Article
Nutrition & Dietetics
Snigdha Guha, Sophie Alvarez, Kaustav Majumder
Summary: The study demonstrated that gamma-glutamyl valine (gamma-EV) can be transported across intestinal cells intact, with the transport rate significantly enhanced by increasing peptide dose or disrupting tight-junction proteins. The findings suggest that the transport route of gamma-EV could be via both PepT1-mediated and paracellular pathways, offering insights into potential mechanisms for enhancing the permeability of dietary anti-inflammatory peptides.
Article
Chemistry, Physical
Karen Saiswani, Aditya Narvekar, Devashree Jahagirdar, Ratnesh Jain, Prajakta Dandekar
Summary: This study investigates the enhancement in intestinal absorption of daptomycin using a new class of permeation enhancers, deep eutectic solvents (DESs), in comparison with sodium caprate. Both DESs and sodium caprate enhance the permeation of daptomycin by reducing the expression of cell junction proteins, leading to the loosening of tight junctions.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Food Science & Technology
Melissa Fanzaga, Carlotta Bollati, Giulia Ranaldi, Sabrina Sucato, Silvia Fustinoni, Gabriella Roda, Carmen Lammi
Summary: In recent years, there has been a growing interest in exploring alternative delivery systems for iron supplements to improve efficacy and reduce side effects. This study demonstrates the advantages of the Ferro Supremo formulation in improving iron absorption compared to standard FeSO4. The results show that Ferro Supremo can enter, accumulate, and be transported by intestinal cells more efficiently than FeSO4, making it a valuable choice for improving iron deficiency.
Article
Environmental Sciences
Jiangbing Qiu, Jingrui Zhang, Aifeng Li
Summary: This review summarizes the application of the Caco-2 cell monolayer model in assessing the uptake and damage of phycotoxins in the intestine. Previous studies have shown that different groups of phycotoxins exhibit varying cytotoxicity and transport mechanisms in Caco-2 cells, suggesting the need for the development of multicellular intestinal models for comprehensive toxicity and absorption studies.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Food Science & Technology
Waqas N. Baba, Bincy Baby, Priti Mudgil, Chee-Yuen Gan, Ranjit Vijayan, Sajid Maqsood
Summary: This study investigated the ACE inhibiting potential of peptic camel whey hydrolysates under different hydrolysis conditions. Through peptide sequencing and in silico analysis, specific peptides with potential ACE and renin inhibitory activities were identified. Enzymatic hydrolysis of camel whey proteins may release peptides with potential anti-hypertensive properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Zhaoguo Wang, Xiaorui Zhai, Jiayuan Fang, Hongyan Wu, Yunyun Cheng, Yuan Gao, Xi Chen, Shuo Zheng, Songcai Liu, Linlin Hao
Summary: This study extracted antler bone calcium (AB-Ca) and bioactive peptides (ABPs) from antler bones (Cervus elaphus) and found that the peptide-calcium chelate can significantly increase calcium transport. In a mouse model, the combination of AB-Ca and ABPs increased bone formation and inhibited bone resorption, which is beneficial for ameliorating senile osteoporosis.
Article
Biochemistry & Molecular Biology
Josefa Domenech, Mariana de Britto, Antonia Velazquez, Susana Pastor, Alba Hernandez, Ricard Marcos, Constanza Cortes
Summary: The study assessed the long-term effects of polystyrene nanoparticles on human intestinal cells, showing that PSNPs accumulated in cells over time and induced changes at the ultrastructural and molecular levels. However, minor effects were observed in genotoxicity-related biomarkers, indicating no DNA damage or oxidative stress after long-term exposure to PSNPs.
