Article
Instruments & Instrumentation
Jun-Yong Wu, Jia-Xin Cai, Yong-Jiang Li, Xiong-Bin Hu, Xin-Yi Liu, Jie-Min Wang, Tian-Tian Tang, Da-Xiong Xiang
Summary: The study successfully prepared an oil-in-water microemulsion loaded with BTM for transdermal therapy of melanoma. The microemulsion can penetrate the skin, increase the retention of BTM in the epidermis, and effectively suppress tumor growth when combined with Taxol, while also having lower toxicity to normal organs. This combination therapy shows potential for skin cancer therapy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Chunxiu Zhou, Xutao Zhang, Cheng-Chao Ruan, Wai San Cheang
Summary: 3,3 ',4,5'-TMS and 3,4', 5-TMS significantly suppressed LPS-induced inflammation in RAW 264.7 cells through inhibition of MAPK and NF-kappa B signaling pathways and also provided anti-oxidative effect.
Article
Biochemistry & Molecular Biology
Xiaoke Yu, Zhiyang Sun, Saiya Nie, Tao Zhang, Hongzhao Lu
Summary: In this study, resveratrol was found to inhibit the proliferation of mouse melanoma B16 cells by regulating the ERK1/2 signaling pathway through SHCBP1. Therefore, resveratrol may be a potential drug for the treatment of melanoma.
Article
Biochemistry & Molecular Biology
Chunxiu Zhou, Yi Tan, Baojun Xu, Yitao Wang, Wai-San Cheang
Summary: This study reveals the potential vaso-protective effect of TMS and its therapeutic potential against endothelial dysfunction in metabolic disorders.
Article
Food Science & Technology
Mirella Noviello, Antonio Francesco Caputi, Giacomo Squeo, Vito Michele Paradiso, Giuseppe Gambacorta, Francesco Caponio
Summary: Vine shoots, a common winery waste, can be a source of bioactive compounds such as stilbenes. The study found that heat treatments had a slight impact on stilbene content, while the variety of vine shoots had a stronger influence.
Article
Oncology
Ze Wu, Qiongqiong Jia, Boqun Liu, Lanlan Fang, Peter C. K. Leung, Jung-Chien Cheng
Summary: This study reveals that upregulation of NPFFR2 is associated with poor overall survival in epithelial ovarian cancer (EOC). NPFF and NPFFR2 are expressed in human EOC cells, with higher levels in SKOV3 cells compared to CaOV3 and OVCAR3 cells. NPFF treatment stimulates cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway. Blocking ERK1/2 signaling abolishes the NPFF-induced MMP-9 expression and cell invasion.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Milena Almeida Santos, Filipe Nogueira Franco, Camila Amaro Caldeira, Glaucy Rodrigues de Araujo, Alessandra Vieira, Miriam Martins Chaves, Raquel Cunha Lara
Summary: Aging is associated with an increase in ROS levels, and resveratrol can reduce ROS levels in both age groups, with greater efficiency observed in the middle-aged group. Inhibiting PKA, Akt/PKB, and MAPK signaling pathways can alter the antioxidant effects of resveratrol and change the signaling pattern of the MAPK pathway during the aging process.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Junichi Sato, Koya Nakano, Hiroaki Miyazaki
Summary: This study found that changes in intracellular chloride ion concentration affect cell migration and invasion in cancer cells. Culturing cells in a low chloride ion medium enhances cell migration and invasion, and leads to transient activation of the ERK1/2 signaling pathway and increased levels of MMP-1 mRNA. Inhibition of ERK1/2 activation reduces the enhancement of MMP-1 mRNA levels and decreases cell migration and invasion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Veterinary Sciences
Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares, Giuseppe Borzacchiello
Summary: This study conducted immunohistochemical and biochemical analysis on MMPs and TIMPs in BPV-2 positive bovine cutaneous fibropapillomas, revealing their significant role in tumor development and their unbalanced expression in tumor samples.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Caimei Wang, Yiyuan Wang, Congrong Liu, Xiaoyu Meng, Zhongxia Hang
Summary: This study reveals the important role of KNTC1 in the development of cervical cancer and identifies the mechanism by which KNTC1 promotes cervical cancer through MMP9 and MMP2-mediated reduction in tumor cell invasion and migration abilities.
Article
Environmental Sciences
Bharath Kumar Velmurugan, Jen-Tsun Lin, B. Mahalakshmi, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Hsin-Yu Ho, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: This study demonstrates that dehydrocrenatidine treatment significantly reduces the motility, migration, and invasion of head and neck cancer cells, decreases MMP-2 expression, and inhibits cell migration by reducing the phosphorylation of ERK1/2 and JNK1/2. Combined treatment with inhibitors enhances the anti-metastatic effects of dehydrocrenatidine.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Clinical Neurology
Jiachen Gu, Zongshan Li, Huimin Chen, Xiaomin Xu, Yongang Li, Yaxing Gui
Summary: The study investigated the effect of trans-resveratrol as a treatment for moderate to mild Alzheimer's disease. While the treatment did not significantly impact Aβ40 levels, it showed a decrease in matrix metallopeptidase 9 levels and reduced brain volume compared to the placebo group after 52 weeks. These results suggest potential neuroprotective roles of trans-resveratrol in reducing Aβ accumulation and neuroinflammation in AD patients.
