Article
Biochemistry & Molecular Biology
Clara Bernard, Charline Jomard, Benedicte Chazaud, Julien Gondin
Summary: Post-injury skeletal muscle regeneration requires interactions between myogenic and non-myogenic cells. The kinetics of changes in muscle stem cells, endothelial cells, fibro-adipogenic progenitors, and macrophages in the regenerating muscle were similar in mild and severe injury models. However, the magnitude of changes in the number of differentiating muscle stem cells, hematopoietic cells, and fibro-adipogenic progenitors was higher in severe muscle damage.
Article
Engineering, Biomedical
Jens Lamsfuss, Swantje Bargmann
Summary: Skeletal muscle has high damage tolerance due to its high toughness, which allows it to withstand cracks while maintaining most of its strength. This study focuses on analyzing the damage behavior in muscle fibers and fascicles, where most serious muscle injuries occur. The results show that the endomysium does not transfer high strains, providing protection to adjacent undamaged fibers. Additionally, titin plays a significant role in stabilizing pre-damaged muscle fibers, resulting in minimal reduction in macroscopic strains of fascicles.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hsuan Chou, Elisabeth R. Barton
Summary: Glucose is a vital energy source for active skeletal muscles, and AMPK plays a crucial role in glucose uptake during muscle contraction. The study aimed to investigate the impact of increased muscle IGF-I on AMPK α phosphorylation and activity. The results demonstrated that high muscle IGF-I enhances glucose uptake under resting conditions but does not inhibit AMPK activity during muscle contraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Ryan N. Marshall, Paul T. Morgan, Benoit Smeuninx, Jonathan I. Quinlan, Matthew S. Brook, Philip J. Atherton, Kenneth Smith, Daniel J. Wilkinson, Leigh Breen
Summary: This study compared the effects of machine resistance training and elastic band resistance training on muscle adaptive remodeling. It found that elastic band resistance training increased myofibrillar protein synthesis in young males, but had limited effects in older males. Further research may be needed to optimize training programs for both age groups.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Multidisciplinary Sciences
David E. Lee, Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, James P. White
Summary: Pathologies associated with sarcopenia include decline in muscular strength, lean mass and regenerative capacity. This study investigates the therapeutic potential of METRNL to improve aged muscle through improving muscle regeneration and countering age-related loss in muscle resilience by triggering apoptosis of fibro/adipogenic progenitor cells.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Laszlo Szabo, Andrea Telek, Janos Fodor, Nora Dobrosi, Klaudia Docs, Zoltan Hegyi, Monika Gonczi, Laszlo Csernoch, Beatrix Dienes
Summary: Sept7 isoform plays a critical role in forming diffusion barriers and scaffolds in phospholipid bilayers. The study investigated its role in skeletal muscle regeneration using a knock-down mouse model. Partial knock-down of Sept7 hindered muscle regeneration kinetics and resulted in inflammatory cell infiltration and abnormal myofibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Andrea L. Estrada, Zackary J. Valenti, Gabriella Hehn, Adam J. Amorese, Nicholas S. Williams, Nicholas P. Balestrieri, Clayton Deighan, Christopher P. Allen, Espen E. Spangenburg, Nicole A. Kruh-Garcia, Daniel S. Lark
Summary: This study found that skeletal muscle tissue secretes more extracellular vesicles (EVs) compared to white adipose tissue (WAT), and a significant proportion of EVs from skeletal muscle tissue are derived from myofibers. Furthermore, it was shown that these myofiber-derived EVs can reach the circulation in vivo.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Sarah J. Blackwood, Baptiste Jude, Theresa Mader, Johanna T. Lanner, Abram Katz
Summary: Phosphorylase, an important protein in muscle metabolism, is regulated by redox state. Experimental results show that peroxynitrite causes nitration of phosphorylase and inhibition of glycogenolysis. The redox state plays a significant role in the control of phosphorylase and glycogenolysis during repeated muscle contractions.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Plant Sciences
Ante Loncaric, Ivana Flanjak, Tihomir Kovac, Ivana Tomac, Ana-Marija Gotal Skoko, Martina Skendrovic Babojelic, Goran Fruk, Sanja Zec Zrinusic, Danijel Cicek, Jurislav Babic, Antun Jozinovic
Summary: This research compares the compositions of juice from old and commercially grown apple cultivars. The analysis reveals significant differences in pH, total acids, soluble dry matter, sugar content, and antioxidant capacity between these two groups. Old apple cultivars have richer compositions, higher concentrations of phenols and flavonoids, and greater antioxidant capacity.
