Article
Biochemistry & Molecular Biology
Joan Gil, Montserrat Marques-Pamies, Elena Valassi, Araceli Garcia-Martinez, Guillermo Serra, Cristina Hostalot, Carmen Fajardo-Montanana, Cristina Carrato, Ignacio Bernabeu, Monica Marazuela, Helena Rodriguez-Lloveras, Rosa Camara, Isabel Salinas, Cristina Lamas, Betina Biagetti, Andreu Simo-Servat, Susan M. Webb, Antonio Pico, Mireia Jorda, Manel Puig-Domingo
Summary: Acromegaly is a condition caused by excessive growth hormone production due to a pituitary tumor. This study examines the relationship between epithelial-mesenchymal transition (EMT) and resistance to somatostatin receptor ligands (SRLs) in GH-producing tumors. The findings suggest that EMT-related gene expression patterns are heterogeneous, which may explain the varying responses to SRLs.
Article
Oncology
Teresa Pecere, Eleonora Ponterio, Enzo Di Iorio, Modesto Carli, Matteo Fassan, Luisa Santoro, Maicol Bissaro, Giulia Bernabe, Stefano Moro, Ignazio Castagliuolo, Giorgio Palu
Summary: The study demonstrates that aloe-emodin enters tumor cells through somatostatin receptors SSTR2 and SSTR5. SSTR2 expression was found in all surgical neuroblastoma specimens analyzed, highlighting the potential clinical application of aloe-emodin as an antitumor agent.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Pedro Marques
Summary: Limited options are available for patients with aggressive or metastatic pituitary neuroendocrine tumours (PitNETs). Peptide receptor radionuclide therapy (PRRT), commonly used for gastroenteropancreatic neuroendocrine tumours, is being considered as a potential treatment for aggressive or metastatic PitNETs when other approaches fail. However, there is limited data on the use of PRRT in this context, mostly derived from case reports or small case series. This review examines the effectiveness and safety of PRRT in managing aggressive or metastatic PitNETs, as well as its effects on pituitary function in other cancer patients.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Noah Lybik, Daniel J. Wale, Ka Kit Wong, Eric Liao, Benjamin L. Viglianti
Summary: Somatostatin receptor imaging, commonly used in neuroendocrine oncology, may have diagnostic utility in various tumors beyond gastroenteropancreatic neuroendocrine neoplasms. In challenging cases, theranostic principles utilizing somatostatin receptor-based therapy could offer potential treatment options.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Cell Biology
Jiri Soukup, Helena Hornychova, Monika Manethova, Kvetoslava Michalova, Ludmila Michnova, Lenka Popovska, Veronika Skarkova, Tomas Cesak, David Netuka, Ales Ryska, Jan Cap, Vaclav Hana, Vaclav Hana, Michal Krsek, Eva Dvorakova, Michal Krcma, Ivica Lazurova, Vera Olsovska, Karel Stary, Peter Vanuga, Filip Gabalec
Summary: In patients with acromegaly, factors significantly associated with SSA treatment outcome include age, IGF1 levels, tumour size, and expression of E-cadherin and SSTR2A. A poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A, and higher Ki67 in the sparsely granulated tumour group. Multiple factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Daniela Modena, Maria Luisa Moras, Giovanni Sandrone, Andrea Stevenazzi, Barbara Vergani, Pooja Dasgupta, Andrea Kliever, Sebastian Gulde, Alessandro Marangelo, Mathias Schillmaier, Raul M. Luque, Stephen Baeuerle, Natalia S. Pellegata, Stefan Schulz, Christian Steinkuehler
Summary: Therapy for nonfunctioning pituitary adenomas (NFPAs) is an unmet medical need. We discovered that ITF2984, a molecule originally developed as a pan-SSTR agonist, is a full agonist of SSTR3 and showed significant antitumor activity in an in vivo model. ITF2984 may provide a new therapeutic option for NFPA patients.
