Article
Neurosciences
Shao-Rui Chen, Hong Chen, Daozhong Jin, Hui-Lin Pan
Summary: Treatment with opioids not only inhibits nociceptive transmission but also elicits a rebound and persistent increase in primary afferent input to the spinal cord. Opioid-elicited long-term potentiation (LTP) from TRPV1-expressing primary afferents plays a major role in opioid-induced hyperalgesia and analgesic tolerance. The study found that opioid-elicited LTP occurs in VGluT2 neurons in the spinal dorsal horn, and not in VGAT neurons, with underlying signaling mechanisms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Anesthesiology
Julien Claron, Vincent Hingot, Isabelle Rivals, Line Rahal, Olivier Couture, Thomas Deffieux, Mickael Tanter, Sophie Pezet
Summary: This study used functional ultrasound imaging and ultrasound localization microscopy to reveal the characteristics of hemodynamic response in the rat spinal cord through natural or electrical stimulation of different categories of afferent fibers. The research found that the responses are fiber-specific, and the C-fiber response is dependent on N-methyl-D-aspartate receptor mechanism, showing enhanced response in inflammatory conditions.
Article
Neurosciences
Meng-Hua Zhou, Shao-Rui Chen, Li Wang, Yuying Huang, Meichun Deng, Jixiang Zhang, Jiyuan Zhang, Hong Chen, Jiusheng Yan, Hui-Lin Pan
Summary: The study identified the roles of PKC and alpha 2 delta-1 in controlling NMDAR activity, showing that co-expression of alpha 2 delta-1 significantly increased NMDAR activity, while PKC activation only increased receptor activity in cells co-expressing alpha 2 delta-1. Furthermore, phosphoproteomics analysis identified the phosphorylation sites responsible for NMDAR potentiation by PKC and alpha 2 delta-1.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Wen-Ling Dai, Yi-Ni Bao, Ji-Fa Fan, Bin Ma, Shan-Shan Li, Wan-Li Zhao, Bo-Yang Yu, Ji-Hua Liu
Summary: The study demonstrates that D1DR and D2DR antagonists reduce NMDAR-mediated spinal neuron activation, alleviate bone cancer pain, and act through the Gq protein and Src pathways.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mehdi Sanatkar, Zohre Nozarian, Fatemeh Bazvand, Parisa Abdi
Summary: This study aimed to determine the safety of topical ketamine for the cornea and evaluate its effect on the repair process of damaged corneal tissue. The results showed that topical ketamine had no significant effect on corneal wound healing in a rat animal model.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
S. Murat Durakoglugil, R. Catherine Wasser, H. Connie Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz
Summary: Alzheimer's disease is characterized by the accumulation of Aβ plaques and neurofibrillary tangles, leading to synaptic dysfunction. Reelin protects synapses against Aβ toxicity through ApoE receptors. Experiments showed that Reelin modulates mGluR-LTD, potentially impacting memory consolidation or neurodegeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Guang-Fen Zhang, Shao-Rui Chen, Daozhong Jin, Yuying Huang, Hong Chen, Hui-Lin Pan
Summary: Systemic treatment with resiniferatoxin (RTX) induces small-fiber sensory neuropathy by damaging TRPV1-expressing primary sensory neurons and leads to distinct thermal sensory impairments and tactile allodynia. The synaptic plasticity associated with RTX-induced tactile allodynia involves alpha 2 delta-1 upregulation in the dorsal root ganglion (DRG) and increased physical interaction between alpha 2 delta-1 and GluN1 in spinal cord synaptosomes, leading to potentiation of nociceptive input and tactile allodynia.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Dmitry Amakhin, Elena B. Soboleva, Anton Chizhov, Aleksey Zaitsev
Summary: The study demonstrates that epileptic activity leads to the rapid insertion of CP-AMPARs into neuronal synapses, affecting the generation rate of epileptiform discharges. The expression of CP-AMPARs in principal neurons reduces the discharge generation rate, potentially serving as a protective mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sandra I. Mota, Ligia Fao, Patricia Coelho, A. Cristina Rego
Summary: This study found that brief exposure to soluble A beta 1-42 oligomers (A beta O) induced H2O2-dependent Src activation, resulting in NMDAR activation, increased cytosolic and mitochondrial H2O2 levels, and mild mitochondrial fragmentation. These effects were prevented by Src inhibition. This study supports the important role of Src kinase in regulating mitochondrial and glutamatergic synapse homeostasis.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
Article
Neurosciences
Shiro Nakamura, Risa Kajiwara, Tsuyoshi Noguchi, Kiyomi Nakayama, Ayako Mochizuki, Masanori Dantsuji, Avijite Kumer Sarkar, Tomio Inoue
Summary: The study found that the motoneurons innervating the jaw-closing and jaw-opening muscles play a critical role in oro-facial behaviors. The developmental patterns of non-NMDA and NMDA receptor-mediated inputs vary among these motoneurons, possibly related to their distinct roles in the postnatal development of feeding behavior.
