Article
Geriatrics & Gerontology
Lindsey J. Anderson, Jonathan Lee, Barbara Anderson, Benjamin Lee, Dorota Migula, Adam Sauer, Nicole Chong, Haiming Liu, Peter C. Wu, Atreya Dash, Yi-Ping Li, Jose M. Garcia
Summary: Cancer-related weight loss is associated with elevated levels of inflammation, lipolysis, and browning markers. BMI is associated with increased energy expenditure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Gemma Arderiu, Guiomar Mendieta, Alex Gallinat, Carmen Lambert, Alberto Diez-Caballero, Carlos Ballesta, Lina Badimon
Summary: Obesity is linked to metabolic disorders and increased cardiovascular risk. The presence of type 2 diabetes mellitus (T2DM) affects the protein composition in adipose tissue and serum, leading to changes in systemic markers and dysregulation of metabolic pathways in visceral adipose tissue (VAT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Medicine, Research & Experimental
Bimit Mahat, Etienne Chasse, Jean-Francois Mauger, Pascal Imbeault
Summary: The amended version has been published and can be accessed through the original article.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Margarete Milek, Yusef Moulla, Matthias Kern, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Peter Kovacs, Michael Stumvoll, Matthias Blueher, Esther Guiu-Jurado
Summary: This study found that serum adipsin concentrations are strongly related to obesity and age, but not to parameters of glucose or lipid metabolism in patients with obesity with or without T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tiago Morais, Alexandre L. Seabra, Barbara G. Patricio, Marta Guimaraes, Mario Nora, Pedro F. Oliveira, Marco G. Alves, Mariana P. Monteiro
Summary: The study revealed that there are differences in VAT metabolic fingerprint between obesity and different glycemic statuses, characterized by higher isoleucine consumption, lower acetate production, and lower pyruvate and pyroglutamate consumption in pre-diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Ho Ting Shiu, Xiaohan Pan, Qing Liu, KeKao Long, Kenneth King Yip Cheng, Ben Chi-Bun Ko, James Kar-Hei Fang, Yuyan Zhu
Summary: The health concerns of microplastics (MPs) and nanoplastics (NPs) have been increasing, but there is still a lack of key indicators to evaluate the adverse risks of MPs/NPs. This study demonstrates that fluorescent polystyrene nanoplastics (nPS) can distribute in white adipose tissue (WAT) of mice and reduce lipolysis under stimulation in vitro and ex vivo. Chronic oral exposure to nPS at relevant concentrations impairs lipid mobilization in obese mice, leading to larger adipocytes in WAT. Additionally, nPS exposure induces macrophage infiltration in the small intestine and increases lipid accumulation in the liver, disrupting systemic metabolism. These findings highlight the potential obesogenic role of nPS via diminishing lipid mobilization in WAT and suggest using lipolysis relevant parameters for evaluating the adverse effect of MPs/NPs in clinics.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Medicine, Research & Experimental
Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jurgen Wess, Kenneth A. Jacobson
Summary: Obesity is a major factor in the global epidemic of type 2 diabetes, with elevated plasma free fatty acids contributing to insulin resistance; adipocyte P2Y(14)Rs play a crucial role in regulating lipid and glucose homeostasis, with their absence enhancing lipolysis, reducing body weight, and improving glucose tolerance; P2Y(14)R antagonists may hold therapeutic potential for obesity and T2D by inhibiting lipolysis.
Article
Endocrinology & Metabolism
Jan W. Eriksson, Robin Visvanathar, Joel Kullberg, Robin Strand, Stanko Skrtic, Simon Ekstrom, Mark Lubberink, Martin H. Lundqvist, Petros Katsogiannos, Maria J. Pereira, Hakan Ahlstrom
Summary: The study utilized a novel imaging approach to quantify tissue-specific glucose metabolism. During the development of T2D, insulin-stimulated glucose disposal was impaired and shifted towards the brain. Changes in glucose handling in the brain and liver fat accumulation may worsen insulin resistance in multiple organs.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Benedikt Dietz, Juergen Machann, Vaibhav Agrawal, Martin Heni, Patrick Schwab, Julia Dienes, Steffen Reichert, Andreas L. Birkenfeld, Hans-Ulrich Haering, Fritz Schick, Norbert Stefan, Andreas Fritsche, Hubert Preissl, Bernhard Schoelkopf, Stefan Bauer, Robert Wagner
Summary: The study indicated that diabetes can be detected through whole-body MRI without additional data, with visceral fat playing a crucial role in diabetes classification. The model identified a high-risk group with increased risk for future diabetes and microalbuminuria.
Article
Endocrinology & Metabolism
Jiyoung Oh, Chu-Sook Kim, Min Kim, Woobeen Jo, Young Hoon Sung, Jiyoung Park
Summary: The study reveals the crucial role of Col6a3 in mature adipocyte differentiation, inflammation, lipolysis, and insulin sensitivity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Gastroenterology & Hepatology
Benjamin Schroeder, Sabine Kahl, Michael Roden
Summary: Individuals with obesity or type 2 diabetes have an increased risk of developing non-alcoholic fatty liver disease, with altered adipose tissue function and hepatic mitochondrial dysfunction playing key roles in the pathogenesis. Genetic testing for high-risk individuals, particularly for the rs738409(G) SNP of the PNPLA3 gene, could improve future screening strategies.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study investigated changes in cardiovascular dynamics, adipose tissue, and kidney pathology associated with obesity and T2D in ZFDM rats. The results showed that heart rate and plasma adrenaline concentration decrease with the progression of obesity and T2D in ZFDM rats. In addition, inflammation occurs in perirenal white adipose tissue, while degeneration and whitening occur in interscapular brown adipose tissue. Furthermore, renal function is impaired. ZFDM rats will be useful for studying metabolic changes associated with obesity and T2D progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes, Emily A. Jordan, Alexis R. White, Stephen E. Flaherty, Barbara Bernardo, Trenton Ross, Kendra K. Bence, Morris J. Birnbaum
Summary: This study examines the relationship between hepatic Activin E and adipose metabolism, suggesting that Activin E functions as part of a liver-adipose feedback loop to suppress adipose tissue lipolysis in response to elevated serum fatty acids and hepatic fatty acid exposure.
MOLECULAR METABOLISM
(2023)
Article
Multidisciplinary Sciences
Aditya Saxena, Nitish Mathur, Pradeep Tiwari, Sandeep Kumar Mathur
Summary: This study revealed that the peripheral subcutaneous adipose tissue among Asian Indians shows pathological characteristics, with a network of regulatory transcription factors, protein kinases, and microRNAs affecting the adipogenesis process, deserving further investigation for potential clinical diagnostic and therapeutic applications.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Agne Kulyte, Alisha Aman, Rona J. Strawbridge, Peter Arner, Ingrid A. Dahlman
Summary: Interindividual differences in the generation of new fat cells are associated with body fat and type 2 diabetes risk. This study identified several genetic loci and candidate genes, including SPATS2L, KCTD18, RPL8, HSD17B12, and PEPD, that are potentially important in controlling fat cell numbers, body fat size, and diabetes risk.
