Article
Multidisciplinary Sciences
Lukmanee Tradtrantip, Michael R. Yeaman, A. S. Verkman
Summary: NMOSD is an autoimmune inflammatory disease where most patients have AQP4-IgG antibodies that cause inflammation and demyelination. Some patients have protective antibodies in their serum that can prevent cytotoxic effects of AQP4-IgG on cells.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Tetsuya Akaishi, Toshiyuki Takahashi, Tatsuro Misu, Kimihiko Kaneko, Yoshiki Takai, Shuhei Nishiyama, Ryo Ogawa, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima
Summary: Intrathecal production of MOG-IgG may occur more frequently than that of AQP4-IgG, suggesting different properties of B-cell trafficking and antibody production between MOG-IgG-associated disease and AQP4-IgG-positive NMOSD.
Article
Immunology
Elia Sechi, Roberto Zarbo, Maria Angela Biancu, Paola Chessa, Maria Laura Idda, Valeria Orru, Sandra Lai, Stefania Leoni, Paolo Solla
Summary: This article describes an unusual case of a 40-year-old woman with AQP4-IgG-NMOSD who showed prolonged B-cell depletion for nearly five years after a single rituximab reinfusion. In similar rare patients with exceptionally long-lasting B-cell depletion, rituximab reinfusions at fixed pre-planned intervals would result in unnecessary treatment-related risks and health-care expenses.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Clinical Neurology
Jie Li, Sam A. Bazzi, Florian Schmitz, Hidetaka Tanno, Jonathan R. McDaniel, Chang-Han Lee, Chaitanya Joshi, Jin Eyun Kim, Nancy Monson, Benjamin M. Greenberg, Kristina Hedfalk, Esther Melamed, Gregory C. Ippolito
Summary: High-throughput sequencing and quantitative immunoproteomics were used to identify distinct AQP4-IgG lineages in NMOSD patients. The composition and polarization of these antibody repertoires may influence the pathogenesis and clinical presentation of NMOSD, with further potential applications in monitoring disease activity and understanding autoimmune diseases.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Luca Bollo, Pietro Iaffaldano, Maddalena Ruggieri, Claudia Palazzo, Mariangela Mastrapasqua, Alessia Manni, Damiano Paolicelli, Antonio Frigeri, Maria Trojano
Summary: The study aimed to evaluate longitudinal changes of serum MOG-IgG and AQP4-IgG antibody titer in NMOSD patients and found that the semiquantitative ratiometric method accurately detects even slight variation, suggesting its usefulness in monitoring disease progression and maintenance immunotherapy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Samantha A. Banks, Padraig P. Morris, John J. Chen, Sean J. Pittock, Elia Sechi, Amy Kunchok, Jan-Mendelt Tillema, James P. Fryer, Brian G. Weinshenker, Karl N. Krecke, A. Sebastian Lopez-Chiriboga, Adam Nguyen, Tammy M. Greenwood, Claudia F. Lucchinetti, Nicholas L. Zalewski, Steven A. Messina, Eoin P. Flanagan
Summary: The study found that involvement of the brainstem or cerebellum is common in MOGAD, usually occurring as part of a multifocal central nervous system attack rather than in isolation. Compared to AQP4-IgG-NMOSD and MS, MOGAD patients are younger and exhibit specific MRI characteristics.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Immunology
Florence Pache, Marius Ringelstein, Orhan Aktas, Ingo Kleiter, Sven Jarius, Nadja Siebert, Judith Bellmann-Strobl, Friedemann Paul, Klemens Ruprecht
Summary: The study found subtle complement consumption in clinically stable AQP4-IgG+ NMOSD patients, but not in MOGAD patients.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Clinical Neurology
Ying Fu, Jin Bi, Yaping Yan, Xiaobo Sun, Ke Li, So Yeon Kim, Sang-Min Han, Luyao Zhou, Rui Li, Qiao Huang, Ning Wang, Aiyu Lin, Ho Jin Kim, Wei Qiu
Summary: The study validates an enzyme immunodot assay as a simple and rapid method for detecting AQP4-IgG. With its time- and cost-efficient characteristics, the immunodot assay may be a practical option for AQP4-IgG detection.
Article
Neurosciences
Valeria Vasciaveo, Antonella Iadarola, Antonino Casile, Davide Dante, Giulia Morello, Lorenzo Minotta, Elena Tamagno, Alessandro Cicolin, Michela Guglielmotto
Summary: This study found that sleep fragmentation accelerates the progression of Alzheimer's disease in 5xFAD mice and affects cognitive behaviors in wild type mice. The impact of sleep fragmentation on AD progression may be related to the modulation of the key water channel protein aquaporin-4 (AQP4).
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ana del Puerto, Julia Pose-Utrilla, Ana Simon-Garcia, Celia Lopez-Menendez, Antonio J. Jimenez, Eva Porlan, Luis S. M. Pajuelo, Guillermo Cano-Garcia, Beatriz Marti-Prado, Alvaro Sebastian-Serrano, Marina P. Sanchez-Carralero, Fabrizia Cesca, Giampietro Schiavo, Isidro Ferrer, Isabel Farinas, Miguel R. Campanero, Teresa Iglesias
Summary: Kidins220 is a critical regulator of cerebrospinal fluid homeostasis, and its deficiency can lead to ventriculomegaly and dysregulation of water balance, affecting the expression of AQP4.
