Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134

Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer

(2013) C Zeng et al.   BRITISH JOURNAL OF CANCER

Assessment of Cellular Proliferation in Tumors by PET Using 18F-ISO-1

(2013) F. Dehdashti et al.   JOURNAL OF NUCLEAR MEDICINE

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

(2012) John R Hornick et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling

(2011) D. Spitzer et al.   CANCER RESEARCH

Pancreatic Ductal Adenocarcinoma Mice Lacking Mucin 1 Have a Profound Defect in Tumor Growth and Metastasis

(2011) D. M. Besmer et al.   CANCER RESEARCH

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

Targeting apoptosis pathways in pancreatic cancer

(2010) Alexander Arlt et al.   CANCER LETTERS

Smac Mimetic Increases Chemotherapy Response and Improves Survival in Mice with Pancreatic Cancer

(2010) Sean P. Dineen et al.   CANCER RESEARCH

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine

(2010) John R Hornick et al.   Molecular Cancer

Evaluation of radioiodinated vesamicol analogs for sigma receptor imaging in tumor and radionuclide receptor therapy

(2009) Kazuma Ogawa et al.   CANCER SCIENCE

Decreased Blood Flow with Increased Metabolic Activity: A Novel Sign of Pancreatic Tumor Aggressiveness

(2009) G. Komar et al.   CLINICAL CANCER RESEARCH

Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

(2009) Hiroyuki Kashiwagi et al.   Journal of Translational Medicine

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics

(2008) Haiying Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

BH3 Mimetic ABT-737 Potentiates TRAIL-Mediated Apoptotic Signaling by Unsequestering Bim and Bak in Human Pancreatic Cancer Cells

(2008) S. Huang et al.   CANCER RESEARCH

Potent, Orally Bioavailable Diazabicyclic Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases

(2008) Yuefeng Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP)†

(2008) Haiying Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY