Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
Review
Biology
Amani A. Mahbub
Summary: Several epidemiological studies have suggested that the use of female sex steroid hormones can reduce the risk of colon cancer. This review summarizes the available data on the effects of estradiol and progesterone treatments in male and female in vitro and in vivo models of colon cancer, along with their potential molecular mechanisms. The studies showed that estradiol treatment and activation of its beta receptor inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis through molecular pathway modulation. Similarly, the inhibition of the alpha receptor also had antitumorigenic effects. Limited studies on progesterone revealed promising tumoricidal actions. Furthermore, the combination of estradiol and progesterone showed enhanced anticancer activities compared to monotherapy. Overall, these studies suggest that female sex steroid hormones could be a novel and effective therapeutic strategy against colon cancer.
Article
Biology
Alejandro La Greca, Nicolas Bellora, Francois Le Dily, Rodrigo Jara, Ana Silvina Nacht, Javier Quilez Oliete, Jose Luis Villanueva, Enrique Vidal, Gabriela Merino, Cristobal Fresno, Inti Tarifa Reischle, Griselda Vallejo, Guillermo Vicent, Elmer Fernandez, Miguel Beato, Patricia Saragueta
Summary: Estrogen and progesterone play important roles in the development and transcriptional regulation of endometrial cancer. PAX2 is involved in fine-tuning the interplay between ERalpha and PR in transcriptional regulation, and the open chromatin state of specific regions is associated with regulated genes.
Article
Obstetrics & Gynecology
Sevtap Han, Ali Fuat Cicek, Aytekin Tokmak, Tugce Yildirir Ustun, Nilufer Ercan Gokay, Mecit Orhan Uludag, Murside Ayse Demirel
Summary: Resveratrol treatment can lower serum estradiol levels, increase progesterone levels, and enhance receptor expression in rats with endometritis. When combined with marbofloxacin, it can further increase receptor expression.
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, General & Internal
Antonio Martinez-Ortega, Alvaro Flores-Martinez, Eva Venegas-Moreno, Elena Dios, Diego Del Can, Eloy Rivas, Ariel Kaen, Eugenio Cardenas Ruiz-Valdepenas, Elena Fajardo, Florinda Roldan, Natividad Gonzalez-Rivera, Rosario Oliva, Jose Ignacio Fernandez-Pena, Alfonso Soto-Moreno, David A. Cano
Summary: This study systematically analyzed the expression of estrogen receptor alpha (ER alpha) and progesterone receptor (PR) in craniopharyngiomas (CPs) and explored their potential association with tumor aggressiveness features. The results showed that a substantial proportion of CPs displayed PR expression, but most CPs expressed low levels of ER alpha. No major association between PR and ER alpha expression and clinical aggressiveness features was observed in CPs. Additionally, beta-catenin accumulation was not related to tumor recurrence in this series.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Michal Kunc, Marta Popeda, Wojciech Biernat, Elzbieta Senkus
Summary: ER alpha(+)/PgR(-) phenotype is not rare in breast cancer, and loss of PgR expression may signify resistance to endocrine therapy and poorer outcomes. Different mechanisms of PgR loss have distinct consequences on cancer cell biology.
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Tai-Han Lin, Hong-Wei Gao, Guo-Shiou Liao, Jyh-Cherng Yu, Ming-Shen Dai, Jar-Yi Ho, Cheng-Ping Yu
Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death of women worldwide. This retrospective study aimed to propose better prognostic cut-off levels for ER and PgR, and found that patients with PgR expression <= 50% or an Allred score <= 5 exhibited a poor prognosis, needing more attention during follow-up.
