Article
Chemistry, Applied
Qiang Chen, Chaochao Jia, Yingran Xu, Zhuanzhuan Jiang, Ting Hu, Conghu Li, Xu Cheng
Summary: Efficient dual-pH responsive chitosan nanoparticles were fabricated to treat MDR tumors, showing high toxicity and strong antitumor efficiency in vivo.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Lili Chen, Ahmed Nabil, Nanami Fujisawa, Emiho Oe, Kai Li, Mitsuhiro Ebara
Summary: A universal vector system for drug-resistant breast cancer was designed to reverse multidrug resistance, achieve thermo-chemotherapy, and enable long-term drug release. The system showed therapeutic effects and could provide personalized treatment options for different breast malignancies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Leticia Bueno Macedo, Daniele Rubert Nogueira-Librelotto, Daniela Mathes, Josiele Melo de Vargas, Raquel Mello da Rosa, Oscar Endrigo Dorneles Rodrigues, Maria Pilar Vinardell, Montserrat Mitjans, Clarice Madalena Bueno Rolim
Summary: In this study, PLGA nanoparticles were developed as an effective carrier for ACAT-Se, a promising nucleoside analogue with antitumor activity. The nanoparticles showed increased antioxidant and antitumor activity in cancer cells, and were hemocompatible. When combined with doxorubicin, the nanoparticles exhibited a synergistic effect in both sensitive and resistant tumor cells, suggesting their potential as a promising delivery system for cancer therapy.
Article
Chemistry, Applied
Lejiao Jia, Zhenyu Li, Dandan Zheng, Zhiying Li, Zhongxi Zhao
Summary: A novel folic acid mediated chitosan oligosaccharide-grafted disulfide-containing polyethylenimine copolymer-based silica nanohybrids were fabricated for co-delivering paclitaxel and P-shRNA. These nanoparticles efficiently protect P-shRNA against degradation and exhibit excellent antitumor effects on multidrug-resistant breast cancer cells.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Yousheng Mo, Wei Liu, Piaoxue Liu, Qiao Liu, Zhongyu Yuan, Qi Wang, Dongsheng Yuan, Xiao-Jia Chen, Tongkai Chen
Summary: A multifunctional graphene oxide tumor-targeting drug delivery system was developed, which improved the delivery of paclitaxel, reversed multi-drug resistance, and increased the therapeutic efficacy of breast cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Hailiang Chen, Chenyu Liu, Simiao Yu, Hengjun Zhou, Farishta Shafiq, Weihong Qiao
Summary: In this study, acid-sensitive mPEG-N=CH-DOB molecules were designed and synthesized for responsive removal of PEG. A drug-loaded lipid PHDGX was obtained by compounding mPEG-N=CH-DOB with DOPG, which showed enhanced cellular uptake and drug release. The results demonstrated that PHDGX had stronger anti-cancer ability, better penetration ability, and could overcome drug resistance in tumor microspheres.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Sarigama Rajesh, Sheeana Gangadoo, Han Nguyen, Jiali Zhai, Chaitali Dekiwadia, Calum J. Drummond, James Chapman, Vi Khanh Truong, Nhiem Tran
Summary: This study presents a novel approach using pH-sensitive lipid nanoparticles to deliver fluconazole and effectively inhibit the growth of resistant Cryptococcus neoformans. The nanoparticles change their structure and charge in response to the acidic environment, facilitating their interaction with the fungal cell wall. This targeted antifungal therapy represents a significant advancement in combating fungal antimicrobial resistance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Sarigama Rajesh, Sheeana Gangadoo, Han Nguyen, Jiali Zhai, Chaitali Dekiwadia, Calum J. Drummond, James Chapman, Vi Khanh Truong, Nhiem Tran
Summary: This study presents a novel approach to improve the delivery of antifungal agent and combat the resistance of Cryptococcus neoformans. By encapsulating the agent in pH-sensitive lipid nanoparticles, the growth of resistant C. neoformans is inhibited. The nanoparticles exhibit different structures and charges at neutral and acidic pH, facilitating interaction with the fungal cell wall and leading to a significant decrease in the minimum inhibitory concentration of the agent. Microscopic observations support these findings, showing distortion and efflux of cytoplasmic molecules in fungal cells exposed to the nanoparticles. This represents a significant advancement in targeted antifungal therapy for combating resistance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
