Nature's inordinate fondness for metabolic enzymes: why metabolic enzyme loci are so frequently targets of selection

The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I

(2013) Theodore A. Craig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population

(2013) Anna W. Santure et al.   MOLECULAR ECOLOGY

Effects of Temperature Variation on Male Behavior and Mating Success in a Montane Beetle

(2013) Cynthia A. Dick et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Functioning of a metabolic flux sensor in Escherichia coli

(2013) K. Kochanowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

(2013) H. P. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

(2013) Selma Masri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Availability of public goods shapes the evolution of competing metabolic strategies

(2013) H. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

(2013) J. Keith Killian et al.   Cancer Discovery

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

(2013) Giovanni Esposito et al.   PLoS Genetics

Mutations in the Isocitrate Dehydrogenase Genes IDH1 and IDH2 in Tumors

(2012) Frank G. Schaap et al.   ADVANCES IN ANATOMIC PATHOLOGY

Target metabolomics revealed complementary roles of hexose- and pentose-phosphates in the regulation of carbohydrate-dependent gene expression

(2012) Santiago Diaz-Moralli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic effects of CO2 anaesthesia in Drosophila melanogaster

(2012) H. Colinet et al.   Biology Letters

Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes

(2012) Hongpeng He et al.   BIOSCIENCE REPORTS

The functional genomics of an eco-evolutionary feedback loop: linking gene expression, trait evolution, and community dynamics

(2012) Lutz Becks et al.   ECOLOGY LETTERS

GENETIC VARIATION IN HIF SIGNALING UNDERLIES QUANTITATIVE VARIATION IN PHYSIOLOGICAL AND LIFE-HISTORY TRAITS WITHIN LOWLAND BUTTERFLY POPULATIONS

(2012) James H. Marden et al.   EVOLUTION

Elevated plasma succinate in PTEN, SDHB and SDHD mutation–positive individuals

(2012) Judith A. Hobert et al.   GENETICS IN MEDICINE

Genetic Variation in the Acorn Barnacle from Allozymes to Population Genomics

(2012) P. A. Flight et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and nonparallel physiological divergence

(2012) M. L. Evans et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Glycogen synthase kinase-3: cryoprotection and glycogen metabolism in the freeze-tolerant wood frog

(2012) C. A. Dieni et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Comparative genomics in ecological physiology: toward a more nuanced understanding of acclimation and adaptation

(2012) A. Whitehead   JOURNAL OF EXPERIMENTAL BIOLOGY

Functional Determinants of Temperature Adaptation in Enzymes of Cold- versus Warm-Adapted Mussels (Genus Mytilus)

(2012) B. L. Lockwood et al.   MOLECULAR BIOLOGY AND EVOLUTION

Differences in transcription levels among wild, domesticated, and hybrid Atlantic salmon (Salmo salar) from two environments

(2012) PAUL V. DEBES et al.   MOLECULAR ECOLOGY

Transcriptome-wide polymorphisms of red abalone (Haliotis rufescens) reveal patterns of gene flow and local adaptation

(2012) Pierre De Wit et al.   MOLECULAR ECOLOGY

Population transcriptomics of cactus host shifts inDrosophila mojavensis

(2012) LUCIANO M. MATZKIN   MOLECULAR ECOLOGY

The genomic basis of adaptive evolution in threespine sticklebacks

(2012) Felicity C. Jones et al.   NATURE

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

Hypoxia-Adaptation Involves Mitochondrial Metabolic Depression and Decreased ROS Leakage

(2012) Sameh S. Ali et al.   PLoS One

Diversifying Selection Underlies the Origin of Allozyme Polymorphism at the Phosphoglucose Isomerase Locus in Tigriopus californicus

(2012) Sean D. Schoville et al.   PLoS One

Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice

(2012) Z. A. Cheviron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions

(2012) Wojciech Rzeski et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Signaling in Control of Cell Growth and Metabolism

(2012) P. S. Ward et al.   Cold Spring Harbor Perspectives in Biology

Genome sequences of wild and domestic bactrian camels

(2012)   Nature Communications

Systematic Identification of Rhythmic Genes Reveals camk1gb as a New Element in the Circadian Clockwork

