Article
Immunology
Lauren A. Vanderlinden, Elizabeth A. Bemis, Jennifer Seifert, Joel M. Guthridge, Kendra A. Young, Mary Kristen Demoruelle, Marie Feser, Wade DeJager, Susan Macwana, Ted R. Mikuls, James R. O'Dell, Michael H. Weisman, Jane Buckner, Richard M. Keating, Patrick M. Gaffney, Jennifer A. Kelly, Carl D. Langefeld, Kevin D. Deane, Judith A. James, Vernon Michael Holers, Jill M. Norris
Summary: Genes associated with vitamin D levels may have a protective role in the development of autoantibodies in first-degree relatives of rheumatoid arthritis patients, but not in systemic lupus erythematosus patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Review
Immunology
Han Wu, Shuxian Chen, Aifen Li, Kangyuan Shen, Shuting Wang, Sijie Wang, Ping Wu, Wenying Luo, Qingjun Pan
Summary: Long non-coding RNAs (lncRNAs) have emerged as potential novel biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), playing key roles in the pathogenesis of these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Lotte van Ouwerkerk, Maarten Boers, Paul Emery, Pascal H. P. de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Patrick Verschueren, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: This study investigated whether patients with rheumatoid arthritis (RA) can discontinue glucocorticoids (GC) after GC 'bridging' in the initial treatment step and identified factors that may affect this. The probability of using GC decreased over time after bridging therapy ended, while the probability of continuous GC use increased. In oral GC bridging studies, the probabilities of later and continuous GC use and the cumulative GC doses were higher compared to studies that included parenteral GC bridging.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chloe Bost, Marina I. Arleevskaya, Wesley H. Brooks, Samuel Plaza, Jean-Charles Guery, Yves Renaudineau
Summary: Growing evidence suggests that the long non-coding RNA Xist expressed in female cells plays a significant role in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Xist controls transcription and sequesters miRNAs, leading to alterations in key inflammatory and proliferative pathways.
CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Latanya N. Coke, Hongxiu Wen, Mary Comeau, Mustafa H. Ghanem, Andrew Shih, Christine N. Metz, Wentian Li, Carl D. Langefeld, Peter K. Gregersen, Kim R. Simpfendorfer
Summary: The study revealed that the SLE risk association in the DNASE1L3 locus is related to the polymorphism rs35677470, which results in reduced secretion of DNASE1L3 protein but does not eliminate its DNase enzyme function. The association of the DNASE1L3/PXK gene locus with SLE risk is dependent on the missense SNP rs35677470, highlighting the importance of this polymorphism in SLE susceptibility.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Pharmacology & Pharmacy
Yuka Kawato, Hidehiko Fukahori, Koji Nakamura, Atsuo Kanno, Kaori Kubo, Masaki Hiramitsu, Toshihiro Matsuda, Yuichi Hanada, Takako Furukawa, Yutaka Nakajima, Fumitaka Kinugasa, Tatsuaki Morokata
Summary: The presence of CatS in SLE patients suggests its involvement in the pathogenesis, making it a potential therapeutic target for SLE treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Qi Huang, Wang-Dong Xu, Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang
Summary: This study investigated CD40 gene polymorphisms in Chinese Han population with SLE and RA, finding associations between certain genotypes and alleles with susceptibility to the diseases. The findings suggest a potential role of CD40 gene polymorphisms in the pathogenesis of SLE and RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
David E. Adams, Wen-Hai Shao
Summary: This article discusses the epigenetic alterations associated with systemic lupus erythematosus (SLE) and their role in the pathophysiology of the disease. It also summarizes the therapeutic potential of the new findings.
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
Summary: The presence of faecal haemoglobin, even in the absence of gastrointestinal bleeding, may indicate systemic inflammation and be linked to the development of immune-mediated inflammatory diseases (IMIDs). Positive faecal immunochemical test (FIT) is associated with an increased risk of rheumatoid arthritis (RA) in the general population.
