Article
Medicine, General & Internal
Richard T. Bryan, Sarah J. Pirrie, Ben Abbotts, Shanna Maycock, Vinnie During, Carolyn Lewis, Margaret Grant, Deborah Bird, Adam J. Devall, D. Michael A. Wallace, Nicholas D. James, Lucinda J. Billingham, Maurice P. Zeegers, K. K. Cheng, SELENIB Investigators
Summary: In this multicenter clinical trial, selenium and vitamin E were found to have no significant effect on the risk of recurrence in patients with newly diagnosed non-muscle-invasive bladder cancer (NMIBC). However, vitamin E supplementation was associated with an increased risk of recurrence.
Article
Oncology
Srimanta Patra, Biswajita Pradhan, Rabindra Nayak, Chhandashree Behera, Laxmidhar Rout, Mrutyunjay Jena, Thomas Efferth, Sujit Kumar Bhutia
Summary: Curcumin and resveratrol, bioactive phytochemicals, have shown promising chemopreventive and chemoprotective effects in cancer therapy. When combined with established anticancer drugs, they enhance anticancer activity while reducing toxicity towards normal organs through improved pharmacokinetics, pharmacodynamics, bioavailability, and metabolism.Development of drug-loaded nanoparticles, nanocarriers, liposomes, and micelles is gaining attention to improve target specificity and drug efficacy in cancer therapeutics.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Oncology
Zhaoying Yao, Thi Ha Le, Qianming Du, Huiwen Mu, Chao Liu, Yubing Zhu
Summary: Curcumin, a naturally occurring polyphenol, has potential in the prevention and treatment of CRC due to its anti-inflammatory and anti-oxidant properties. Research shows that curcumin and its derivatives have anticancer activity in CRC and may serve as chemopreventive agents. Clinical trials have demonstrated that curcumin treatment is well-tolerated and safe for CRC patients.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Paul Bangirana, Andrea L. Conroy, Robert O. Opoka, Margaret Semrud-Clikeman, Jeong H. Jang, Claire Apayi, Abel Kakuru, Mary K. Muhindo, Michael K. Georgieff, Grant M. Dorsey, Moses R. Kamya, Diane Havlir, Chandy C. John
Summary: Malaria in pregnancy and early childhood was associated with worse neurodevelopmental outcomes in children, but more effective maternal and child malaria chemoprevention regimens did not result in better neurodevelopmental outcomes.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Michele Pellegrino, Emilia Bevacqua, Luca Frattaruolo, Anna Rita Cappello, Stefano Aquaro, Paola Tucci
Summary: Prostate cancer is the second most common cancer in men. Higher intake of polyphenols, curcumin, and quercetin has been associated with lower prostate cancer risk. In this study, the combination of curcumin and quercetin showed synergic anticancer and anti-inflammatory effects, inhibiting proliferation, inducing apoptosis, and modulating inflammation-mediated signaling pathways.
Review
Nutrition & Dietetics
Krystyna Fabianowska-Majewska, Agnieszka Kaufman-Szymczyk, Aldona Szymanska-Kolba, Jagoda Jakubik, Grzegorz Majewski, Katarzyna Lubecka
Summary: Curcumin, a bioactive compound derived from turmeric, has shown potential in inhibiting cancer by modulating DNA methylation. It may play a significant role in the treatment of breast cancer.