(2012) Adi Tovin et al.   PLoS Genetics

Genetic adaptation to high altitude in the Ethiopian highlands

(2012) Laura B Scheinfeldt et al.   GENOME BIOLOGY

Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release

(2011) M Fu et al.   CELL DEATH AND DIFFERENTIATION

PUMPING IONS: RAPID PARALLEL EVOLUTION OF IONIC REGULATION FOLLOWING HABITAT INVASIONS

(2011) Carol Eunmi Lee et al.   EVOLUTION

Altitudinal Variation at Duplicated β-Globin Genes in Deer Mice: Effects of Selection, Recombination, and Gene Conversion

(2011) Jay F. Storz et al.   GENETICS

The Genetic Consequences of Spatially Varying Selection in the Panmictic American Eel ( Anguilla rostrata )

(2011) Pierre-Alexandre Gagnaire et al.   GENETICS

Differential expression in RNA-seq: A matter of depth

(2011) S. Tarazona et al.   GENOME RESEARCH

Bacterial Virulence in the Moonlight: Multitasking Bacterial Moonlighting Proteins Are Virulence Determinants in Infectious Disease

(2011) Brian Henderson et al.   INFECTION AND IMMUNITY

Circadian rhythm of enolase in suprachiasmatic nucleus depends on mitochondrial function

(2011) Yoshiaki Isobe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Functional genomics of life history variation in a butterfly metapopulation

(2011) CHRISTOPHER W. WHEAT et al.   MOLECULAR ECOLOGY

Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry

(2011) Mathieu Joron et al.   NATURE

Molecular spandrels: tests of adaptation at the genetic level

(2011) Rowan D. H. Barrett et al.   NATURE REVIEWS GENETICS

Revisiting the TCA cycle: signaling to tumor formation

(2011) Nuno Raimundo et al.   TRENDS IN MOLECULAR MEDICINE

Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster

(2010) Patricia Jumbo-Lucioni et al.   BMC GENOMICS

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation

(2010) Yuji Tanaka et al.   EMBO JOURNAL

INTEGRATING EVOLUTIONARY AND FUNCTIONAL APPROACHES TO INFER ADAPTATION AT SPECIFIC LOCI

(2010) Jay F. Storz et al.   EVOLUTION

Ecological genetics and genomics of plant defences: evidence and approaches

(2010) Jill T. Anderson et al.   FUNCTIONAL ECOLOGY

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

(2010) Linda O'Flaherty et al.   HUMAN MOLECULAR GENETICS

Recombination and selection in the maintenance of the adaptive value of inversions

(2010) C. PEGUEROLES et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Lifespan and oxidative stress show a non-linear response to atmospheric oxygen in Drosophila

(2010) B. Rascon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Transcriptomic responses to heat stress in invasive and native blue mussels (genus Mytilus): molecular correlates of invasive success

(2010) B. L. Lockwood et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

(2010) Daniel A. Tennant et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

SNP signatures of selection on standing genetic variation and their association with adaptive phenotypes along gradients of ecological speciation in lake whitefish species pairs (Coregonus spp.)

(2010) SÉBASTIEN RENAUT et al.   MOLECULAR ECOLOGY

The transcriptomics of sympatric dwarf and normal lake whitefish (Coregonus clupeaformis spp., Salmonidae) divergence as revealed by next-generation sequencing

(2010) JULIE JEUKENS et al.   MOLECULAR ECOLOGY

Mining transcriptome sequences towards identifying adaptive single nucleotide polymorphisms in lake whitefish species pairs (Coregonusspp. Salmonidae)

(2010) SÉBASTIEN RENAUT et al.   MOLECULAR ECOLOGY

Towards identifying genes underlying ecologically relevant traits in Arabidopsis thaliana

(2010) Joy Bergelson et al.   NATURE REVIEWS GENETICS

On the origin of species: insights from the ecological genomics of lake whitefish

(2010) L. Bernatchez et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Adaptation genomics: the next generation

(2010) Jessica Stapley et al.   TRENDS IN ECOLOGY & EVOLUTION

Quantitative and Molecular Genetic Analyses of Mutations Increasing Drosophila Life Span

