Review
Food Science & Technology
Ting Yi Heung, Jessica Yue Shuen Huong, Wan Yeng Chen, Yi Wen Loh, Kooi Yeong Khaw, Bey-Hing Goh, Yong Sze Ong
Summary: Papaya extracts or their bioactive compounds may serve as a potential broad-spectrum therapy for cancer by targeting multiple characteristics of cancer development.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Genetics & Heredity
Ziwei Zhou, Rebecca Ford, Ido Bar, Chutchamas Kanchana-udomkan
Summary: The papaya industry faces challenges in fruit quality consistency and flavor, necessitating a better understanding of genetic and biochemical mechanisms for breeding new varieties with improved taste. Research methods such as studying sugar components, volatile compounds, and genomics are used to identify the flavor profile of papaya.
Review
Food Science & Technology
Rebecca A. Haber, Reicelle D. Garcia, Jamie N. Hernandez, Sarah Jamieson, Arijit Mondal, Anupam Bishayee
Summary: This paper provides a comprehensive analysis of the cancer-preventive potential of Carica papaya extracts, fractions, and isolated phytochemicals. It discusses the cellular and molecular mechanisms of action, bioavailability, pharmacokinetics, and safety profiles of these phytochemicals, as well as the limitations, challenges, and future directions of research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Horticulture
Carlos Lopez Encina, Manuel Lopez Granero, Jose Javier Regalado
Summary: In this article, the authors present a reliable method for the long-term micropropagation of papaya, using microshoots developed from the axillary buds of papaya shoots as primary explants. The proliferation medium (PPRM) was found to maintain papaya shoots under continuous proliferation for 20 years, while the elongation medium (PELM) and rooting medium (PROM) were designed to recover shoots with poor growth and induce high-quality roots from nonrooted shoots, respectively. The main objective of this work was to provide a micropropagation method that can maintain healthy elite genotypes of papaya for long periods of time and produce a high number of good quality plants.
Article
Agronomy
Juan Alberto Cabrera, Axel Ritter, Vanesa Raya, Eudaldo Perez, Maria Gloria Lobo
Summary: To optimize papaya yield and quality, crop phenology studies are necessary, involving measurement of meteorological variables and morphological characteristics, as well as calculation of source-sink ratios and study of fruit quality. Results indicated that better environmental control inside greenhouses and screenhouses is needed to maintain good fruit quality.
Article
Public, Environmental & Occupational Health
Sandhanasamy Devanesan, Murugesan Jayamala, Mohamad S. AlSalhi, Sankaran Umamaheshwari, Amirtham Jacob A. Ranjitsingh
Summary: The study synthesized silver nanoparticles using a biologically active molecule isolated from Carica papaya leaves, demonstrating good antibacterial and antiproliferative effects while showing low toxicity to normal cells.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Review
Pharmacology & Pharmacy
Md Moklesur Rahman Sarker, Farzana Khan, Isa Naina Mohamed
Summary: Dengue fever, caused by the Aedes aegypti virus, has seen a drastic increase in prevalence and mortality rates in recent years in countries like Bangladesh, Philippines, Thailand, Brazil, and India. While traditional medicine using papaya leaves has shown some effectiveness in treating the disease, physicians in Bangladesh do not recommend its use.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Bee Ping Teh, Norzahirah Binti Ahmad, Saharuddin Bin Mohamad, Terence Yew Chin Tan, Mohd Ridzuan Bin Mohd Abd Razak, Adlin Binti Afzan, Ami Fazlin Binti Syed Mohamed
Summary: This scoping review critically appraised the scientific evidence related to the efficacy of Carica papaya leaf juice in relieving dengue related manifestations. The review revealed that besides its larvicidal activity, Carica papaya leaf juice also exhibited anti-thrombocytopenic and immunomodulatory effects on dengue infection. This study suggests that Carica papaya leaf juice has the potential to be a new safe and effective drug against dengue disease.
Article
Multidisciplinary Sciences
Juan Liu, Jennifer Han, Anupma Sharma, Ching Man Wai, Ray Ming, Qingyi Yu
Summary: The study found that dosage compensation in papaya is regulated on a gene-by-gene level rather than whole sex-linked region, with seven genes on the papaya X chromosome showing dosage compensation. Expression ratios in different evolutionary strata suggest different mechanisms of gene regulation and maintenance of transcriptional balance between females and males.
