Article
Fisheries
Takavar Mohammadian, Reza Ghanei-Motlagh, Taravat Molayemraftar, Mehrzad Mesbah, Mojtaba Zarea, Hamzeh Mohtashamipour, Abdolhossein Jangaran Nejad
Summary: Dietary supplementation with Immunogen? significantly improves growth parameters, carcass protein content, intestinal microflora, and immune responses in shabout fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Po-Yun Teng, Roshan Adhikari, Sara Llamas-Moya, Woo Kyun Kim
Summary: The study found that both mannan-oligosaccharides and beta-glucan improved growth performance in broiler chickens during the starter phase, with beta-glucan additionally increasing body weight gain. Furthermore, the combination of MOS and beta-glucan resulted in higher villi height in the jejunum of the chickens, indicating potential benefits for intestinal health.
Article
Immunology
Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman, Bart J. L. Eggen
Summary: This study demonstrated that preconditioning with both BG and LPS induced immune training of microglia at two days after the first challenge. However, with a 7-day interval between the first and second challenge, LPS-preconditioning resulted in immune tolerance in microglia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Agriculture, Dairy & Animal Science
Fernando Gonzalez, Amanda Carelli, Alina Komarcheuski, Mayara Uana, Rodolpho Martin do Prado, Diogo Rossoni, Marcia Gomes, Ricardo Vasconcellos
Summary: This study assessed the effects of adding yeast cell wall compounds (YCWs) to cat food on hindgut fermentation metabolites and fecal microbiota. The results showed that even at low dietary concentrations, YCWs could modulate the metabolism and fecal microbiota traits in cats. This effect was more pronounced in vitro, suggesting that YCWs could potentially contribute to the intestinal health of adult cats fed extruded diets.
Article
Immunology
Henna-Riikka Malmberg, Andrea Hanel, Mari Taipale, Sami Heikkinen, Carsten Carlberg
Summary: This study found that 1,25(OH)(2)D-3 significantly modulates the functional consequences of immune challenges, but the effects largely depend on treatment sequence. The results suggest that a sufficient vitamin D status before an infection may be more important than vitamin D supplementation afterwards.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Karine de Melo Santos, Larissa Wuensche Risolia, Mariana Fragoso Rentas, Andressa Rodrigues Amaral, Roberta Bueno Ayres Rodrigues, Maria Isabel Gonzalez Urrego, Thiago Henrique Annibale Vendramini, Ricardo Vieira Ventura, Julio Cesar de Carvalho Balieiro, Cristina de Oliveira Massoco, Joao Paulo Fernandes Santos, Cristiana Fonseca Ferreira Pontieri, Marcio Antonio Brunetto
Summary: This study evaluated the effects of supplementing different levels of dehydrated yeast culture on the fecal microbiota, nutrient digestibility, and immune parameters of healthy adult dogs. The results showed that the yeast addition modulated the proportions of certain phyla and genera in the microbiota, improved nutrient digestibility, and affected fermentative products and immunity in the dogs.
FERMENTATION-BASEL
(2022)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Public, Environmental & Occupational Health
Jingna Xun, Shuyan Guo, Yumin Xu, Rong Chen, Qi Tang, Xinyu Zhang, Danping Liu, Renfang Zhang, Yinzhong Shen, Li Liu, Jiangrong Wan, Jun Chen, Hongzhou Lu
Summary: This study assessed the association of plasma beta DG levels with inflammation and immune activation in people living with HIV (PLWH) and the effect of antiretroviral therapy (ART) on beta DG levels. The results showed that beta DG levels were positively correlated with immune activation markers and decreased significantly after 1 year of ART, suggesting it could serve as a biomarker of immune activation and efficacy monitoring in PLWH.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Jules Petit, Irene de Bruijn, Mark R. G. Goldman, Erik van den Brink, Wilbert F. Pellikaan, Maria Forlenza, Geert F. Wiegertjes
Summary: Dietary supplementation of fish with beta-glucans has been found to have immunomodulatory effects, but the exact mechanisms are still unclear. In this study, the researchers identified the active naive microbiota in the intestine of common carp and found that certain bacteria are capable of fermenting dietary beta-glucans. They also observed fermentation of two different beta-glucan preparations in vitro, resulting in the production of distinct short-chain fatty acids (SCFA). Additionally, they demonstrated the potential immunomodulatory effects of SCFAs on head kidney leukocytes, suggesting a possible role in beta-glucan-induced immunomodulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Saif Hameed, Sandeep Hans, Shweta Singh, Ruby Dhiman, Ross Monasky, Ramendra Pati Pandey, Shankar Thangamani, Zeeshan Fatima
Summary: Candida genus is a common human fungal pathogen with complex cell wall and the ability to mask immunogenic molecules, contributing to its virulence. Understanding the masking mechanism of Candida can lead to the identification of new antifungal targets and improve therapeutic approaches for candidiasis.
