualize and detect these events, but advanced imaging methodologies such as two-photon imaging and in vivo chemical and fluorescent protein-expressing viral-tracers offer more advantages in terms of tissue sectioning, 3D reconstructed imaging, and minimal invasiveness. This review discusses the future development of these advanced imaging techniques to explore the fundamental mechanisms after SCI.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Sagar Salave, Suchita Dattatray Shinde, Dhwani Rana, Bichismita Sahu, Hemant Kumar, Rikin Patel, Derajram Benival, Nagavendra Kommineni
Summary: Bone-specific functionalization strategies on liposomes can deliver drugs specifically to the bone surface, reducing the dose and off-target effects of the drug, and thereby reducing its toxicity.
Review
Clinical Neurology
Lahanya Guha, Nidhi Singh, Hemant Kumar
Summary: Cell death is a complex process involving multiple pathways, some of which have been well-studied while others are still being explored. In neurological diseases, impairments in various programmed cell death signaling processes are observed. Spinal cord injury, characterized by the death of neuronal and glial cells, can be influenced by different cell death pathways. A better understanding of the molecular basis of these pathways may enhance neuronal and glial survival, promoting a curative path for spinal cord injury.
Review
Neurosciences
Ayub Mohammed Butt, Vimal Rupareliya, A. Hariharan, Hemant Kumar
Summary: The extracellular matrix (ECM) is a complex network of macromolecules that surround cells in tissues, providing structural support and regulating cellular functions. ECM remodeling is a dynamic process involved in tissue growth, wound healing, and tissue repair. Dysregulated ECM remodeling can lead to the formation of fibrotic and glial scars in CNS injuries.
Review
Cell Biology
Meenal Verma, Manjeet Chopra, Hemant Kumar
Summary: This article reviews the role of EphA4 in neurological diseases and discusses its potential as a therapeutic target for CNS diseases. It also provides an overview of multiple signaling pathways that regulate EphA4-associated biological processes.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vimal P. Rupareliya, Aditya A. Singh, Ayub Mohammed Butt, A. Hariharan, Hemant Kumar
Summary: Astrocytes, with their diverse populations and functions, play essential roles in regulating CNS physiology and are implicated in various neurological and psychiatric disorders. The heterogeneity of astrocytes in morphology, function, and gene expression contributes to their region-specific functions and interactions with neurons. Further investigation into astrocytic heterogeneity may provide new insights and therapeutic approaches for targeting neurological conditions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Neurosciences
Alisha Vartak, Divya Goyal, Hemant Kumar
Summary: Guidance molecules are essential for neural development, particularly in guiding axons to their target regions during spinal cord development. Defects in these molecules' expression or function can lead to abnormalities in axonal pathfinding, growth cone navigation, axonal branching, and synapse formation, affecting neuronal circuit construction and function after central nervous system traumas such as spinal cord injury (SCI).
Review
Chemistry, Medicinal
Monu Kumar Kashyap, Shubhada V. Mangrulkar, Sapana Kushwaha, Akash Ved, Mayur B. Kale, Nitu L. Wankhede, Brijesh G. Taksande, Aman B. Upaganlawar, Milind J. Umekar, Sushruta Koppula, Spandana Rajendra Kopalli
Summary: Cardiotoxicity is a well-known adverse effect of cancer-related therapy, and it significantly affects patient outcomes and quality of life. The use of antineoplastic drugs to treat colorectal cancers (CRCs) can result in cardiac complications. The mechanisms underlying cardiotoxicity associated with CRC treatment are complex and involve the modulation of various signaling pathways, ultimately damaging cardiac tissue. Therefore, the identification and management of cardiotoxicity associated with CRC drug therapy have become increasingly important.
Review
Pharmacology & Pharmacy
Lahanya Guha, Hemant Kumar
Summary: Spinal cord injury (SCI) is a leading cause of morbidity and mortality worldwide, involving complex mechanisms such as cell death pathways, neurodegeneration, glutaminergic transmission, and inflammation. Current treatment options, including corticosteroids and non-steroidal anti-inflammatory drugs, have limitations in their effectiveness and are focused on symptomatic relief. Drug repurposing offers a promising approach to expand therapy alternatives for SCI, utilizing approved drugs with known safety and efficacy data. This review summarizes marketed drugs that could be repurposed and discusses ongoing clinical trials for SCI therapy.
PHARMACEUTICAL MEDICINE
(2023)