Review
Clinical Neurology
Louis K. Balcziak, Andrew F. Russo
Summary: Migraine, the most common neurological disorder, may not have a singular molecular cause but is likely due to dysregulated physiology of multiple mechanisms. Recent studies have shown the involvement of the immune system in migraine, suggesting that dysregulation in the immune system and the interactions between immune cells and trigeminal afferents play key roles in migraine.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Dan Levy, Michael A. Moskowitz
Summary: Migraine is a complex neurovascular pain disorder associated with the meninges and trigeminal nerve. The trigeminal nerve, which innervates the meninges, can trigger headaches similar to migraines when stimulated around blood vessels. Interactions between trigeminal afferents, neuropeptides, and meningeal tissues cause neurogenic inflammation, a key target for migraine therapies. This review emphasizes the importance of the cranial meninges, discusses trigeminal meningeal afferents, and explores emerging concepts like meningeal neuroimmune interactions.
ANNUAL REVIEW OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Amanda Avona, Theodore J. Price, Gregory Dussor
Summary: The study found that stimulation of upper body regions with IL-6 can cause widespread hypersensitivity spreading to the paws, but similar stimulation of the lower body does not cause the spread of hypersensitivity into the head. These findings are consistent with whole body hypersensitivity being specific to conditions such as migraine where pain is present in the head.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Anesthesiology
Jessica R. Ansari, Meredith Barad, Steven Shafer, Pamela Flood
Summary: The study found that women who experienced unintentional dural puncture had a higher prevalence of chronic disabling headache at 2 and 6 months postpartum, but there was no significant difference in back pain prevalence.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Plant Sciences
Jianan Song, Mengyuan Jiang, Yuchen Jin, Hongrui Li, Yanhong Li, Yumei Liu, Haibo Yu, Xiangzhong Huang
Summary: This study aimed to evaluate the analgesic effect of Faeces Bombycis extract (FBE) on migraine and investigate its main active constituents and pharmacological mechanisms. The results demonstrated that phytol is the major anti-migraine ingredient of Faeces Bombycis and alleviates migraine behaviors by acting on Nav1.7 sodium channels in the trigeminal ganglion neurons.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Georgii Krivoshein, Abdulhameed Bakreen, Arn M. J. M. van den Maagdenberg, Tarja Malm, Rashid Giniatullin, Jukka Jolkkonen
Summary: This study assessed the changes in meningeal afferent activity after stroke in mice. The results showed increased activity of mechanosensitive Piezo1 channels and nociceptive TRPV1 channels in meningeal afferents, which may be associated with trigeminal headache pain responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maram H. Alshareef, Bayan Hashim Alsharif
Summary: This study investigated the prevalence of primary headache disorders and associated risk factors in Makkah. The results showed a high prevalence of headaches, particularly among young adults. Age, chronic diseases, work, caffeine consumption, and smoking were found to be associated with headaches. The prevalence of headaches in Makkah has increased compared to previous studies.
Article
Cell Biology
Richard L. Kraus, Fuqiang Zhao, Parul S. Pall, Dan Zhou, Joshua D. Vardigan, Andrew Danziger, Yuxing Li, Christopher Daley, Jeanine E. Ballard, Michelle K. Clements, Rebecca M. Klein, Marie A. Holahan, Thomas J. Greshock, Ronald M. Kim, Mark E. Layton, Christopher S. Burgey, Jordi Serra, Darrell A. Henze, Andrea K. Houghton
Summary: Humans with mutations in the Na(v)1.7 channel gene can either be insensitive to pain or suffer from inherited pain syndromes. Clinical studies using Na(v)1.7 inhibitors have not shown significant pain relief, leading researchers to develop rhesus macaque models to measure target modulation and efficacy.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Food Science & Technology
Carlo Baraldi, Flavia Lo Castro, Raffaele Ornello, Simona Sacco, Luca Pani, Simona Guerzoni
Summary: OnabotulinumtoxinA (BT-A) is a drug used for preventive treatment of chronic migraine. Its exact mechanism of action is still debated, but it is known to inhibit the release of inflammatory mediators and reduce activation of nerve fibers. Clinical trials have shown its efficacy, and recent findings have improved understanding of its pharmacological actions. This review summarizes the available data on BT-A and discusses its role in chronic migraine treatment.
