Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Tuo Zhang, Meina He, Lihua Zhao, Shaogang Qin, Zijian Zhu, Xinhua Du, Bo Zhou, Yi Yang, Xinfeng Liu, Guoliang Xia, Tengxiang Chen, Yuanxi Wang, Hua Zhang, Chao Wang
Summary: The primordial follicle pool established during perinatal development is a non-renewable resource that determines female fertility in mammals. HDAC6 functions as a key negative regulator of mTOR in dormant primordial follicles, playing a crucial role in balancing the maintenance and activation of primordial follicles.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Hua Fang, Hua-Feng Li, Ming-Hai He, Miao Yang, Jian-Ping Zhang
Summary: Histone deacetylase (HDAC) inhibitors can protect the brain from ischemic injury. HDAC3 inhibition reduces TNF-alpha, IL-6, and IL-8 levels by suppressing miR-19a and promoting SDC1 degradation, leading to JAK1/STAT3 activation in cerebral ischemic injury.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rui Zhou, Guodong Wang, Qi Li, Fanxi Meng, Can Liu, Rui Gan, Dapeng Ju, Meimei Liao, Junjie Xu, Di Sang, Xue Gao, Shuang Zhou, Kejia Wu, Quanzhi Sun, Ying Guo, Chongyang Wu, Zhiyu Chen, Lin Chen, Bihan Shi, Haiyan Wang, Xia Wang, Huaiye Li, Tao Cai, Bin Li, Fengchao Wang, Hiromasa Funato, Masashi Yanagisawa, Eric Erquan Zhang, Qinghua Liu
Summary: This study characterizes a major signaling pathway for the transcriptional regulation of sleep in mice, involving the LKB1-SIK3 pathway and phosphorylation of HDAC4/HDAC5. The findings provide insights into the molecular mechanisms that regulate sleep quantity and offer new potential targets for the treatment of sleep disorders.
Article
Cell Biology
Henry F. Duncan, Yoshifumi Kobayashi, Yukako Yamauchi, Angela Quispe-Salcedo, Zhi Chao Feng, Jia Huang, Nicola C. Partridge, Teruyo Nakatani, Jeanine D'Armiento, Emi Shimizu
Summary: Matrix-metalloproteinase-13 (MMP13) plays an important role in tooth development and mineralization processes. Knockout of MMP13 in mice resulted in altered dentin phenotype, reduced dentin volume, and decreased calcium deposition. The study also revealed an interaction between MMP13 and the Wnt-signaling pathway. These findings highlight the critical role of MMP13 in tooth development and mineralization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Wenwen Zhang, Fang Xue, Shangdan Xie, Cheng Chen, Jingwei Li, Xueqiong Zhu
Summary: Isoflurane enhances the proliferation of cervical cancer cells by upregulating histone deacetylase 6 through a mTOR-dependent pathway. The AKT-mediated pathway has no effect on isoflurane-induced expression of histone deacetylase 6.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Meiqi Fan, Nishala Erandi Wedamulla, Young-Jin Choi, Qun Zhang, Sung Mun Bae, Eun-Kyung Kim
Summary: This study investigated the effects of Tenebrio molitor trypsin hydrolysate (TMTH) as an anti-atopic dermatitis (AD) agent and its underlying mechanism in a DNCB-induced AD mouse model. The findings showed that TMTH significantly reduced mast cell infiltration, dermal and epidermal thickness, and serum IgE levels. Furthermore, TMTH suppressed the MyD88-dependent MAPK signaling pathway. Therefore, TMTH has potential as a treatment for AD.
Article
Chemistry, Medicinal
Jingyun Liu, Chenghong Zhang, Jiale Wang, Yufei Huang, Di Shen, Yingqiu Hu, Haiying Chu, Xuebin Yu, Liyuan Zhang, Haiying Ma
Summary: Alzheimer's disease (AD) is a serious threat to the health and life of elderly individuals, and there are currently no effective clinical treatments available. However, a study found that the class I histone deacetylase inhibitor BG45 can upregulate synapse-related proteins, improve learning and memory, and alleviate damage in primary neurons. These findings suggest that BG45 may be a promising drug for early clinical treatment of AD.
Article
Biochemistry & Molecular Biology
Hiroyuki Inoue, Shun-ichiro Asahara, Yumiko Sugiura, Yukina Kawada, Asuka Imai, Chisako Hara, Ayumi Kanno, Maki Kimura-Koyanagi, Yoshiaki Kido
Summary: In this study, the role of histone deacetylases (HDACs) in regulating insulin signaling in pancreatic beta cells was examined. Findings showed that HDAC6 plays an important role in downregulating insulin signaling in pancreatic beta cells and its expression is decreased in a type 2 diabetes mouse model. This suggests that targeting HDAC6 could be a valuable approach for the treatment of type 2 diabetes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Jianglei Li, Meihong Yu, Shifeng Fu, Deliang Liu, Yuyong Tan
Summary: This review summarizes the research progress and underlying mechanism of ACY-1215 in cancer and other human diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Long Xu, Xiaoyu Yan, Jian Wang, Yuanxin Zhao, Qingqing Liu, Jiaying Fu, Xinyi Shi, Jing Su
Summary: This article provides an overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. It discusses the roles of HDACs in the regulation of ovarian cancer metastasis and highlights the importance of developing compounds that target HDACs in the future of ovarian cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Seong-Kyu Kim, Jung-Yoon Choe, Ji-Won Kim, Ki-Yeun Park
Summary: This study aimed to investigate the effect of the HDAC6 inhibitor CKD-WID on RANKL-mediated osteoclast formation. The results showed that CKD-WID suppressed the expression of osteoclast-related markers and inhibited the calcineurin-NFAT pathway, thereby attenuating MSU-induced osteoclast formation.
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nuechel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Gyoerfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Joerg H. W. Distler
Summary: This study demonstrates that TGF beta activates autophagy through an epigenetic mechanism, promoting fibrotic diseases. Inhibition of aberrant autophagy activation can suppress TGF beta-induced fibroblast activation and ameliorate experimental dermal and pulmonary fibrosis.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Fabin Dang, Wenyi Wei
Summary: Acetylation is a major post-translational modification that can regulate protein function. It plays important roles in tumorigenesis through its effect on gene regulation, and also affects the roles of non-histone proteins in cellular processes. Therefore, targeting the acetylation signaling pathway has therapeutic potential in cancer.
SEMINARS IN CANCER BIOLOGY
(2022)