Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Laura Brabenec, Katharina E. M. Hellenthal, Melanie Mueller, Sebastian Kintrup, Finnja Zurek-Leffers, Marina Kardell, Mandy Otto, Nana-Maria Wagner
Summary: Procalcitonin contributes to endothelial dysfunction by antagonizing CGRP signaling in obesity, and targeting hyperprocalcitonemia may be a means to preserve endothelial function and reduce comorbidity burden in obese subjects.
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Article
Biochemistry & Molecular Biology
Max L. B. Gronloh, Janine J. G. Arts, Sebastian Palacios Martinez, Amerens A. van Der Veen, Lanette Kempers, Abraham C. van Steen, Joris J. T. H. Roelofs, Martijn A. Nolte, Joachim Goedhart, Jaap D. van Buul
Summary: Using a photoconvertible probe, researchers traced and identified the original endothelial transmigration hotspots, and found that these hotspots function to limit vascular leakage during transmigration events. The distribution of ICAM-1 determines the location of the transmigration hotspot.
Article
Immunology
Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M. J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A. D. T. G. Wagener, Peter Pickkers
Summary: Inflammation-induced free radical release is important in the pathogenesis of several diseases. This study investigated the impact of atazanavir-induced hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. The results showed that hyperbilirubinemia increased antioxidant capacity, attenuated interleukin-10 release, and prevented vascular hyporesponsiveness during systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
George S. S. Prousi, Amogh M. M. Joshi, Varun Atti, Daniel Addison, Sherry-Ann Brown, Avirup Guha, Brijesh Patel
Summary: Cancer and cardiovascular disease, two leading causes of morbidity and mortality in the USA, share common inflammatory processes that contribute to their development and progression. Inflammatory signaling plays a critical role in both diseases, and certain chemotherapeutic agents can worsen existing cardiovascular disease or induce its presence by exacerbating inflammation. The exact mechanisms underlying these interactions remain poorly understood. Further investigation of this relationship is crucial for the development of new diagnostic and therapeutic approaches.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Nutrition & Dietetics
Yuehan Wang, Xutao Zhang, Chunxiu Zhou, Haroon Khan, Manqin Fu, Wai San Cheang
Summary: The study found that CRP extract has a protective effect on endothelial function and inflammation in type 2 diabetic rats. It can normalize blood pressure, plasma lipid profile, and liver enzyme levels, improve endothelium-dependent relaxations in arteries, suppress vascular inflammatory markers, and activate AMPK. In experiments, co-incubation of CRP extract with high glucose prevented the impairment of vasodilation.
Article
Biochemistry & Molecular Biology
Xiaoyun Cao, Yalan Wu, Huiling Hong, Xiao Yu Tian
Summary: Atherosclerosis is linked to endothelial dysfunction and vascular inflammation, and SIRT3 and NAD(+) play critical roles in maintaining normal mitochondrial function and improving endothelial function. The deletion of SIRT3 in endothelial cells accelerates atherosclerosis and amplifies vascular inflammation and oxidative stress. Treatment with NAD(+) attenuates these effects. The study also shows that NAD(+) supplementation improves endothelial function and reduces plaque formation in mouse models of atherosclerosis.
Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Fayaz A. Mir, Niharika Singh, Ian Chin, Ali Hafezi-Moghadam, Sharmila Masli
Summary: This study investigates the role of thrombospondin (TSP)-1 in regulating leukocyte recruitment and VCAM-1 expression in mouse models of uveitis. The results show that TSP-1 deficiency can reduce retinal leukocyte adhesion in LPS-mediated acute uveitis, while TSP-1-derived CD47-binding peptide can reduce the clinical disease course and retinal leukocyte adhesion in chronic uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cleo C. L. van Aanhold, Angela Koudijs, Kyra L. Dijkstra, Ron Wolterbeek, Jan A. Bruijn, Cees van Kooten, Hans J. Baelde
Summary: The study found that transfection with sFLT1 did not aggravate renal fibrosis and peritubular capillary loss, but reduced the expression of pro-fibrotic and pro-inflammatory markers. sFLT1 mRNA levels were not correlated with interstitial fibrosis or PTC loss in human samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Dagmar Hildebrand, Jana Boehringer, Eva Koerner, Ute Chiriac, Sandra Foermer, Aline Saehr, Torsten Hoppe-Tichy, Klaus Heeg, Dennis Nurjadi
Summary: This study investigates the potential effect of cefiderocol on the barrier function of vascular endothelial cells. The results suggest that cefiderocol can reduce the permeability of intercellular gaps and decrease the release of inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Marcelo Queiroz, Adriana Leandro, Lara Azul, Artur Figueirinha, Raquel Seica, Cristina M. Sena
Summary: Luteolin was found to improve endothelial function, vascular oxidative stress, and perivascular adipose tissue in type 2 diabetes mellitus rats, showing therapeutic potential for vascular complications associated with type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yang Liu, Hong-lin Yin, Chao Li, Feng Jiang, Shi-jun Zhang, Xin-rong Zhang, Yun-lun Li
Summary: Inflammation plays a significant role in the occurrence and development of hypertension, and the potential mechanism between inflammation and hypertensive endothelial injury is still unclear. Sinapine thiocyanate (ST) has a protective effect on hypertensive endothelial damage.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Filipa Martins, Ana Catarina Neto, Adriana Raquel Rodrigues, Sandra Marisa Oliveira, Claudia Sousa-Mendes, Adelino Leite-Moreira, Alexandra Maria Gouveia, Henrique Almeida, Delminda Neves
Summary: Treatment with metformin can alleviate endothelial dysfunction in the heart of mice with endometriosis, but it does not mitigate cardiac fibrosis and the increase in NF-kB expression.
