Physiological and Pathological Functions of Mechanosensitive Ion Channels

Ankyrin-G Directly Binds to Kinesin-1 to Transport Voltage-Gated Na+ Channels into Axons

(2014) Joshua Barry et al.   DEVELOPMENTAL CELL

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1

(2013) I. Andolfo et al.   BLOOD

A TRPV4 Channel C-terminal Folding Recognition Domain Critical for Trafficking and Function

(2013) Lei Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels

(2013) J. Barry et al.   JOURNAL OF CELL SCIENCE

Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices

(2013) Timothy A. Simeone et al.   NEUROBIOLOGY OF DISEASE

Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain

(2013) Jizhe Hao et al.   NEURON

TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear

(2013) Bifeng Pan et al.   NEURON

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased susceptibility ofTrpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet

(2012) Christopher J O'Conor et al.   ANNALS OF THE RHEUMATIC DISEASES

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Touch sense

(2012) Yann Roudaut et al.   Channels

Kv1.1 and Kv1.2: Similar channels, different seizure models

(2012) Carol A. Robbins et al.   EPILEPSIA

Altered Distribution of Juxtaparanodal Kv1.2 Subunits Mediates Peripheral Nerve Hyperexcitability in Type 2 Diabetes Mellitus

(2012) J. Zenker et al.   JOURNAL OF NEUROSCIENCE

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

The mechanobiology of brain function

(2012) William J. Tyler   NATURE REVIEWS NEUROSCIENCE

Coupling Mechanical Forces to Electrical Signaling

(2012) Joshua Barry et al.   NEUROSCIENTIST

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Sensing pressure with ion channels

(2012) Bernd Nilius et al.   TRENDS IN NEUROSCIENCES

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons

(2011) Cécile Hilaire et al.   BIOCHEMICAL JOURNAL

Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood–brain barrier endothelial cells

(2011) Jonathan Berrout et al.   BRAIN RESEARCH

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Alternative Splicing Regulates Kv3.1 Polarized Targeting to Adjust Maximal Spiking Frequency

(2011) Yuanzheng Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Methyl-d-aspartate Receptor Mechanosensitivity Is Governed by C Terminus of NR2B Subunit

(2011) Pallab Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clustering and Activity Tuning of Kv1 Channels in Myelinated Hippocampal Axons

(2011) Chen Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonal Neuropathy-associated TRPV4 Regulates Neurotrophic Factor-derived Axonal Growth

(2011) Yongwoo Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DEG/ENaC Protein MEC-10 Regulates the Transduction Channel Complex in Caenorhabditis elegans Touch Receptor Neurons

(2011) J. Arnadottir et al.   JOURNAL OF NEUROSCIENCE

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

(2011) Stuart M. Brierley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

(2011) Shireen R Lamandé et al.   NATURE GENETICS

Function and mechanism of axonal targeting of voltage-sensitive potassium channels

(2011) Chen Gu et al.   PROGRESS IN NEUROBIOLOGY

Mechanosensitive Channels: What Can They Do and How Do They Do It?

(2011) Elizabeth S. Haswell et al.   STRUCTURE

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies

(2010) Magdalena Zimoń et al.   BRAIN

Mechanosensitive Channels: In Touch with Piezo

(2010) Rui Xiao et al.   CURRENT BIOLOGY

Pressing and squeezing with Piezos

(2010) Bernd Nilius   EMBO REPORTS

Kinesin I Transports Tetramerized Kv3 Channels through the Axon Initial Segment via Direct Binding

(2010) M. Xu et al.   JOURNAL OF NEUROSCIENCE

Multiple Desensitization Mechanisms of Mechanotransducer Channels Shape Firing of Mechanosensory Neurons

(2010) J. Hao et al.   JOURNAL OF NEUROSCIENCE

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanosensitive gating of CFTR

(2010) Wei Kevin Zhang et al.   NATURE CELL BIOLOGY

C. elegans TRP Family Protein TRP-4 Is a Pore-Forming Subunit of a Native Mechanotransduction Channel

(2010) Lijun Kang et al.   NEURON

Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture

(2010) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

Stretch-Activated Ion Channels: What Are They?

(2010) Frederick Sachs   PHYSIOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Lysophosphatidyl choline modulates mechanosensitive L-type Ca2+ current in circular smooth muscle cells from human jejunum

(2009) Robert E. Kraichely et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Transient Receptor Potential Vanilloid Type 4–Deficient Mice Exhibit Impaired Endothelium-Dependent Relaxation Induced by Acetylcholine In Vitro and In Vivo

(2009) David X. Zhang et al.   HYPERTENSION

Functional Analysis of the Kv1.1 N255D Mutation Associated with Autosomal Dominant Hypomagnesemia

(2009) Jenny van der Wijst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A missense mutation in the Kv1.1 voltage-gated potassium channel–encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia

(2009) Bob Glaudemans et al.   JOURNAL OF CLINICAL INVESTIGATION

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

(2009) Michaela Auer-Grumbach et al.   NATURE GENETICS

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4

(2009) Han-Xiang Deng et al.   NATURE GENETICS

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

(2009) Guida Landouré et al.   NATURE GENETICS

Tuning the mechanosensitivity of a BK channel by changing the linker length

(2008) Hucheng Zhao et al.   CELL RESEARCH

Stimulus-specific Modulation of the Cation Channel TRPV4 by PACSIN 3

(2008) Dieter D'hoedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IP3Receptor Binds to and Sensitizes TRPV4 Channel to Osmotic Stimuli via a Calmodulin-binding Site

(2008) Anna Garcia-Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IP3sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

(2008) Jacqueline Fernandes et al.   JOURNAL OF CELL BIOLOGY

Interaction of Transient Receptor Potential Vanilloid 4, Integrin, and Src Tyrosine Kinase in Mechanical Hyperalgesia

(2008) N. Alessandri-Haber et al.   JOURNAL OF NEUROSCIENCE