期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 57, 期 10, 页码 1718-1728出版社
WILEY
DOI: 10.1002/mnfr.201200794
关键词
AMPK signaling; Atherosclerosis; Inflammation; Lipid metabolism; Xanthohumol
资金
- Austrian Science Fund (FWF) [F30 SFB LIPOTOX, W1226 DK-MCD, P19186, P22832]
- Austrian Science Fund (FWF) [F 3007, P 22832, F 3004] Funding Source: researchfish
- Austrian Science Fund (FWF) [W1241] Funding Source: Austrian Science Fund (FWF)
ScopeXanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. Based on its favorable biological properties, we investigated whether XN attenuates atherosclerosis in western-type diet-fed apolipoprotein-E-deficient (ApoE(-/-)) mice. Methods and resultsXN supplementation markedly reduced plasma cholesterol concentrations, decreased atherosclerotic lesion area, and attenuated plasma concentrations of the proinflammatory cytokine monocyte chemoattractant protein 1. Decreased hepatic triglyceride and cholesterol content, activation of AMP-activated protein kinase, phosphorylation and inactivation of acetyl-CoA carboxylase, and reduced expression levels of mature sterol regulatory element-binding protein (SREBP)-2 and SREBP-1c mRNA indicate reduced lipogenesis in the liver of XN-fed ApoE(-/-) mice. Concomitant induction of hepatic mRNA expression of carnitine palmitoyltransferase-1a in ApoE(-/-) mice-administered XN suggests increased fatty acid beta-oxidation. Fecal cholesterol concentrations were also markedly increased in XN-fed ApoE(-/-) mice compared with mice fed western-type diet alone. ConclusionThe atheroprotective effects of XN might be attributed to combined beneficial effects on plasma cholesterol and monocyte chemoattractant protein 1 concentrations and hepatic lipid metabolism via activation of AMP-activated protein kinase.
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