Article
Biotechnology & Applied Microbiology
Delphine Sehedic, Loris Roncali, Amel Djoudi, Nela Buchtova, Sylvie Avril, Michel Cherel, Frank Boury, Franck Lacoeuille, Francois Hindre, Emmanuel Garcion
Summary: The study investigates a novel method for the formulation of safe rapamycin nanocarriers and confirms its potential in cancer treatment. Results show that LNC-rapa selectively inhibits the mTORC1 signaling pathway in the U87MG glioblastoma model. Additionally, there are differences in the mTOR inhibition response to rapamycin under different oxygen concentration conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Immunology
Kai Yang, Shuo Xu, Hongmei Zhao, Lingshuang Liu, Xiaofang Lv, Fang Hu, Lei Wang, Qiuxia Ji
Summary: The combination of hypoxia and P. gingivalis-LPS significantly enhances the activation of the NLRP3 inflammasome in human gingival fibroblasts, leading to an inflammatory response through high levels of interleukin-1? and GSDMD-mediated pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Jessica Perochon, Yachuan Yu, Gabriel N. Aughey, Andre B. Medina, Tony D. Southall, Julia B. Cordero
Summary: In Drosophila, a previously unrecognized crosstalk between adult intestinal stem cells and the vasculature-like tracheal system has been uncovered, which is essential for intestinal regeneration. Gut-derived reactive oxygen species activate tracheal signaling pathways, leading to reversible remodeling of gut-associated terminal tracheal cells and intestinal stem cell proliferation. This inter-organ communication program is crucial for adapting the stem cell response to the proliferative demands of the intestinal epithelium.
NATURE CELL BIOLOGY
(2021)
Article
Oncology
Han Mu, Ge Yu, Huikai Li, Mengmeng Wang, Yunlong Cui, Ti Zhang, Tianqiang Song, Changfu Liu
Summary: This study aims to investigate the balance between HIF-1 alpha and HIF-2 alpha in hypoxic tumor growth, particularly in HCC. The results revealed that HIF-2 alpha expression positively correlated with c-MYC in tumor tissues, and under mild chronic hypoxia, HIF-2 alpha competed with HIF-1 alpha to bind to c-MYC. Targeting the PI3K/mTORC2/HIF-2 alpha/c-MYC axis may provide a potential treatment option for HCC patients, especially those with rapidly growing tumors under mild chronic hypoxic conditions.
Article
Multidisciplinary Sciences
Anie P. Masilamani, Rana Schulzki, Shuai Yuan, Ira Haase, Eva Kling, Franziska Dewes, Geoffroy Andrieux, Melanie Boerries, Oliver Schnell, Dieter H. Heiland, Oliver Schilling, Roberto Ferrarese, Maria S. Carro
Summary: Proteolytic cleavage is an important post-translational mechanism that enhances protein variability and functionality. In glioblastoma, the tumor suppressor gene ZBTB18 undergoes cleavage by the intracellular protease calpain, leading to the loss of its inhibitory function and activation of the HIF1A signaling pathway.
Article
Biochemistry & Molecular Biology
Deborah Fratantonio, Fabio Virgili, Alessandro Zucchi, Kate Lambrechts, Tiziana Latronico, Pierre Lafere, Peter Germonpre, Costantino Balestra
Summary: The study found that exposure to different concentrations of hyperoxia leads to activation of different oxygen-sensitive transcription factor patterns in human peripheral blood mononuclear cells. Mild hyperoxia is perceived as hypoxic stress, leading to activation of HIF-1α and NRF2, while high and very high concentrations of hyperoxia induce an oxidative stress response, characterized by activation of NRF2 and NF-κB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Liqun Jiang, Mi Zhang, Yuting Bai, Feiyan Cui, Cong Zhang, Ziyao Wang, Sujia Si, Ling Yang, Yun Wang, Yudong Zhang, Lei Li, Shuo Liu, Xiangrong Wei, Yan Wang, Ya Xu, Jian Meng
Summary: The carboxymethyl chitosan-based micelles designed in this study provide a comprehensive strategy for tumor treatment by relieving hypoxia and overexpression of HIF-1 alpha and PD-L1 in tumor, as well as inducing cytotoxicity in tumor cells through multiple mechanisms.
