Article
Agriculture, Dairy & Animal Science
Narayana H. H. Mohan, Prajwalita Pathak, Lipika Buragohain, Juri Deka, Jaya Bharati, Anil Kumar Das, Rajendran Thomas, Rajendra Singh, Dilip Kumar Sarma, Vivek Kumar Gupta, Bikash Chandra Das
Summary: Muscle development is vital in pig breeding programs, but the mechanisms regulating myogenesis remain unclear. Integrating transcriptome data with histology and meat yield, this study compared two pig breeds (Mali and Hampshire) to identify differences in myogenesis during early growth. The analysis revealed differentially expressed genes and highlighted the importance of myoblast fusion and myogenic activities in breed muscularity. The results could aid in selecting animals with desired muscularities.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Veterinary Sciences
Yaolu Zhao, Elke Albrecht, Zeyang Li, Johannes Schregel, Quentin L. Sciascia, Cornelia C. Metges, Steffen Maak
Summary: This study investigated the impact of Gln supplementation on lipid deposition in piglets and the role of PLIN family members, revealing the importance of birth weight and age for intramuscular lipid deposition and the diverse roles of PLIN family members in this process.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Lijun Shi, Huihui Li, Xiaoyu Huang, Ze Shu, Jingna Li, Ligang Wang, Hua Yan, Lixian Wang
Summary: Understanding the molecular mechanisms of sow pregnancy development is crucial for genetic improvement of pig breeding traits and provides resources for biomedical research on human pregnancy diseases. However, there is a lack of transcriptome and metabolome data across different stages of sow pregnancy. In this study, we analyzed 84 RNA sequencing and 42 metabolome datasets from pig blood samples across six developmental stages. The findings revealed the sequence features, stage-specific molecules, expression patterns, regulatory mechanisms, and important pregnancy-related metabolites in both pigs and humans. These results are expected to contribute essential resources for pig breeding and biomedical research on human pregnancy diseases.
Article
Nutrition & Dietetics
Matthew Stefan, Matthew Sharp, Raad Gheith, Ryan Lowery, Charlie Ottinger, Jacob Wilson, Shane Durkee, Aouatef Bellamine
Summary: The study indicates that L-carnitine tartrate supplementation can improve short-term recovery among athletes, while longer-term effects in the general population need further research. The experiment found that L-carnitine tartrate supplementation for 5 weeks could enhance perceived recovery and reduce soreness, as well as lower serum creatine kinase levels.
Article
Environmental Sciences
Walaa A. Rashad, Sara F. Saadawy, Nehal E. Refaay
Summary: This study investigated the toxic impact of atrazine (ATR) on the liver and the potential protective effects of L-carnitine (LC). The results showed that ATR induced oxidative stress, inflammation, and apoptosis in the liver of rats, while LC alleviated these toxic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nutrition & Dietetics
Roger A. Fielding, Donato Rivas, Gregory J. Grosicki, Yassine Ezzyat, Lisa Ceglia, Lori Lyn Price, Cemal Orhan, Kazim Sahin, Kelli Fowler, Tyler White, Shane Durkee, Katja Kritsch, Aouatef Bellamine
Summary: The study found that the combination of low doses of L-carnitine tartrate and creatine monohydrate can significantly increase muscle protein synthesis, and the LMP formulation can improve the bioavailability of creatine.
Article
Engineering, Biomedical
Cort H. Thompson, Blake M. Evans, Dorothy X. Zhao, Erin K. Purcell
Summary: Implantation of electrodes in the brain can be used to record from or stimulate neural tissues to treat neurological disease and injury. Recent RNA-seq datasets identify genes associated with gliosis, neuronal function, myelination, and cellular metabolism following the insertion of microelectrodes. This study validates mRNA as a predictor of protein expression and provides insight into the spatiotemporal distribution of proteins in neural tissues after implantation.