MOLECULAR PSYCHIATRY
(2021)
Article
Immunology
Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suarez, Patrick Schindler, Cesar Alvarez-Gonzalez, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Gruetz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Huebsch, Friedemann Paul, Carmen Infante-Duarte
Summary: This study aimed to evaluate cell death in neutrophils from Aquaporin-4 (AQP4)-IgG seropositive NMOSD and MOGAD patients. The results showed that neutrophils from AQP4 + NMOSD patients exhibited enhanced survival capacity in response to PMA stimulation, but also increased early apoptotic response.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Clinical Neurology
Giulia Fadda, Eoin P. Flanagan, Laura Cacciaguerra, Jiraporn Jitprapaikulsan, Paolo Solla, Pietro Zara, Elia Sechi
Summary: Inflammatory myelopathies can cause motor, sensory, and autonomic dysfunction. Early recognition and treatment are crucial to prevent long-term disability.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Vanina Netti, Juan Fernandez, Luciana Melamud, Pablo Garcia-Miranda, Gisela Di Giusto, Paula Ford, Miriam Echevarria, Claudia Capurro
Summary: The study reveals that binding of AQP4-IgG to AQP4 in Muller cells leads to partial internalization of AQP4, reducing membrane water permeability and swelling-induced increase in intracellular calcium levels, thereby affecting cell volume regulation and proliferation functions of Muller cells.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Angeliki G. Filippatou, Eleni S. Vasileiou, Yufan He, Kathryn C. Fitzgerald, Grigorios Kalaitzidis, Jeffrey Lambe, Maureen A. Mealy, Michael Levy, Yihao Liu, Jerry L. Prince, Ellen M. Mowry, Shiv Saidha, Peter A. Calabresi, Elias S. Sotirchos
Summary: This study compared retinal layer thicknesses between AQP4-IgG+ NMOSD eyes without a history of ON and healthy controls using OCT, finding evidence of subclinical retinal ganglion cell neuronal and axonal loss, as well as photoreceptor layer involvement in AQP4-nonON eyes. These results suggest that subclinical anterior visual pathway involvement may occur in AQP4-IgG+ NMOSD.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Cheng Wu, Qun Zhang, Yi-Wei Feng, Ni Zhang, Qi Liu, Zi-Tong Ou, Tuo Lin, Qian Ding, Ge Li, Zhong Pei, Yue Lan, Guang-Qing Xu
Summary: The glymphatic system, which is responsible for removing protein solutes and metabolic waste from the brain, is influenced by the neurotransmitter GABA. Activation of the GABA system promotes glymphatic clearance, and cTBS can modulate the glymphatic pathway through the GABA system. These findings suggest that regulating the GABA system may be beneficial for preventing and treating diseases related to abnormal protein deposition.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Anne Joutel, Iman Haddad, Julien Ratelade, Mark T. Nelson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Article
Clinical Neurology
Lamia Ghezali, Carmen Capone, Celine Baron-Menguy, Julien Ratelade, Soren Christensen, Lars Ostergaard Pedersen, Valerie Domenga-Denier, Jan Torleif Pedersen, Anne Joutel
ANNALS OF NEUROLOGY
(2018)
Article
Oncology
Julien Ratelade, Nicolas Mezouar, Valerie Domenga-Denier, Ambre Rochey, Emmanuelle Plaisier, Anne Joutel
JOURNAL OF PATHOLOGY
(2018)
Article
Clinical Neurology
Nithi Asavapanumas, Julien Ratelade, A. S. Verkman
ACTA NEUROPATHOLOGICA
(2014)
Article
Clinical Neurology
Julien Ratelade, Nithi Asavapanumas, Alanna M. Ritchie, Scott Wemlinger, Jeffrey L. Bennett, A. S. Verkman
ACTA NEUROPATHOLOGICA
(2013)
Article
Clinical Neurology
Lukmanee Tradtrantip, Julien Ratelade, Hua Zhang, A. S. Verkman
ANNALS OF NEUROLOGY
(2013)
Article
Neurosciences
Julien Ratelade, Alex J. Smith, A. S. Verkman
EXPERIMENTAL NEUROLOGY
(2014)
Article
Biochemistry & Molecular Biology
Ryuichi Katada, Gokhan Akdemir, Nithi Asavapanumas, Julien Ratelade, Hua Zhang, A. S. Verkman
Review
Biochemistry & Molecular Biology
Julien Ratelade, A. S. Verkman
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Puay-Wah Phuan, Julien Ratelade, Andrea Rossi, Lukmanee Tradtrantip, A. S. Verkman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Cell Biology
Alex J. Smith, Byung-Ju Jin, Julien Ratelade, Alan S. Verkman
JOURNAL OF CELL BIOLOGY
(2014)
Article
Immunology
Nithi Asavapanumas, Julien Ratelade, Marios C. Papadopoulos, Jeffrey L. Bennett, Marc H. Levin, Alan S. Verkman
JOURNAL OF NEUROINFLAMMATION
(2014)
Article
Clinical Neurology
Rabia Malik, Aaron Lewis, Bruce A. C. Cree, Julien Ratelade, Andrea Rossi, Alan S. Verkman, Andrew W. Bollen, Jeffrey W. Ralph
Article
Neurosciences
Goekhan Akdemir, Julien Ratelade, Nithi Asavapanumas, A. S. Verkman
NEUROSCIENCE LETTERS
(2014)