Article
Biochemistry & Molecular Biology
Xin Li, Suzhen Lei, Lu Liu, Yi Zhang, Baodong Zheng, Hongliang Zeng
Summary: The combination of lotus seed resistant starch (LRS) and short-chain fatty acids (SCFAs) can promote the growth of fecal microbiota, increase the production of SCFAs, and influence the intestinal flora, which is beneficial for health and disease management.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Medicine, General & Internal
Sara Deleu, Kathleen Machiels, Jeroen Raes, Kristin Verbeke, Severine Vermeire
Summary: Short-chain fatty acids play important roles in the gut microbiome and intestinal immune system, exerting various effects on host metabolism and immune system. Further research is needed on the cross-feeding mechanisms in the gut microbiome and the therapeutic potential of SCFAs in different disease models.
Review
Food Science & Technology
Cheng Li, Yiming Hu
Summary: The current definitions of resistant starch (RS) types are mainly based on their interactions with human digestive enzymes in the upper gastrointestinal tract, and do not adequately consider their effects on gut microbiota. This review highlights the limitations of the current definitions and proposes new definitions of RS types from the perspective of gut microbiota, taking into account fermentation rate, fermentation end products, specificity towards gut microbiota, and shifts in gut microbiota caused by RS consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Multidisciplinary Sciences
Saurabh Kadyan, Gwoncheol Park, Bo Wang, Prashant Singh, Bahram Arjmandi, Ravinder Nagpal
Summary: Emerging evidence suggests that plant-based fiber-rich diets improve ageing-associated health through a healthier gut microbiome and microbial metabolites. However, the effects and mechanisms of resistant starches from dietary pulses are not well-studied. This study examines the prebiotic effects of resistant starch from different dietary pulses on the gut metabolome in aged mice. The results show differential abundance of specific metabolites among different resistant starch groups, with lentils and chickpeas increasing butyrate, and inulin promoting propionate. The study also reveals the association of beneficial metabolites with certain microbial groups and harmful metabolites with others.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Sara Gomes, Fatima Baltazar, Elisabete Silva, Ana Preto
Summary: The composition of colon microbiota affects the development of colorectal cancer and has an impact on cellular phenotypes. Short-chain fatty acids (SCFAs) exhibit selective and anticancer effects on colon cancer cells and could be a potential therapy for CRC by modulating the composition of colon microbiota.
Article
Biochemistry & Molecular Biology
Rui Wang, Fenfen Wang, Xuedong Kang, Jing Wang, Mei Li, Jinguang Liu, Padraig Strappe, Zhongkai Zhou
Summary: This study investigated the impact of ultrasonication on the reaction efficiency of rice starch acylation from three short-chain fatty acids, revealing that lower power density ultrasonication can improve acetylation efficiency but reduce propionylation reactivity, while butyrylation efficiency is significantly enhanced. The ultrasonic-assisted SCFAs-modified rice starch showed lower peak viscosity and setback value, suggesting avoidance of starch molecules rearrangement, and destroyed gel textural property. These findings highlight the importance of appropriate ultrasonication for enhancing acylation efficiency and improving starch rheological property.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Agriculture, Multidisciplinary
Senbin Cao, Cheng Li
Summary: This review discusses the production methods of rice RS and their interactions with gut microbiota, and explores the effects on human health. Different strategies can produce rice RS with varying contents, types, and structures, which greatly influence the composition and metabolites of gut microbiota. The findings can provide guidance for the rice industry to develop healthier rice products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mingjing Hu, Bilal Alashkar Alhamwe, Brigitte Santner-Nanan, Sarah Miethe, Hani Harb, Harald Renz, Daniel P. Potaczek, Ralph K. Nanan
Summary: This study aimed to generate fully functional human iTregs in vitro using SCFAs and to identify potential phenotypic markers best characterizing human iTregs. The results showed that the addition of butyrate or propionate can potentiate the differentiation of human naive CD4(+) non-Tregs towards iTregs and enhance their suppressive capacity. GITR, ICOS, CD39, PD-1, and PD-L1 were proven to be potential markers of human iTregs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tianqun Lang, Runqi Zhu, Xiao Zhu, Wenlu Yan, Yu Li, Yihui Zhai, Ting Wu, Xin Huang, Qi Yin, Yaping Li
Summary: Gut microbiota plays a significant role in colorectal cancer (CRC) therapy. Researchers have developed nanoparticles loaded with the chemotherapy drug capecitabine, which are made from prebiotic micelles. These nanoparticles enhance the probiotic response, increase anti-tumour immunity, and improve survival in CRC preclinical murine models when administered orally. This prebiotics-based nanoparticle shows promise as a combination therapy for CRC by modulating gut microbiota and providing chemotherapy.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Franziska Dengler, Anika Kraetzig, Gotthold Gaebel
Summary: The large intestinal epithelium has a strong adaptive capacity to hypoxia, and the protective effect of butyrate on colon epithelium under hypoxia may not only be based on its nutritive function, but rather on the intracellular signaling effects of SCFA.
Article
Food Science & Technology
Dan Liang, Nan Li, Xiaofeng Dai, Hong Zhang, Honghai Hu
Summary: Potato resistant starches had significant effects on gut microbiota composition, reducing the Firmicutes/Bacteroidetes ratio and promoting the abundance of Bifidobacterium. Different resistant starches also varied in their production of short-chain fatty acids, with RS2 demonstrating prominent probiotic functions.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Peter DeMartino, Emily A. Johnston, Kristina S. Petersen, Penny M. Kris-Etherton, Darrell W. Cockburn
Summary: The composition of gut microbiota along with short-chain fatty acids in feces are linked to cardiometabolic health and risk of diseases. Intake of dietary fibers, including resistant starch, has been shown to have positive effects on the gut microbiome.
Article
Microbiology
Zhen Chen, Qingqing Xu, Yang Liu, Yihan Wei, Shancai He, Wei Lin, Yingge Wang, Li Li, Yuanteng Xu
Summary: This study found that gut microbiota dysbiosis increased susceptibility and severity of allergic rhinitis, which is significantly related to reduced SCFA-producing bacteria, fecal SCFAs, and specific bacterial taxa. Treatment with sodium butyrate significantly reduced levels of total IgE, OVA-sIgE, IL-4, and IL-5 in serum, and improved inflammation infiltration in nasal and colon mucosa.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Peripheral Vascular Disease
Natalie C. Ward, Revathy Carnagarin, Janis M. Nolde, Leslie Marisol Lugo-Gavidia, Justine Chan, Ancy Jose, Sandi Robinson, Anu Joyson, Markus P. Schlaich
Summary: This study found that serum acetate levels were significantly lower in patients with resistant hypertension, while propionate levels were lower and butyrate levels were higher in patients with essential hypertension. The number and class of antihypertensive drugs may influence the levels of short-chain fatty acids. This study identified a potential therapeutic target for patients with resistant hypertension for the first time.
JOURNAL OF HYPERTENSION
(2022)
Review
Microbiology
Ziyang Zhan, Hao Tang, Ying Zhang, Xinxiang Huang, Min Xu
Summary: Short-chain fatty acids (SCFAs) are important metabolites located in the gut that play a crucial role in regulating gut function and resisting pathogens. Different SCFAs influence bacterial processes by promoting the acylation of key bacterial proteins, and they also prevent pathogenic bacteria invasion by regulating host gut barrier function and immune status.
FRONTIERS IN MICROBIOLOGY
(2022)