ACTA BIOMATERIALIA
(2023)
Article
Clinical Neurology
Ayuka Murakami, Seiya Noda, Tomoyuki Kazuta, Satoko Hirano, Seigo Kimura, Hirotaka Nakanishi, Koji Matsuo, Koyo Tsujikawa, Madoka Iida, Haruki Koike, Kazuma Sakamoto, Yuichiro Hara, Satoshi Kuru, Kenji Kadomatsu, Teppei Shimamura, Tomoo Ogi, Masahisa Katsuno
Summary: This study identified alterations of several metabolic pathways in muscle samples of sIBM patients. Mast cells, chondroitin sulfate biosynthesis, carnitine, and creatine were found to play roles in sIBM pathophysiology.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Veterinary Sciences
Cristina Cuello, Cristina A. Martinez, Josep M. Cambra, Alejandro Gonzalez-Plaza, Inmaculada Parrilla, Heriberto Rodriguez-Martinez, Maria A. Gil, Emilio A. Martinez
Summary: The study showed that vitrification altered the gene expression pattern of porcine morulae produced in vivo, leading to disruptions in metabolic pathways that may interfere with embryo quality and developmental potential.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Reproductive Biology
Xu-dong Jiang, Yu Liu, Jian-fei Wu, San-ni Gong, Yao Ma, Xiang-dong Zi
Summary: Supplementation with acetyl-L-carnitine (ALC) improved the viability of yak granulosa cells (GCs), reduced the levels of reactive oxygen species (ROS) and lipid droplets, and promoted hormone synthesis.
Article
Cell Biology
Claudia Kalbe, Katharina Metzger, Claude Gariepy, Marie-France Palin
Summary: It has been found that carnosine content is higher in glycolytic muscle fibers compared to oxidative muscle fibers, but the underlying mechanisms responsible for this difference are still unclear. The study showed that the expression levels of carnosine-related enzymes and transporters were higher in oxidative muscle fibers. Additionally, the addition of carnosine to myoblasts resulted in a dose-dependent increase in the expression of SLC15A3, suggesting its role in carnosine uptake and cellular homeostasis.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Cell Biology
Damian Tanski, Agnieszka Skowronska, Malgorzata Tanska, Ewa Lepiarczyk, Mariusz T. Skowronski
Summary: The research shows that estradiol, progesterone, and arachidonic acid regulate the expression of AQP1 and AQP5 in porcine luminal epithelial cells through the PKA and MAPK signaling pathways.
Article
Genetics & Heredity
Ryan J. Corbett, Andrea M. Luttman, Kaitlin E. Wurtz, Janice M. Siegford, Nancy E. Raney, Laura M. Ford, Catherine W. Ernst
Summary: The weaning stress in piglets results in genome-wide methylation changes associated with differential gene expression, reduced T cell activation, and altered HPA axis response.
FRONTIERS IN GENETICS
(2021)
Review
Nutrition & Dietetics
Alberto Caballero-Garcia, David C. Noriega-Gonzalez, Enrique Roche, Franchek Drobnic, Alfredo Cordova
Summary: Exercise-induced muscle damage leads to decreased physical performance and an inflammatory response in muscle tissue. L-carnitine supplementation has the potential to improve postexercise recovery by reducing oxidative damage and inflammation. However, further research is needed to fully understand the mechanisms underlying these effects and evaluate its efficacy on fatigue perception and muscle soreness.
Article
Agriculture, Dairy & Animal Science
Fatemeh Mohammadinejad, Mohammadreza Mohammadabadi, Zahra Roudbari, Tomasz Sadkowski
Summary: This study aimed to identify the hub genes and mechanisms involved in skeletal muscle maturation and hypertrophy in livestock species (Bos taurus, Ovis aries, and Sus scrofa). Gene expression profiles were analyzed, and differentially expressed genes and enriched pathways were identified in each species. Common genes and pathways were also identified, which play important roles in the development and maturation of skeletal muscles. This study provides valuable insights into the relationships between genes and biological pathways in the skeletal muscle maturation process.