Article
Food Science & Technology
Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao
Summary: 7,8-DHF is a biologically active flavone with various physiological activities. Previous studies have found that the efflux protein P-glycoprotein (P-gp) significantly affects the oral bioavailability of 7,8-DHF. In this study, 14 dietary plant flavonoids were investigated as potential P-gp inhibitors using a Caco-2 cell model, and their effects on the transepithelial transport and in vitro digestion of 7,8-DHF were explored. The results showed that certain flavonoids, especially kaempferol and quercetin, improved the transepithelial transport of 7,8-DHF, thereby enhancing its oral bioavailability.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Juliana Santos de Espindola, Milena Ferreira Taccola, Vera Sonia Nunes da Silva, Lucilene Delazari dos Santos, Bruno Cesar Rossini, Bruna Cavecci Mendonca, Maria Teresa Bertoldo Pacheco, Fabiana Galland
Summary: During digestion in the gastrointestinal tract, whey peptides are formed and exhibit antioxidant activity, protecting the gastrointestinal cells from oxidative damage. These peptides contain hydrophobic and acidic amino acids, with lysine, valine, and tyrosine being the most abundant, which have antioxidant properties. The antioxidant activity of these peptides was found to be twice as potent as that of protein isolates at the same concentration. This study highlights the importance of whey peptides in preventing oxidative stress in the digestive system.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Hanne Vissenaekens, Guy Smagghe, Hanne Criel, Charlotte Grootaert, Katleen Raes, Andreja Rajkovic, Geert Goeminne, Nico Boon, Kristof De Schutter, John Van Camp
Summary: The study demonstrates that quercetin can partially restore mitochondrial dysfunction, especially FCCP-induced dysfunction, in intestinal cells by accumulating in the mitochondria.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Mingjie Zhou, Wenzhu Zhao, Wenjun Xue, Jingbo Liu, Zhipeng Yu
Summary: This study clarified the antihypertensive mechanisms of QIGLF on spontaneously hypertensive rats by using a serum proteomic approach. QIGLF was found to potentially exert antihypertensive effects by inhibiting Na+ reabsorption and oxidative stress, and restoring gap junction and tight junction.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Zhipeng Yu, Mingjie Zhou, Jingbo Liu, Wenzhu Zhao
Summary: This study investigated the hypotensive effects of peptide QIGLF in spontaneously hypertensive rats (SHRs) by using metabolomics technology. The results showed that QIGLF could regulate the synthesis and degradation of ketone bodies, arachidonic acid metabolism, pyrimidine metabolism, and arginine biosynthesis. These findings suggest the potential of QIGLF in alleviating hypertension by inhibiting renal inflammation, promoting natriuresis, and regulating renal nitric oxide production.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yunqing Wang, Ganwarige Sumali N. Fernando, Natalia N. Sergeeva, Nikolaos Vagkidis, Victor Chechik, Thuy Do, Lisa J. Marshall, Christine Boesch
Summary: The present study compared the absorption and transport patterns of three main betalains, betanin, vulgaxanthin I, and indicaxanthin, in intestinal epithelial cells. The results showed that these compounds have different molecular effects on inflammatory and redox-related cell signaling. Betanin demonstrated a potent dose-dependent radical scavenging activity.
Article
Food Science & Technology
Wenya Jiao, Yaxin Sang, Xianghong Wang, Shuo Wang
Summary: This study explored the hypoglycemic mechanism of 6-shogaol from the perspective of glucose uptake, absorption transport, and protection of intestinal barrier function. The findings showed that 6-shogaol effectively inhibits the activity of alpha-glucosidase, reduces glucose uptake, down-regulates the expression of glucose transporters, and promotes the up-regulation of tight junction proteins, protecting the intestinal barrier function and promoting intestinal material absorption.
Article
Food Science & Technology
Dan Su, Jiawen Lu, Chunchao Nie, Ziyan Guo, Chang Li, Qiang Yu, Jianhua Xie, Yi Chen
Summary: This study aimed to investigate the effects of AA and OTA individually and collectively on Caco-2 cells. The results showed that AA and OTA significantly inhibited Caco-2 cell viability, decreased TEER values, and increased LY permeabilization, LDH release, and ROS levels. Furthermore, AA and OTA treatment led to increased levels of IL-1 beta, IL-6, and TNF-alpha, while IL-10 levels decreased. Western blot analysis revealed that AA and OTA damaged the intestinal barrier by reducing the expression of tight junction proteins.
