Article
Immunology
Isabel M. Alonso Bellido, Mercedes Posada-Perez, Francisco Hernandez-Rasco, Sandra Vazquez-Reyes, Maria Cabanillas, Antonio J. Herrera, Sara Bachiller, Jesus Soldan-Hidalgo, Ana M. Espinosa-Oliva, Bertrand Joseph, Rocio M. de Pablos, Jose L. Venero, Rocio Ruiz
Summary: The study aims to investigate the role of Caspase-3 in neurogenesis-related microglial functions. Using Caspase-3 conditional knockout mice, it was found that the reduction of Caspase-3 led to decreased microglia and neurogenic neurons in the hippocampus, as well as a lower phagocytic capacity of microglia. Behavioral analysis also showed impaired memory and learning in the absence of Caspase-3. These findings highlight the essential role of Caspase-3 in microglial function and the importance of a specific microglial phenotype in the maintenance of adult hippocampal neurogenesis.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Health Care Sciences & Services
Carlos Marquez, Barbara Angel, Lydia Lera, Rebecca Bendayan, Hugo Sanchez, Cecilia Albala
Summary: This longitudinal study explored the association between vitamin D levels and cognitive performance in older Chilean people and found that low vitamin D levels were a risk factor for mild cognitive impairment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Xiuyue Zhang, Ping Wang, Li Shi, Na Li
Summary: The study found that patients with the comorbidity of T2DM and MDD had more severe cognitive impairment compared to the other two groups, and their caspase-1 levels were higher. The research suggests that caspase-1 may be involved in the mechanism of cognitive impairment aggravation in patients with the comorbidity of T2DM and MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Nutrition & Dietetics
Michael A. A. Mong
Summary: Vitamin K plays a unique and potentially important role in the visual system, separate from its hepatic carboxylation of proteins. However, there has been a lack of review articles on this topic in medical literature. Recent studies have shown that vitamin K-dependent protein MGP is crucial for regulating intraocular pressure. A randomized trial demonstrated a significant reduction in the risk of cataract surgery with higher dietary vitamin K1 intake. The specific requirements and optimized status of vitamin K for the eye and visual system are currently unknown and require further investigation.
Article
Clinical Neurology
Sujuan Li, Xuelei Xu, Yan Qiu, Ziwei Teng, Jieyu Liu, Hui Yuan, Jindong Chen, Yuxi Tan, Min Yang, Kun Jin, Baoyan Xu, Hui Tang, Ziru Zhao, Bolun Wang, Hui Xiang, Haishan Wu
Summary: This study found that patients with bipolar disorder have higher levels of vitamin D in their serum and these levels are negatively associated with cognitive impairment. For patients with bipolar disorder, more physical activity is less beneficial to cognition than longer resting.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Nutrition & Dietetics
Zhe Ding, Lihui Luo, Shaohui Guo, Qing Shen, Yueying Zheng, Shengmei Zhu
Summary: The association between folate and vitamin B12 with cognitive performance was studied using cross-sectional data of older adults. The study found an inverse U-shaped relationship between folate/vitamin B12 status and cognitive function. Older adults could be categorized into different status groups based on biochemical examination, and these groups showed significantly different cognitive test outcomes.
Article
Anesthesiology
Lin Su, Xiaoqing Bai, Tongxiang Niu, Xinqi Zhuang, Beibei Dong, Yize Li, Yonghao Yu, Guolin Wang
Summary: The study found that orexinergic neurons in the PeFLH can influence the maintenance and emergence from isoflurane and desflurane anesthesia, as well as affect the induction under desflurane anesthesia. This specific effect is likely mediated by orexinergic PeFLH-PVT circuitry, especially OX2Rs in the PVT.
ANESTHESIA AND ANALGESIA
(2021)
Article
Food Science & Technology
Giou-Teng Yiang, Tsu-Yi Chen, Cian Chen, Yu-Ting Hung, Kuan-Chun Hsueh, Tsai-Kun Wu, Ying-Ru Pan, Yi-Chung Chien, Chao-Hsuan Chen, Yung-Lung Yu, Chyou-Wei Wei
Summary: The combination of vitamin C and E with MTX can exhibit anticancer activities on glioblastoma, enhancing the anticancer effects on low-concentration methotrexate-treated glioblastoma.