(2010) Michael M. Magwire et al.   PLoS Genetics

Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade

(2010) Simon W. Baxter et al.   PLoS Genetics

Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in Heliconius erato

(2010) Brian A. Counterman et al.   PLoS Genetics

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Oxaloacetate supplementation increases lifespan inCaenorhabditis elegansthrough an AMPK/FOXO-dependent pathway

(2009) David S. Williams et al.   AGING CELL

New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants

(2009) Jean-Francois Briat et al.   ANNALS OF BOTANY

Geographic distributions of Idh-1 alleles in a cricket are linked to differential enzyme kinetic performance across thermal environments

(2009) Diana L Huestis et al.   BMC EVOLUTIONARY BIOLOGY

Regulation of Angiogenesis by Oxygen and Metabolism

(2009) Peter Fraisl et al.   DEVELOPMENTAL CELL

The Evolution of Control and Distribution of Adaptive Mutations in a Metabolic Pathway

(2009) K. M. Wright et al.   GENETICS

Alcohol Sensitivity in Drosophila: Translational Potential of Systems Genetics

(2009) T. V. Morozova et al.   GENETICS

Tracheal remodelling in response to hypoxia

(2009) Lazaro Centanin et al.   JOURNAL OF INSECT PHYSIOLOGY

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase

(2009) Maria Fairbank et al.   Molecular BioSystems

Linking genotypes to phenotypes and fitness: how mechanistic biology can inform molecular ecology

(2009) ANNE C. DALZIEL et al.   MOLECULAR ECOLOGY

Maintenance of genetic variation in plants and pathogens involves complex networks of gene-for-gene interactions

(2009) SHARON A. HALL et al.   MOLECULAR PLANT PATHOLOGY

Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep

(2009) Susan T Harbison et al.   NATURE GENETICS

The genetics of quantitative traits: challenges and prospects

(2009) Trudy F. C. Mackay et al.   NATURE REVIEWS GENETICS

An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs

(2009) H. G. Parker et al.   SCIENCE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

The functional duality of iron regulatory protein 1

(2008) Karl Volz   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cell Autonomy of HIF Effects in Drosophila: Tracheal Cells Sense Hypoxia and Induce Terminal Branch Sprouting

(2008) Lázaro Centanin et al.   DEVELOPMENTAL CELL

The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast

(2008) E. Easlon et al.   GENES & DEVELOPMENT

Direct Evidence That Genetic Variation in Glycerol-3-Phosphate and Malate Dehydrogenase Genes (Gpdh and Mdh1) Affects Adult Ethanol Tolerance in Drosophila melanogaster

(2008) W. F. Eanes et al.   GENETICS

Fitness differences associated with Pgi SNP genotypes in the Glanville fritillary butterfly (Melitaea cinxia)

(2008) L. ORSINI et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Candidate Genes and Adaptive Radiation: Insights from Transcriptional Adaptation to the Limnetic Niche among Coregonine Fishes (Coregonus spp., Salmonidae)

(2008) J. Jeukens et al.   MOLECULAR BIOLOGY AND EVOLUTION

The transcriptomics of life-history trade-offs in whitefish species pairs (Coregonussp.)

(2008) J. ST-CYR et al.   MOLECULAR ECOLOGY

Transcriptomic variation and plasticity in rufous-collared sparrows (Zonotrichia capensis) along an altitudinal gradient

(2008) ZACHARY A. CHEVIRON et al.   MOLECULAR ECOLOGY

Genetic basis of fitness differences in natural populations

(2008) Hans Ellegren et al.   NATURE

Effects of Temperature on Physiology and Reproductive Success of a Montane Leaf Beetle: Implications for Persistence of Native Populations Enduring Climate Change

(2008) Elizabeth P. Dahlhoff et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Acetoacetate and β-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion

(2007) Michael J. MacDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nutrient Sensing by the Early Mouse Embryo: Hexosamine Biosynthesis and Glucose Signaling During Preimplantation Development1

(2007) Marie Pantaleon et al.   BIOLOGY OF REPRODUCTION