Review
Pharmacology & Pharmacy
Miguel A. A. Lasuncion, Javier Martinez-Botas, Covadonga Martin-Sanchez, Rebeca Busto, Diego Gomez-Coronado
Summary: The mevalonate pathway is essential for the synthesis of isoprenoids, including sterols, and plays a crucial role in cell division and cell cycle progression.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Maria-Carmen Lopez Hazas, Lorena del Pozo-Acebo, Maria S. Hansen, Judit Gil-Zamorano, Diana C. Mantilla-Escalante, Diego Gomez-Coronado, Francisco Marin, Almudena Garcia-Ruiz, Jan T. Rasmussen, Alberto Davalos
Summary: Extracellular RNAs are unstable and can be degraded, but milk EVs protect and promote the uptake of miRNAs. However, the concentration of miRNAs in EVs may not be sufficient for gene modulation, although orally delivered EV-loaded miRNAs can reach tissues in vivo, potentially exerting biological effects. Further research is warranted for potential implications in nutrition and health.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Eva Bruna-Garcia, Beatriz Isabel Redondo, Marta Miguel Castro
Summary: This study extracted a new bioactive ingredient from Iberian ham trimming fat with high levels of antioxidants and MUFA. The new ingredient demonstrated better sensory characteristics and higher antioxidant capacity compared to the raw material.
Article
Biochemistry & Molecular Biology
Roubi Abuobeid, Javier Sanchez-Marco, Maria J. Felices, Carmen Arnal, Juan Carlos Burillo, Roberto Lasheras, Rebeca Busto, Miguel A. Lasuncion, Maria Jesus Rodriguez-Yoldi, Roberto Martinez-Beamonte, Jesus Osada
Summary: Squalene and its post-squalene metabolites play important roles in hepatic transcriptional changes required to protect the liver against malfunction, involving regulation of protein and sterol transporters, lipid metabolism, lipogenesis, as well as anti-inflammatory and anti-cancer properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Aurelia Bertholet-Thomas, Maria A. Manso-Silvan, Victor Navas-Serrano, Catherine Guittet, Sophie Joukoff, Justine Bacchetta, Olivia Boyer, Mariano Rodriguez Portillo, Luc-Andre Granier
Summary: ADV7103 treatment for dRTA improves bone parameters and promotes growth.
Article
Genetics & Heredity
Michael Acquadro, Alexia Marrel, Maria A. Manso-Silvan, Catherine Guittet, Sophie Joukoff, Aurelia Bertholet-Thomas
Summary: This study explores the impact of dRTA on quality of life (QoL) and finds that ADV7103 treatment improves daily life and reduces treatment burden, resulting in higher satisfaction levels for patients and their families.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Yessenia L. Molina, David Garcia-Seisdedos, Bohdan Babiy, Milagros Lerma, Javier Martinez-Botas, Maria J. Casarejos, Maria T. Vallejo, Diego Gomez-Coronado, Miguel A. Lasuncion, Oscar Pastor, Rebeca Busto
Summary: In this study, the effects of rottlerin on exosome/microvesicle secretion in a model of intracellular lipid trafficking impairment were investigated. The results showed that rottlerin increased exosome/microvesicle secretion by activating beta-glucosidase via the AMPK pathway, leading to the reduction of intracellular lipid deposition.
Review
Nutrition & Dietetics
Andrea del Saz-Lara, Maria-Carmen Lopez de las Hazas, Francesco Visioli, Alberto Davalos
Summary: This article systematically reviews the effects of extra virgin olive oil (EVOO) and its phenolic compounds on the epigenetic landscape. The results show that EVOO and its phenolic compounds can induce epigenetic changes that regulate gene expression and molecular targets involved in various metabolic processes. Oleuropein and hydroxytyrosol, for example, have been shown to have epigenetic effects in cancer and other diseases. Understanding the epigenetic effects of EVOO and its phenolic compounds can contribute to the development of pharma-nutritional strategies.