Review
Oncology
Andrea Ronchi, Francesca Pagliuca, Federica Zito Marino, Marina Accardo, Immacolata Cozzolino, Renato Franco
Summary: Biomarkers on cancer tissue samples can be identified through technologies like immunohistochemistry and in situ hybridization, especially in breast cancer pathology for diagnostic, prognostic, and therapeutic response purposes. Pathologists play an increasingly important role in defining prognosis and choosing therapy based on immunohistochemical biomarkers, guiding treatment and classifying breast cancer into distinct subtypes.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Hengqiang Zhao, Yiping Gong
Summary: Single estrogen receptor (ER)+ and progesterone receptor (PR)+ tumors account for about 10% of all breast cancers. The prognosis of these tumors varies based on HER2 status, with single ER+ and PR+ patients showing different survival outcomes in different HER2 subtypes. In HER2- subtype, single PR+ patients had poorer prognoses than single ER+ patients, while in HER2+ subtype, single ER+ and PR+ patients showed similar prognoses compared with ER-PR- patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
H. Mirzaei-Alamouti, R. Hadionnejad, A. Abdollahi, A. Bahari, F. Fatahnia, R. Masoumi, M. P. Green, M. Vazirigohar, M. Mansouryar
Summary: This study investigated the effects of varying the plane of nutrition on gene expression related to mammary gland development in a seasonal sheep breed. The findings showed a positive impact of high-nutrient diet on mammary gland development, and revealed a complex relationship between the expression of genes critical for mammary gland function and development. These findings provide valuable insights for future nutritional strategies to optimize animal liveweight gain and mammary gland development.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Oncology
Danian Dai, Hongmei Wu, Hongkai Zhuang, Rong Chen, Cheng Long, Bo Chen
Summary: This study investigated the clinical and genetic characteristics of ER + / PR- breast cancer patients in China. Different PR statuses indicated diverse biological processes of ER + breast cancer and survival outcomes. Tailored treatment strategies may be needed for ER + / PR- patients.
Article
Surgery
Maria Santa Cruz, Nikita Singh, Elona Poltiyelova, Natalie Marks, Enrico Ascher, Anil Hingorani
Summary: The study examines the seasonal variation in lower extremity edema among patients with chronic venous insufficiency. Results show that 56.6% of the patients experienced worsened edema during warmer weather, particularly among women and younger women. The study also suggests a correlation between patient sex, age, and the season of questioning with the reported worsening of edema.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Review
Pathology
Shi Wei
Summary: Breast cancer is the most common cancer affecting women, and estrogen receptor (ER) signaling plays a crucial role in its development. ER expression levels are strongly correlated with the therapeutic effects of endocrine therapies targeting ER. Controversies exist regarding the biology and prognostic power of progesterone receptor (PR) status, especially in uncommon subtypes of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Nutrition & Dietetics
Fabrizio Ceraudo, Giovanna Caparello, Angelo Galluccio, Ennio Avolio, Giuseppina Augimeri, Daniela De Rose, Adele Vivacqua, Catia Morelli, Ines Barone, Stefania Catalano, Cinzia Giordano, Diego Sisci, Daniela Bonofiglio
Summary: The study evaluated the impact of Mediterranean food choices on lipid and glycemic metabolic profile in adolescents. The results indicated that adopting a Mediterranean diet could significantly reduce glucose and lipid profile in healthy adolescents.
Review
Nutrition & Dietetics
Elisa Mattavelli, Elena Olmastroni, Daniela Bonofiglio, Alberico L. Catapano, Andrea Baragetti, Paolo Magni
Summary: The Mediterranean diet is a comprehensive lifestyle that promotes health and reduces the prevalence of chronic diseases. Its implementation is influenced by sociocultural and geographical factors, as well as personal food preferences and nutrition habits.
Editorial Material
Nutrition & Dietetics
Daniela Bonofiglio
Article
Food Science & Technology
Serena Carpentieri, Giuseppina Augimeri, Jessica Ceramella, Adele Vivacqua, Maria Stefania Sinicropi, Gianpiero Pataro, Daniela Bonofiglio, Giovanna Ferrari
Summary: The study utilized pulsed electric field pretreatment to enhance the extractability of valuable compounds from artichoke by-products, demonstrating the antioxidant and anti-inflammatory properties of the extracts. Biological effects on THP-1 macrophages were investigated.
