Z-360, a Novel Therapeutic Agent for Pancreatic Cancer, Prevents Up-Regulation of Ephrin B1 Gene Expression and Phosphorylation of NR2B via Suppression of Interleukin-1β Production in a Cancer-Induced Pain Model in Mice

Z-360, a Novel Cholecystokinin-2/Gastrin Receptor Antagonist, Inhibits Gemcitabine-Induced Expression of the Vascular Endothelial Growth Factor Gene in Human Pancreatic Cancer Cells

(2010) Nobuyoshi Kobayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pharmacological Evaluation of Analgesic Effects of the Cholecystokinin2 Receptor Antagonist Z-360 in Mouse Models of Formalin- and Cancer-Induced Pain

(2010) Koji Yoshinaga et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer

(2009) Rainer Hamacher et al.   CYTOKINE

A phase Ib/IIa trial to evaluate the CCK2 receptor antagonist Z-360 in combination with gemcitabine in patients with advanced pancreatic cancer

(2009) T. Meyer et al.   EUROPEAN JOURNAL OF CANCER

Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice

(2009) Masahide Fujita et al.   EUROPEAN JOURNAL OF PAIN

Management of Cancer Pain: Basic Principles and Neuropathic Cancer Pain

(2008) B. Laird et al.   EUROPEAN JOURNAL OF CANCER

Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid: ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia

(2008) Hitoshi Uchida et al.   NEUROCHEMISTRY INTERNATIONAL

EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia

(2008) S. Slack et al.   NEUROSCIENCE

Interleukin 1β facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation

(2008) R.-X. Zhang et al.   NEUROSCIENCE

EphrinB-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal synaptic plasticity in rats

(2008) Xue-Jun Song et al.   PAIN

IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats

(2007) Rui-Xin Zhang et al.   PAIN

Pre-clinical evaluation of a new orally-active CCK-2R antagonist, Z-360, in gastrointestinal cancer models

(2007) A.M. Grabowska et al.   REGULATORY PEPTIDES