CARBOHYDRATE POLYMERS
(2022)
Article
Peripheral Vascular Disease
Lixin Zhang, Xilang Wang
Summary: This study revealed that LNC01136 suppresses cell growth by recruiting HIF-1α to induce BTG2 expression. The low expression of LNC01136 in human retinal microvascular endothelial cells compared to other eye-associated cells may contribute to retinal neovascularization under hypoxic conditions.
MICROVASCULAR RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Jiali Yuan, Yiqun Mo, Yuanbao Zhang, Yue Zhang, Qunwei Zhang
Summary: This study demonstrates that exposure to nickel nanoparticles can induce epithelial-mesenchymal transition (EMT) in human bronchial epithelial cells, leading to reduced histone acetylation through HIF-1 alpha-mediated HDAC3 upregulation. These findings contribute to a better understanding of the molecular mechanisms underlying nickel nanoparticle-induced fibrosis and carcinogenesis.
Article
Oncology
Shohei Matsufuji, Yoshihiko Kitajima, Kazuki Higure, Naoya Kimura, Sachiko Maeda, Kohei Yamada, Kotaro Ito, Tomokazu Tanaka, Keita Kai, Hirokazu Noshiro
Summary: Combining HIF-1 alpha inhibition with palmitic acid (PA) + L-carnitine (LC) treatment effectively induces apoptosis in hypoxic hepatocellular carcinoma (HCC) cells, providing a potential new therapeutic option for targeting hypoxic cancer cells.
CANCER & METABOLISM
(2023)
Article
Genetics & Heredity
Juan A. Sanchez, Duarte Mesquita, Maria C. Ingaramo, Federico Ariel, Marco Milan, Andres Dekanty
Review
Biochemistry & Molecular Biology
Renald Delanoue, Nuria M. Romero
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
L. Gandara, L. Durrieu, C. Behrensen, P. Wappner
SCIENTIFIC REPORTS
(2019)
Article
Developmental Biology
Jana Franziska Fuhrmann, Lorena Buono, Leonie Adelmann, Juan Ramon Martinez-Morales, Lazaro Centanin
Article
Cell Biology
Rocio de la Riva-Carrasco, Sebastian Perez-Pandolfo, Sofia Suarez Freire, Nuria M. Romero, Zambarlal Bhujabal, Terje Johansen, Pablo Wappner, Mariana Melani
Summary: Exocytosis is a fundamental physiological process for communication between cells, organs, and organisms, involving various proteins and regulators. The Drosophila transmembrane immunophilin Zonda (Zda) is a novel component of the exocytic machinery, highly expressed in secretory tissues and regulating exocytosis in multiple organs including the ring gland, insulin-producing cells, and salivary gland. The small GTPase RalA was identified as a crucial regulator of secretory granule exocytosis, required for fusion with the plasma membrane similar to Zda.
Review
Endocrinology & Metabolism
Celia G. Barredo, Beatriz Gil-Marti, Derya Deveci, Nuria M. Romero, Francisco A. Martin
Summary: Puberty and metamorphosis are two major developmental transitions associated with reproductive maturation, regulated by neuroendocrine pathways. These pathways play key roles not only in reproductive functions, but also in metabolism, sleep, and behavior. Some neuroendocrine circuits may have originated from a common bilaterian ancestor Urbilateria, leading to many conserved functions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Ayelen Valko, Sebastian Perez-Pandolfo, Eleonora Sorianello, Andreas Brech, Pablo Wappner, Mariana Melani
Summary: Hypoxia induces autophagy in Drosophila melanogaster, which is essential for adaptation and survival. The process involves a bona fide autophagic response with waves of autophagosome formation and maturation, and is induced cell autonomously in different tissues. Autophagy under hypoxic conditions can be studied using D. melanogaster as a model organism, offering insights into its role in hypoxia-associated pathologies and developmentally regulated processes.