Review
Biochemistry & Molecular Biology
Adele Chimento, Arianna De Luca, Maria D'Amico, Francesca De Amicis, Vincenzo Pezzi
Summary: Various literature data suggest that a diet rich in vegetables can reduce the incidence of cancer by utilizing the natural polyphenols present in them. Polyphenols possess various pharmacological actions such as anti-inflammatory, anti-oxidant, antibiotic, antiseptic, anti-allergic, cardioprotective, and even anti-tumor properties. The anti-tumor action of polyphenols involves multiple mechanisms associated with cell proliferation, differentiation, migration, angiogenesis, metastasis, and cell death. This review aims to provide an updated understanding of the apoptotic molecular mechanisms induced by representative polyphenols in cancer cells, which can be utilized in the development of new therapeutic strategies against cancer involving polyphenols as adjuvants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Giuseppina Augimeri, Marco Fiorillo, Catia Morelli, Salvatore Panza, Cinzia Giordano, Ines Barone, Stefania Catalano, Diego Sisci, Sebastiano Ando, Daniela Bonofiglio
Summary: Triple-negative breast cancer (TNBC), lacking effective targeted therapies, can be attenuated by DHEA through reducing cell migration, invasion, and metabolic activity. In addition, DHEA suppresses macrophage recruitment by reducing CCL5 secretion from TNBC cells, providing a potential treatment option against TNBC.
Review
Biology
Adele Chimento, Maria D'Amico, Arianna De Luca, Francesca Luisa Conforti, Vincenzo Pezzi, Francesca De Amicis
Summary: Plant-derived bioactive compounds are being widely studied for their significant anti-cancer properties, including cancer prevention, improved chemotherapy effectiveness, and mitigation of chemotherapy side effects. This paper provides an overview of the literature on the anti-cancer effects of three extensively studied plant-derived compounds, namely resveratrol, epigallocatechin gallate, and curcumin, with a focus on their molecular mechanisms inducing apoptosis in major types of cancers globally.
Review
Biochemistry & Molecular Biology
Giuseppina Augimeri, Daniela Bonofiglio
Summary: Unhealthy dietary habits increase the risk of cancer, and adopting a healthy eating pattern, such as the Mediterranean diet high in omega-3 polyunsaturated fatty acids (N-3 PUFAs), is recommended to prevent various types of cancers, including breast cancer. The consumption of N-3 PUFAs, particularly EPA and DHA, reduces the risk and progression of breast cancer, and also helps counteract side effects of chemotherapy. DHA, in particular, has shown significant antitumoral effects in breast cancer cells and its derivative DHEA has potential therapeutic benefits.
Article
Chemistry, Multidisciplinary
Giovanna Caparello, Angelo Galluccio, Fabrizio Ceraudo, Claudio Pecorella, Fabio Buzzanca, Francesco Cuccomarino, Daniela Bonofiglio, Ennio Avolio
Summary: An optimal body composition in volleyball players can be achieved by monitoring training plans and nutritional habits, and the Mediterranean Diet (MD) is a good choice to meet the nutritional needs of athletes. This study used bioelectrical impedance vector analysis (BIVA) to monitor body composition changes in volleyball players following MD recommendations. The results showed that athletes maintained an optimal MD adherence and experienced significant changes in BIVA parameters, indicating improved body cell mass and skeletal muscle mass. These findings support the use of BIVA as a tool to monitor athlete's body adaptations and highlight the importance of the MD in sports settings.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Roberto Castiglione, Adele Vivacqua, Marta Santoro, Daniela De Rose, Giuseppina Peluso, Salvatore Panza, Saveria Aquila, Rosario D'Agata
Summary: Recent evidence suggests that the male gonad is a potential target of glucagon-like peptide-1 (GLP-1). This study investigated the effects of GLP-1 on sperm function and the molecular mechanisms involved. Incubation of semen samples with a GLP-1 mimetic analog prevented a decline in sperm motility and attenuated the negative effects of tumor necrosis factor (TNF-a) on sperm parameters. GLP-1 also reduced levels of negative kinases in sperm, suggesting a potential role in sperm physiopathology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Marta Claudia Nocito, Paola Avena, Lucia Zavaglia, Arianna De Luca, Adele Chimento, Tarig Hamad, Davide La Padula, Davide Stancati, Constanze Hantel, Rosa Sirianni, Ivan Casaburi, Vincenzo Pezzi
Summary: Extensive research suggests that curcumin interferes with multiple cell signaling pathways involved in cancer development and progression. This study aimed to evaluate the effects of curcumin on adrenocortical carcinoma (ACC), showing that curcumin reduced growth, migration and activated apoptosis in ACC cell lines through metabolic rewiring towards glutamine metabolism. Moreover, the effectiveness of curcumin against ACC growth and progression was improved by concomitant use of inhibitors for glutamine metabolism.