Article
Medicine, General & Internal
Kathryn Connelly, Eric F. Morand
Summary: SLE is a complex autoimmune disease with significant diversity among individual patients. Accurate diagnosis and appropriate treatment require a deep understanding of disease diversity, personalized treatment plans, and attention to the impact on patients' quality of life.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Allergy
J. Suurmond, A. L. Dorjee, E. F. Knol, T. W. J. Huizinga, R. E. M. Toes
CLINICAL AND EXPERIMENTAL ALLERGY
(2015)
Article
Rheumatology
Felice Rivellese, Jolien Suurmond, Kim Habets, Annemarie L. Dorjee, Nandhini Ramamoorthi, Michael J. Townsend, Amato de Paulis, Gianni Marone, Tom W. J. Huizinga, Costantino Pitzalis, Rene E. M. Toes
ARTHRITIS & RHEUMATOLOGY
(2015)
Article
Hematology
Myoungsun Son, Amit Porat, Mingzhu He, Jolien Suurmond, Frances Santiago-Schwarz, Ulf Andersson, Thomas R. Coleman, Bruce T. Volpe, Kevin J. Tracey, Yousef Al-Abed, Betty Diamond
Review
Immunology
Jolien Suurmond, Justine Calise, Susan Malkiel, Betty Diamond
CURRENT OPINION IN IMMUNOLOGY
(2016)
Article
Immunology
Jolien Suurmond, Annemarie L. Dorjee, Tom W. J. Huizinga, Rene E. M. Toes
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Pharmacology & Pharmacy
Jolien Suurmond, Daniel van der Velden, Johan Kuiper, Ilze Bot, Rene E. M. Toes
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Allergy
Jolien Suurmond, Kim L. L. Habets, Zuotian Tatum, Joris J. Schonkeren, Peter A. C. 't Hoen, Tom W. J. Huizinga, Jeroen F. J. Laros, Rene E. M. Toes, Fina Kurreeman
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Immunology
Jolien Suurmond, Kim L. L. Habets, Annemarie L. Dorjee, Tom W. Huizinga, Rene E. M. Toes
JOURNAL OF IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Rosanne A. van Schaarenburg, Jolien Suurmond, Kim L. L. Habets, Mieke C. Brouwer, Diana Wouters, Fina A. S. Kurreeman, Tom W. J. Huizinga, Rene E. M. Toes, Leendert A. Trouw
MOLECULAR IMMUNOLOGY
(2016)
Review
Immunology
Susan Malkiel, Ashley N. Barlev, Yemil Atisha-Fregoso, Jolien Suurmond, Betty Diamond
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Rheumatology
J. Suurmond, F. Rivellese, A. L. Dorjee, A. M. Bakker, Y. J. P. C. Rombouts, T. Rispens, G. Wolbink, A. Zaldumbide, R. C. Hoeben, T. W. J. Huizinga, R. E. M. Toes
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Article
Allergy
Jolien Suurmond, Yemil Atisha-Fregoso, Emiliano Marasco, Ashley N. Barlev, Naveed Ahmed, Silvia A. Calderon, Mei Yin Wong, Meggan C. Mackay, Cynthia Aranow, Betty Diamond
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Medicine, Research & Experimental
Sanne Reijm, Joanneke C. Kwekkeboom, Nienke J. Blomberg, Jolien Suurmond, Diane van der Woude, Rene E. M. Toes, Hans U. Scherer
Summary: This study visualizes the B cell response against posttranslational modification antigens in autoimmune diseases. The results demonstrate extensive cross-reactivity of B cells against different antigens and the presence of PTM-directed plasmablasts in patients. The expression of CXCR3 suggests the potential involvement of chemokines in this process.
Article
Medicine, Research & Experimental
Ashley N. Barlev, Susan Malkiel, Izumi Kurata-Sato, Annemarie L. Dorjee, Jolien Suurmond, Betty Diamond
Summary: Fc gama RIIB is an inhibitory receptor that plays a role in B cell development. This study found that higher expression of Fc gama RIIB in marginal zone B cells is associated with increased activation, phosphorylation, and calcium flux. Loss of Fc gama RIIB led to spontaneous increase in autoantibody production in mice. Patients with lupus also showed decreased expression of Fc gama RIIB in marginal zone B cells.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Jolien Suurmond, Yemil Atisha-Fregoso, Ashley N. Barlev, Silvia A. Calderon, Meggan C. Mackay, Cynthia Aranow, Betty Diamond