K. Laxmi Swetha, Milan Paul, Kavya Sree Maravajjala, Soniya Kumbham, Swati Biswas, Aniruddha Roy
Summary: Previous studies have shown that breast cancer cells employ various strategies to resist anticancer drugs, such as docetaxel, through drug-resistance mechanisms like overexpression of P-glycoprotein and cancer stem cells. By inhibiting both P-glycoprotein and cancer stem cells, the combination of docetaxel and disulfiram shows potential in sensitizing drug-resistant breast cancer cells. This study developed a pH-responsive nanoparticle system for the co-delivery of docetaxel and disulfiram, which demonstrated improved drug release, penetration, and cytotoxic efficacy against drug-resistant breast cancer cells in vitro, as well as enhanced tumor drug delivery and anti-tumor efficacy in vivo.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
Zhuo Peng, Keni Ning, Xiaoyan Tang, Ruikai He, Dong-Yang Zhang, Yan Ma, Shixia Guan, Junqiu Zhai
Summary: An APE1 and magnetic dual-responsive nanocarrier was designed for targeted chemotherapy, with the AP-DNA hydrolyzed by APE1 to release doxorubicin and inhibit tumor growth. In vitro and in vivo experiments demonstrated the specificity of the nanosystem to APE1 and its effective drug release in cancer cells.
MATERIALS & DESIGN
(2023)
Article
Oncology
Qing Zhou, Li Zhang, Yujiao Li, Jiao Wang, Xiaolu He, Jieyu Zhang, Youbei Qiao, Hong Wu, Lin Zhu
Summary: The study developed a dual-responsive hybrid ZnO nanoparticle (ZnO/DPPG/PEG-pp-PE) for tumor-targeted drug delivery and multidrug resistant cancer treatment. The ZnO/DPPG/PEG-pp-PE showed excellent physicochemical properties, stability, and sensitivity to both tumor matrix metalloproteinase 2 (MMP2) and intracellular acidic pH. It effectively loaded the model drug doxorubicin (DOX) and improved anticancer activity in both in vitro and in vivo experiments.
CANCER NANOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Yang He, Zepeng Deng, Yan-Jie Wang, Yiping Zhao, Li Chen
Summary: In this study, a nanocomposite hydrogel with functionalities of adhesiveness, self-healing, and conductivity was fabricated by incorporating highly conductive Ti3C2Tx MXene nanosheets into a polysaccharide-based hydrogel network. The resulting hydrogels exhibited excellent stretchability, rapid self-healing ability, high adhesiveness, and outstanding electrical conductivity. Additionally, the hydrogels showed fast and stable photothermal conversion performance, and real-time and reversible humidity sensing for respiration monitoring.
CARBOHYDRATE POLYMERS
(2022)
Review
Medicine, Research & Experimental
Xiao Wei, Mingzhu Song, Weijie Li, Jing Huang, Guang Yang, Yi Wang
Summary: The primary cause of chemotherapy failure is cancer multidrug resistance (MDR), leading to recurrence and metastasis of cancer. Dual-therapeutic combination using multifunctional nanoplatforms is gaining attention for overcoming resistant cancers. Smart co-delivery nanocarriers can improve drug properties, enhance therapeutic efficacy, and even overcome drug resistance.
Article
Biotechnology & Applied Microbiology
Xiangyang Zhang, Min Wang, Junyi Feng, Bin Qin, Chenglin Zhang, Chengshen Zhu, Wentao Liu, Yaohe Wang, Wei Liu, Lei Huang, Shuangshuang Lu, Zhimin Wang
Summary: The development of multidrug resistance (MDR) in cancer chemotherapy is a major challenge. This study identified MVP and BCL2 as potential factors driving MDR in ESCC. A self-assembling nanoparticle platform was designed to deliver Adriamycin and siRNAs targeting MVP and BCL2, reducing drug efflux and promoting apoptosis. The nanoparticles effectively inhibited cancer cell growth and tumor development.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