Article
Neurosciences
Silvano R. Gefferie, Angelina Maric, Hanne Critelli, Sophie Gueden, Gerhard Kurlemann, Salome Kurth, Margherita Nosadini, Barbara Plecko, Maya Ringli, Kevin Rostasy, Stefano Sartori, Bernhard Schmitt, Agnese Suppiej, Patrick Van Bogaert, Flavia M. Wehrle, Reto Huber, Bigna K. Bolsterli
Summary: The plasticity of synaptic strength and density, critical for memory consolidation and learning, is strongly dependent on NMDAR function. A study on pediatric patients with anti-NMDAR encephalitis revealed alterations in sleep EEG markers for synaptic plasticity, indicating impaired synaptic plasticity in this unique human model of NMDAR deficiency.
Review
Neurosciences
Hovy Ho-Wai Wong, Sabine Rannio, Victoria Jones, Aurore Thomazeau, P. Jesper Sjostrom
Summary: Axonally located preNMDARs have been reported in the literature for decades, with recent discoveries showing their key involvement in different brain regions and forms of plasticity, highlighting the role of unusual subunit composition. These preNMDARs can signal through both ionotropic action and metabotropic mode, explaining the controversy surrounding this receptor type.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Elham Ghanavati, Mohammad Ali Salehinejad, Lorena De Melo, Michael A. Nitsche, Min-Fang Kuo
Summary: Dopamine modulates LTP-like plasticity by regulating NMDA receptor activity, reducing diffuse plasticity through D2 receptor-mediated decrease of NMDA receptor activity.
Article
Neurosciences
Xu-Ben Yu, Kai-Long Zhong, Chuang Chen, Jing Fu, Fang Chen, Hong-Min Zhou, Xiu-Hua Zhang, Kwonseop Kim, Jing-Ye Pan
Summary: In this study, it was found that simvastatin can improve the dysfunction of NMDAR and ameliorate hippocampal synaptic plasticity impairment in depressed mice.
PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Vincent Cibert-Goton, Justin P. Phillips, Peter J. Shortland
SOMATOSENSORY AND MOTOR RESEARCH
(2015)
Article
Gastroenterology & Hepatology
Mira M. Wouters, Dafne Balemans, Sander Van Wanrooy, James Dooley, Vincent Cibert-Goton, Yeranddy A. Alpizar, Eduardo E. Valdez-Morales, Yasmin Nasser, Paul P. Van Veldhoven, Winde Vanbrabant, Schalk Van der Merwe, Raf Mols, Bart Ghesquiere, Carla Cirillo, Inge Kortekaas, Peter Carmeliet, Willy E. Peetermans, Severine Vermeire, Paul Rutgeerts, Patrick Augustijns, Peter W. Hellings, Ann Belmans, Stephen Vanner, David C. Bulmer, Karel Talavera, Pieter Vanden Berghe, Adrian Liston, Guy E. Boeckxstaens
Article
Gastroenterology & Hepatology
Cian McGuire, George Boundouki, James R. F. Hockley, David Reed, Vincent Cibert-Goton, Madusha Peiris, Victor Kung, John Broad, Qasim Aziz, Christopher Chan, Shafi Ahmed, Mohamed A. Thaha, Gareth J. Sanger, L. Ashley Blackshaw, Charles H. Knowles, David C. Bulmer
Article
Neurosciences
James R. F. Hockley, Michael M. Tranter, Cian McGuire, George Boundouki, Vincent Cibert-Goton, Mohamed A. Thaha, L. Ashley Blackshaw, Gregory J. Michael, Mark D. Baker, Charles H. Knowles, Wendy J. Winchester, David C. Bulmer
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
