Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Cell Biology
Bram DeWulf, Laurens Minsart, Franck Verdonk, Veronique Kruys, Michael Piagnerelli, Mervyn Maze, Sarah Saxena
Summary: Targeting HMGB1 can be a strategy to reduce sepsis-induced encephalopathy and complement non-pharmacological interventions.
Article
Cardiac & Cardiovascular Systems
Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: The study found that HMGB1 is an independent risk factor for carotid plaque vulnerability in diabetic patients, with higher levels of HMGB1 and inflammatory cytokines in ICAS patients compared to WICAS patients. Among ICAS patients, those with unstable plaque had even higher levels of these cytokines. HMGB1 and osteoprotegerin were independently associated with unstable plaque in ICAS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Immunology
Li Li, Yuan-Qiang Lu
Summary: HMGB1 is a crucial player in the inflammatory response and immunosuppression of sepsis, mediating the release of inflammatory factors and potentially contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ilijana Grigorov, Snezana Pejic, Ana Todorovic, Dunja Drakulic, Filip Veljkovic, Jadranka Miletic Vukajlovic, Katarina Bobic, Ivan Soldatovic, Sinisa Durasevic, Nebojsa Jasnic, Sanja Stankovic, Sofija Glumac, Violeta Mihailovic-Vucinic, Branislava Milenkovic
Summary: Careful monitoring of mild/moderate COVID-19 patients is crucial due to the rapid progression of complications. This study identified HMGB1 and HO-1 as potential biomarkers for COVID-19 management, based on their serum concentrations at hospital admission. The increase in HO-1 may provide protection against oxidative stress and inflammation, while the level of HMGB1 reflects the activity of the innate immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wataru Takaki, Hirotaka Konishi, Daiki Matsubara, Katsutoshi Shoda, Tomohiro Arita, Satoshi Kataoka, Jun Shibamoto, Hirotaka Furuke, Kazuya Takabatake, Hiroki Shimizu, Shuhei Komatsu, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Eigo Otsuji
Summary: This study reveals that extracellular HMGB1 promotes the progression and metastasis of gastric cancer, and plasma HMGB1 concentrations can serve as a prognostic marker in gastric cancer patients. Recombinant human soluble thrombomodulin (rTM) targeting HMGB1 shows potential therapeutic effects in gastric cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Luay Alkazmi, Ola A. Habotta, Gaber El-Saber Batiha
Summary: HMGB1 is a multifunctional nuclear protein that plays a critical role in the inflammatory signaling pathway. Elevated levels of HMGB1 in COVID-19 patients are associated with disease severity and complications. Targeting the HMGB1 pathway may be beneficial in reducing the severity of the disease.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shingo Kishi, Yukiko Nishiguchi, Kanya Honoki, Shiori Mori, Rina Fujiwara-Tani, Takamitsu Sasaki, Kiyomu Fujii, Isao Kawahara, Kei Goto, Chie Nakashima, Akira Kido, Yasuhito Tanaka, Yi Luo, Hiroki Kuniyasu
Summary: CML modification of HMGB1 enhances cancer-promoting effects by promoting cell proliferation, invasion, resistance to therapy, and is associated with oxidative stress and resistance in cancer tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Souad Belmadani, Khalid Matrougui
Summary: This review discusses the role of HMGB1 in cardiovascular complications, particularly in inflammation, and its pathological link with diseases.
Review
Cell Biology
Souad Belmadani, Khalid Matrougui
Summary: HMGB1 is a protein that can be found in the nucleus and cytoplasm, and its biological roles depend on its cellular location and modifications. While its role in inflammation is well-established, its role in cardiovascular diseases is not well understood. This review discusses the latest research on the link between HMGB1 and cardiovascular complications, with a focus on inflammation.
Article
Immunology
Anette Teo Hansen Selno, Stephanie Schlichtner, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Steffen M. Berger, Elena Klenova, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Summary: HMGB1, a non-histone protein, is released by stressed, dying, or dead cells into the extracellular matrix, potentially impacting cancer cells' ability to evade immune surveillance. Through recognition as a ligand, TLR4 mediates the induction of TGF-beta by HMGB1, leading to the expression of the immunosuppressive protein galectin-9 in cancer cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Tuo Tang, Shengnan Wang, Tianyu Cai, Zhenyu Cheng, Yu Meng, Shimei Qi, Yao Zhang, Zhilin Qi
Summary: This study found that HMGB1 promotes proliferation and migration of gastric cancer cells through the RAGE-mediated signaling pathways, involving multiple molecular mechanisms. It highlights HMGB1 as a potential therapeutic target for GC, providing important evidence for future research and treatment strategies.