Article
Medicine, General & Internal
Hee-Jin Im, Yoo-Ha Hong, Soo-Jin Cho
Summary: Neck pain is a common symptom among migraine patients, and its impact on headaches and contributing factors are unclear. This study aimed to investigate the disability caused by neck pain on headaches and factors linked to comorbid neck pain, including sleep-related variables. The study found that neck pain was present in 51.9% of migraine patients, with high disability observed in some patients. Factors such as medication days per month, severe disability of migraine, and excessive daytime sleepiness were significant predictors for the severe impact of headaches. The study also found a positive correlation between neck pain and higher monthly headache days, female gender, and likelihood of obstructive sleep apnea among migraine patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Benedetta Pasquini, Viola Seravalli, Silvia Vannuccini, Francesco La Torre, Pierangelo Geppetti, Luigi Iannone, Silvia Benemei, Felice Petraglia
Summary: In women with endometriosis, many experience headache, and about 53.4% of them are diagnosed with migraine. Among these, 18.6% have pure menstrual migraine, 45.7% have menstrually related migraine, and 35.7% have non-menstrual migraine. Patients with endometriosis and migraine are more likely to have dysmenorrhea and dysuria compared to those without migraine.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Clinical Neurology
Inna E. Tchivileva, Richard Ohrbach, Roger B. Fillingim, Feng-Chang Lin, Pei Feng Lim, Samuel J. Arbes, Gary D. Slade
Summary: Headache attributed to Temporomandibular Disorder (HATMD) is a common secondary headache among patients with chronic myogenous TMD and primary headaches, often presenting as migraine. Unlike primary headaches, HATMD is associated with higher headache frequency and examination-evoked masticatory muscle pain, but surprisingly few measures of facial pain, general health, and psychological distress. Understanding these differences is important for developing targeted strategies for HATMD management.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Integrative & Complementary Medicine
Laurel P. Gibson, Leah N. Hitchcock, Angela D. Bryan, L. Cinnamon Bidwell
Summary: The study examined patterns of cannabis use and its associated relief among migraineurs in states with full legal access. Results showed that the majority of migraineurs using cannabis for migraine relief were not medical cardholders, indicating that they were self-medicating without physician guidance.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Review
Clinical Neurology
Bruno Colombo, Massimo Filippi
Summary: In literature, migraine is portrayed as an untreatable disease that acts as a barrier to social, familial, and work activities, with no mention of scientific advancements in new therapies.
NEUROLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Hedwig A. van der Meer, Leticia B. Calixtre, Caroline M. Speksnijder, Raoul H. H. Engelbert, Maria W. G. Nijhuis-van der Sanden, Corine M. Visscher
Summary: The study found that for patients with TMD and migraine, improvement in TMD-related disability was comparable to headache-related disability, while no improvements in disability were found for TMD-pain patients with TTH or headaches attributed to TMD.
APPLIED SCIENCES-BASEL
(2021)
Article
Anesthesiology
Nilesh M. Agalave, Resti Rudjito, Alex Bersellini Farinotti, Payam Emami Khoonsari, Katalin Sandor, Yuki Nomura, Thomas A. Szabo-Pardi, Carlos Morado Urbina, Vinko Palada, Theodore J. Price, Helena Erlandsson Harris, Michael D. Burton, Kim Kultima, Camilla Svensson
Summary: The study explored the differential effects of TLR4-activating HMGB1 on microglia in male and female mice, finding higher cytokine and chemokine expression in males. Only male mice were protected from HMGB1-induced mechanical hypersensitivity with TLR4 ablation in myeloid-derived cells and minocycline treatment. Liquid chromatography-mass spectrometry revealed upregulation of antinociceptive proteins in male mice after minocycline administration, with alpha-1-antitrypsin offering partial protection against HMGB1-induced pain specifically in males.
Article
Anesthesiology
Resti Rudjito, Nilesh M. Agalave, Alex Bersellini Farinotti, Peter Lundback, Thomas A. Szabo-Pardi, Theodore J. Price, Helena Erlandsson Harris, Michael D. Burton, Camilla Svensson
Summary: The study found elevated expression of HMGB1 in ankle joints of male and female mice with collagen antibody-induced arthritis. Blocking peripheral HMGB1 reversed hypersensitivity only in male mice. The study also showed a sex- and cellular location-dependent roles of HMGB1 and TLR4 in peripheral pain mechanisms.
Article
Clinical Neurology
Jacob Lackovic, Theodore J. Price, Gregory Dussor
Summary: This study indicates that protein synthesis plays a critical role in the development of priming in preclinical models of migraine, suggesting that targeting the regulation of protein synthesis may offer new approaches for migraine treatment strategies.
Article
Clinical Neurology
Juliet Mwirigi, Moeno Kume, Shayne N. Hassler, Ayesha Ahmad, Pradipta R. Ray, Changyu Jiang, Alexander Chamessian, Nakleh Mseeh, Breya P. Ludwig, Benjamin D. Rivera, Marvin T. Nieman, Thomas van de Ven, Ru-Rong Ji, Gregory Dussor, Scott Boitano, Josef Vagner, Theodore J. Price
Summary: PAR3, a member of the PAR family of GPCRs, is expressed widely in DRG neurons and may act as a coreceptor for other PARs in the peripheral sensory nervous system. Its selective activation by a peptide agonist suggests a contribution to nociception in various contexts and modulation of other PARs' activity.