Article
Biochemistry & Molecular Biology
Rosa Tundis, Giuseppina Augimeri, Adele Vivacqua, Rosa Romeo, Vincenzo Sicari, Daniela Bonofiglio, Monica Rosa Loizzo
Summary: This study characterized bamboo leaf and sheath extracts, revealing their antioxidant and anti-inflammatory properties. Bamboo leaves contain phenolic compounds, while sheaths are rich in phenolic acids. These findings suggest potential applications of bamboo leaf and sheath in the nutraceutical, cosmetic, and pharmaceutical industries.
Article
Biochemistry & Molecular Biology
Cinzia Giordano, Felice Maria Accattatis, Luca Gelsomino, Piercarlo Del Console, Balazs Gyorffy, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Erica Pietroluongo, Francesco Zinno, Daniela Bonofiglio, Sebastiano Ando, Ines Barone, Stefania Catalano
Summary: This study identified novel miRNA signatures, miRNA-27a and miRNA-128, in breast cancer by analyzing the expression profiles of EV-derived miRNAs in the blood circulation. These miRNAs showed diagnostic accuracy in distinguishing breast cancer patients from non-cancer controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Giuseppina Augimeri, Marco Fiorillo, Giovanna Caparello, Fabrizio Ceraudo, Ennio Avolio, Catia Morelli, Ines Barone, Stefania Catalano, Sebastiano Ando, Cinzia Giordano, Diego Sisci, Adele Vivacqua, Daniela Bonofiglio
Summary: This study found that the COVID-19 lockdown had a negative impact on the metabolic and inflammatory profile of adolescents, despite no significant differences in anthropometric measurements and adherence to the Mediterranean diet. Post-lockdown adolescents had higher levels of fasting glucose, triglycerides, total cholesterol, LDL, tumor necrosis factor (TNF)-alpha, interleukin-1 beta, and ferritin, along with lower levels of high-density lipoprotein (HDL). The study also identified several serum markers as predictors for metabolic and inflammatory profiling after the lockdown period.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Simona De Angelis, Emanuela Medda, Daniela Rotondi, Maria Masocco, Valentina Minardi, Benedetta Contoli, Valentina Possenti, Angela Sorbo, Marilena D'Amato, Anna Chiara Turco, Alberto Augusto Pastorelli, Paolo Stacchini, Roberto Da Cas, Marcello Bagnasco, Daniela Bonofiglio, Maurizio Gasperi, Domenico Meringolo, Caterina Mian, Mariacarla Moleti, Francesco Vermiglio, Efisio Puxeddu, Augusto Taccaliti, Massimo Tonacchera, Salvatore Ulisse, Antonio Dimida, Teresa Rago, Elena Nazzari, Mara Schiavo, Irene Bossert, Giacomo Sturniolo, Carlo Corbetta, Cristina Cereda, Laura Cappelletti, Marta Camilot, Francesca Teofoli, Renzo Ciatti, Elisabetta Tarsi, Nicola Perrotti, Onorina Marasco, Giovanna Scozzafava, Francesca Righetti, Sebastiano Ando, Stefania Catalano, Mariarosaria Cristofaro, Giovanni Sorrenti, Simona Censi, Silvia Morelli, Enke Baldini, Giuseppe Plutino, Roberto Copparoni, Elena Alonzo, Claudia Giacomozzi, Marco Silano, Antonella Olivieri
Summary: This study evaluated the efficiency and adverse effects of the iodine prophylaxis program in Italy. The results showed that Italy has achieved iodine sufficiency through the program, but there are still concerns about iodine nutritional status during pregnancy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)