Review
Neurosciences
Fathimath Zaha Ikram, Alina Arulsamy, Thaarvena Retinasamy, Mohd Farooq Shaikh
Summary: HMGB1 plays a crucial role in neurodegenerative diseases, with levels elevated in most cases. It may act on distinctive pathways to elicit its pathological response leading to various neurodegenerative processes.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Carlo Ticconi, Stefania Mardente, Emanuela Mari, Federica Barreca, Manuela Montanaro, Alessandro Mauriello, Giuseppe Rizzo, Alessandra Zicari
Summary: The levels of HMGB1 in plasma, platelets, and plasma-derived microvesicles were significantly higher in women with unexplained recurrent pregnancy loss (uRPL) compared to control women. Expression of HMGB1 in the endometrium was also higher in women with uRPL. These findings suggest the involvement of HMGB1 in uRPL.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Zhiwu Wu, Liping Liang, Qianliang Huang
Summary: HMGB1 is a cytokine that serves as a marker of inflammation and has multiple functions depending on its subcellular location. CSF HMGB1 may play a role in the pathological mechanisms underlying complications associated with CNS diseases. Measuring the level of HMGB1 in the CSF can help predict disease progression and contribute to pathological alterations in distant areas.
Review
Oncology
Amir Ajoolabady, Daolin Tang, Guido Kroemer, Jun Ren
Summary: Hepatocellular carcinoma is a prevalent form of liver cancer, with genetic, environmental, and behavioral factors influencing its development. Ferroptosis, a form of nonapoptotic cell death, has potential for suppressing hepatocellular carcinoma. However, malignant cells can develop mechanisms to resist ferroptosis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Fangquan Chen, Xiutao Cai, Rui Kang, Jiao Liu, Daolin Tang
Summary: Autophagy determines cell fate in response to environmental stresses and its dependence in cell death signals and mechanisms are still unclear. The discovery of autophagy-dependent ferroptosis provides insights into the relationship between aberrant degradation pathways and excessive lipid peroxidation in driving regulated cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Cell Biology
Liangchun Yang, Fanghua Ye, Jiao Liu, Daniel J. Klionsky, Daolin Tang, Rui Kang
Summary: This study reveals that extracellular SQSTM1 acts as a mediator of acute pancreatitis (AP) by enhancing sensitivity to autophagy-dependent ferroptotic cell death. High levels of serum SQSTM1 are found in AP patients and mice. Administration of SQSTM1-neutralizing antibodies protects mice against experimental AP.
Article
Biochemistry & Molecular Biology
Ruochan Chen, Ju Zou, Rui Kang, Daolin Tang
Summary: HMGB1 is a redox-sensitive protein that regulates stress responses, cell death, and inflammatory diseases. Understanding its role in cellular redox homeostasis is crucial for deciphering cellular functions and pathological manifestations.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Daolin Tang, Rui Kang
Summary: Over the past decade, research has focused on understanding oxidative cell death, particularly the transition from oxytosis to ferroptosis. Oxytosis, a form of nerve cell death induced by glutamate, was associated with intracellular glutathione depletion and inhibition of cystine uptake. The term ferroptosis was coined during a compound screening in 2012 and is induced by inhibitors of system xc(-) and GPX4. This article reviews the significant findings, models, and mechanisms of ferroptosis, and discusses its implications in various pathological conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Yang Liu, Yuan Wang, Zhi Lin, Rui Kang, Daolin Tang, Jiao Liu
Summary: SLC25A22 acts as a metabolic repressor of ferroptosis by producing glutathione and monounsaturated fatty acids, providing a previously unrecognized defense pathway against ferroptotic cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Cell Biology
Yangchun Xie, Rui Kang, Daniel J. Klionsky, Daolin Tang
Summary: Selenoprotein GPX4 is the main oxidoreductase that uses glutathione to scavenge lipid peroxidation products. It has three isoforms with distinct expression patterns and its loss can trigger various forms of cell death and inflammation. GPX4's interaction with autophagy pathway modulates cell fate in response to oxidative stress. Impairment of GPX4 function is implicated in various diseases. Furthermore, a specific mutation in GPX4 is associated with a rare and fatal disease in newborns. This article discusses the roles of GPX4 in cell death, autophagy, and disease.
