Article
Medicine, Research & Experimental
Yoon-Hee Cheon, Chang Hoon Lee, Soojin Kim, Gyeong Do Park, Sung Chul Kwak, Hae Joong Cho, Ju-Young Kim, Myeung Su Lee
Summary: Pitavastatin shows potential as a candidate for treating osteoporosis by enhancing osteoblast differentiation and bone growth, as well as inhibiting osteoclast differentiation and bone resorption. Its mechanisms include inhibiting signaling pathways and downregulating transcription factors to regulate osteoclast activity, and stimulating osteoblast differentiation and mineralization to promote bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Orthopedics
Yaosheng Xiao, Shanshan Zhang, Yongjun Ye, Jincai Chen, Youjia Xu
Summary: In this study, geniposide, an active compound from Eucommia ulmoides, was found to protect against osteoblast apoptosis induced by oxidized low-density lipoproteins (OX-LDL) by regulating the NRF2/NF-kappa B signaling pathway, thereby preserving bone health.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Chemistry, Medicinal
Xuedong Li, Xixi Lin, Zuoxing Wu, Yuangang Su, Jiamin Liang, Runfeng Chen, Xue Yang, Lei Hou, Jinmin Zhao, Qian Liu, Feng Xu
Summary: The study demonstrates that PRI has therapeutic potential in treating osteolytic diseases like osteoporosis by inhibiting osteoclast formation and bone resorption activity both in vitro and in vivo. PRI exerts its effects through the suppression of NF-κB and ERK MAPK signaling pathways, preventing the production of mature osteoclasts.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Hong Chen, Fangfang Song, Fanxin Long
Summary: Glucocorticoids are a common cause for osteoporosis and fractures, but current treatments are not effective due to side effects. This study shows that WNT7B can restore bone mass after glucocorticoid-induced bone loss by increasing osteoblast number and function. However, WNT7B overexpression does not improve abnormal fat accumulation.
Article
Chemistry, Multidisciplinary
Kwansung Seo, Ji Hye Yoo, Jisu Kim, Sung Jun Min, Dong Nyoung Heo, Il Keun Kwon, Ho-Jin Moon
Summary: Ginseng-derived extracellular nanovesicles (GDNs) have the potential to inhibit osteoclast differentiation and may be used for the prevention and treatment of bone loss diseases.
Article
Chemistry, Medicinal
Jun-ming Huang, Chen-zhong Wang, Shun-yi Lu, Zhe Wang, Zuo-qin Yan
Summary: The study demonstrated that Oroxin B may act as an anti-osteoporosis agent by inhibiting osteoclast maturation and attenuating bone resorption.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Changwei Li, Minglong Qiu, Leilei Chang, Jin Qi, Lianfang Zhang, Bernhard Ryffel, Lianfu Deng
Summary: This study identified USP26 as a regulator of bone homeostasis that coordinates bone formation and resorption. USP26 stabilizes beta-catenin to promote osteogenesis and inhibits osteoclastic differentiation by stabilizing inhibitors of NF-kappa B alpha. These findings highlight the osteoprotective effect of USP26 and suggest it as a potential therapeutic target for osteoporosis.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Chemistry, Medicinal
Sophia Ogechi Ekeuku, Kok-Lun Pang, Kok-Yong Chih
Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Xiao Lin, Fang Xu, Ke-Wen Zhang, Wu-Xia Qiu, Hui Zhang, Qiang Hao, Meng Li, Xiao-Ni Deng, Ye Tian, Zhi-Hao Chen, Ai-Rong Qian
Summary: In this study, the function of acacetin on bone remodeling and H type vessel formation was explored. Acacetin was found to inhibit osteoclast formation and bone resorption, as well as promote angiogenesis and migration of endothelial progenitor cells (EPCs). Furthermore, acacetin was shown to prevent bone loss in mice through inhibition of osteoclast function and promotion of type H vessel formation via Akt/GSK3 beta and NF-kappa B signaling pathway, making it a potential therapeutic agent for the treatment of osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yongjie Chen, Linlin Zhang, Zongguang Li, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui, Ren Xu, Guangrong Ji
Summary: Mogrol, an active component of Siraitia grosvenorii, exhibits anti-inflammatory, anticancer and neuroprotective effects. This study demonstrated that mogrol dose-dependently inhibited osteoclast formation and function by regulating gene expression and signaling pathway. Furthermore, mogrol reduced bone mass loss in postmenopausal mice, suggesting its promising potential for osteoporosis prevention or therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xinwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan, Yaosheng Zhang, Weifeng Xu, An Qin, Shanyong Zhang
Summary: This study demonstrates the important role of Dlk2 in osteoclast development and bone homeostasis, as well as the interaction between Dlk2 and the Syap1 signaling pathway. The results indicate that Dlk2 deletion inhibits osteoclast formation and leads to a high-bone-mass phenotype, with increased bone mass observed in ovariectomized mice.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sumin Lee, Jae-Hyun Kim, Minsun Kim, Sooyeon Hong, Hoyeon Park, Eom Ji Kim, Eun-Young Kim, Chungho Lee, Youngjoo Sohn, Hyuk Sang Jung, Jose Luis Perez-Castrillon
Summary: This study investigated the potential of a natural compound called daucosterol (DC) as a treatment for osteoporosis. The results showed that DC effectively inhibited osteoclast differentiation, promoted osteoblast activity, and prevented bone density loss caused by LPS. These findings suggest that DC may be a new therapeutic alternative for osteoporosis patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yi-Fan Guo, Tian Su, Mi Yang, Chang-jun Li, Qi Guo, Ye Xiao, Yan Huang, Ya Liu, Xiang-Hang Luo
Summary: Autophagy is a crucial intracellular process that recovers nutrients and energy, serving as an anti-aging mechanism. It plays a significant role in cellular homeostasis and is essential in the pathogenesis of bone diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tao Li, Guangyao Jiang, Xuantao Hu, Daishui Yang, Tingting Tan, Zhi Gao, Zhuoyuan Chen, Cheng Xiang, Shizhen Li, Zhengxiao Ouyang, Xiaoning Guo
Summary: Punicalin inhibits osteoclast formation and bone resorption by suppressing the NF-κB signaling pathway, showing potential in suppressing breast cancer-induced bone metastasis and promoting apoptosis of breast cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)