Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease

(2013) Elisabet Barbero-Camps et al.   HUMAN MOLECULAR GENETICS

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

(2013) Masayasu Okochi et al.   Cell Reports

Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

(2012) Jack-Christophe Cossec et al.   HUMAN MOLECULAR GENETICS

Enhanced  -secretase processing alters APP axonal transport and leads to axonal defects

(2012) E. M. Rodrigues et al.   HUMAN MOLECULAR GENETICS

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

(2012) Jiaqi Yao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Icy: an open bioimage informatics platform for extended reproducible research

(2012) Fabrice de Chaumont et al.   NATURE METHODS

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Dynein Dysfunction Disrupts Intracellular Vesicle Trafficking Bidirectionally and Perturbs Synaptic Vesicle Docking via Endocytic Disturbances

(2011) Nobuyuki Kimura et al.   AMERICAN JOURNAL OF PATHOLOGY

Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission

(2011) Belle Chang-Ileto et al.   DEVELOPMENTAL CELL

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length

(2011) Thomas L. Kukar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway

(2011) Jean-Christophe Roux et al.   NEUROBIOLOGY OF DISEASE

Molecular Mechanism of Cyclodextrin Mediated Cholesterol Extraction

(2011) Cesar A. López et al.   PLoS Computational Biology

Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

(2010) Jack-Christophe Cossec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate

(2009) Yoon Sun Chun et al.   JOURNAL OF NEUROCHEMISTRY

APP Anterograde Transport Requires Rab3A GTPase Activity for Assembly of the Transport Vesicle

(2009) A. Szodorai et al.   JOURNAL OF NEUROSCIENCE

Cholesterol Synthesis Inhibitor U18666A and the Role of Sterol Metabolism and Trafficking in Numerous Pathophysiological Processes

(2009) Richard J. Cenedella   LIPIDS

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Cholesterol Level Regulates Endosome Motility via Rab Proteins

(2007) Hongtao Chen et al.   BIOPHYSICAL JOURNAL

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE