期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 56, 期 8, 页码 1353-1357出版社
WILEY
DOI: 10.1002/mnfr.201200122
关键词
Apples; Colon carcinogenesis; High-fat diet; Inflammation; Precancerous lesions
资金
- AICR (American Institute for Cancer Research)
- WCRF NL (World Cancer Research Fund, the Netherlands)
- University of Florence
Inflammation may increase cancer risk, therefore, we studied whether polyphenol-rich Marie Menard (MM) apples with reported anti-inflammatory activity prevent 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats and, likewise whether high-fat (HF) diet promoting carcinogenesis, may affect inflammation. DMH-induced rats were fed for 15 weeks with: an HF diet (23% corn oil w/w); an HF diet containing 7.6% w/w lyophilized MM (apple diet (AD)); a low-fat (LF) diet and an HF diet containing piroxicam (PXC) (0.01% w/w) as control. Mucin depleted foci (MDF), precancerous lesions in the colon, were dramatically reduced in the AD, LF, and PXC groups compared with the HF. Peritoneal macrophage activation, an index of systemic inflammation, was significantly decreased in the AD, LF, and PXC groups. TNF-alpha, iNOS, IL-1 beta, IL-6 m-RNA expression in the colon, as well as CD68 cells and plasmatic PGE2 were lower in the AD, but not in the LF group. Apoptosis in the MDF of both the AD and LF-fed rats was significantly higher than in HF rats. In conclusion, AD has a strong chemopreventive effect, reducing inflammation, and increasing apoptosis, while the chemopreventive effect of the LF diet seems mediated mainly by increased apoptosis in MDF.
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