Article
Multidisciplinary Sciences
Tom Skaria, Julia Burgener, Esther Bachli, Gabriele Schoedon
Editorial Material
Immunology
Tom Skaria, Gabriele Schoedon
JOURNAL OF INFLAMMATION-LONDON
(2017)
Article
Immunology
Tom Skaria, Esther Bachli, Gabriele Schoedon
JOURNAL OF INFLAMMATION-LONDON
(2017)
Article
Cell Biology
Rene G. Feichtinger, Daniel Neureiter, Tom Skaria, Silja Wessler, Timothy L. Cover, Johannes A. Mayr, Franz A. Zimmermann, Gernot Posselt, Wolfgang Sperl, Barbara Kofler
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Pharmacology & Pharmacy
Tom Skaria, Esther Bachli, Gabriele Schoedon
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Tom Skaria, Katharyn Jean Mitchell, Olga Vogel, Thomas Walchli, Max Gassmann, Johannes Vogel
CIRCULATION RESEARCH
(2019)
Editorial Material
Biochemistry & Molecular Biology
Tom Skaria, Thomas Walchli, Johannes Vogel
Summary: The US FDA has authorized a drug repurposing trial using CGRP receptor antagonists to reduce lung inflammation in COVID-19. However, concerns about potential cardiopulmonary adverse effects of antagonizing CGRP have been raised, highlighting the importance of early detection and prevention.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Tom Skaria, Esther Bachli, Gabriele Schoedon
Summary: Recent research has demonstrated that the lipid-modified protein Wnt5A induces the expression of drug metabolizing enzymes CYP1A1 and CYP1B1 in human coronary artery endothelial cells, potentially affecting the metabolism of a broad spectrum of drugs including chloroquine. This finding suggests further studies are needed to explore the role of vascular endothelial cell CYP1A1 and CYP1B1 in modulating myocardial pharmacokinetics in inflammatory and cardiovascular diseases associated with Wnt5A.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ahsan Anjoom Sunil, Tom Skaria
Summary: This article reviews the endogenous factors and mechanisms that disrupt the airway epithelial barrier during inflammation, and discusses whether these factors can be specifically targeted by repurposing existing drugs.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Physiology
Tom Skaria, Johannes Vogel
Summary: Regular physical activity has cardiovascular protective effects and increases the concentration of alpha-calcitonin gene-related peptide (alpha CGRP). Alpha CGRP plays a role in vasodilation and migraine. Mouse models suggest that loss of alpha CGRP disrupts the cardiovascular system's adaptation to exercise and worsens cardiovascular damage in chronic hypertension, which can be reversed by alpha CGRP administration. This suggests that alpha CGRP agonists may be a therapeutic option for cardiovascular protection when exercise is not possible or contraindicated. However, the long-term cardiovascular safety of anti-CGRP therapy in individuals with cardiovascular diseases is still uncertain.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Tom Skaria, Mostafa A. Aboouf, Johannes Vogel
Summary: This study presents an improved version of the 1K1C surgery in mice, which successfully induces chronic hypertension and its target organ complications without any intraoperative mortality and with excellent survival rates. The key to this method is performing unilateral nephrectomy one week after renal artery clipping to slow down the increase in blood pressure.
Meeting Abstract
Cardiac & Cardiovascular Systems
T. Skaria, K. Mitchell, J. A. Fischer, W. Born, M. Gassmann, J. Vogel
EUROPEAN HEART JOURNAL
(2019)