Editorial Material
Neurosciences
William Renthal, Alexander Chamessian, Michele Curatolo, Steve Davidson, Michael Burton, Sulayman Dib-Hajj, Patrick M. Dougherty, Allison D. Ebert, Robert W. Gereau, Andre Ghetti, Michael S. Gold, Gwendolyn Hoben, Daniela Maria Menichella, Philippe Mercier, Wilson Z. Ray, Daniela Salvemini, Rebecca P. Seal, Stephen Waxman, Clifford J. Woolf, Cheryl L. Stucky, Theodore J. Price
Summary: Chronic pain is a debilitating disease with limited treatment options. Understanding pain cells and networks in humans is crucial for translating knowledge from animal models to therapeutic applications. A multi-institutional collaboration is proposed to address this challenge rigorously and ethically.
Article
Neurosciences
Andi Wangzhou, Candler Paige, Pradipta R. Ray, Gregory Dussor, Theodore J. Price
Summary: Through analysis of single cell RNA sequencing resources from mouse, it was found that somatosensory, sympathetic, and enteric neurons show similar receptor expression diversity to CNS neurons, with greater diversity in GPCRs and cytokine receptors in the PNS. Many receptors were found to be specifically expressed in subsets of PNS neurons, highlighting the complexity of receptor expression in the PNS.
Article
Multidisciplinary Sciences
Tiphaine Voisin, Caroline Perner, Marie-Angele Messou, Stephanie Shiers, Saltanat Ualiyeva, Yoshihide Kanaoka, Theodore J. Price, Caroline L. Sokol, Lora G. Bankova, K. Frank Austen, Isaac M. Chiu
Summary: This study uncovered the role of LTC4 and its receptor CysLT(2)R in inducing itch, providing a promising approach for treating inflammatory itch. The research highlights the importance of targeting CysLT signaling in managing inflammatory itch.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Andi Wangzhou, Candler Paige, Sanjay Neerukonda, Dhananjay K. Naik, Moeno Kume, Eric T. David, Gregory Dussor, Pradipta R. Ray, Theodore J. Price
Summary: The research identified ligand-receptor interactions between sensory neurons and peripheral cells, focusing particularly on the roles of HBEGF and EGFR in disease-associated pain. These findings offer new insights for treating pain and illustrate the complexity of cell-to-neuron signaling in chronic pain states.
Article
Genetics & Heredity
Keira J. A. Johnston, Joey Ward, Pradipta R. Ray, Mark J. Adams, Andrew M. McIntosh, Blair H. Smith, Rona J. Strawbridge, Theodore J. Price, Daniel J. Smith, Barbara Nicholl, Mark E. S. Bailey
Summary: This study found significant differences in chronic pain between males and females, with gender-specific genes and SNPs closely associated with chronic pain. While male and female chronic pain were highly genetically correlated, there were differences between the sexes.
Article
Clinical Neurology
Amanda Avona, Theodore J. Price, Gregory Dussor
Summary: The study found that stimulation of upper body regions with IL-6 can cause widespread hypersensitivity spreading to the paws, but similar stimulation of the lower body does not cause the spread of hypersensitivity into the head. These findings are consistent with whole body hypersensitivity being specific to conditions such as migraine where pain is present in the head.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Cell Biology
Katelyn E. Sadler, Francie Moehring, Stephanie Shiers, Lauren J. Laskowski, Alexander R. Mikesell, Zakary R. Plautz, Allison N. Brezinski, Christina M. Mecca, Gregory Dussor, Theodore J. Price, John D. McCorvy, Cheryl L. Stucky
Summary: The study identified TRPC5 as a key contributor to tactile and spontaneous pain in multiple rodent pain models, particularly in conditions characterized by elevated LPC concentrations. 75% of human sensory neurons express TRPC5, and its activity is directly modulated by LPC.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Review
Clinical Neurology
Steven J. Middleton, Allison M. Barry, Maddalena Comini, Yan Li, Pradipta R. Ray, Stephanie Shiers, Andreas C. Themistocleous, Megan L. Uhelski, Xun Yang, Patrick M. Dougherty, Theodore J. Price, David L. Bennett
Summary: Studying human nociceptors has led to significant advances in understanding chronic pain mechanisms and identifying potential new therapeutic targets. However, challenges remain in implementing these techniques at scale, generating a full diversity of nociceptor populations from induced pluripotent stem cells, and understanding inter-individual variation in nociceptors.
Article
Medicine, Research & Experimental
Jenolyn F. Alexander, Alexandre Seua, Luis D. Arroyo, Pradipta R. Ray, Andi Wangzhou, Laura Heiss-Lueckemann, Manfred Schedlowski, Theodore J. Price, Annemieke Kavelaars, Cobi J. Heijnen
Summary: The study demonstrated that nasal administration of mitochondria isolated from human mesenchymal stem cells restored cognitive function in mice and reversed cisplatin-induced cognitive deficits by altering gene expression in the hippocampus.
Review
Neurosciences
Amelia J. McFarland, Muhammad S. Yousuf, Stephanie Shiers, Theodore J. Price
Summary: COVID-19 infection interacts with the peripheral nervous system to induce pain through multiple potential mechanisms, including direct and indirect effects on neuronal excitability to promote and worsen pain states.