James R. F. Hockley, Rafael Gonzalez-Cano, Sheridan McMurray, Miguel A. Tejada-Giraldez, Cian McGuire, Antonio Torres, Anna L. Wilbrey, Vincent Cibert-Goton, Francisco R. Nieto, Thomas Pitcher, Charles H. Knowles, Jose Manuel Baeyens, John N. Wood, Wendy J. Winchester, David C. Bulmer, Cruz Miguel Cendan, Gordon McMurray
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Neurosciences
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R. Tough, Paulo Watanabe, Eduardo J. A. Araujo, Sahar D. Mohammed, Jean-Marie Delalande, David C. Bulmer, S. Mark Scott, Helen M. Cox, Nicol C. Voermans, Qasim Aziz, L. Ashley Blackshaw
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Biochemical Research Methods
Justin P. Phillips, Vincent Cibert-Goton, Richard M. Langford, Peter J. Shortland
JOURNAL OF BIOMEDICAL OPTICS
(2013)
Article
Anesthesiology
James R. F. Hockley, George Boundouki, Vincent Cibert-Goton, Cian McGuire, Ping K. Yip, Christopher Chan, Michael Tranter, John N. Wood, Mohammed A. Nassar, L. Ashley Blackshaw, Qasim Aziz, Gregory J. Michael, Mark D. Baker, Wendy J. Winchester, Charles H. Knowles, David C. Bulmer
Article
Multidisciplinary Sciences
Vincent Cibert-Goton, Guanglu Yuan, Anna Battaglia, Sarah Fredriksson, Mark Henkemeyer, Thomas Sears, Isabella Gavazzi
Article
Multidisciplinary Sciences
D. Balemans, S. U. Mondelaers, V. Cibert-Goton, N. Stakenborg, J. Aguilera-Lizarraga, J. Dooley, A. Liston, D. C. Bulmer, P. Vanden Berghe, G. E. Boeckxstaens, M. M. Wouters
SCIENTIFIC REPORTS
(2017)
Article
Anesthesiology
Vincent Cibert-Goton, Victor W. S. Kung, Cian McGuire, James R. F. Hockley, Michael M. Tranter, Harween Dogra, Abi Belai, L. Ashley Blackshaw, Gareth J. Sanger, Charles H. Knowles, Eduardo J. A. Araujo, Wendy J. Winchester, David C. Bulmer
Article
Gastroenterology & Hepatology
Vincent Cibert-Goton, Ching Lam, Melanie Lingaya, Yirga Falcone, John N. Wood, David C. Bulmer, Robin Spiller
Summary: This study compared gut-related symptoms, psychological scores, and biopsy samples in a cohort of IBS-D patients, finding that pain severity correlated with daily symptoms but not psychological scores, suggesting peripheral pronociceptive changes in the bowel may be more important in determining pain severity in this patient population. Nerve targeting therapeutic approaches may be more successful than mediator-driven approaches for treating pain in IBS-D.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Madusha Peiris, Rubina Aktar, David Reed, Vincent Cibert-Goton, Ausra Zdanaviciene, Writaja Halder, Adam Robinow, Simon Corke, Harween Dogra, Charles H. Knowles, Ashley Blackshaw
Summary: Colonic enteroendocrine cells store and release anorectic hormones and express nutrient sensing receptors for medium-chain fatty acids (MCFAs), such as GPR84 and FFAR4. Non-surgical targeted colonic delivery of MCFA in obese adults induced EEC and neuronal activation, leading to reduced calorie intake and increased postprandial PYY levels. Activation of GPR84 and FFAR4 in colonic EECs activates parallel intracellular pathways and synergistically evokes hormone release, with further synergism in sensory nerve responses to MCFA and EEC mediators.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.