Article
Endocrinology & Metabolism
Joan Gil, Montserrat Marques-Pamies, Elena Valassi, Guillermo Serra, Isabel Salinas, Gemma Xifra, Paula Casano-Sancho, Cristina Carrato, Betina Biagetti, Gemma Sesmilo, Jennifer Marcos-Ruiz, Helena Rodriguez-Lloveras, Anna Rueda-Pujol, Anna Aulinas, Alberto Blanco, Cristina Hostalot, Andreu Simo-Servat, Fernando Munoz, Marta Rico, Javier Ibanez-Dominguez, Esteban Cordero, Susan M. Webb, Mireia Jorda, Manel Puig-Domingo
Summary: This study evaluated the expression of epithelial-mesenchymal transition (EMT)-related markers in non-functioning pituitary neuroendocrine tumors (NF-PitNET) and found that NF-PitNET had an enhanced EMT phenomenon. SSTR3 targeting could be a potential therapeutic option for NF-PitNET, except for silent corticotroph adenomas. PEBP1 could be an informative biomarker for tumor regrowth in NF-PitNET.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Clarissa G. Borba Herkenhoff, Ericka B. Trarbach, Rafael Loch Batista, Ibere Cauduro Soares, Fernando Pereira Frassetto, Felipe Barjud Pereira do Nascimento, Isabella Pacetti Pajaro Grande, Paula P. B. Silva, Felipe H. G. Duarte, Marcello D. Bronstein, Raquel S. Jallad
Summary: In somatotropinomas, low expression of survivin is predictive of resistance to fg-SRL, but not of tumor invasiveness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Shista Priyadarshini, Derek B. Allison, Aman Chauhan
Summary: This systematic review compiles and discusses the prevalence of somatostatin receptor expression in various neoplasms, highlighting the significance of somatostatin receptors as targets for diagnostics and therapeutics.
Article
Multidisciplinary Sciences
Caroline Lamarche, Kirsten Ward-Hartstonge, Tian Mi, David T. S. Lin, Qing Huang, Andrew Brown, Karlie Edwards, Gherman E. Novakovsky, Christopher N. Qi, Michael S. Kobor, Caitlin C. Zebley, Evan W. Weber, Crystal L. Mackall, Megan K. Levings
Summary: Regulatory T cells (Tregs) are susceptible to exhaustion, which can limit their therapeutic effect. A comprehensive investigation on exhaustion in Tregs reveals key similarities and differences with exhausted conventional T cells. This finding has important implications for the design of CAR Treg adoptive immunotherapy strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Rihards Saksis, Olesja Rogoza, Helvijs Niedra, Kaspars Megnis, Ilona Mandrika, Inga Balcere, Liva Steina, Janis Stukens, Austra Breiksa, Jurijs Nazarovs, Jelizaveta Sokolovska, Ilze Konrade, Raitis Peculis, Vita Rovite
Summary: In this study, the transcriptomic landscape of GH-producing PitNETs was investigated, revealing distinct changes in growth hormone related pathways and other cellular processes. The treatment regimens in the pituispheres model were found to affect specific cell proliferation and core functionality pathways. This study emphasizes the importance of selecting the correct model system for cell transcriptomic profiling and data interpretation.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Review
Biochemistry & Molecular Biology
Daniel G. Henriques, Elisa B. Lamback, Romulo S. Dezonne, Leandro Kasuki, Monica R. Gadelha
Summary: This review focuses on the most validated miRNAs involved in the pathogenesis of acromegaly and resistance to first-generation somatostatin receptor ligands (fg-SRL), as well as circulating miRNAs in acromegaly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Giovanni Tulipano, Andrea Giustina
Summary: Autophagy is an important cellular process involved in degradation and recycling, regulated by various stimuli and having complex roles in tumor cells. Research on autophagy in the pituitary gland and pituitary tumors is still relatively limited, but gaining attention for its potential implications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Endocrinology & Metabolism
Yuheng Hu, Zeng Ye, Fei Wang, Yi Qin, Xiaowu Xu, Xianjun Yu, Shunrong Ji