NEUROLOGY AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Huimin Shi, Renyu Kong, Xu Miao, Lingshan Gou, Xin Yin, Yuning Ding, Xiliang Cao, Qingyong Meng, Maosheng Gu, Feng Suo
Summary: Reduced levels of PPP1R3G may contribute to the progression of pre-eclampsia by suppressing trophoblast invasion and migration and targeting the Akt/MMP-9 signaling pathway.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Joao C. Fernandes, Elizangela G. Schemitt, Juliana Da Silva, Norma P. Marroni, Ana Lima, Ricardo B. Ferreira
Summary: Our study found that the combination of trans-resveratrol and epsilon-viniferin can reduce oxidative damage, have a hepatoprotective effect, and regulate antioxidant pathways while inhibiting inflammatory development.
Article
Biochemistry & Molecular Biology
Zih-Ying Li, Yu-Tang Tung, Sheng-Yi Chen, Gow-Chin Yen
Article
Food Science & Technology
Chieh-Yu Lan, Sheng-Yi Chen, Chia-Wen Kuo, Chi-Cheng Lu, Gow-Chin Yen
JOURNAL OF FOOD AND DRUG ANALYSIS
(2019)
Review
Food Science & Technology
K. J. Senthil Kumar, M. Gokila Vani, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-xi Lin, Fang-Hua Chu, Gow-Chin Yen, Sheng-Yang Wang
JOURNAL OF FOOD AND DRUG ANALYSIS
(2020)
Article
Biochemistry & Molecular Biology
Chun-Ching Wu, Yu-Tang Tung, Sheng-Yi Chen, Wei-Ting Lee, Hsin-Tang Lin, Gow-Chin Yen
Article
Biochemistry & Molecular Biology
Ming-Hong Weng, Sheng-Yi Chen, Zih-Ying Li, Gow-Chin Yen
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Chemistry, Medicinal
Ji-Hua Lin, Sheng-Yi Chen, Chi-Cheng Lu, Jer-An Lin, Gow-Chin Yen
PHYTOTHERAPY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Yi-Hao Hsu, Sheng-Yi Chen, Sheng-Yang Wang, Jer-An Lin, Gow-Chin Yen
Article
Agricultural Engineering
Sheng-Yi Chen, Guan-Yu Wang, Ji-Hua Lin, Gow-Chin Yen
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Plant Sciences
Guan-Yu Wang, Sheng-Yi Chen, Ying-Yin Chen, Cheng-Jie Hong, Yi-Hao Hsu, Gow-Chin Yen
Summary: The results of this study demonstrated the remarkable gastroprotective effect of 80EETC treatment in vitro and in vivo, including suppressing inflammatory mediator protein levels, improving antiapoptotic ability and wound healing capability, promoting gastric mucosal healing, increasing gut microbiota diversity, and short-chain fatty acid production. These findings are the first to show the powerful protective effect of T. khasianum Clarke leaves against gastric mucosal injury development.
Article
Environmental Sciences
Chia-Hua Chang, Chow-Feng Chiang, Jiunn-Wang Liao, Gow-Chin Yen, Yi-Chen Huang, Shih-Pei Ni, Chia-Chin Chang, Hsin-Tang Lin
Summary: This study proposed a novel dose estimation method to assess mercury content in fish, finding high levels of methylmercury in certain samples. The research revealed potential health risks of methylmercury consumption for women and children.
Article
Agriculture, Multidisciplinary
Jui-Yi Chen, Gow-Chin Yen, Nien-Ting Tsai, Jer-An Lin
Summary: This study evaluated the quality of natural and commercial dark brown sugar products, finding higher total flavonoid content and lower levels of harmful Maillard reaction products in natural DBS compared to commercial DBS, but higher acrylamide content in natural DBS. The study provides useful information for risk-benefit assessment of DBS products, aiding in food safety management.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Jui-Yi Chen, Xin-Wei Chen, Yu-Yu Lin, Gow-Chin Yen, Jer-An Lin
Summary: The study evaluates the use of spectroscopy methods to quickly authenticate the authenticity and quality of dark brown sugar using chemical technology. Results show that three-dimensional fluorescence spectroscopy is an effective method for DBS authentication, helping to reduce food fraud and ensure food safety.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siao-Ling Fan, Jer-An Lin, Sheng-Yi Chen, Jia-Hong Lin, Hsin-Tang Lin, Ying-Yin Chen, Gow-Chin Yen
Summary: The study showed that extracts of Hsian-tsao and its polysaccharides have positive effects on impaired wound healing in diabetic individuals. They inhibit glycation and ROS production, restore impaired healing factors, and enhance phagocytosis of bacteria by macrophages, ultimately promoting wound healing.
Review
Food Science & Technology
Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin-Lin Hsu
JOURNAL OF FOOD AND DRUG ANALYSIS
(2020)
Article
Biochemistry & Molecular Biology
Wei-Ling Yang, Sheng-Yi Chen, Cheng-Ying Ho, Gow-Chin Yen