Article
Biochemistry & Molecular Biology
Danilo D'Avino, Ida Cerqua, Hammad Ullah, Michele Spinelli, Rita Di Matteo, Elisabetta Granato, Raffaele Capasso, Lucianna Maruccio, Armando Ialenti, Maria Daglia, Fiorentina Roviezzo, Antonietta Rossi
Summary: The root of Astragalus membranaceus (Fisch.) Bunge is used in Chinese medicine for its immunomodulating activities. Recent studies have shown that it has beneficial effects on allergic diseases. This study investigated the anti-inflammatory properties of a commercial extract of A. membranaceus and its therapeutic application in asthma. The extract was found to inhibit inflammation and improve lung function, making it a potential treatment option for asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yanan Xu, Weifeng Wu, Yi Chen, Tingting Zhang, Keling Tu, Yun Hao, Hailu Cao, Xuehui Dong, Qun Sun
Summary: The non-destructive and highly accurate discrimination of Astragalus membranaceus var. mongholicus, A. membranaceus, and similar seeds using hyperspectral imaging was achieved, providing support for standardization in the Astragalus production industry.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Juan Yu, Xiao-dan Dong, Jian-shuang Jiao, Hai-yu Ji, An-jun Liu
Summary: The Astragalus membranaceus polysaccharide (APS4) shows direct cytotoxicity on various cancer cells and has potential therapeutic effects on solid tumors. Through experiments on S180 tumor-bearing mice, it was found that APS4 can regulate the immune system, inhibit solid tumor growth, and promote apoptosis of tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Plant Sciences
Aliya Sheik, Kwanwoo Kim, Ganji Lakshmi Varaprasad, Hoomin Lee, Suheon Kim, Eunsu Kim, Jin-Yong Shin, Seo Yeong Oh, Yun Suk Huh
Summary: Astragalus membranaceus, as a traditional herb with a long history in cancer treatment, has attracted researchers' attention for its immunomodulatory effects and potential in alleviating cancer-related fatigue. Its natural phytoconstituents show high anti-cancer activity and have been studied in clinical trials for overcoming the toxic effects of chemotherapy drugs.
Article
Biology
Szu-Ju Chen, Sunderiya Dalanbaatar, Huey-Yi Chen, Shih-Jing Wang, Wei-Yong Lin, Po-Len Liu, Ming-Yen Tsai, Der-Cherng Chen, Yung-Hsiang Chen, Wen-Chi Chen
Summary: The study found that the use of Astragalus membranaceus (AM) can reduce the ratio of calcium oxalate crystal formation in the Drosophila Malpighian tubules and significantly improve the reduction of lifespan caused by ethylene glycol (EG). However, AM cannot directly dissolve pre-existing calcium oxalate crystals in the Drosophila Malpighian tubules.
Article
Oncology
Zoya Cohen, Yair Maimon, Noah Samuels, Hadar Brand, Aaron Sulkes, Baruch Brenner, Raanan Berger
Summary: The study screened traditionally used botanicals and discovered that a combination of Astragalus membranaceus and Vaccaria hispanica has strong synergic anti-cancer effects on cancer cells. The combination interferes with the cell cycle of cancer cells, causing G2/M phase accumulation and ultimately leading to apoptosis. Further research is needed to validate its generalizability and understand its mechanism of action.