Summary: SSTRs have significant clinical significance in pNETs, serving as important targets for diagnosis and treatment, but further research is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Raul M. Luque, Alejandro Ibanez-Costa, Leonardo Vieira Neto, Giselle F. Taboada, Daniel Hormaechea-Agulla, Leandro Kasuki, Eva Venegas-Moreno, Alberto Moreno-Carazo, Maria Angeles Galvez, Alfonso Soto-Moreno, Rhonda D. Kineman, Michael D. Culler, Manuel D. Gahete, Monica R. Gadelha, Justo P. Castano
Article
Oncology
Raul M. Luque, Miguel Sampedro-Nunez, Manuel D. Gahete, Ana Ramos-Levi, Alejandro Ibanez-Costa, Esther Rivero-Cortes, Ana Serrano-Somavilla, Magdalena Adrados, Michael D. Culler, Justo P. Castano, Monica Marazuela
Article
Oncology
Miguel Sampedro-Nunez, Raul M. Luque, Ana M. Ramos-Levi, Manuel D. Gahete, Ana Serrano-Somavilla, Alicia Villa-Osaba, Magdalena Adrados, Alejandro Ibanez-Costa, Elena Martin-Perez, Michael D. Culler, Monica Marazuela, Justo P. Castano
Article
Multidisciplinary Sciences
Alejandro Ibanez-Costa, Manuel D. Gahete, Esther Rivero-Cortes, David Rincon-Fernandez, Richard Nelson, Manuel Beltran, Andres de la Riva, Miguel A. Japon, Eva Venegas-Moreno, Ma Angeles Galvez, Juan A. Garcia-Arnes, Alfonso Soto-Moreno, Jennifer Morgan, Natia Tsomaia, Michael D. Culler, Carlos Dieguez, Justo P. Castano, Raul M. Luque
SCIENTIFIC REPORTS
(2015)
Article
Endocrinology & Metabolism
Thomas Guenther, Michael Culler, Stefan Schulz
MOLECULAR ENDOCRINOLOGY
(2016)
Article
Oncology
Manuel D. Gahete, David Rincon-Fernandez, Mario Duran-Prado, Marta Hergueta-Redondo, Alejandro Ibanez-Costa, Alejandro Rojo-Sebastian, Francisco Gracia-Navarro, Michael D. Culler, Oriol Casanovas, Gema Moreno-Bueno, Raul M. Luque, Justo P. Castano
Article
Biochemistry & Molecular Biology
Daniel Hormaechea-Agulla, Juan M. Jimenez-Vacas, Enrique Gomez-Gomez, Fernando L. - Lopez, Julia Carrasco-Valiente, Jose Valero-Rosa, Maria M. Moreno, Rafael Sanchez-Sanchez, Rosa Ortega-Salas, Francisco Gracia-Navarro, Michael D. Culler, Alejandro Ibanez-Costa, Manuel D. Gahete, Maria J. Requena, Justo P. Castano, Raul M. Luque
Article
Biochemistry & Molecular Biology
Daniel Hormaechea-Agulla, Manuel D. Gahete, Juan M. Jimenez-Vacas, Enrique Gomez-Gomez, Alejandro Ibanez-Costa, Fernando L-Lopez, Esther Rivero-Cortes, Andre Sarmento-Cabral, Jose Valero-Rosa, Julia Carrasco-Valiente, Rafael Sanchez-Sanchez, Rosa Ortega-Salas, Maria M. Moreno, Natia Tsomaia, Steve M. Swanson, Michael D. Culler, Maria J. Requena, Justo P. Castano, Raul M. Luque
Article
Genetics & Heredity
Kristina B. Dossing, Christina Kjaer, Jonas Vikesa, Tina Binderup, Ulrich Knigge, Michael D. Culler, Andreas Kjaer, Birgitte Federspiel, Lennart Friis-Hansen
Article
Medicine, Research & Experimental
Lex Van der Ploeg, Haley Laken, Shubh Sharma, Rakesh Datta, Heather Halem, Jesse Dong, Caroline Touvay, Marc Teillot, Patrick Noonan, Lou Tartaglia, Liz Stoner, Bart Henderson, Keith Gottesdiener, Michael Culler
Article
Cell Biology
M. Ruscica, P. Magni, L. Steffani, F. Gatto, M. Albertelli, R. Rametta, L. Valenti, P. Amen, V. Magnaghi, M. D. Culler, F. Minuto, D. Ferone, M. Arvigo
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2014)
Review
Pharmacology & Pharmacy
Thomas Guenther, Giovanni Tulipano, Pascal Dournaud, Corinne Bousquet, Zsolt Csaba, Hans-Juergen Kreienkamp, Amelie Lupp, Marta Korbonits, Justo P. Castano, Hans-Juergen Wester, Michael Culler, Shlomo Melmed, Stefan Schulz
PHARMACOLOGICAL REVIEWS
(2018)
Article
Multidisciplinary Sciences
Alejandro Ibanez-Costa, Laura M. Lopez-Sanchez, Manuel D. Gahete, Esther Rivero-Cortes, Mari C. Vazquez-Borrego, Maria A. Galvez, Andres de la Riva, Eva Venegas-Moreno, Luis Jimenez-Reina, Alberto Moreno-Carazo, Francisco J. Tinahones, Silvia Maraver-Selfa, Miguel A. Japon, Juan A. Garcia-Arnes, Alfonso Soto-Moreno, Susan M. Webb, Rhonda D. Kineman, Michael D. Culler, Justo P. Castano, Raul M. Luque
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Aura D. Herrera-Martinez, Rosanna van den Dungen, Fadime Dogan-Oruc, Peter M. van Koetsveld, Michael D. Culler, Wouter W. de Herder, Raul M. Luque, Richard A. Feelders, Leo J. Hofland
ENDOCRINE-RELATED CANCER
(2019)
Article
Oncology
David Rincon-Fernandez, Michael D. Culler, Natia Tsomaia, Gema Moreno-Bueno, Raul M. Luque, Manuel D. Gahete, Justo P. Castano