SCIENTIFIC REPORTS
(2021)
Review
Multidisciplinary Sciences
Joachim M. Dotto, Siri A. Abihudi
Summary: Papaya, a widely studied plant known for its nutritional and medicinal value, contains valuable phytochemicals that play key roles in ameliorating and treating various medical conditions. While there is considerable literature on the biomedical uses of different parts of the papaya plant, further studies are needed to validate the dosage, mode of actions, and safety profile when used as medicine.
SCIENTIFIC AFRICAN
(2021)
Article
Microbiology
Swetha Reddy Vundela, Naveen Kumar Kalagatur, Anusuya Nagaraj, Krishna Kadirvelu, Siddaiah Chandranayaka, Kasturi Kondapalli, Abeer Hashem, Elsayed Fathi Abd-Allah, Sudhakar Poda
Summary: The present study successfully fabricated selenium nanoparticles from Carica papaya extract and explored their multi-biofunctional features. The selenium nanoparticles showed antioxidant, antimicrobial, antimycotoxin, and anticancer activities, as well as high biocompatibility.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Pallavi S. Patil, Umesh B. Deshannavar, M. Ramasamy, Sampath Emani
Summary: The study investigated the use of sugarcane juice blended with different fruit juices as substrate for wine production, identifying a promising blend of sugarcane-papaya juice based on total alcohol content and overall acceptability. Optimum fermentation conditions were determined for the sugarcane-papaya wine, resulting in high overall acceptability and physicochemical parameters within standard range. GC-HRMS analysis identified 12 volatile compounds in the wine, while inductively coupled plasma atomic emission spectroscopy revealed the presence of minerals such as Ca, Cu, K, Mg, Mn, Na, Zn, and P.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Pharmacology & Pharmacy
V. S. Tambe, D. D. Waichal, R. R. Chanshetty
Summary: Carica papaya leaves have been traditionally used in folklore medicine for treating thrombocytopenia associated with diseases and drugs. Scientific studies have confirmed the efficacy of papaya leaves extract in increasing platelet count, especially through the alkaloid carpaine.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Plant Sciences
Sumit K. Soni, Manoj Kumar Mishra, Maneesh Mishra, Swati Kumari, Sangeeta Saxena, Virendra Shukla, Sudeep Tiwari, Pramod Shirke
Summary: The present investigation revealed that the infection of papaya leaves by PaLCuV resulted in significant changes in the anatomy, physiology, and pharmacological properties of the leaves. The infected leaves showed reduced stomatal density, photosynthesis rate, and enzymatic activity, while the size of guard cells, transpiration rate, and anthocyanin content increased. Moreover, the pharmacological potential of the infected leaves was significantly decreased.
Review
Food Science & Technology
Sherif Shaheen, Charis M. Galanakis, Mohamed A. Farag
Summary: Papaya is a tropical fruit known for its nutritional value and health benefits. The seeds and peels of papaya, which account for 20% of the fruit weight, contain valuable chemical constituents such as glucosinolates, lipids, proteins, and dietary fibers. This review outlines the composition of papaya fruit biowastes, their biological functions, and their applications in functional food, bioenergy, and other industries.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Cell Biology
Wenjun Pu, Jiawen Qiu, Zeyad D. Nassar, Paul N. Shaw, Kerrie-Ann McMahon, Charles Ferguson, Robert G. Parton, Gregory J. Riggins, Jonathan M. Harris, Marie-Odile Parat
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Engineering, Chemical
Kooi-Yeong Khaw, Paul Nicholas Shaw, Marie-Odile Parat, Saurabh Pandey, James Robert Falconer
Article
Chemistry, Applied
Zhengzheng Zou, Claire Bouchereau-De Pury, Amitha K. Hewavitharana, Saad S. Al-Shehri, John A. Duley, David M. Cowley, Pieter Koorts, Paul N. Shaw, Nidhi Bansal
Summary: A high-throughput fluorescence assay method was developed for determination of oxidase activities in milk samples, showing high sensitivity, good repeatability and reproducibility. The method was successfully applied to survey different animal milk samples and can be adapted for measurements of other oxidase activities.
Article
Chemistry, Applied
Zhengzheng Zou, Julien Bauland, Amitha K. Hewavitharana, Saad S. Al-Shehri, John A. Duley, David M. Cowley, Pieter Koorts, Paul N. Shaw, Nidhi Bansal
Summary: A more sensitive microplate fluorescent assay was developed for measuring LPO activity in milk, which is suitable for both laboratory and commercial scales. The method eliminates the influences of indigenous milk components and has good precision. The assay showed that LPO activities ranked as bovine > goat > camel > human in the four types of milk analyzed.