Article
Plant Sciences
Zhiyuan Li, Jinfeng Qi, Tiankang Guo, Junliang Li
Summary: This study aims to introduce and discuss the specific mechanism of action of Astragalus membranaceus in the treatment of peritoneal metastasis, providing a new perspective for treatment and further research. It was found that Astragalus membranaceus contains polysaccharides, saponins, and flavonoids as its main bioactive components, which have extensive effects on cancer. However, due to the lack of reliable in vivo experiments, clinical data, and evidence of clinical efficacy, its use is not currently recommended.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Juyoung Hwang, Wei Zhang, Yadav Dhananjay, Eun-Koung An, Minseok Kwak, Sang Guan You, Peter Chang-Whan Lee, Jun-O Jin
Summary: Intranasal administration of Astragalus membranaceus polysaccharides (APS) activated mucosal immune cell populations and inhibited pulmonary metastatic melanoma in mice by stimulating NK cells and T cells in the mesenteric lymph nodes. The combination treatment of APS with anti-PD-L1 antibody showed a synergistic effect in inhibiting melanoma cell infiltration, with NK cells and CD8 T cells playing a critical role in mediating the anti-cancer immunity. These findings suggest that APS could serve as a topical mucosal adjuvant to enhance the anti-cancer effect of immune checkpoint inhibitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Plant Sciences
Baoyu Ji, Liangshuang Xuan, Yunxiang Zhang, Guoqi Zhang, Jie Meng, Wenrong Mu, Jingjing Liu, Kee-Yoeup Paek, So-Young Park, Juan Wang, Wenyuan Gao
Summary: This review focuses on the biotechnological research of Astragalus membranaceus, including tissue culture, metabolic regulation of chemical compounds, and the synthetic biology of astragalosides. It aims to provide a broader development prospect for the in-depth study of medicinal plants.
Article
Biochemistry & Molecular Biology
Xue-Feng Bao, Pei-Hong Cao, Jin Zeng, Luo-Min Xiao, Zhi-Hui Luo, Jian Zou, Chuan-Xi Wang, Zhong-Xiang Zhao, Zheng-Qun Zhou, Hui Zhi, Hao Gao
Summary: Eleven unknown and three known pterocarpans were isolated and identified from Huang-qi, a traditional Chinese medicine. Among them, nine rare apiosyl-containing pterocarpan glycosides were discovered. These compounds exhibited hypoglycemic and antioxidant activities.
Article
Biochemistry & Molecular Biology
Guangming Chen, Nan Jiang, Junping Zheng, Haiming Hu, Huabing Yang, Aizhen Lin, Baifei Hu, Hongtao Liu
Summary: In this study, two homogeneous polysaccharides (APS-A1 and APS-B1) were isolated from Astragalus membranaceus and their chemical structures were characterized. APS-A1 had a 1,4-alpha-D-Glcp backbone with a 1,4,6-alpha-D-Glcp branch every ten residues, while APS-B1 was a heteropolysaccharide composed of glucose, galactose, and arabinose. Bioactivity assays showed that both APS-A1 and APS-B1 exhibited potential anti-inflammatory activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Liu Junqiu, Nile Shivraj Hariram, Xu Guoliang, Wang Yuesheng, Kai Guoyin
Summary: AM and PG are both able to enhance immune system functions, including increased spleen and thymus index, enhanced proliferation of splenic lymphocytes, and increased cytotoxic activity of NK cells. Furthermore, through analysis of potential bioactive compounds, enzyme actions, and pathways, the different molecular mechanisms of AM and PG on immune regulation were investigated.
Article
Fisheries
Hany M. R. Abdel-Latif, Hamada A. Ahmed, Mustafa Shukry, Md Reaz Chaklader, Rasha M. Saleh, Mohamed A. Khallaf
Summary: The present study evaluated the impacts of powdered Astragalus membranaceus extract on the growth, physiological responses, and serum immunity of Pangasianodon hypophthalmus juveniles. The results showed that Astragalus membranaceus extract can improve the growth performance and immune function of fish.
Article
Fisheries
Tingshuang Pan, Min Yang, He Jiang, Tong Li, Guoqing Duan, Jun Ling, Qian Gao
Summary: The intensive culturing of hybrid yellow catfish has increased their mortality. Astragalus membranaceus, used as an immune stimulant and antioxidant, was mixed with the fish diet. The study analyzed the spleen transcriptome data and relative percentage survival to understand the function of A. membranaceus in the defense against Aeromonas hydrophila. The results showed differentially expressed genes in the spleen and improved survival rates for the fish challenged with A. hydrophila.
