Article
Chemistry, Applied
Qiang Chen, Chaochao Jia, Yingran Xu, Zhuanzhuan Jiang, Ting Hu, Conghu Li, Xu Cheng
Summary: Efficient dual-pH responsive chitosan nanoparticles were fabricated to treat MDR tumors, showing high toxicity and strong antitumor efficiency in vivo.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Huong Thi Hoang, Trung Thang Vu, Viswanathan Karthika, Sung-Han Jo, Yi-Jun Jo, Jeong-Woo Seo, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim
Summary: A physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate was developed for the delivery of ketoprofen. The hydrogel showed outstanding hydrophobic drug loading and sustained release, as well as pH responsiveness, making it a potential candidate for hydrophobic drug delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Hsi-Chin Wu, Wei-Ting Kuo
Summary: The study developed a smart tumor-targeting co-delivery system capable of simultaneously delivering chemotherapy drugs and siRNA, with dual responsiveness and high cellular uptake efficiency. This system shows potential for application in functional co-delivery and tumor therapy.
Article
Materials Science, Multidisciplinary
Bagher Kazemi Heragh, Hakimeh Taherinezhad, Gholam Reza Mahdavinia, Shahrzad Javanshir, Parisa Labib, Sara Ghasemsolb
Summary: Combining natural antioxidants with synthetic anticancer agents is a helpful approach in chemotherapy. This study designed cross-linked chitosan/laponite RD nanoparticles for co-encapsulation of doxorubicin and saffron extract. The nanocarriers showed pH-responsive release behavior and exhibited high cytotoxicity against cancer cells and antibacterial activity.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Biotechnology & Applied Microbiology
Enping Chen, Ting Wang, Junmei Zhang, Xiang Zhou, Yafan Niu, Fu Liu, Yinan Zhong, Dechun Huang, Wei Chen
Summary: The study developed a mitochondria-directed pH-sensitive PVA nanogel that combined hexokinase inhibitor and chemotherapeutic drug, enhancing drug loading capacity, promoting drug release, and achieving mitochondrial targeting within cells, leading to significant anti-tumor effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Shumin Chen, Xiaoguo Ji, Mengyao Zhao, Jiayang Jin, Haiping Zhang, Liming Zhao
Summary: A chitooligosaccharide-based nanoparticle with enhanced delivery efficiency and endocytosis was constructed in this study, which improved the therapeutic effect of AZD9291 and overcame drug resistance. The surface charge of the nanoparticles changed in the weakly acidic tumor microenvironment and released drugs in the cytoplasm.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Yifu Liu, Chang Liu, Cui Tang, Chunhua Yin
Summary: By using a simple sonication-driven drug loading approach, chitosan-based nanoparticles co-delivering DOX and QUE with dual sensitivity to GSH and pH were prepared. The nanoparticles exhibited enhanced tumor inhibition efficacy due to their pH and redox responsiveness and the synergy of DOX and QUE, demonstrating a promising choice for cancer therapy using combinational therapy based on dual stimulus-responsive nanoparticles.
Article
Biotechnology & Applied Microbiology
Xuandi Lai, Xinran Geng, Mengqing Li, Mengxiong Tang, Qiong Liu, Mengsu Yang, Lin Shen, Yu Zhu, Shubin Wang
Summary: The study developed a drug delivery system based on PEG-modified PLGA, named DCNP, which effectively overcomes tumor multidrug resistance. Through in vitro and in vivo experiments, it was found that DCNPs release drugs under high GSH concentration, enhance the toxicity to MDR cancer cells, and show better biocompatibility and anti-tumor efficacy.
Article
Chemistry, Inorganic & Nuclear
Qianqian Zhang, Xinli Li, Lichao Peng, Xueyan Zou, Yanbao Zhao
Summary: Porous silica nanoparticles engineered with disulfide-linked gatekeepers were used for controlled drug release. The large-pored drug carriers were coated with PEI/gCDs shell which can detach at tumor-relevant GSH levels to release encapsulated cargo. The pH/redox-responsive behavior of the system was shown to be effective for drug release, with gCDs serving as drug release monitoring tools.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
He Wang, Wenwen Shi, Danning Zeng, Qiudi Huang, Jiacui Xie, Huaying Wen, Jinfang Li, Xiyong Yu, Linghao Qin, Yi Zhou
Summary: In this study, an acid-activated mitochondria-targeting and redox-responsive drug nanocarrier was constructed to deliver paclitaxel (PTX) for enhancing therapeutic efficacy in drug-resistant lung cancer. The nanocarrier demonstrated selective mitochondrial targeting and inhibition of P-glycoprotein activity, leading to the suppression of drug resistance and cancer metastasis. The promising results suggest that this nanocarrier represents a significant advancement in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Panpan Song, Nannan Song, Li Li, Minghao Wu, Zhongxia Lu, Xia Zhao
Summary: A pH/reduction-sensitive carboxymethyl chitosan nanogel modified by targeting peptide angiopep-2 loaded with doxorubicin shows promising potential for targeted chemotherapy of glioblastoma. The targeted nanogel exhibited good stability, biocompatibility, and enhanced BBB penetration and tumor targeting ability, leading to higher drug uptake and stronger antitumor activity compared to nontargeted nanogels. This innovative nanogel platform with pH/reduction dual-stimuli response may hold great significance for GBM-targeted therapy.
Article
Oncology
Qing Zhou, Li Zhang, Yujiao Li, Jiao Wang, Xiaolu He, Jieyu Zhang, Youbei Qiao, Hong Wu, Lin Zhu
Summary: The study developed a dual-responsive hybrid ZnO nanoparticle (ZnO/DPPG/PEG-pp-PE) for tumor-targeted drug delivery and multidrug resistant cancer treatment. The ZnO/DPPG/PEG-pp-PE showed excellent physicochemical properties, stability, and sensitivity to both tumor matrix metalloproteinase 2 (MMP2) and intracellular acidic pH. It effectively loaded the model drug doxorubicin (DOX) and improved anticancer activity in both in vitro and in vivo experiments.
CANCER NANOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Linlin Zhang, Qiuping Li, Jinxuan Chen, Cui Tang, Chunhua Yin
Summary: The co-delivery of chemotherapeutic drugs, genes, and immune agents by redox-sensitive chitosan-based nanoparticles showed promising results in enhancing antitumor efficacy and improving tumor-induced immunosuppression at a low dose.
CARBOHYDRATE POLYMERS
(2021)
Article
Biophysics
Daquan Wang, Na Zhou, Ning Zhang, Zhe Zhi, Yongping Shao, Lingjie Meng, Demei Yu
Summary: A novel redox/pH dual-responsive and biodegradable polyphosphazene (PPZ) nano-prodrugs have been prepared, which can achieve controlled drug release in tumor microenvironment, exhibit significant cytotoxicity to cancer cells, and have negligible side effects on normal cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)