Article
Agriculture, Dairy & Animal Science
Michel B. Verwoolde, Jurgen van Baa, Christine A. Jansen, Elisabeth A. M. Graat, David M. Lamot, Aart Lammers, Lieske van Eck
Summary: This study is the first to investigate the impact of stimulating the maternal innate immune system with lipopolysaccharides (LPS) or beta-glucan on growth performance and immune responses in the next generation. The findings show that offspring of LPS-treated broiler breeders have higher feed efficiency post-NE challenge, with more intestinal lesions observed. Additionally, both LPS and beta-glucan maternal treatments resulted in transgenerational effects on blood-derived monocytes, indicating a potential impact on immune responsiveness in the offspring.
Article
Dermatology
Johannes Forster, Karl Dichtl, Johannes Wagener
Summary: This study evaluated the impact of a recent update to the manufacturer-recommended cut-off for beta-1,3-D-glucan (BDG) testing on the diagnosis of candidemia. The results showed that BDG testing had higher sensitivity compared to antigen and antibody testing, and lowering the BDG cut-off value improved sensitivity, mainly for non-albicans Candida species bloodstream infections.
Article
Food Science & Technology
Michele O'Sullivan, Elaine Dempsey, Sarah Case, Emer E. Hackett, Anna E. Ledwith, Hannah Prendeville, Tara O'Brien, Faye Lewis, Dearbhla M. Murphy, Supriya Yadav, Jude Wilson, Sinead C. Corr, Frederick J. Sheedy
Summary: Mushrooms have been valued as an edible and medical resource for thousands of years. Research on powdered A. bisporus mushrooms shows that they can attenuate immune signaling triggered by microbial ligands and inhibit the development of colitis in vivo. This study highlights the importance of mushrooms in developing complementary approaches to modulate chronic inflammation and disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Microbiology
Johannes Traeger, Sarah Draeger, Sidonia Mihai, Franziska Cipa, Andrea Busse Grawitz, Thomas Epting, Renate Meyer, Elfriede Rappold, Juergen Held
Summary: In patients with candidemia, biomarker positivity usually precedes culture positivity. Relapses are mostly accompanied by secondary biomarker increases. Rising concentrations of BDG and Mn predict lethality, whereas decreasing levels suggest a favorable outcome in the majority of patients.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Immunology
Dani Sukkar, Ali Kanso, Philippe Laval-Gilly, Jairo Falla-Angel
Summary: This study evaluated the effect of co-presence of multiple pesticides on immune-related gene expression in honeybees. The results showed that these pesticides and immune activators mainly affect gene expression in the Toll pathway. The presence of multiple pesticides and pathogens has complex interactions on the immune system of honeybees.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Nicklas Brustad, Nadia R. Fink, Jakob Stokholm, Klaus Bonnelykke, Nilofar V. Folsgaard, David Hougaard, Susanne Brix, Jessica Lasky-Su, Scott T. Weiss, Bo Chawes
Summary: This study found associations between early life trajectories and 25(OH)D levels with hs-CRP concentrations. In two Danish mother-child cohorts, the researchers observed associations between 25(OH)D concentrations during pregnancy, infancy, and childhood with hs-CRP levels.
Article
Pediatrics
Inge A. L. P. van Beijsterveldt, Stuart G. Snowden, Pernille Neve Myers, Kirsten S. de Fluiter, Bert van de Heijning, Susanne Brix, Ken K. Ong, David B. Dunger, Anita C. S. Hokken-Koelega, Albert Koulman
Summary: The study shows that plasma metabolite profile at 3 months can predict body composition at 2 years, especially the ratio of truncal to peripheral fat skinfold. The predictive value is higher in boys, and there is an association with visceral fat at 2 years of age.
