Article
Biochemistry & Molecular Biology
Zhen Pan, Shi-jie Li, Hua Guo, Zhao-hui Li, Xiang Fei, Shi-min Chang, Qing-cheng Yang, Dong-dong Cheng
Summary: Numerous studies have shown that anti-inflammatory agents can have antitumor effects in cancer therapy by directly increasing apoptosis and sensitivity to therapies, and decreasing invasion and metastasis. In this study, ebastine, a H1-histamine receptor antagonist, was screened and found to have antitumor effects in osteosarcoma cells. Ebastine treatment induced cell cycle arrest, inhibited metastasis, and induced apoptosis and autophagy both in vitro and in vivo. Mechanistically, ebastine activated the AMPK/ULK1 signaling pathway, triggering proapoptotic autophagy. IPMK was identified as a positive regulator of AMPK in osteosarcoma cells, and IPMK knockdown reversed the effects of ebastine on autophagy and AMPK/ULK1 signaling. This study suggests that ebastine has potential as a therapeutic candidate for osteosarcoma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Khoa Nguyen, Katherine Hebert, Emily McConnell, Nicole Cullen, Thomas Cheng, Susanna Awoyode, Elizabeth Martin, Weina Chen, Tong Wu, Suresh K. Alahari, Reza Izadpanah, Bridgette M. Collins-Burow, Sean B. Lee, David H. Drewry, Matthew E. Burow
Summary: The liver is an important organ involved in biological functions such as digestion, nutrient storage, and detoxification. It plays an active role in regulating metabolism and is susceptible to hepatocellular carcinoma, which is often associated with chronic inflammation. LKB1 signaling has been found to regulate cellular metabolism and has a tumor suppressive role in many cancers. Using the KMPlotter database, this review correlates RNA levels of LKB1 signaling genes with hepatocellular carcinoma patient survival outcomes and identifies potential biomarkers for clinical use.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Navid Omidkhoda, Sina Mahdiani, A. Wallace Hayes, Gholamreza Karimi
Summary: This article summarizes in vitro and in vivo studies on the effect of natural bioactive compounds on NAFLD through the LKB1/AMPK signaling pathway, providing clues for finding new therapeutic agents for NAFLD management.
PHYTOTHERAPY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Qing-Bo Lu, Yi Ding, Yao Liu, Zi-Chao Wang, Yu-Jie Wu, Kai -Ming Niu, Ke-Xue Li, Ji -Ru Zhang, Hai-Jian Sun
Summary: Metrnl plays a protective role in diabetic cardiomyopathy and may serve as a therapeutic target or regimen.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jun H. Heo, Sang R. Lee, Seong Lae Jo, Je-Won Ko, Hyo-Jung Kwon, Eui-Ju Hong
Summary: The incidence of non-alcoholic fatty liver disease (NAFLD) increases in males aged >45 years, which indicates that androgens are associated with the development and/or progression of NAFLD, although excess dietary intake is the primary causative factor. Our study demonstrates that testosterone can influence the development of NAFLD by increasing the expression of AMP-activated protein kinase (AMPK) and LKB1 and modulating the AMPK-ACC signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yi Zhang, Fang Zhou, Jiaheng Guan, Lukun Zhou, Baoan Chen
Summary: Hematologic malignancies pose a serious threat to human life and health, and existing treatments have limited options and can result in tumor recurrence and drug resistance. Metformin, a first-line drug for type 2 diabetes, has been found to have potential anti-cancer abilities in both diabetic and non-diabetic patients. It may activate the AMPK signaling pathway and other pathways to exert anti-cancer effects, and combining it with conventional anti-cancer drugs may improve efficacy and reduce adverse reactions. Therefore, metformin can be used as an adjuvant therapeutic agent for hematologic malignancies.