Article
Psychiatry
Kurt Buhagiar, Stefan Priebe, Justyna Klingemann, Antonio Lasalvia, Pablo Nicaise, Bettina Soltmann, Domenico Giacco
Summary: Objective and subjective social relationship indicators were weakly correlated concepts among patients with severe mental illness. While patients with psychotic disorders initially reported less social contact with friends, this difference disappeared when confounders were taken into account, suggesting that interventions targeting social relationships do not necessitate diagnosis-specific adaptations.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2021)
Article
Psychology, Clinical
Emma Millard, Jessica Cardona, Jane Fernandes, Stefan Priebe, Catherine Carr
Summary: Patient preferences play a critical role in engagement with psychosocial interventions. This study conducted semi-structured interviews with 17 participants in order to understand their preferences and expectations of arts therapies. The findings revealed that past experiences of the art forms, social interactions in the groups, and expectations of helpfulness were key factors influencing decision-making and engagement with the arts therapies.
ARTS IN PSYCHOTHERAPY
(2021)
Review
Psychology, Developmental
Kimberley Anderson, Stefan Priebe
Summary: The study examined the concept of resilience in adolescent mental health literature and identified three dimensions capturing various resilience concepts. Each dimension has two endpoints, aiding in comparing and clarifying different concepts of adolescent resilience.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Computer Science, Artificial Intelligence
Mina Bishay, Petar Palasek, Stefan Priebe, Ioannis Patras
Summary: The study analyzed facial behavior of 91 outpatients with schizophrenia using a novel neural network architecture called SchiNet, which showed significant correlations between automatically detected facial expressions and schizophrenia symptoms. The proposed network for estimating symptom severity showed promising results for patient-independent prediction of schizophrenia symptoms.
IEEE TRANSACTIONS ON AFFECTIVE COMPUTING
(2021)
Article
Clinical Neurology
Eleni Petkari, Stefan Priebe
Summary: A two-factor structure of subjective quality of life (SQoL) was established for patients with schizophrenia, and this study investigated whether the same structure applies in patients with mood and anxiety disorders. Through Confirmatory Factor Analyses, the study found that the two-factor structure also applies across mood and anxiety disorders. The study also found that the dimension scores differ significantly between the three diagnostic groups, with the lowest scores in patients with anxiety disorders and the highest in patients with schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Health Care Sciences & Services
Carlos Gomez-Restrepo, Maria Jose Sarmiento-Suarez, Magda Alba-Saavedra, Victoria Jane Bird, Stefan Priebe, Francois van Loggerenberg
Summary: This research aims to adapt the patient-centered digital intervention DIALOG+ from a clinical setting to an educational setting. The study will evaluate the feasibility, acceptability, and estimated effect of implementing this intervention as a tool for identifying and mobilizing personal and social resources to mitigate the impact of social difficulties and promote mental well-being. The research will be conducted in public schools in postconflict areas in Tolima, Colombia.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Health Care Sciences & Services
Carlos Gomez-Restrepo, Jose Alejandro Rumbo Romero, Martha Rodriguez, Laura Ospina-Pinillos, Diliniya Stanislaus Sureshkumar, Stefan Priebe, Victoria Bird
Summary: This study aims to evaluate the effectiveness, acceptability, and feasibility of the DIALOG-A intervention for adolescents with depression and anxiety in Colombia. The trial recruited 18 clinicians and 108 adolescents, with 12 clinicians and 72 adolescents in the intervention group and 6 clinicians and 36 adolescents in the control group. The results of this study can provide valuable insight for other middle-income countries.
JMIR RESEARCH PROTOCOLS
(2023)
Editorial Material
Psychiatry
Stefan Priebe
Summary: Financial incentives for medication adherence in mental healthcare are controversial, but often misunderstood. They are not intended to influence treatment decisions, but to bridge the intention-behavior gap and help patients adhere to agreed-upon treatment. Patients' positive views suggest that financial incentives can actually support the therapeutic relationship rather than undermine it.