Article
Allergy
Casper-Emil Tingskov Pedersen, Anders Ulrik Eliasen, Matthias Ketzel, Jorgen Brandt, Steffen Loft, Lise Marie Frohn, Jibran Khan, Susanne Brix, Morten A. Rasmussen, Jakob Stokholm, Bo Chawes, Andreanne Morin, Carole Ober, Hans Bisgaard, Marie Pedersen, Klaus Bonnelykke
Summary: Prenatal exposure to ambient air pollution is associated with immune perturbations in early life, increasing the risk of allergic rhinitis and asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
O. Yelamos, D. Andersen, M. Pont, P. Iglesias, M. Potrony, M. Dominguez, A. Herrero, B. Alejo, J. Mateu, M. Ropke, N. B. Danneskiold-Samsoe, J. Malvehy, R. H. Guy, S. Brix, S. Puig
Summary: We developed a minimally invasive and image-guided tape stripping method for sampling atopic skin in children. This method is safe, reliable, and provides reproducible acquisition of cDNA. By comparing and optimizing skin tape stripping procedures using multiple imaging techniques, we successfully established a protocol that produced good cDNA yield without significant adverse events in a shorter time compared to previous methods. This minimally invasive method enables rapid sample collection, which is crucial in clinical practice.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peter Riber Johnsen, Cecilia Pinna, Luce Mattio, Mathilde Bech Strube, Mattia Di Nunzio, Stefania Iametti, Sabrina Dallavalle, Andrea Pinto, Hanne Frokiaer
Summary: This study compares the effects of seven different structural types of stilbenoids on the modulation of cytokine production and antioxidant response. Monomeric compounds showed dose-dependent inhibition of cytokine production induced by E. coli, with resveratrol and piceatannol also inhibiting IL-10 production. All monomers, except trimethoxy-resveratrol, inhibited cytokine production induced by L. acidophilus. However, the dimer dehydro-delta-viniferin remarkably enhanced IL-12 production induced by L. acidophilus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Florence Thirion, Finn Sellebjerg, Yong Fan, Liwei Lyu, Tue H. Hansen, Nicolas Pons, Florence Levenez, Benoit Quinquis, Evelina Stankevic, Helle B. Sondergaard, Thomas M. Dantoft, Casper S. Poulsen, Sofia K. Forslund, Henrik Vestergaard, Torben Hansen, Susanne Brix, Annette Oturai, Per Soelberg Sorensen, Stanislav D. Ehrlich, Oluf Pedersen
Summary: This study found significant differences in the gut microbiota of patients with multiple sclerosis, which are directly associated with inflammation markers. In treatment-naive cases, the bacterial richness is positively linked to disease activity. However, two symbiotic bacterial species that produce beneficial immune-modulating compounds were found in non-disease-active cases, providing a rationale for testing these bacteria as adjunct therapeutics in future clinical trials.
Article
Allergy
Yuan Gao, Jakob Stokholm, Martin O'Hely, Anne-Louise Ponsonby, Mimi L. K. Tang, Sarath Ranganathan, Richard Saffery, Leonard C. Harrison, Fiona Collier, Lawrence Gray, David Burgner, John Molloy, Peter D. Sly, Susanne Brix, Hanne Frokiaer, Peter Vuillermin
Summary: Having older siblings can decrease the risk of IgE-mediated food allergy by accelerating the maturation of the infant gut microbiota.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Maryia Khomich, Huang Lin, Andrei Malinovschi, Susanne Brix, Lucia Cestelli, Shyamal Peddada, Ane Johannessen, Carsten Eriksen, Francisco Gomez Real, Cecilie Svanes, Randi Jacobsen Bertelsen
Summary: This study investigated the association between oral microbiota composition and fractional exhaled nitric oxide (F-eNO) levels. The overall composition of oral bacteria was found to be significantly associated with increasing F-eNO levels, and 27 bacterial genera showed differences between individuals with high F-eNO and low F-eNO levels. Hexa- and penta-acylated LPS producers accounted for 2.4% and 40.8% of the oral bacterial genera, respectively. The similarity within each community and F-eNO levels were associated with increasing F-eNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high F-eNO.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Daniel Andersen, Janne Marie Moll, Pankaj Arora, Niels Banhos Danneskiold-Samsoe, Si Brask Sonne, Christopher Thomas Workman, Andrew Richard Williams, Karsten Kristiansen, Susanne Brix
Summary: Intestinal tuft cells and immune responses were examined in mice fed a high-fat diet and gavaged with helminth PCF. Helminth PCF upregulated gene expression in tuft cells and increased levels of innate lymphoid cells and eosinophils. Network analyses revealed immunometabolic cues linking tuft cell response to fat mass ratio and eosinophils in eWAT to body fat mass regulation.