FOOD SCIENCE & NUTRITION
(2021)
Review
Nutrition & Dietetics
Zsolt Gall, Orsolya Szekely
Summary: The review highlights the importance of the neuronal effects of 1,25(OH)2D in cognitive development and maintenance, as well as the association between vitamin D deficiency and neurological disorders. It also discusses the expression of vitamin D receptors in the central nervous system and the potential implications for therapeutic applications.
Article
Neurosciences
Wei Wang, Wenwei Gao, Lei Zhang, Zhongyuan Xia, Bo Zhao
Summary: This study reveals that SNAP25 plays a protective role in postoperative cognitive dysfunction (POCD) by regulating mitochondrial quality control and reducing apoptosis.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Beata M. Gruber-Bzura
Summary: Vitamin C may have immune-modulating effects, but there is no literature support for reducing viral diseases through dietary supplements based on vitamin C. However, many still believe that extra intake of vitamin C can enhance the effectiveness of the immune system. No studies were found on high-dose vitamin C supplementation for preventing COVID-19 in healthy individuals.
Article
Immunology
Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping Gu
Summary: Research indicates that prolonged exposure to low-concentration anesthetics may induce neuroinflammation and cognitive decline, but pretreatment with metformin can alleviate these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Jiajun Liu, Fangzheng Wu, Minghui Wang, Menglin Tao, Zhengjie Liu, Zijuan Hai
Summary: A tumor-targeted fluorescent/photoacoustic probe was developed to monitor the activity of Caspase-3 in vivo. The probe could enter and accumulate in tumor cells, resulting in increased fluorescence and photoacoustic signals. This study provides a new method for clinical imaging of tumor apoptosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Critical Care Medicine
Jean-Remi Lavillegrand, Lisa Raia, Tomas Urbina, Geoffroy Hariri, Paul Gabarre, Vincent Bonny, Naike Bige, Jean-Luc Baudel, Arnaud Bruneel, Thierry Dupre, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella
Summary: This study aimed to investigate the effects of vitamin C supplementation on microvascular function and peripheral tissue perfusion in septic shock patients. The results showed that vitamin C supplementation significantly improved microvascular reactivity and peripheral tissue perfusion.
Article
Neurosciences
Huihui Miao, Yuanlin Dong, Yiying Zhang, Hui Zheng, Yuan Shen, Gregory Crosby, Deborah J. Culley, Edward R. Marcantonio, Zhongcong Xie
MOLECULAR NEUROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Xiaoning Wang, Yuanlin Dong, Yiying Zhang, Tianzuo Li, Zhongcong Xie
Article
Neurosciences
Hua Zheng, Hoai Ton, Lei Yang, Ning Liufu, Yuanlin Dong, Yiying Zhang, Zhongcong Xie
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Cell Biology
Ning Liufu, Ling Liu, Shiqian Shen, Zengliang Jiang, Yuanlin Dong, Yanyan Wang, Deborah Culley, Gregory Crosby, Minghui Cao, Yuan Shen, Edward Marcantonio, Zhongcong Xie, Yiying Zhang
Article
Cell Biology
Yiying Zhang, Pan Lu, Feng Liang, Liufu Ning, Yuanlin Dong, Jialin Charles Zheng, Zhongcong Xie
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Anesthesiology
Yang Yu, Yongyan Yang, Hong Tan, Myriam Boukhali, Ashok Khatri, Yonghao Yu, Fuzhou Hua, Ling Liu, Mengzhu Li, Guang Yang, Yuanlin Dong, Yiying Zhang, Wilhelm Haas, Zhongcong Xie
Article
Multidisciplinary Sciences
Lei Yang, Hoai Ton, Ruohe Zhao, Erez Geron, Mengzhu Li, Yuanlin Dong, Yiying Zhang, Buwei Yu, Guang Yang, Zhongcong Xie
SCIENTIFIC REPORTS
(2020)
Article
Biology
Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E. Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xie