Review
Immunology
Xingyu Wang, Lan Zhou
Summary: Skeletal muscle is crucial for physical activity, energy metabolism, and temperature maintenance. Muscle stem cells, satellite cells, play a vital role in maintaining homeostasis and promoting muscle regeneration. Intramuscular macrophages, functionally diverse, regulate the quiescence, activation, and differentiation of satellite cells. Aberrant activation of intramuscular macrophages, often triggered by altered muscle microenvironment, disrupts muscle homeostasis and regenerative repair. Manipulating the functional activation of macrophages has potential therapeutic implications for muscle diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wan-Jing Chen, I-Hsuan Lin, Chien-Wei Lee, Yi-Fan Chen
Summary: Aging leads to decline in skeletal muscle function, with reduced regenerative capacity and changes in extracellular matrix structure. This can result in increased collagen deposition and decreased ECM degradation in aged skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Sport Sciences
Samantha E. E. Moser, Austin M. M. Brown, Muni Swamy Ganjayi, Jeffrey S. S. Otis, Cory W. W. Baumann
Summary: This study aimed to determine whether muscle recovery is impaired after repetitive bouts of physical stress in skeletal muscle during excessive short-term and long-term alcohol consumption. The results showed that excessive alcohol intake did not affect the muscle's ability to regain strength after repeated bouts of physical stress in a mouse model, suggesting that alcohol may not be as detrimental to recovery as once predicted.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Neurosciences
Ever Espino-Gonzalez, Peter G. Tickle, Alan P. Benson, Roger W. P. Kissane, Graham N. Askew, Stuart Egginton, T. Scott Bowen
Summary: This study comprehensively characterized skeletal muscle impairments induced by obese-HFpEF in rats, showing decreased muscle blood flow, fibre atrophy, and contractile dysfunction in locomotor muscles, while the diaphragm phenotype remained preserved. These findings suggest potential mechanisms for exercise intolerance in obese-HFpEF.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Nutrition & Dietetics
Xin Xu, Hua-Yong Du, Zuliyaer Talifu, Chun-Jia Zhang, Ze-Hui Li, Wu-Bo Liu, Yi-Xiong Liang, Xu-Luan Xu, Jin-Ming Zhang, De-Gang Yang, Feng Gao, Liang-Jie Du, Yan Yu, Ying-Li Jing, Jian-Jun Li
Summary: The combination of BWSTT and GlyNAC has neuroprotective effects, promotes motor function recovery, and delays skeletal muscle atrophy in rats with SCI. GlyNAC alone improves motor function, but the combination with BWSTT is more effective.
Article
Geriatrics & Gerontology
James G. Tidball, Ivan Flores, Steven S. Welc, Michelle Wehling-Henricks, Eisuke Ochi
Summary: The regeneration of skeletal muscle following acute injury is influenced by interactions with immune cells, particularly myeloid cells and lymphoid cells. Aging leads to a decline in the regenerative capacity of muscle, with age-related changes in the immune system affecting the process. Aging immune cells alter their expression of factors that impact the function of muscle stem cells, contributing to defects in muscle regeneration.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Nutrition & Dietetics
Yosuke Tsuchiya, Hisashi Ueda, Naoki Sugita, Eisuke Ochi
Summary: The study found that low-dose HMB supplementation significantly improved maximal voluntary contraction torque and range of motion in muscles, and helped reduce muscle damage. The results of this study provide new insights into the application of HMB in reducing muscle damage.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2021)
Review
Oncology
Katsunori Tsuji, Yutaka J. Matsuoka, Eisuke Ochi
Summary: Most studies on HIIT for breast cancer survivors are lab-based with supervised interventions, showing promising results in improving cardiorespiratory fitness. Additional research is needed to determine the effects of HIIT on other outcomes.