PARASITE IMMUNOLOGY
(2023)
Article
Oncology
Mikail Gogenur, Lukas Balsevicius, Mustafa Bulut, Nesibe Colak, Tobias Freyberg Justesen, Anne-Marie Kanstrup Fiehn, Marianne Bogevang Jensen, Kathrine Host-Rasmussen, Britt Cappelen, Shruti Gaggar, Asma Tajik, Jawad Ahmad Zahid, Astrid Louise Bjorn Bennedsen, Tommaso Del Buono D'Ondes, Hans Raskov, Susanne Gjorup Saekmose, Lasse Bremholm Hansen, Ali Salanti, Susanne Brix, Ismail Gogenur
Summary: A clinical trial was conducted to investigate the safety and efficacy of intratumoral influenza vaccine in patients with non-metastasizing sigmoid or rectal cancer. The results showed that the vaccine was safe and feasible, and induced infiltration of CD8+T cells and upregulation of PD-L1 in proficient mismatch repair tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Kirstine K. Rasmussen, Quenia dos Santos, Cameron Ross Macpherson, Adrian G. Zucco, Lars Klingen Gjaerde, Emma E. Ilett, Isabelle Lodding, Marie Helleberg, Jens D. Lundgren, Susanne D. Nielsen, Susanne Brix, Henrik Sengelov, Daniel D. Murray
Summary: This study investigated the associations between metabolic profiles and cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (aHSCT). The results showed that lower levels of trimethylamine N-oxide were associated with subsequent CMV infection. Exploratory analysis also revealed other metabolic clusters associated with CMV infection.
Article
Gastroenterology & Hepatology
Marie Vibeke Vestergaard, Kristine H. Allin, Carsten Eriksen, Oliwia Zakerska-Banaszak, Ramesh P. Arasaradnam, Mohammad T. Alam, Karsten Kristiansen, Susanne Brix, Tine Jess
Summary: This study re-analyzed fecal microbiota data from 45 cohorts of inflammatory bowel disease (IBD) patients. The analysis identified a large number of genera associated with IBD, providing potential new treatment targets.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Cell Biology
Liang Sun, Zhiming Li, Caiyou Hu, Jiahong Ding, Qi Zhou, Guofang Pang, Zhu Wu, Ruiyue Yang, Shenghui Li, Jian Li, Jianping Cai, Yuzhe Sun, Rui Li, Hefu Zhen, Shuqin Sun, Jianmin Zhang, Mingyan Fang, Zhihua Chen, Yuan Lv, Qizhi Cao, Yanan Sun, Ranhui Gong, Zezhi Huang, Yong Duan, Hengshuo Liu, Jun Dong, Junchun Li, Jie Ruan, Haorong Lu, Benjin He, Ninghu Li, Tao Li, Wenbin Xue, Yan Li, Juan Shen, Fan Yang, Cheng Zhao, Qinghua Liang, Mingrong Zhang, Chen Chen, Huan Gong, Yong Hou, Jian Wang, Ying Zhang, Huanming Yang, Shida Zhu, Liang Xiao, Zhen Jin, Haiyun Guo, Peng Zhao, Susanne Brix, Xun Xu, Huijue Jia, Karsten Kristiansen, Ze Yang, Chao Nie
Summary: This study analyzed the gut microbiota and serum metabolome of individuals from a Chinese longevity cohort, as well as two other aging cohorts, and discovered age-dependent differences in both microbiota and serum metabolome. They also found potential causal relationships between specific gut microbes and serum metabolite markers related to impaired renal function and aging. The findings provide valuable insights into the effects of microbiota-metabolite interplay on renal function and healthy aging.
Article
Anesthesiology
Lukas Balsevicius, Paulo C. M. Urbano, Rune Petring Hasselager, Ahmed Abdirahman Mohamud, Maria Olausson, Melina Svraka, Kirsten L. Wahlstrom, Carolin Oppermann, Dilara Seyma Gogenur, Emma Rosenkrantz Holmich, Britt Cappelen, Susanne Gjorup Saekmose, Katrine Tanggaard, Thomas Litman, Jens Borglum, Susanne Brix, Ismail Gogenur
Summary: This study aimed to investigate the effect of bilateral anterior quadratus lumborum nerve block on the immune response. The results showed that performing bilateral anterior quadratus lumborum nerve block does not alter the systemic immune response after laparoscopic hemicolectomy.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