Article
Fisheries
Zhengshi Zhang, Xiucong Hu, Qianying Diao, Panpan Zhang, Ying Wu, Zhenjie Cao, Yongcan Zhou, Chunsheng Liu, Yun Sun
Summary: In this study, a macrophage migration inhibitory factor (TroMIF) was identified from golden pompano and its function was analyzed. TroMIF showed high similarity with other known MIF sequences and was most closely related to large yellow croaker. TroMIF was highly expressed in the liver and head kidney and its expression was up-regulated after E. tarda infection. In vitro experiments showed that rTroMIF could inhibit the migration of lymphocytes and macrophages and enhance macrophage phagocytic activity. Furthermore, rTroMIF increased the expression levels of pro-inflammatory cytokines and had enzymatic redox activity. Overexpression of TroMIF enhanced the ability to resist E. tarda infection, while knockdown of TroMIF expression increased the bacterial load. These results suggest that TroMIF plays an important role in antibacterial immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Min Yang, Guang Xu, Lilu Ling, Jianying Niu, Tong Lu, Xin Du, Yong Gu
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2017)
Article
Immunology
Jianying Niu, Changhong Li, Yinji Jin, Rui Xing, Lin Sun, Ruohan Yu, Leilei Jian, Xiangyuan Liu, Lin Yang
IMMUNOLOGY LETTERS
(2018)
Article
Biochemistry & Molecular Biology
Haoran Yuan, Changhong Li, Jianying Niu, Lin Yang
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2019)
Article
Transplantation
Ying Zheng, Li Tang, Weiguang Zhang, Delong Zhao, Dong Zhang, Li Zhang, Guangyan Cai, Xiangmei Chen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Obstetrics & Gynecology
Guixiang Chen, Xiaohong Jin, Lihong Zhang, Jianying Niu, Yong Gu
REPRODUCTIVE SCIENCES
(2019)
Article
Immunology
Lin Yang, Haoran Yuan, Ying Yu, Nan Yu, Lilu Ling, Jianying Niu, Yong Gu
CLINICAL IMMUNOLOGY
(2019)
Article
Health Care Sciences & Services
Zhaohui Ni, Haijiao Jin, Gengru Jiang, Niansong Wang, Ai Peng, Zhiyong Guo, Shoujun Bai, Rong Zhou, Jianrao Lu, Yi Wang, Ying Li, Shougang Zhuang, Chen Yu, Yueyi Deng, Huimin Jin, Xudong Xu, Junli Zhang, Junli Zhao, Xiuzhi Yu, Xiaoxia Wang, Liming Zhang, Jianying Niu, Kun Liu, Bao Xiaorong, Qin Wang, Jun Ma, Chun Hu, Xiujuan Zang, Qing Yu
JOURNAL OF MEDICAL INTERNET RESEARCH
(2019)
Article
Endocrinology & Metabolism
Qiaojing Qin, Yingjun Qian, Guanghua Zhu, Weifeng Fan, Jianying Niu, Yong Gu
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Physiology
Min Yang, Yonghua Zou, Tong Lu, Yule Nan, Jianying Niu, Xin Du, Yong Gu
KIDNEY & BLOOD PRESSURE RESEARCH
(2019)
Article
Urology & Nephrology
Chen Yu, Wen Ping, Yang Junwei, Niu Jianying
Article
Urology & Nephrology
Bin Wang, Honglei Guo, Lilu Ling, Jialing Ji, Jianying Niu, Yong Gu
Article
Physiology
Honglei Guo, Bin Wang, Hongmei Li, Lilu Ling, Jianying Niu, Yong Gu
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)
Article
Cell Biology
Honglei Gun, Hongmei Li, Bin Wang, Wei Ding, Lilu Ling, Min Yang, Jianying Niu, Yong Gu
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Endocrinology & Metabolism
Guang Xu, Qiaojing Qin, Min Yang, Zhongdong Qiao, Yong Gu, Jianying Niu
DIABETES RESEARCH AND CLINICAL PRACTICE
(2017)
Article
Physiology
Ying Yu, Lihong Zhang, Guang Xu, Zhenghong Wu, Qian Li, Yong Gu, Jianying Niu
KIDNEY & BLOOD PRESSURE RESEARCH
(2018)