Article
Biochemistry & Molecular Biology
Fotian Xie, Yuanming Zhong, Dongmei Wang, Kwok Fai So, Jia Xiao, Yi Lv
Summary: This study found that metformin can protect against lipid formation in ALD by activating the LKB1/AMPK/ACC axis. This research is important for understanding the lipid metabolism mechanisms in ALD and developing therapeutic strategies for ALD.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Medicinal
Xinxin Zhang, Yating Qin, Weibin Ruan, Xiaoning Wan, Chao Lv, Lin He, Li Lu, Xiaomei Guo
Summary: Baicalein, a flavonoid phytochemical, demonstrates anti-inflammatory properties in macrophages, endothelial cells, and vascular smooth muscle cells by activating the AMPK/Mfn-2 axis and inhibiting MAPKs/NF-kappa B signaling transduction pathway. Baicalein effectively reduces proinflammatory cytokine levels, suggesting its potential role in atherosclerosis treatment. Further studies may be needed to fully understand the mechanisms of baicalein's anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Review
Endocrinology & Metabolism
Marc Foretz, Bruno Guigas, Benoit Viollet
Summary: This Review presents the latest advances in understanding the mechanisms of action of metformin and discusses its potential repurposing for other indications. Metformin is currently the first-line medication for treating type 2 diabetes in most guidelines and is widely used by over 200 million patients. Its therapeutic action involves complex mechanisms that are not fully understood. Although the liver was initially identified as the main organ involved, increasing evidence suggests the involvement of other sites, including the gastrointestinal tract, gut microbial communities, and tissue-resident immune cells. The molecular mechanisms of metformin vary depending on the dose and duration of treatment, and recent studies have revealed a novel action on the lysosome surface at low concentrations. Considering its efficacy and safety in diabetes, attention has been given to using metformin as adjunct therapy for cancer, age-related diseases, inflammatory diseases, and COVID-19.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Cell Biology
Zeli Song, Haoyue Mao, Jinxuan Liu, Wenchang Sun, Shengwen Wu, Xiaobo Lu, Cuihong Jin, Jinghua Yang
Summary: This study found that LaCl3 exposure can cause abnormal axons in offspring rats by interfering with the normal effects of LKB1 and downregulating the LKB1-MARK2 and LKB1-STK25-GM130 signaling pathways.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Plant Sciences
Guangsen Li, Yuanjie Xu, Yingxi Li, Degui Chang, Peihai Zhang, Ziyang Ma, Di'ang Chen, Yaodong You, Xiaopeng Huang, Jian Cai
Summary: This study investigated the effects of Qiangjing tablets on asthenozoospermia and the underlying mechanism. The results showed that Qiangjing tablets significantly improved sperm motility and pathological symptoms, and improved mitochondrial structure and oxidative stress through mitochondrial ubiquitination and mitophagy. The beneficial effects of Qiangjing tablets on asthenozoospermia were mediated by the LKB1/AMPK/ULK1 signaling pathway, providing a theoretical basis for the treatment of male infertility.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Laetitia Dard, Christophe Hubert, Pauline Esteves, Wendy Blanchard, Ghina Bou About, Lyla Baldasseroni, Elodie Dumon, Chloe Angelini, Megane Delourme, Veronique Guyonnet-Duperat, Stephane Claverol, Laura Fontenille, Karima Kissa, Pierre-Emmanuel Seguela, Jean-Benoit Thambo, Levy Nicolas, Yann Herault, Nadege Bellance, Nivea Dias Amoedo, Frederique Magdinier, Tania Sorg, Didier Lacombe, Rodrigue Rossignol
Summary: This study analyzed the molecular determinants of Costello syndrome and found that mitochondrial proteostasis and bioenergetics play a crucial role in the pathophysiology of the disease. The study suggests that patients with Costello syndrome may benefit from treatment with mitochondrial modulators.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Medicine, Research & Experimental
Guangli Lu, Zhen Wu, Jia Shang, Zhenxing Xie, Chaoran Chen, Chuning Zhang
Summary: Metformin is the first-line option for treating diabetic patients and has various pharmacological actions, including antitumor, anti-aging, and ovarian protection effects. Recent research has shown that autophagy is a crucial mechanism through which metformin exerts its pharmacological actions, although the effects on autophagy remain inconsistent.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Chunyang Chen, He Wang, Xinyu Geng, Dongze Zhang, Zhengyu Zhu, Guangbo Zhang, Jianquan Hou
Summary: This study confirmed the inhibitory effect of metformin on prostate cancer cell lines, with mechanisms involving autophagy and cell cycle arrest at G0/G1 phase. Metformin induced AMPK activation, promoted LC3II expression, and down-regulated p62/SQSTM1 expression. Animal experiments demonstrated that metformin reduced tumor volume, upregulated p-AMPK (Thr172) and LC3B, and downregulated Ki-67 levels without abnormal biochemical indicators.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao, Qian Wang, Wenyong Xiong
Summary: As a global epidemic disease, obesity leads to dysfunction of glucose and lipid metabolism, resulting in high morbidity and mortality. This study found that alisol B, a triterpene monomer from the Chinese medicine Alisma orientale, can suppress adipogenesis, reduce subcutaneous adipose tissue mass, and improve obesity-related metabolic disorders. The effects of alisol B on adipogenesis are mediated by the LKB1-AMPK signaling pathway. Overall, alisol B could be a potential lead compound for the treatment of obesity-related metabolic disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)