ADVANCES IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Edina da Luz Abreu, Camila Rodrigues Moro, Samia Hassan Husein Kanaan, Ricardo Bernardino de Paula, Camila Teixeira Herrera, Pedro Henrique Dorneles Costa, Franck Maciel Pecanha, Dalton Valentim Vassallo, Luciana Venturini Rossoni, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: This study aimed to evaluate the potential antihypertensive effect of egg white hydrolysate (EWH) and its beneficial effects on blood vessels in rats with severe hypertension. The results showed that EWH significantly reduced blood pressure and improved vascular function. This effect may be attributed to the antioxidant and anti-inflammatory properties of EWH.
Review
Nutrition & Dietetics
Marta Garces-Rimon, Diego Morales, Marta Miguel-Castro
Summary: This study reviewed the beneficial actions of legumes proteins and peptides, with a focus on their effects on metabolic syndrome. In vitro tests have shown the promising potential of bioactive hydrolysates and peptides from pulses, but only a few animal models have validated these effects. Further research, including clinical trials, is needed to clarify the effective health implications.
Article
Biochemistry & Molecular Biology
Caroline Silveira Martinez, Jose Antonio Uranga-Ocio, Franck Maciel Pecanha, Dalton Valentim Vassallo, Christopher Exley, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can protect rats from the effects of long-term exposure to high and low levels of aluminum in the diet on reproductive function. The supplementation of EWH can reduce inflammation and oxidative stress in the reproductive organs, and maintain normal sperm production and quality.
Article
Pharmacology & Pharmacy
Leonore Diezi, Kim Dao, Vincent Jullien, Caroline Roussel-Maupetit, Ingrid Burton, Pascal Andre, Carine Bardinet, Laura E. Rothuizen, Haithem Chtioui, Maria A. Manso-Silvan, Catherine Guittet, Francoise Brunner-Ferber, Francois Vandenhende, Catherine Chiron, Luc-Andre Granier, Thierry Buclin
Summary: This study aimed to develop a sugar-free and tasteless granule formulation for childhood absence epilepsy. Two granule formulations, A and B, were evaluated and compared to the syrup formulation. It was found that granule formulation A had bitterness and adherence issues, while granule formulation B had excellent palatability and low adherence. The relative bioavailability of both granule formulations compared to the syrup was slightly different but still met the required pharmacokinetic profile.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Biochemistry & Molecular Biology
Miguel Lopez-Moreno, Estefania Jimenez-Moreno, Antonio Marquez Gallego, Gema Vera Pasamontes, Jose Antonio Uranga Ocio, Marta Garces-Rimon, Marta Miguel-Castro
Summary: In recent years, quinoa has been proposed as an emerging crop for functional food production. Quinoa hydrolysates obtained from the crop have shown in vitro biological activity. This study aimed to evaluate the beneficial effects of red quinoa hydrolysate on oxidative stress and cardiovascular health in an in vivo experimental model of hypertension. The results revealed that oral administration of red quinoa hydrolysate significantly reduced blood pressure and exhibited antioxidant effects, thereby ameliorating hypertension and its associated complications.
Article
Nutrition & Dietetics
Miguel Lopez-Moreno, Marta Garces-Rimon, Marta Miguel-Castro, Elia Fernandez-Martinez, Maria Teresa Iglesias Lopez
Summary: This study aimed to evaluate the effect of a one-year nutrition education course on cardiometabolic parameters in undergraduate health science students. The findings suggest that the nutrition intervention resulted in changes in dietary patterns, with increased consumption of vegetables, nuts and legumes, as well as improvements in HDL-cholesterol levels.
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