Article
Nutrition & Dietetics
Yosuke Tsuchiya, Hisashi Ueda, Kenichi Yanagimoto, Ayaka Kato, Eisuke Ochi
Summary: Short-term supplementation of EPA and DHA benefits joint flexibility and muscle fiber protection following eccentric contractions of the elbow flexors.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2021)
Article
Physiology
Eisuke Ochi, Hisashi Ueda, Yosuke Tsuchiya, Koichi Nakazato
Summary: ECCs of the FPBM caused sensory nerve dysfunction, while IL- or CL-RBE was not observed in this study.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Eisuke Ochi, Katsunori Tsuji, Tomomi Narisawa, Yoichi Shimizu, Aya Kuchiba, Akihiko Suto, Kenjiro Jimbo, Shin Takayama, Taro Ueno, Naomi Sakurai, Yutaka Matsuoka
Summary: The study found that the newly developed habit-B program, involving home-based HIIT training, can improve CRF and muscle strength in early-stage breast cancer survivors. This highlights the importance of regular high-intensity training for this population.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Oncology
Yoichi Shimizu, Katsunori Tsuji, Eisuke Ochi, Ryo Okubo, Aya Kuchiba, Taichi Shimazu, Noriatsu Tatematsu, Naomi Sakurai, Hiroji Iwata, Yutaka J. Matsuoka
Summary: The study revealed that only around one fifth of OCPs routinely provided physical activity information to BCSs, with barriers including poor awareness, self-efficacy, and lack of resources.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Katsunori Tsuji, Yutaka J. Matsuoka, Aya Kuchiba, Akihiko Suto, Eisuke Ochi
Summary: This study aimed to examine if cardiorespiratory fitness and leg strength can be predicted based on their relationship with physical performance tests in Japanese breast cancer survivors. Multiple regression analysis was used to develop prediction equations, and the results suggest that leg strength can be predicted using physical performance tests. However, further research is needed to determine if cardiorespiratory fitness can be predicted based on the 6-min walk test.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Physiology
Yutaka Matsuoka, Katsunori Tsuji, Eisuke Ochi
Summary: Cancer-related fatigue (CRF) is a common and disabling symptom in cancer survivors, with omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) potentially impacting its occurrence and alleviation. Exercise interventions have been shown to significantly benefit CRF, with potential associations with blood PUFA balance.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Takuma Morishima, Eisuke Ochi
Summary: The study investigated the impact of acute resistance exercise on serum Klotho levels and found a significant increase post-exercise. However, this increase was not associated with the acute reduction in endothelial function as measured by FMD. A significant positive correlation was observed between Klotho and ET-1 responses to resistance exercise.
PHYSIOLOGICAL REPORTS
(2021)
Article
Physiology
Takuma Morishima, Motoyuki Iemitsu, Shumpei Fujie, Eisuke Ochi
Summary: The present study demonstrates that ingestion of beetroot juice before prolonged sitting can counteract sitting-induced leg endothelial dysfunction. The data from this study provides novel physiological information that enhancing NO bioavailability through dietary nitrate supplementation is an effective tool for preventing the detrimental vascular effects of prolonged sitting.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Yosuke Tsuchiya, Takuma Morishima, Eisuke Ochi
Summary: This study demonstrates that slow-low exercise can maintain brachial artery endothelial function and reduce systolic blood pressure, making it a potentially effective exercise training method to improve muscle hypertrophy without causing temporary endothelial dysfunction.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Article
Physiology
Einar Eftestol, Eisuke Ochi, Inga S. Juvkam, Kenth-Arne Hansson, Kristian Gundersen
Summary: This study aimed to investigate whether juvenile exercise could induce a long-term muscle memory, boosting the effects of exercise in adults. The results showed that climbing exercise during early life increased fiber cross-sectional area (fCSA), nuclear accretion, and decreased intraperitoneal fat content and body weight. During the detraining period, the fCSA became similar between the climbing and naive groups, but the elevated number of myonuclei induced by climbing was maintained. When naive rats were subjected to adult exercise or unilateral surgical overload, the increase in fCSA was significant in the climbing group but not in the naive group.
Article
Nutrition & Dietetics
Yosuke Tsuchiya, Kenichi Yanagimoto, Norihiko Sunagawa, Hisashi Ueda, Katsunori Tsuji, Eisuke Ochi
Summary: This study suggests that supplementation with BCAA and fish oil may improve immediate recovery of peak torque production, while BCAA supplementation may reduce creatine kinase levels compared to the placebo group.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2022)
Article
Oncology
Taro Ueno, Daisuke Ichikawa, Yoichi Shimizu, Tomomi Narisawa, Katsunori Tsuji, Eisuke Ochi, Naomi Sakurai, Hiroji Iwata, Yutaka J. Matsuoka
Summary: The prevalence of suspected insomnia in breast cancer survivors was found to be 37.5% in a nationwide survey in Japan. Machine learning algorithms, such as L2 penalized logistic regression and XGBoost, were able to predict the presence of suspected insomnia with high accuracy. Cancer-related fatigue was identified as a predictor of insomnia in breast cancer survivors.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Sport Sciences
Eisuke Ochi, Kenichi Yanagimoto, Yosuke Tsuchiya
Summary: This study found that levels of eicosapentaenoic acid (EPA) and EPA/arachidonic acid are positively associated with muscle strength, and higher levels of EPA and docosahexaenoic acid can prevent strength loss and limited joint flexibility after exercise.