Summary: Using nanobeam-sensor technology, researchers found that the anesthesia sevoflurane induces tau trafficking from neurons to microglia in mice, with microglia capable of taking up tau and leading to IL-6 production, shedding light on the mechanism of sevoflurane-mediated cognitive impairment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tao Zhang, Cheng Ni, Cheng Li, Pan Lu, Dan Chen, Yuanlin Dong, Johnathan R. Whetstine, Yiying Zhang, Zhongcong Xie
Summary: The anesthetic isoflurane has been shown to decrease the numbers of embryos and unfertilized eggs, increase dead cells and ROS levels, and impair oogenesis in C. elegans. This impairment is associated with abl-1 and ced-3, but not cep-1. The use of an oxidative stress inhibitor can mitigate the effects of isoflurane on oogenesis, while mating with male C. elegans does not have a protective effect. Further investigation is needed to determine the mechanisms by which isoflurane affects fecundity.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Jiefu Lin, Fuyi Shen, Jing Lu, Feng Liang, Yiying Zhang, Zhongcong Xie, Yuanlin Dong
Summary: The study demonstrates that treatment with WS635 can mitigate anesthesia/surgery-induced cognitive impairment in mice, suggesting the need for further experiments to determine its potential as an intervention for PND in patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Anesthesiology
Yongyan Yang, Feng Liang, Jie Gao, Yuanlin Dong, Yiying Zhang, Guang Yang, Sulpicio G. Soriano, Hua-Jun Feng, Zhongcong Xie
Summary: The study showed that lower brain testosterone concentrations in neonatal male mice compared to adult male mice contributed to age-dependent tau phosphorylation and cognitive impairment after sevoflurane anesthesia. Testosterone treatment increased brain testosterone concentrations and alleviated anesthesia-induced tau phosphorylation and cognitive impairment.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Psychiatry
Yiying Zhang, Kathryn Baldyga, Yuanlin Dong, Wenyu Song, Mirella Villanueva, Hao Deng, Ariel Mueller, Timothy T. Houle, Edward R. Marcantonio, Zhongcong Xie
Summary: Postoperative delirium is a common complication in older patients, and the association between gut microbiota and postoperative delirium is explored in this study. The study found that gut bacteria Parabacteroides distasonis was associated with postoperative delirium. Further research is needed to confirm these findings and understand the role of the gut-brain axis in postoperative outcomes.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Anesthesiology
Feng Liang, Mengzhu Li, Miao Xu, Yiying Zhang, Yuanlin Dong, Sulpicio G. Soriano, Mary Ellen Mccann, Guang Yang, Zhongcong Xie
Summary: Multiple exposures to sevoflurane can induce sequential tau phosphorylation, leading to cognitive impairment in young mice. Further investigation is needed to explore the underlying mechanisms of anaesthesia-induced tau phosphorylation in the developing brain.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Kathleen F. Vincent, Olivia G. Mallari, Emmaline J. Dillon, Victoria G. Stewart, Angel J. Cho, Yuanlin Dong, Andrea G. Edlow, Fumito Ichinose, Zhongcong Xie, Ken Solt
Summary: This study demonstrates that the oestrous cycle in female rats affects the emergence time from dexmedetomidine-induced unconsciousness, particularly during the early dioestrus stage. The EEG spectra also showed changes 30 minutes after dexmedetomidine administration.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Mingyang Sun, Yuanlin Dong, Mengzhu Li, Yiying Zhang, Feng Liang, Jiaqiang Zhang, Sulpicio G. Soriano, Zhongcong Xie
Summary: The study found that dexmedetomidine and clonidine can inhibit sevoflurane-induced tau phosphorylation and cognitive impairment by activating alpha-2 adrenergic receptor in young mice.
ANESTHESIA AND ANALGESIA
(2021)