Review
Psychology, Clinical
Eleni Petkari, Elena Nikolaou, Sandra Oberleiter, Stefan Priebe, Jakob Pietschnig
Summary: This study conducted a meta-analysis of Randomized Controlled Trials (RCTs) to examine the impact of different interventions on the quality of life (QoL) in individuals with schizophrenia-spectrum disorders. The findings suggest that psychological interventions can improve patients' QoL, with psychoeducation having the largest effect on objective QoL and combined interventions having the largest effect on subjective QoL.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Mattia Marchi, Giulia Venturi, Chiara Visentini, Margherita Pinelli, Stefan Priebe, Gian Maria Galeazzi
Summary: This systematic review examines the therapeutic relationship (TR) between mental health professionals (MHPs) and their patients in community mental health services (CMHS). The findings suggest that patients and MHPs generally agree on TR ratings, although patients give lower ratings. Factors such as a recovery-oriented service, shared decision-making, and recognition of patient needs contribute to more positive TR ratings.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Carlos Gomez-Restrepo, Maria Jose Sarmiento-Suarez, Magda Alba-Saavedra, Maria Gabriela Calvo-Valderrama, Carlos Javier Rincon-Rodriguez, Victoria Jane Bird, Stefan Priebe, Francois van Loggerenberg
Summary: This study aimed to adapt and evaluate the effectiveness of the DIALOG+ intervention in promoting mental well-being and resilience in the school context. The results showed that the intervention has the potential to improve aspects of mental health, especially quality of life, resilience, and emotional symptoms. Teachers and students found the intervention to be feasible, acceptable, and beneficial in improving mental health and behavior.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychiatry
N. P. Maric, L. J. B. Lazarevic, S. Priebe, L. J. Mihic, M. Pejovic-Milovancevic, Z. Terzic-Supic, O. Toskovic, O. Vukovic, J. Todorovic, G. Knezevic
Summary: This study aimed to investigate the association between Covid-19-related stressors and mental disorders, depressive and anxiety symptoms. The results showed significant associations between Covid-19-related stressors and various mental disorders and symptom levels.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2022)
Article
Health Care Sciences & Services
Marcelo Santos Cruz, Eliana Sousa Silva, Zivile Jakaite, Miriam Krenzinger, Leandro Valiati, Dalcio Goncalves, Eduardo Ribeiro, Paul Heritage, Stefan Priebe
Summary: This study examined the personal experiences and fears of residents in favelas in Brazil, and found that higher levels of neighborhood violence experiences and fear predicted increased mental health symptoms and poorer quality of life. Even within a context of violence and poverty, individual variations in experiences of violence significantly impact mental distress and quality of life.
LANCET REGIONAL HEALTH-AMERICAS
(2021)
Article
Medicine, Research & Experimental
Robert Freudenthal, Louise Marston, Jacki L. Stansfeld, Stefan Priebe, Joanna Moncrieff
Summary: The study aimed to investigate the clinical relevance of reducing antipsychotic drugs in patients diagnosed with schizophrenia or psychosis. The trial sample resembled the wider population in terms of past admissions, legal detentions, and perceived risk levels, but had a lower proportion of people from minority ethnic backgrounds. This suggests that trial recruits were similar to the wider population in terms of condition severity, rather than being a highly selective sample of individuals with milder issues.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)
Article
Psychiatry
Jade Donaghy, Kurt Buhagiar, Penny Xanthopoulou, Kayonda Ngamaba, Stefan Priebe, Domenico Giacco
Summary: The study found that only about one-fifth of patients with psychotic disorders completed >=150 minutes of fitness activities in the previous week. Participants who were female, older, in a relationship, unemployed and had fewer social contacts were less likely to meet these recommendations.
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2021)