Review
Biochemistry & Molecular Biology
Lukasz Huminiecki
Summary: This paper presents an updated and contextualized literature review on functional genomic studies of natural phenols in the context of cancer. It suggests the multilevel chemopreventive and anticancer mechanisms of action shared by multiple dietary natural phenols. Specifically, evidence is cited for the multilevel anti-cancer effects of curcumin and resveratrol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Francesca Celiberto, Adriana Aloisio, Bruna Girardi, Maria Pricci, Andrea Iannone, Francesco Russo, Giuseppe Riezzo, Benedetta D'Attoma, Enzo Ierardi, Giuseppe Losurdo, Alfredo Di Leo
Summary: Colorectal cancer is a major cause of cancer-related deaths in developed countries and is strongly influenced by dietary habits. Inadequate fiber intake in Western countries may contribute to the increased incidence of colorectal cancer. Daily fiber intake has been inversely associated with the risk of colorectal cancer, and dietary interventions based on high-fiber diets have shown promising results in preventing the development of this type of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Thomas Seufferlein, Thomas J. Ettrich, Stefan Menzler, Helmut Messmann, Gerhard Kleber, Alexander Zipprich, Stefanie Frank-Gleich, Hana Alguel, Klaus Metter, Frank Odemar, Theodor Heuer, Ulrich Huegle, Ruediger Behrens, Andreas W. Berger, Catharina Scholl, Katharina L. Schneider, Lukas Perkhofer, Friederike Rohlmann, Rainer Muche, Julia C. Stingl
Summary: The study suggests that green tea extract (GTE) and its active component epigallocatechingallate (EGCG) may have potential antitumor effects in the colorectum. However, a randomized trial did not find a significant difference in adenoma rate between the GTE and placebo groups.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Obstetrics & Gynecology
Alison Edelman, Emily Boniface, Kaitlin Schrote, Marci Messerle-Forbes, Andrea O'Donnell, Jeffrey T. Jensen, Leo Han
Summary: This study aimed to evaluate whether curcumin decreases frequent or prolonged bleeding or spotting in contraceptive implant users. The results showed that daily use of curcumin did not improve bleeding patterns.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Gastroenterology & Hepatology
Peter S. Liang, Aasma Shaukat, Seth D. Crockett
Summary: This expert review provides best practice advice for the chemoprevention of colorectal neoplasia, recommending the use of low-dose aspirin, metformin, and advising against the use of non-aspirin NSAIDs, calcium, vitamin D for prevention.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kirti S. Pawar, Rahul N. Mastud, Satheesh K. Pawar, Samragni S. Pawar, Rahul R. Bhoite, Ramesh R. Bhoite, Meenal Kulkarni, Aditi R. Deshpande
Summary: The study found that using curcumin/piperine treatment in COVID-19 can improve symptoms, reduce deterioration, and improve clinical outcomes. In addition, curcumin/piperine treatment also appears to shorten hospitalization for severe patients and reduce mortality.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biology
Adele Chimento, Maria D'Amico, Arianna De Luca, Francesca Luisa Conforti, Vincenzo Pezzi, Francesca De Amicis
Summary: Plant-derived bioactive compounds are being widely studied for their significant anti-cancer properties, including cancer prevention, improved chemotherapy effectiveness, and mitigation of chemotherapy side effects. This paper provides an overview of the literature on the anti-cancer effects of three extensively studied plant-derived compounds, namely resveratrol, epigallocatechin gallate, and curcumin, with a focus on their molecular mechanisms inducing apoptosis in major types of cancers globally.
Article
Food Science & Technology
Saeedeh Talebi, Andrew S. Day, Mahammad Safarian, Seyed Javad Sayedi, Mahmood Reza Jaafari, Zahra Abbasi, Hanieh Barghchi, Hamid Reza Kianifar
Summary: This prospective randomized clinical trial aimed to evaluate the effects of nano-curcumin as an anti-inflammatory agent and a CFTR modulator on clinical and inflammatory markers in children with CF. The results showed that nano-curcumin decreased the levels of high-sensitivity C-reactive protein and fecal calprotectin, and increased the level of interleukin-10. Moreover, it improved the overall quality of life and the subscale scores of the questionnaire.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Medicinal
Afsane Bahrami, Asghar Zarban, Hadis Rezapour, Akram Agha Amini Fashami, Gordon A. Ferns
Summary: This study found that curcumin had a comparable effect to placebo in alleviating symptoms of PMS and dysmenorrhea. Further research with larger samples, higher doses of curcumin for longer durations, and perhaps in combination therapy is recommended for validation.
PHYTOTHERAPY RESEARCH
(2021)