Article
Multidisciplinary Sciences
Danielle L. Michell, Waled A. Shihata, Karen L. Andrews, Nurul Aisha Zainal Abidin, Ann-Maree Jefferis, Amanda K. Sampson, Natalie G. Lumsden, Olivier Huet, Marie-Odile Parat, Garry L. Jennings, Robert G. Parton, Kevin J. Woollard, David M. Kaye, Jaye P. F. Chin-Dusting, Andrew J. Murphy
Summary: High intraluminal pressure can lead to vascular inflammation and subsequent hypertension development; Studies have shown that deficiency of caveolin-1 can reduce pressure-induced inflammatory responses and leukocyte adhesion; These findings demonstrate that Cav1 plays an important role in pressure-induced inflammation.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Thao Nhu Dinh, Marie-Odile Parat, Yong Sze Ong, Kooi Yeong Khaw
Summary: BITC, a common isothiocyanate found in cruciferous vegetables, has shown anticancer activities by modulating various signaling pathways. Further studies are needed to validate its effectiveness in humans for future development.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Iqira Saeed, Adam La Caze, Markus W. Hollmann, Paul N. Shaw, Marie-Odile Parat
Summary: Tramadol is considered to possess anti-inflammatory properties and preserve immune responses, including natural killer cell activity, which are important in anti-cancer defences, according to recent clinical evidence.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Biology
Kerrie-Ann Mcmahon, David A. Stroud, Yann Gambin, Vikas Tillu, Michele Bastiani, Emma Sierecki, Mark E. Polinkovsky, Thomas E. Hall, Guillermo A. Gomez, Yeping Wu, Marie-Odile Parat, Nick Martel, Harriet P. Lo, Kum Kum Khanna, Kirill Alexandrov, Roger Daly, Alpha Yap, Michael T. Ryan, Robert G. Parton
Summary: Cavin3 plays a key role in DNA repair and interacts directly with BRCA1. Loss of cavin3 can increase the sensitivity of tumor cells to UV-induced apoptosis, while also affecting DNA repair and cell survival.
Review
Oncology
Mai Mahmoud Gabr, Iqira Saeed, Jared A. Miles, Benjamin P. Ross, Paul Nicholas Shaw, Markus W. Hollmann, Marie-Odile Parat
Summary: Recent evidence suggests that opioids can interact with the Toll-like receptor 4 (TLR4) on innate immune and cancer cells, potentially influencing tumor growth and metastasis. Opioids have been shown to weakly activate TLR4 and can inhibit its activation by lipopolysaccharide (LPS). The interaction of opioids with TLR4 is complex, involving non-competitive mechanisms and downstream effects on NF-kappa B activation.
Review
Oncology
Claudia A. Scroope, Zane Singleton, Markus W. Hollmann, Marie-Odile Parat
Summary: Opioids are commonly used in cancer patients for pain management during tumor excision and to alleviate cancer-related pain. However, the effects of opioids on tumor growth and metastasis, as well as their impact on disease outcomes, are still under debate in literature. It is clear that opioids have direct and indirect effects on solid tumor biology, the anticancer immune response, inflammation, angiogenesis, and the tumor-promoting effects of pain.
FRONTIERS IN ONCOLOGY
(2021)
Article
Food Science & Technology
Zhengzheng Zou, John A. Duley, David M. Cowley, Sarah Reed, Buddhika J. Arachchige, Bhesh Bhandari, Paul N. Shaw, Nidhi Bansal
Summary: This study compared the physicochemical properties and protein profiles of camel milk powders produced by different concentration and dehydration processes. The results showed that direct freeze drying is the most ideal method for preserving bioactive proteins in camel milk powder production, but the freeze-drying technique has limitations in terms of cost and scalability. The current spray-drying technique needs improvement to better retain the bioactivity of camel milk during powder processing.
Review
Polymer Science
Ritu Thapa, Shila Gurung, Marie-Odile Parat, Harendra S. Parekh, Preeti Pandey
Summary: Approaches for effective and sustained drug delivery to the female reproductive tract remain limited, but the development of versatile delivery platforms like sol-gels shows promise. Sol-gels, which transition from solution to gel triggered by physiological conditions, offer advantages for drug formulations and can be used as drug delivery vehicles for diverse drug molecules. The review discusses the challenges and opportunities in optimal drug delivery and highlights the potential of sol-gels for improved treatment of gynaecological conditions.