Editorial Material
Biotechnology & Applied Microbiology
Ruoxi Zhang, Rui Kang, Daolin Tang
Summary: The balance of oxidants and antioxidants, known as redox homeostasis, is crucial for cell function. Disruption of redox homeostasis is linked to the development and treatment of various diseases, including cancer. Recent studies have shown that both oxidative and reductive stress can trigger regulated cell death, such as disulfidptosis and pyroptosis, in cancer and immune cells. Exploring the relationship between oxidative and reductive cell death could lead to novel disease treatments.
CANCER GENE THERAPY
(2023)
Article
Oncology
Ruoxi Zhang, Rui Kang, Daolin Tang
Summary: Ferroptosis is a regulated cell death process triggered by excessive lipid peroxidation, leading to plasma membrane damage and the release of damage-associated molecular patterns. It has gained attention in cancer research, specifically in gastrointestinal (GI) cancers, due to its unique mechanism compared to other forms of regulated cell death. Exploring the role of ferroptosis in GI cancers may offer new treatment strategies for overcoming drug resistance caused by defects in apoptotic pathways.
Article
Otorhinolaryngology
Zhengyu Lin, Baihui He, Chun Chen, Qiong Wu, Xiaowen Wang, Mingyue Hou, Maoli Duan, Jun Yang, Lianhua Sun
Summary: This study utilized mass spectrometry technology to analyze the expression changes of proteins in peripheral blood mononuclear cells (PBMCs) of patients with Meniere's disease (MD). The results identified potential differential proteins and revealed bioinformatics-related mechanisms of the disease. The findings suggest that endocytosis may be involved in the pathogenesis of sporadic MD, and CHMP1A, VPS4A, FCN3, and MMP9 could be potential biomarkers.
ACTA OTO-LARYNGOLOGICA
(2023)
Review
Cell Biology
Zhi Lin, Fei Long, Rui Kang, Daniel J. Klionsky, Minghua Yang, Daolin Tang
Summary: This article provides a comprehensive summary of the latest research on the role and potential mechanisms of different lipids in regulating regulated cell death processes, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy.
Article
Biochemistry & Molecular Biology
Daolin Tang, Rui Kang
Summary: Inflammation is an immune response triggered by harmful stimuli, and protein degradation plays a crucial role in regulating this process. SQSTM1 protein, initially identified as a partner of lymphocyte-specific protein tyrosine kinase, interacts with various substrates, facilitating their delivery to the lysosome for degradation. In addition, SQSTM1 is reported to be secreted or released, orchestrating inflammatory responses. Its significance has been highlighted in various inflammation-related diseases. Further investigations are needed to unravel the precise functions of SQSTM1.
Review
Immunology
Daolin Tang, Guido Kroemer, Rui Kang
Summary: Ferroptosis is a regulated cell death process that occurs when there is an accumulation of toxic lipid peroxides, particularly in the plasma membrane, due to iron-dependency. While it is crucial for maintaining overall health, it can also lead to tissue damage and pathological conditions. Understanding the immune characteristics of ferroptosis in infection, sterile inflammation, and tumor immunity is important for developing therapeutic strategies.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Lanlan Tang, Yan Yu, Wenjun Deng, Jiao Liu, Yichun Wang, Fanghua Ye, Rui Kang, Daolin Tang, Qingnan He
Summary: A study has identified a mechanism of ferroptosis resistance involving the upregulation of TXNDC12, which inhibits lipid peroxidation without affecting iron accumulation during ferroptosis. The study also found that the absence of TXNDC12 enhances the tumor-suppressive effects of ferroptosis induction. These findings demonstrate a potential translational application in cancer treatment.
Review
Immunology
Daolin Tang, Rui Kang, Herbert J. Zeh, Michael T. Lotze
Summary: Fifty years since the discovery of HMGB1 protein, its physiological and pathological roles have been extensively studied. This Review covers the structure, localization, and functions of HMGB1 in immune responses, including historical foundations and recent advances.
NATURE REVIEWS IMMUNOLOGY
(2023)