Article
Developmental Biology
Ali Seleit, Karen Gross, Jasmin Onistschenko, Oi Pui Hoang, Jonas Theelke, Lazaro Centanin
Summary: This study investigates the establishment of sensory systems in vertebrates, focusing on the arrangement of neuromasts in the posterior lateral line system of medaka fish. The patterning in the peripheral nervous system is shown to be established independently by organ precursors, with the keratin 15 gene playing a crucial role in epithelial integrity and pLL patterning. These findings suggest that intrinsic programs are essential for proper organ morphogenesis, while interactions from surrounding tissues help accommodate sensory organs within diverse body plans among teleosts.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Ali Seleit, Satoshi Ansai, Kazunori Yamahira, Kawilarang W. A. Masengi, Kiyoshi Naruse, Lazaro Centanin
Summary: A study on 29 Oryzias species and strains reveals a rapid diversification of lateral line system within this genus, showing a strong dependence of lateral line elaboration on adult species body size. The research also suggests a polygenic control over neuromast numbers and positioning in the genus Oryzias, with differences in patterning during embryonic development and post-embryonic stages leading to diversity in lateral lines in adult fishes.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Diana-Patricia Danciu, Julian Stolper, Lazaro Centanin, Anna Marciniak-Czochra
Summary: Uncovering the number of stem cells necessary for organ growth in vertebrate systems is challenging. By developing a mathematical model characterizing stem cells in the fish gill, the study found that a reduced number of stem cells actively contribute to growing and maintaining the gills, highlighting functional heterogeneity among the stem cells involved.
Article
Biochemistry & Molecular Biology
Milton Osmar Aguilera, Esteban Robledo, Mariana Melani, Pablo Wappner, Maria Isabel Colombo
Summary: In this article, the protein FKBP38 is reported to be a novel modulator of the initial steps of the autophagic pathway, specifically in starvation-induced autophagy. FKBP38 interacts with the VPS34 lipid kinase complex, with the transmembrane domain of FKBP38 being critical for its biological function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mostafa A. Aboouf, Julia Armbruster, Markus Thiersch, Franco Guscetti, Glen Kristiansen, Peter Schraml, Anne Bicker, Ruben Petry, Thomas Hankeln, Max Gassmann, Thomas A. Gorr
Summary: The expression of myoglobin is associated with better prognosis in breast cancer patients, but its role in mammary tumorigenesis is unclear. Through CRISPR/Cas9 technology, we generated myoglobin-deficient breast cancer cell lines and found that loss of myoglobin increased cell survival and expression of cell cyclins, as well as enhanced cell migration and invasion under hypoxia. In human invasive mammary ductal carcinoma tissues, myoglobin levels were positively correlated with apoptotic markers, and myoglobin expression was associated with a positive prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Juan A. Sanchez, Maria C. Ingaramo, Maria P. Gerve, Maria G. Thomas, Graciela L. Boccaccio, Andres Dekanty
Summary: The adipose tissue plays a crucial role in metabolism, stress resistance, and longevity. The depletion of Dicer1 in the fat body leads to changes in lipid metabolism, enhanced resistance to stress, and increased lifespan. The JNK-FOXO axis controls nutrient responses in the fat body by suppressing Dicer1 expression, providing a novel understanding of physiological responses at the organismal level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Developmental Biology
Pablo Wappner, Mario Zurita
Summary: Despite being a new society, the Latin American Society for Developmental Biology (LASDB) has had a significant impact on the advancement of Developmental Biology in Latin America and globally since its establishment. By organizing congresses, courses, and fostering collaborations with prominent societies, LASDB has successfully promoted Developmental Biology beyond Latin America. Now, LASDB looks towards the future to continue supporting scientific endeavors in the region and around the world.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Maria Clara Ingaramo, Juan Andres Sanchez, Norbert Perrimon, Andres Dekanty